Antidepressant Utilization and Suicide in Europe: An Ecological Multi-National Study
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{"title"=>"Antidepressant Utilization and Suicide in Europe: An Ecological Multi-National Study", "type"=>"journal", "authors"=>[{"first_name"=>"Ricardo", "last_name"=>"Gusmão", "scopus_author_id"=>"24331260700"}, {"first_name"=>"Sónia", "last_name"=>"Quintão", "scopus_author_id"=>"55371176700"}, {"first_name"=>"David", "last_name"=>"McDaid", "scopus_author_id"=>"6603668364"}, {"first_name"=>"Ella", "last_name"=>"Arensman", "scopus_author_id"=>"6603445271"}, {"first_name"=>"Chantal", "last_name"=>"Van Audenhove", "scopus_author_id"=>"55901763400"}, {"first_name"=>"Claire", "last_name"=>"Coffey", "scopus_author_id"=>"36022023200"}, {"first_name"=>"Airi", "last_name"=>"Värnik", "scopus_author_id"=>"55888321300"}, {"first_name"=>"Peeter", "last_name"=>"Värnik", "scopus_author_id"=>"36021912700"}, {"first_name"=>"James", "last_name"=>"Coyne", "scopus_author_id"=>"26643586400"}, {"first_name"=>"Ulrich", "last_name"=>"Hegerl", "scopus_author_id"=>"7005991260"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84879210440", "pui"=>"369155286", "sgr"=>"84879210440", "issn"=>"19326203", "pmid"=>"23840475", "doi"=>"10.1371/journal.pone.0066455"}, "id"=>"32192b08-47e3-3acf-a80a-363ff1975fed", "abstract"=>"BackgroundResearch concerning the association between use of antidepressants and incidence of suicide has yielded inconsistent results and is the subject of considerable controversy. The first aim is to describe trends in the use of antidepressants and rates of suicide in Europe, adjusted for gross domestic product, alcohol consumption, unemployment, and divorce. The second aim is to explore if any observed reduction in the rate of suicide in different European countries preceded the trend for increased use of antidepressants.MethodsData were obtained for 29 European countries between 1980 and 2009. Pearson correlations were used to explore the direction and magnitude of associations. Generalized linear mixed models and Poisson regression distribution were used to clarify the effects of antidepressants on suicide rates, while an autoregressive adjusted model was used to test the interaction between antidepressant utilization and suicide over two time periods: 1980–1994 and 1995–2009.FindingsAn inverse correlation was observed in all countries between recorded Standardised Death Rate (SDR) for suicide and antidepressant Defined Daily Dosage (DDD), with the exception of Portugal. Variability was marked in the association between suicide and alcohol, unemployment and divorce, with countries depicting either a positive or a negative correlation with the SDR for suicide. Every unit increase in DDD of an antidepressant per 1000 people per day, adjusted for these confounding factors, reduces the SDR by 0.088. The correlation between DDD and suicide related SDR was negative in both time periods considered, albeit more pronounced between 1980 and 1994.ConclusionsSuicide rates have tended to decrease more in European countries where there has been a greater increase in the use of antidepressants. These findings underline the importance of the appropriate use of antidepressants as part of routine care for people diagnosed with depression, therefore reducing the risk of suicide.", "link"=>"http://www.mendeley.com/research/antidepressant-utilization-suicide-europe-ecological-multinational-study", "reader_count"=>91, "reader_count_by_academic_status"=>{"Unspecified"=>4, "Professor > Associate Professor"=>7, "Librarian"=>4, "Student > Doctoral Student"=>12, "Researcher"=>14, "Student > Ph. D. 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  • {"files"=>["https://ndownloader.figshare.com/files/1093643"], "description"=>"<p>Suicide and use of antidepressants, by country, more than 19 years of simultaneous data (P<sub>>75</sub>).</p>", "links"=>[], "tags"=>["Clinical research design", "epidemiology", "Pharmacoepidemiology", "Mental health", "psychiatry", "Mood disorders", "therapies", "Drug psychotherapy", "Public health", "Drug policy", "Sociology", "suicide", "19", "years", "simultaneous"], "article_id"=>725654, "categories"=>["Medicine", "Sociology"], "users"=>["Ricardo Gusmão", "Sónia Quintão", "David McDaid", "Ella Arensman", "Chantal Van Audenhove", "Claire Coffey", "Airi Värnik", "Peeter Värnik", "James Coyne", "Ulrich Hegerl"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0066455.g001", "stats"=>{"downloads"=>5, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Suicide_and_use_of_antidepressants_by_country_more_than_19_years_of_simultaneous_data_P_gt_75_/725654", "title"=>"Suicide and use of antidepressants, by country, more than 19 years of simultaneous data (P<sub>>75</sub>).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-19 01:34:14"}
