Carvedilol Decrease IL-1β and TNF-α, Inhibits MMP-2, MMP-9, COX-2, and RANKL Expression, and Up-Regulates OPG in a Rat Model of Periodontitis
Publication Date
July 03, 2013
Journal
PLOS ONE
Authors
Raimundo Fernandes De Araújo Júnior, Tatiana Oliveira Souza, Caroline Addison Xavier De Medeiros, Lélia Batista De Souza, et al
Volume
8
Issue
7
Pages
e66391
DOI
https://dx.plos.org/10.1371/journal.pone.0066391
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0066391
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/23843954
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700994
Europe PMC
http://europepmc.org/abstract/MED/23843954
Web of Science
000321733000047
Scopus
84879772484
Mendeley
http://www.mendeley.com/research/carvedilol-decrease-il1%CE%B2-tnf%CE%B1-inhibits-mmp2-mmp9-cox2-rankl-expression-upregulates-opg-rat-model-per
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Mendeley | Further Information

{"title"=>"Carvedilol Decrease IL-1β and TNF-α, Inhibits MMP-2, MMP-9, COX-2, and RANKL Expression, and Up-Regulates OPG in a Rat Model of Periodontitis", "type"=>"journal", "authors"=>[{"first_name"=>"Raimundo Fernandes", "last_name"=>"de Araújo Júnior", "scopus_author_id"=>"30867511400"}, {"first_name"=>"Tatiana Oliveira", "last_name"=>"Souza", "scopus_author_id"=>"55762320200"}, {"first_name"=>"Caroline Addison Xavier", "last_name"=>"de Medeiros", "scopus_author_id"=>"56176879000"}, {"first_name"=>"Lélia Batista", "last_name"=>"de Souza", "scopus_author_id"=>"9733179300"}, {"first_name"=>"Maria Lourdes", "last_name"=>"de Freitas", "scopus_author_id"=>"50061068500"}, {"first_name"=>"Hévio Freitas", "last_name"=>"de Lucena", "scopus_author_id"=>"25722001500"}, {"first_name"=>"Maria", "last_name"=>"do Socorro Costa Feitosa Alves", "scopus_author_id"=>"25635174900"}, {"first_name"=>"Aurigena Antunes", "last_name"=>"de Araújo", "scopus_author_id"=>"37022977400"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"23843954", "sgr"=>"84879772484", "doi"=>"10.1371/journal.pone.0066391", "scopus"=>"2-s2.0-84879772484", "pui"=>"369253412", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "issn"=>"19326203"}, "id"=>"7dcc9c8c-e1c7-3c57-b24a-d58a19c65640", "abstract"=>"Periodontal diseases are initiated primarily by Gram-negative, tooth-associated microbial biofilms that elicit a host response that causes osseous and soft tissue destruction. Carvedilol is a β-blocker used as a multifunctional neurohormonal antagonist that has been shown to act not only as an anti-oxidant but also as an anti-inflammatory drug. This study evaluated whether Carvedilol exerted a protective role against ligature-induced periodontitis in a rat model and defined how Carvedilol affected metalloproteinases and RANKL/RANK/OPG expression in the context of bone remodeling. Rats were randomly divided into 5 groups (n = 10/group): (1) non-ligated (NL), (2) ligature-only (LO), and (3) ligature plus Carvedilol (1, 5 or 10 mg/kg daily for 10 days). Periodontal tissue was analyzed for histopathlogy and using immunohistochemical analysis characterized the expression profiles of MMP-2, MMP-9, COX-2, and RANKL/RANK/OPG and determined the presence of IL-1β, IL-10 and TNF-α, myeloperoxidase (MPO), malonaldehyde (MDA) and, glutathione (GSH). MPO activity in the group with periodontal disease was significantly increased compared to the control group (p<0.05). Rats treated with 10 mg/kg Carvedilol presented with significantly reduced MPO and MDA concentrations (p<0.05) in addition to presenting with reduced levels of the pro-inflammatory cytokines IL-1 β and TNF-α (p<0.05). IL-10 levels in Carvedilol-treated rats remained unaltered. Immunohistochemical analysis demonstrated reduced expression of MMP-2, MMP-9, RANK, RANKL, COX-2, and OPG in rats treated with 10 mg/kg Carvedilol. This study demonstrated that Carvedilol affected bone formation/destruction and anti-inflammatory activity in a rat model of periodontitis.", "link"=>"http://www.mendeley.com/research/carvedilol-decrease-il1%CE%B2-tnf%CE%B1-inhibits-mmp2-mmp9-cox2-rankl-expression-upregulates-opg-rat-model-per", "reader_count"=>17, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>3, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>1, "Other"=>2, "Student > Bachelor"=>5, "Professor"=>2}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>3, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>1, "Other"=>2, "Student > Bachelor"=>5, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>2, "Medicine and Dentistry"=>6, "Agricultural and Biological Sciences"=>3, "Neuroscience"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>6}, "Neuroscience"=>{"Neuroscience"=>1}, "Social Sciences"=>{"Social Sciences"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>3}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Brazil"=>2}, "group_count"=>0}

Scopus | Further Information

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PMC Usage Stats | Further Information

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Relative Metric

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