Tectorigenin Attenuates Palmitate-Induced Endothelial Insulin Resistance via Targeting ROS-Associated Inflammation and IRS-1 Pathway
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{"title"=>"Tectorigenin Attenuates Palmitate-Induced Endothelial Insulin Resistance via Targeting ROS-Associated Inflammation and IRS-1 Pathway", "type"=>"journal", "authors"=>[{"first_name"=>"Qi", "last_name"=>"Wang", "scopus_author_id"=>"57069193900"}, {"first_name"=>"Xiao Lan", "last_name"=>"Cheng", "scopus_author_id"=>"24484644300"}, {"first_name"=>"Dong Yan", "last_name"=>"Zhang", "scopus_author_id"=>"55567188600"}, {"first_name"=>"Xue Jiao", "last_name"=>"Gao", "scopus_author_id"=>"55840776900"}, {"first_name"=>"Ling", "last_name"=>"Zhou", "scopus_author_id"=>"55487971300"}, {"first_name"=>"Xiao Ying", "last_name"=>"Qin", "scopus_author_id"=>"37021802300"}, {"first_name"=>"Guo Yong", "last_name"=>"Xie", "scopus_author_id"=>"36954745100"}, {"first_name"=>"Kang", "last_name"=>"Liu", "scopus_author_id"=>"8936012300"}, {"first_name"=>"Yong", "last_name"=>"Qin", "scopus_author_id"=>"57196017972"}, {"first_name"=>"Bao Lin", "last_name"=>"Liu", "scopus_author_id"=>"55720718000"}, {"first_name"=>"Min Jian", "last_name"=>"Qin", "scopus_author_id"=>"34870708800"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84879229420", "pmid"=>"23840461", "doi"=>"10.1371/journal.pone.0066417", "pui"=>"369155296", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "sgr"=>"84879229420"}, "id"=>"664e1995-7450-3081-8499-02c2b2ba5876", "abstract"=>"Tectorigenin is a plant isoflavonoid originally isolated from the dried flower of Pueraria thomsonii Benth. Although its anti-inflammatory and anti-hyperglycosemia effects have been well documented, the effect of tectorigenin on endothelial dysfunction insulin resistance involved has not yet been reported. Herein, this study aims to investigate the action of tectorigenin on amelioration of insulin resistance in the endothelium. Palmitic acid (PA) was chosen as a stimulant to induce ROS production in endothelial cells and successfully established insulin resistance evidenced by the specific impairment of insulin PI3K signaling. Tectorigenin effectively inhibited the ability of PA to induce the production of reactive oxygen species and collapse of mitochondrial membrane potential. Moreover, tectorigenin presented strong inhibition effect on ROS-associated inflammation, as TNF-alpha and IL-6 production in endothelial cells was greatly reduced with suppression of IKKbeta/NF-kappaB phosphorylation and JNK activation. Tectorigenin also can inhibit inflammation-stimulated IRS-1 serine phosphorylation and restore the impaired insulin PI3K signaling, leading to a decreased NO production. These results demonstrated its positive regulation of insulin action in the endothelium. Meanwhile, tectorigenin down-regulated endothelin-1 and vascular cell adhesion molecule-1 overexpression, and restored the loss of insulin-mediated vasodilation in rat aorta. These findings suggested that tectorigenin could inhibit ROS-associated inflammation and ameliorated endothelial dysfunction implicated in insulin resistance through regulating IRS-1 function. Tectorigenin might have potential to be applied for the management of cardiovascular diseases involved in diabetes and insulin resistance.", "link"=>"http://www.mendeley.com/research/tectorigenin-attenuates-palmitateinduced-endothelial-insulin-resistance-via-targeting-rosassociated", "reader_count"=>10, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Student > Ph. D. Student"=>4, "Student > Master"=>2, "Lecturer"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Student > Ph. D. Student"=>4, "Student > Master"=>2, "Lecturer"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>3, "Medicine and Dentistry"=>2, "Neuroscience"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Neuroscience"=>{"Neuroscience"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>2}}, "reader_count_by_country"=>{"China"=>1}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1092928"], "description"=>"<p>Cells were pretreated with tectorigenin (0.1, 1, 10 μM) or GSH for 30 min, and then stimulated without or with PA (100 μM) for an additional 30 min. The blank was treated with an equal amount of the vehicle (medium containing 0.1% DMSO and 10% BSA). Fluorescence images were shown by using a fluorescence microscope, and the intensity of red fluorescence is used to assess Δψm.