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  • {"files"=>["https://ndownloader.figshare.com/files/1093647"], "description"=>"<p>Suicide and use of antidepressants, by country, 7 to 14 years of simultaneous data (P<sub>25–50</sub>).</p>", "links"=>[], "tags"=>["Clinical research design", "epidemiology", "Pharmacoepidemiology", "Mental health", "psychiatry", "Mood disorders", "therapies", "Drug psychotherapy", "Public health", "Drug policy", "Sociology", "suicide", "14", "years", "simultaneous"], "article_id"=>725658, "categories"=>["Medicine", "Sociology"], "users"=>["Ricardo Gusmão", "Sónia Quintão", "David McDaid", "Ella Arensman", "Chantal Van Audenhove", "Claire Coffey", "Airi Värnik", "Peeter Värnik", "James Coyne", "Ulrich Hegerl"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0066455.g003", "stats"=>{"downloads"=>2, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Suicide_and_use_of_antidepressants_by_country_7_to_14_years_of_simultaneous_data_P_25_8211_50_/725658", "title"=>"Suicide and use of antidepressants, by country, 7 to 14 years of simultaneous data (P<sub>25–50</sub>).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-19 01:34:18"}
  • {"files"=>["https://ndownloader.figshare.com/files/1093648"], "description"=>"<p>Suicide and use of antidepressants, by country, 6 or less years of simultaneous data (P<sub><25</sub>).</p>", "links"=>[], "tags"=>["Clinical research design", "epidemiology", "Pharmacoepidemiology", "Mental health", "psychiatry", "Mood disorders", "therapies", "Drug psychotherapy", "Public health", "Drug policy", "Sociology", "suicide", "years", "simultaneous"], "article_id"=>725659, "categories"=>["Medicine", "Sociology"], "users"=>["Ricardo Gusmão", "Sónia Quintão", "David McDaid", "Ella Arensman", "Chantal Van Audenhove", "Claire Coffey", "Airi Värnik", "Peeter Värnik", "James Coyne", "Ulrich Hegerl"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0066455.g004", "stats"=>{"downloads"=>2, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Suicide_and_use_of_antidepressants_by_country_6_or_less_years_of_simultaneous_data_P_lt_25_/725659", "title"=>"Suicide and use of antidepressants, by country, 6 or less years of simultaneous data (P<sub><25</sub>).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-19 01:34:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/1093649"], "description"=>"***<p>p≤.001.</p>", "links"=>[], "tags"=>["Clinical research design", "epidemiology", "Pharmacoepidemiology", "Mental health", "psychiatry", "Mood disorders", "therapies", "Drug psychotherapy", "Public health", "Drug policy", "Sociology", "suicide", "correlations", "5-years", "means", "sdr", "deaths", "quartiles", "countries", "years", "simultaneous"], "article_id"=>725660, "categories"=>["Medicine", "Sociology"], "users"=>["Ricardo Gusmão", "Sónia Quintão", "David McDaid", "Ella Arensman", "Chantal Van Audenhove", "Claire Coffey", "Airi Värnik", "Peeter Värnik", "James Coyne", "Ulrich Hegerl"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0066455.t002", "stats"=>{"downloads"=>5, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Pearson_correlations_between_last_5_years_means_of_DDD_1000_day_and_SDR_suicide_million_population_and_number_of_suicide_deaths_within_quartiles_of_countries_by_years_of_SDR_suicide_and_DDD_1000_d_simultaneous_data_/725660", "title"=>"Pearson correlations between last 5-years means of DDD/1000/day and SDR suicide, million population and number of suicide deaths within quartiles of countries by years of SDR suicide and DDD/1000/d simultaneous data.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-06-19 01:34:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/1093650"], "description"=>"<p>Magnitude of correlations between suicide SDR and antidepressant utilization and potentially confounding variables.</p>", "links"=>[], "tags"=>["Clinical research design", "epidemiology", "Pharmacoepidemiology", "Mental health", "psychiatry", "Mood disorders", "therapies", "Drug psychotherapy", "Public health", "Drug policy", "Sociology", "suicide", "correlations", "sdr", "antidepressant", "confounding"], "article_id"=>725661, "categories"=>["Medicine", "Sociology"], "users"=>["Ricardo Gusmão", "Sónia Quintão", "David McDaid", "Ella Arensman", "Chantal Van Audenhove", "Claire Coffey", "Airi Värnik", "Peeter Värnik", "James Coyne", "Ulrich Hegerl"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0066455.t003", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Magnitude_of_correlations_between_suicide_SDR_and_antidepressant_utilization_and_potentially_confounding_variables_/725661", "title"=>"Magnitude of correlations between suicide SDR and antidepressant utilization and potentially confounding variables.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-06-19 01:34:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/1093651"], "description"=>"<p>For some countries, data is missing for some years:</p>1<p>Belgium, years 2000 until 2003;</p>2<p>Estonia, years 1983 and 1984;</p>3<p>Italy, years 2004 and 2005;</p>4<p>Lithuania, years 1983 and 1984; and <sup>5</sup>Poland, years 1997 and 1998 (SDR suicide, all);</p>6<p>Hungary, years 1992 and 1994 (DDD/1000/day).</p>*<p>mean weighted by number of years of data available.