Abnormal MEG Oscillatory Activity during Visual Processing in the Prefrontal Cortices and Frontal Eye-Fields of the Aging HIV Brain
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{"title"=>"Abnormal MEG oscillatory activity during visual processing in the prefrontal cortices and frontal eye-fields of the aging HIV brain", "type"=>"journal", "authors"=>[{"first_name"=>"Tony W.", "last_name"=>"Wilson", "scopus_author_id"=>"34573961300"}, {"first_name"=>"Howard S.", "last_name"=>"Fox", "scopus_author_id"=>"55515957200"}, {"first_name"=>"Kevin R.", "last_name"=>"Robertson", "scopus_author_id"=>"7102891308"}, {"first_name"=>"Uriel", "last_name"=>"Sandkovsky", "scopus_author_id"=>"16176116200"}, {"first_name"=>"Jennifer", "last_name"=>"O'Neill", "scopus_author_id"=>"55754160400"}, {"first_name"=>"Elizabeth", "last_name"=>"Heinrichs-Graham", "scopus_author_id"=>"54392917700"}, {"first_name"=>"Nichole L.", "last_name"=>"Knott", "scopus_author_id"=>"54393373500"}, {"first_name"=>"Susan", "last_name"=>"Swindells", "scopus_author_id"=>"7003773038"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"23840428", "sgr"=>"84891468565", "doi"=>"10.1371/journal.pone.0066241", "scopus"=>"2-s2.0-84891468565", "pui"=>"372579986", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "issn"=>"19326203"}, "id"=>"22394432-40c8-387c-9c00-356bfdc2777b", "abstract"=>"OBJECTIVE: Shortly after infection, HIV enters the brain and causes widespread inflammation and neuronal damage, which ultimately leads to neuropsychological impairments. Despite a large body of neuroscience and imaging studies, the pathophysiology of these HIV-associated neurocognitive disorders (HAND) remains unresolved. Previous neuroimaging studies have shown greater activation in HIV-infected patients during strenuous tasks in frontal and parietal cortices, and less activation in the primary sensory cortices during rest and sensory stimulation. METHODS: High-density magnetoencephalography (MEG) was utilized to evaluate the basic neurophysiology underlying attentive, visual processing in older HIV-infected adults and a matched non-infected control group. Unlike other neuroimaging methods, MEG is a direct measure of neural activity that is not tied to brain metabolism or hemodynamic responses. During MEG, participants fixated on a centrally-presented crosshair while intermittent visual stimulation appeared in their top-right visual-field quadrant. All MEG data was imaged in the time-frequency domain using beamforming. RESULTS: Uninfected controls had increased neuronal synchronization in the 6-12 Hz range within the right dorsolateral prefrontal cortex, right frontal eye-fields, and the posterior cingulate. Conversely, HIV-infected patients exhibited decreased synchrony in these same neural regions, and the magnitude of these decreases was correlated with neuropsychological performance in several cortical association regions. CONCLUSIONS: MEG-based imaging holds potential as a noninvasive biomarker for HIV-related neuronal dysfunction, and may help identify patients who have or may develop HAND. Reduced synchronization of neural populations in the association cortices was strongly linked to cognitive dysfunction, and likely reflects the impact of HIV on neuronal and neuropsychological health.", "link"=>"http://www.mendeley.com/research/abnormal-meg-oscillatory-activity-during-visual-processing-prefrontal-cortices-frontal-eyefields-agi", "reader_count"=>20, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>3, "Student > Ph. D. Student"=>6, "Student > Master"=>5, "Other"=>2, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>3, "Student > Ph. D. Student"=>6, "Student > Master"=>5, "Other"=>2, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Engineering"=>1, "Medicine and Dentistry"=>7, "Agricultural and Biological Sciences"=>2, "Neuroscience"=>2, "Psychology"=>2, "Social Sciences"=>2}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>7}, "Neuroscience"=>{"Neuroscience"=>2}, "Social Sciences"=>{"Social Sciences"=>2}, "Psychology"=>{"Psychology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Unspecified"=>{"Unspecified"=>4}}, "group_count"=>1}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1552486"], "description"=>"<p>(A) axial images showing the maximum response in uninfected controls (top left) and HIV-infected patients (top right). Consistent with the right dorsolateral prefrontal cortex findings, HIV-infected patients exhibited significant ERD in the right FEF in response to the visual stimulation, whereas uninfected controls exhibited strong ERS that was slightly more midline focused. The rendition (bottom) shows the ERS (orange) found in controls, the ERD (blue) found in patients, and the FEF cortical region where significant group differences were found (green) superimposed on the same standardized brain. All maps have been thresholded at (p<0.01, corrected) and the images are displayed in radiological convention (R = L). The color scale bar shows t-statistical values.