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Endocrine system", "Endocrine physiology", "insulin", "immunology", "immunity", "inflammation", "Model organisms", "Animal models", "rat", "Molecular cell biology", "Cellular types", "Endothelial cells", "Plant science", "plants", "flowers", "cardiovascular", "Complementary and alternative medicine", "Endocrinology", "Metabolic disorders", "reversed", "pa-induced", "mitochondrial", "membrane"], "article_id"=>725045, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Qi Wang", "Xiao-Lan Cheng", "Dong-Yan Zhang", "Xue-Jiao Gao", "Ling Zhou", "Xiao-Ying Qin", "Guo-Yong Xie", "Kang Liu", "Yong Qin", "Bao-Lin Liu", "Min-Jian Qin"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0066417.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Tectorigenin_reversed_PA_induced_collapse_of_mitochondrial_membrane_potential_916_968_m_in_HUVECs_/725045", "title"=>"Tectorigenin reversed PA-induced collapse of mitochondrial membrane potential (Δψm) in HUVECs.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-19 01:24:05"}
  • {"files"=>["https://ndownloader.figshare.com/files/1092929"], "description"=>"<p>(A–C): Cells were incubated with tectorigenin (0.1, 1, 10 μM), salicylate or GSH for 30 min, then stimulated without or with PA (100 μM) for 30 min. IKKβ (A), P65 (B) and JNK (C) phosphorylation were analyzed by Western blot. Salicylate and GSH were used as positive controls. The blank was treated with an equal amount of the vehicle (medium containing 0.1% DMSO and 10% BSA). The results were expressed as mean ± SD (<i>n</i> = 3). * p<0.05 vs control group.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Endocrine system", "Endocrine physiology", "insulin", "immunology", "immunity", "inflammation", "Model organisms", "Animal models", "rat", "Molecular cell biology", "Cellular types", "Endothelial cells", "Plant science", "plants", "flowers", "cardiovascular", "Complementary and alternative medicine", "Endocrinology", "Metabolic disorders", "inhibited", "pa-treated"], "article_id"=>725046, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Qi Wang", "Xiao-Lan Cheng", "Dong-Yan Zhang", "Xue-Jiao Gao", "Ling Zhou", "Xiao-Ying Qin", "Guo-Yong Xie", "Kang Liu", "Yong Qin", "Bao-Lin Liu", "Min-Jian Qin"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0066417.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Tectorigenin_inhibited_IKK_946_NF_954_B_JNK_signaling_in_PA_treated_HUVECs_/725046", "title"=>"Tectorigenin inhibited IKKβ/NF-κB/JNK signaling in PA-treated HUVECs.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-19 01:24:06"}
  • {"files"=>["https://ndownloader.figshare.com/files/1092931"], "description"=>"<p>HUVECs were pretreated with tectorigenin, salicylate for 30 min, and then incubated with PA (100 μM) for 12 h. The concentrations of TNF-α and IL-6 in the conditioned medium were measured with ELISA Kits. Salicylate was taken as positive control. The blank group was treated with an equal amount of the vehicle (medium containing 0.1% DMSO and 10% BSA). The results were expressed as the mean ± SD (<i>n</i> = 3). * p<0.05 vs control group.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Endocrine system", "Endocrine physiology", "insulin", "immunology", "immunity", "inflammation", "Model organisms", "Animal models", "rat", "Molecular cell biology", "Cellular types", "Endothelial cells", "Plant science", "plants", "flowers", "cardiovascular", "Complementary and alternative medicine", "Endocrinology", "Metabolic disorders", "inhibited", "il-6", "pa-", "stimulated"], "article_id"=>725048, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Qi Wang", "Xiao-Lan Cheng", "Dong-Yan Zhang", "Xue-Jiao Gao", "Ling Zhou", "Xiao-Ying Qin", "Guo-Yong Xie", "Kang Liu", "Yong Qin", "Bao-Lin Liu", "Min-Jian Qin"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0066417.g004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Tectorigenin_inhibited_IL_6_and_TNF_945_production_in_PA_stimulated_HUVECs_/725048", "title"=>"Tectorigenin inhibited IL-6 and TNF-α production in PA- stimulated HUVECs.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-19 01:24:08"}