</p>", "links"=>[], "tags"=>["Clinical research design", "epidemiology", "Pharmacoepidemiology", "Mental health", "psychiatry", "Mood disorders", "therapies", "Drug psychotherapy", "Public health", "Drug policy", "Sociology", "suicide", "n06", "antidepressant", "1000", "inhabitants", "registered", "rates"], "article_id"=>725662, "categories"=>["Medicine", "Sociology"], "users"=>["Ricardo Gusmão", "Sónia Quintão", "David McDaid", "Ella Arensman", "Chantal Van Audenhove", "Claire Coffey", "Airi Värnik", "Peeter Värnik", "James Coyne", "Ulrich Hegerl"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0066455.t001", "stats"=>{"downloads"=>7, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_ATC_N06_antidepressant_utilization_DDD_per_1000_inhabitants_per_day_and_utilization_growth_and_registered_suicide_standard_death_rate_SDR_suicide_all_and_rates_variation_by_year_and_country_/725662", "title"=>"ATC N06 antidepressant utilization (DDD per 1000 inhabitants per day) and utilization growth, and registered suicide standard death rate (SDR suicide, all) and rates variation, by year and country.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-06-19 01:34:22"}
  • {"files"=>["https://ndownloader.figshare.com/files/1093652"], "description"=>"<p>Poisson distribution regression with SDR suicide rate as outcome.</p>", "links"=>[], "tags"=>["Clinical research design", "epidemiology", "Pharmacoepidemiology", "Mental health", "psychiatry", "Mood disorders", "therapies", "Drug psychotherapy", "Public health", "Drug policy", "Sociology", "suicide", "regression", "sdr"], "article_id"=>725663, "categories"=>["Medicine", "Sociology"], "users"=>["Ricardo Gusmão", "Sónia Quintão", "David McDaid", "Ella Arensman", "Chantal Van Audenhove", "Claire Coffey", "Airi Värnik", "Peeter Värnik", "James Coyne", "Ulrich Hegerl"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0066455.t006", "stats"=>{"downloads"=>7, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Poisson_distribution_regression_with_SDR_suicide_rate_as_outcome_/725663", "title"=>"Poisson distribution regression with SDR suicide rate as outcome.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-06-19 01:34:23"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"29", "full-text"=>"47", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
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  • {"unique-ip"=>"31", "full-text"=>"45", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"28", "full-text"=>"38", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"30", "full-text"=>"47", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"15", "full-text"=>"19", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"22", "full-text"=>"19", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"21", "full-text"=>"25", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
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  • {"unique-ip"=>"15", "full-text"=>"18", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"44", "full-text"=>"57", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"31", "full-text"=>"39", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"11", "full-text"=>"18", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"23", "full-text"=>"25", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"33", "full-text"=>"36", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"25", "full-text"=>"40", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"19", "full-text"=>"26", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"13", "full-text"=>"14", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"16", "full-text"=>"17", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"18", "full-text"=>"22", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"28", "full-text"=>"34", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"32", "full-text"=>"33", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"22", "full-text"=>"21", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"28", "full-text"=>"22", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"17", "full-text"=>"18", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
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  • {"unique-ip"=>"59", "full-text"=>"70", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}

Relative Metric

{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[269, 466, 588, 697, 800, 896, 988, 1076, 1165, 1254, 1340, 1417]}, {"subject_area"=>"/Biology and life sciences/Nutrition", "average_usage"=>[264, 463, 602, 708, 816, 908, 1015, 1103, 1200, 1297, 1389, 1476, 1538]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[264, 460, 584, 692, 794, 887, 978, 1067, 1154, 1241, 1328, 1408, 1474]}, {"subject_area"=>"/Medicine and health sciences/Nutrition", "average_usage"=>[273, 476, 611, 714, 821, 911, 1005, 1103, 1201, 1287, 1388, 1478, 1557]}, {"subject_area"=>"/Medicine and health sciences/Pharmacology", "average_usage"=>[265, 471, 604, 723, 827, 926, 1022, 1113, 1210, 1290, 1377, 1454, 1532]}, {"subject_area"=>"/Medicine and health sciences/Public and occupational health", "average_usage"=>[291, 491, 610, 723, 817, 906, 991, 1071, 1153, 1238, 1324, 1411, 1478]}, {"subject_area"=>"/People and places/Demography", "average_usage"=>[253, 440, 552, 650, 735, 820, 902, 976, 1042, 1112, 1192, 1271, 1337]}, {"subject_area"=>"/People and places/Geographical locations", "average_usage"=>[263, 456, 571, 673, 776, 866, 955, 1040, 1132, 1217, 1310, 1391, 1454]}]}
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