</p>", "links"=>[], "tags"=>["neuroscience", "Cognitive neuroscience", "cognition", "Sensory systems", "Visual system", "neuroimaging", "neurophysiology", "neuropsychology", "Anatomy and physiology", "Physiological processes", "aging", "Diagnostic medicine", "Clinical neurophysiology", "electroencephalography", "pathology", "General pathology", "biomarkers", "Infectious diseases", "Viral diseases", "hiv", "Mental health", "psychology", "Cognitive psychology", "neurology", "Cognitive neurology", "dementia", "responses", "frontal", "eye-fields"], "article_id"=>1072588, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Tony W. Wilson", "Howard S. Fox", "Kevin R. Robertson", "Uriel Sandkovsky", "Jennifer O’Neill", "Elizabeth Heinrichs-Graham", "Nichole L. Knott", "Susan Swindells"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0066241.g003", "stats"=>{"downloads"=>1, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_MEG_Responses_in_the_Frontal_Eye_Fields_FEF_/1072588", "title"=>"MEG Responses in the Frontal Eye-Fields (FEF).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-20 09:51:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/1552478"], "description"=>"<p>Time (in ms) is denoted on the x-axis, with 0 ms defined as the onset of visual stimulation and the baseline being the −400 to 0 ms time period. Frequency (in Hz) is shown on the y-axis. The average spectra for a MEG gradiometer in the right frontal area, expressed as percent difference from baseline (scale bar appears on far right side), are shown for un-infected participants on the left and for HIV-infected patients on the right. The early 6–12 Hz synchronization can be easily discerned in controls, whereas patients exhibited a slight desynchronization during this time period. In contrast, after 300 ms both groups exhibited desynchronization in the 6–12 Hz range, with HIV-infected patients showing a slightly stronger desynchronization on average, although this response was highly variable across participants and did not approach significance.</p>", "links"=>[], "tags"=>["neuroscience", "Cognitive neuroscience", "cognition", "Sensory systems", "Visual system", "neuroimaging", "neurophysiology", "neuropsychology", "Anatomy and physiology", "Physiological processes", "aging", "Diagnostic medicine", "Clinical neurophysiology", "electroencephalography", "pathology", "General pathology", "biomarkers", "Infectious diseases", "Viral diseases", "hiv", "Mental health", "psychology", "Cognitive psychology", "neurology", "Cognitive neurology", "dementia", "time-frequency", "spectra", "un-infected", "controls", "hiv-infected"], "article_id"=>1072580, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Tony W. Wilson", "Howard S. Fox", "Kevin R. Robertson", "Uriel Sandkovsky", "Jennifer O’Neill", "Elizabeth Heinrichs-Graham", "Nichole L. Knott", "Susan Swindells"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0066241.g001", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Average_Time_Frequency_Spectra_in_Un_Infected_Controls_and_HIV_Infected_Patients_/1072580", "title"=>"Average Time-Frequency Spectra in Un-Infected Controls and HIV-Infected Patients.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-20 09:51:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/1552481"], "description"=>"<p>(A) Group statistical maps (p<0.01) show strong ERS responses in the right DLPFC of uninfected controls (top row) and strong ERD activity in the same neural regions of HIV-infected patients (bottom row). Thus, visual stimulation elicited activity in opposite directions within the DLPFC and other regions of patients and controls. Color scale bars indicate t-statistical values. (B) A -rendition showing neural regions where significant (p<0.01, corrected) group differences were detected during visual processing. As shown, HIV-infected patients exhibited strong reductions in neuronal responses between 6–12 Hz in the right DLPFC, right frontal eye fields (not shown), and a small area of the inferior posterior cingulate. All images are shown in radiological convention (R = L). Blue: ERD, Orange: ERS.</p>", "links"=>[], "tags"=>["neuroscience", "Cognitive neuroscience", "cognition", "Sensory systems", "Visual system", "neuroimaging", "neurophysiology", "neuropsychology", "Anatomy and physiology", "Physiological processes", "aging", "Diagnostic medicine", "Clinical neurophysiology", "electroencephalography", "pathology", "General pathology", "biomarkers", "Infectious diseases", "Viral diseases", "hiv", "Mental health", "psychology", "Cognitive psychology", "neurology", "Cognitive neurology", "dementia", "prefrontal", "cortex"], "article_id"=>1072583, "categories"=>["Biological Sciences", "Medicine"], "users"=>["Tony W. Wilson", "Howard S. Fox", "Kevin R. Robertson", "Uriel Sandkovsky", "Jennifer O’Neill", "Elizabeth Heinrichs-Graham", "Nichole L. Knott", "Susan Swindells"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0066241.g002", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Dorsolateral_Prefrontal_Cortex_DLPFC_Activity_during_Visual_Processing_/1072583", "title"=>"Dorsolateral Prefrontal Cortex (DLPFC) Activity during Visual Processing.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-20 09:51:53"}

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Relative Metric

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