  • {"files"=>["https://ndownloader.figshare.com/files/1092932"], "description"=>"<p>Cells were incubated with tectorigenin, salicylate or GSH for 30 min, and then stimulated without or with PA (100 μM) for 30 min. (A): Serine (S307) phosphorylation of IRS-1 was assayed by Western blot; (B): After stimulated with PA, HUVECs were then treated with insulin (100 nM) for 20 min. Tyrosine phosphorylation of IRS-1(detected by PY99 antibody) was then determined by Western blot. Salicylate and GSH were taken as positive controls. The blank was treated with an equal amount of the vehicle (medium containing 0.1% DMSO and 10% BSA). The results were expressed as mean ± SD of three independent experiments. * p<0.05 vs control group.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Endocrine system", "Endocrine physiology", "insulin", "immunology", "immunity", "inflammation", "Model organisms", "Animal models", "rat", "Molecular cell biology", "Cellular types", "Endothelial cells", "Plant science", "plants", "flowers", "cardiovascular", "Complementary and alternative medicine", "Endocrinology", "Metabolic disorders", "modulated", "irs-1", "phosphorylation", "pa-treated"], "article_id"=>725049, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Qi Wang", "Xiao-Lan Cheng", "Dong-Yan Zhang", "Xue-Jiao Gao", "Ling Zhou", "Xiao-Ying Qin", "Guo-Yong Xie", "Kang Liu", "Yong Qin", "Bao-Lin Liu", "Min-Jian Qin"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0066417.g005"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Tectorigenin_modulated_IRS_1_serine_tyrosine_phosphorylation_in_PA_treated_HUVECs_/725049", "title"=>"Tectorigenin modulated IRS-1 serine/tyrosine phosphorylation in PA-treated HUVECs.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-19 01:24:09"}
  • {"files"=>["https://ndownloader.figshare.com/files/1092934"], "description"=>"<p>(A–B): HUVECs were pretreated with tectorigenin, salicylate or GSH for 30 min, and then co-incubated with 100 μM PA for 30 min. After addition of insulin (100 nM) for 20 min, p-Akt (A) and p-eNOS (B) was determined by Western blot. The results were presented as mean ± SD of three independent experiments. * p<0.05 vs control group. (C) HUVECs were pretreated with tectorigenin or salicylate for 30 min, then incubated with 100 μM PA for another 30 min, followed by insulin (100 nM) stimulation for 5 min. Intracellular NO production was tested with fluorescence microscopy.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Endocrine system", "Endocrine physiology", "insulin", "immunology", "immunity", "inflammation", "Model organisms", "Animal models", "rat", "Molecular cell biology", "Cellular types", "Endothelial cells", "Plant science", "plants", "flowers", "cardiovascular", "Complementary and alternative medicine", "Endocrinology", "Metabolic disorders", "tectorigenin", "insulin-mediated", "akt", "enos", "phosphorylation"], "article_id"=>725051, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Qi Wang", "Xiao-Lan Cheng", "Dong-Yan Zhang", "Xue-Jiao Gao", "Ling Zhou", "Xiao-Ying Qin", "Guo-Yong Xie", "Kang Liu", "Yong Qin", "Bao-Lin Liu", "Min-Jian Qin"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0066417.g006"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_effects_of_tectorigenin_on_insulin_mediated_Akt_and_eNOS_phosphorylation_and_NO_production_in_HUVECs_/725051", "title"=>"The effects of tectorigenin on insulin-mediated Akt and eNOS phosphorylation and NO production in HUVECs.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-19 01:24:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/1092936"], "description"=>"<p>HUVECs were pretreated with tectorigenin, PD98059 or wortmannin (Wort) for 0.5 h and incubated with PA (100 μM) for another 2 h. Then cells were stimulated with or without insulin (0.1 μM) for 20 min. ET-1 (A) and VCAM-1 (B) mRNA expression was detected by RT-PCR. Salicylate was taken as a positive control. The results were expressed as the mean±SD of three independent experiments. <sup>#</sup><i>p</i><0.05 vs. blank 2 (Bla2); * <i>p</i><.05 vs. control 2 (Cont2).</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Endocrine system", "Endocrine physiology", "insulin", "immunology", "immunity", "inflammation", "Model organisms", "Animal models", "rat", "Molecular cell biology", "Cellular types", "Endothelial cells", "Plant science", "plants", "flowers", "cardiovascular", "Complementary and alternative medicine", "Endocrinology", "Metabolic disorders", "reduced", "et-1", "vcam-1", "pa-stimulated", "endothelial"], "article_id"=>725053, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Qi Wang", "Xiao-Lan Cheng", "Dong-Yan Zhang", "Xue-Jiao Gao", "Ling Zhou", "Xiao-Ying Qin", "Guo-Yong Xie", "Kang Liu", "Yong Qin", "Bao-Lin Liu", "Min-Jian Qin"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0066417.g007"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Tectorigenin_reduced_ET_1_and_VCAM_1_expression_in_PA_stimulated_endothelial_cells_/725053", "title"=>"Tectorigenin reduced ET-1 and VCAM-1 expression in PA-stimulated endothelial cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-19 01:24:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/1092938"], "description"=>"<p>The aortic ring was pretreated with tectorigenin or salicylate for 30 min, then stimulated with PA (100 μM) for 30 min. After washing out of tectorigenin and PA, the aortic ring was pre-contracted with phenylephrine (10<sup>−6</sup> M), and then the relaxation was induced by insulin treatment. Salicylate was used as a positive control. The blank was treated with an equal amount of the vehicle (medium containing 0.1% DMSO and 10% BSA). The results were expressed as the mean±SD (<i>n</i> = 4).</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Endocrine system", "Endocrine physiology", "insulin", "immunology", "immunity", "inflammation", "Model organisms", "Animal models", "rat", "Molecular cell biology", "Cellular types", "Endothelial cells", "Plant science", "plants", "flowers", "cardiovascular", "Complementary and alternative medicine", "Endocrinology", "Metabolic disorders", "restored", "pa-induced", "endothelium-dependent", "relaxation"], "article_id"=>725055, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Qi Wang", "Xiao-Lan Cheng", "Dong-Yan Zhang", "Xue-Jiao Gao", "Ling Zhou", "Xiao-Ying Qin", "Guo-Yong Xie", "Kang Liu", "Yong Qin", "Bao-Lin Liu", "Min-Jian Qin"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0066417.g008"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Tectorigenin_restored_PA_induced_loss_of_endothelium_dependent_vessel_relaxation_in_the_rat_aorta_/725055", "title"=>"Tectorigenin restored PA-induced loss of endothelium-dependent vessel relaxation in the rat aorta.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-19 01:24:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/1092939"], "description"=>"<p>Schematic representation of the effects of tectorigenin to block hyperglycaemia-induced vascular endothelial dysfunction.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Endocrine system", "Endocrine physiology", "insulin", "immunology", "immunity", "inflammation", "Model organisms", "Animal models", "rat", "Molecular cell biology", "Cellular types", "Endothelial cells", "Plant science", "plants", "flowers", "cardiovascular", "Complementary and alternative medicine", "Endocrinology", "Metabolic disorders", "tectorigenin", "hyperglycaemia-induced", "vascular", "endothelial"], "article_id"=>725056, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Qi Wang", "Xiao-Lan Cheng", "Dong-Yan Zhang", "Xue-Jiao Gao", "Ling Zhou", "Xiao-Ying Qin", "Guo-Yong Xie", "Kang Liu", "Yong Qin", "Bao-Lin Liu", "Min-Jian Qin"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0066417.g009"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Schematic_representation_of_the_effects_of_tectorigenin_to_block_hyperglycaemia_induced_vascular_endothelial_dysfunction_/725056", "title"=>"Schematic representation of the effects of tectorigenin to block hyperglycaemia-induced vascular endothelial dysfunction.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-19 01:24:16"}

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Relative Metric

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