Identification of the Tyrosine-Protein Phosphatase Non-Receptor Type 2 as a Rheumatoid Arthritis Susceptibility Locus in Europeans
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{"title"=>"Identification of the Tyrosine-Protein Phosphatase Non-Receptor Type 2 as a Rheumatoid Arthritis Susceptibility Locus in Europeans", "type"=>"journal", "authors"=>[{"first_name"=>"Joanna E.", "last_name"=>"Cobb", "scopus_author_id"=>"55243689300"}, {"first_name"=>"Darren", "last_name"=>"Plant", "scopus_author_id"=>"12761963000"}, {"first_name"=>"Edward", "last_name"=>"Flynn", "scopus_author_id"=>"26649909900"}, {"first_name"=>"Meriem", "last_name"=>"Tadjeddine", "scopus_author_id"=>"55771395800"}, {"first_name"=>"Philippe", "last_name"=>"Dieudé", "scopus_author_id"=>"56206750400"}, {"first_name"=>"François", "last_name"=>"Cornélis", "scopus_author_id"=>"7004374334"}, {"first_name"=>"Lisbeth", "last_name"=>"Ärlestig", "scopus_author_id"=>"6508068516"}, {"first_name"=>"Solbritt Rantapää", "last_name"=>"Dahlqvist", "scopus_author_id"=>"56360978500"}, {"first_name"=>"George", "last_name"=>"Goulielmos", "scopus_author_id"=>"6701555078"}, {"first_name"=>"Dimitrios T.", "last_name"=>"Boumpas", "scopus_author_id"=>"7007045263"}, {"first_name"=>"Prodromos", "last_name"=>"Sidiropoulos", "scopus_author_id"=>"6603219836"}, {"first_name"=>"Sophine B.", "last_name"=>"Krintel", "scopus_author_id"=>"45761294200"}, {"first_name"=>"Lykke M.", "last_name"=>"Ørnbjerg", "scopus_author_id"=>"24069275900"}, {"first_name"=>"Merete L.", "last_name"=>"Hetland", "scopus_author_id"=>"6603809586"}, {"first_name"=>"Lars", "last_name"=>"Klareskog", "scopus_author_id"=>"7101784599"}, {"first_name"=>"Thomas", "last_name"=>"Haeupl", "scopus_author_id"=>"6507757665"}, {"first_name"=>"Andrew", "last_name"=>"Filer", "scopus_author_id"=>"6603511236"}, {"first_name"=>"Christopher D.", "last_name"=>"Buckley", "scopus_author_id"=>"7202815221"}, {"first_name"=>"Karim", "last_name"=>"Raza", "scopus_author_id"=>"24169603700"}, {"first_name"=>"Torsten", "last_name"=>"Witte", "scopus_author_id"=>"7005033491"}, {"first_name"=>"Reinhold E.", "last_name"=>"Schmidt", "scopus_author_id"=>"56393151400"}, {"first_name"=>"Oliver", "last_name"=>"FitzGerald", "scopus_author_id"=>"7006631752"}, {"first_name"=>"Douglas", "last_name"=>"Veale", "scopus_author_id"=>"7102803280"}, {"first_name"=>"Stephen", "last_name"=>"Eyre", "scopus_author_id"=>"7004612837"}, {"first_name"=>"Jane", "last_name"=>"Worthington", "scopus_author_id"=>"26322894900"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"isbn"=>"1932-6203", "pmid"=>"23840476", "doi"=>"10.1371/journal.pone.0066456", "pui"=>"369157916", "issn"=>"19326203", "sgr"=>"84879258952", "scopus"=>"2-s2.0-84879258952"}, "id"=>"a05ba3a6-dda7-3f0c-a123-4fda43617851", "abstract"=>"OBJECTIVES: Genome-wide association studies have facilitated the identification of over 30 susceptibility loci for rheumatoid arthritis (RA). However, evidence for a number of potential susceptibility genes have not so far reached genome-wide significance in studies of Caucasian RA.\\n\\nMETHODS: A cohort of 4286 RA patients from across Europe and 5642 population matched controls were genotyped for 25 SNPs, then combined in a meta-analysis with previously published data.\\n\\nRESULTS: Significant evidence of association was detected for nine SNPs within the European samples. When meta-analysed with previously published data, 21 SNPs were associated with RA susceptibility. Although SNPs in the PTPN2 gene were previously reported to be associated with RA in both Japanese and European populations, we show genome-wide evidence for a different SNP within this gene associated with RA susceptibility in an independent European population (rs7234029, P = 4.4×10(-9)).\\n\\nCONCLUSIONS: This study provides further genome-wide evidence for the association of the PTPN2 locus (encoding the T cell protein tyrosine phosphastase) with Caucasian RA susceptibility. This finding adds to the growing evidence for PTPN2 being a pan-autoimmune susceptibility gene.", "link"=>"http://www.mendeley.com/research/identification-tyrosineprotein-phosphatase-nonreceptor-type-2-rheumatoid-arthritis-susceptibility-lo", "reader_count"=>12, "reader_count_by_academic_status"=>{"Researcher"=>3, "Student > Ph. D. Student"=>1, "Student > Master"=>1, "Other"=>1, "Student > Bachelor"=>1, "Professor"=>3, "Unspecified"=>2}, "reader_count_by_user_role"=>{"Researcher"=>3, "Student > Ph. D. Student"=>1, "Student > Master"=>1, "Other"=>1, "Student > Bachelor"=>1, "Professor"=>3, "Unspecified"=>2}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Agricultural and Biological Sciences"=>3, "Medicine and Dentistry"=>4, "Business, Management and Accounting"=>1, "Unspecified"=>3}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Unspecified"=>{"Unspecified"=>3}}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1095636"], "description"=>"<p>SNPs allocated to group 1, 2 or 3 based on previously published evidence. The SNPs<sup>†</sup> in group 2 do not reach genome-wide significance in Stahl et al used in this meta-analysis <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0066456#pone.0066456-Stahl1\" target=\"_blank\">[6]</a>, but have in prior publications <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0066456#pone.0066456-Gregersen1\" target=\"_blank\">[4]</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0066456#pone.0066456-Raychaudhuri1\" target=\"_blank\">[5]</a>.</p>α<p>Additionally, the TAGAP locus has previously been associated with RA at a genome-wide level, however not for the SNP investigated here <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0066456#pone.0066456-Chen1\" target=\"_blank\">[19]</a>. Het <i>P</i> = meta-analysis heterogeneity χ<sup>2</sup><i>P</i> value, OR = odds ratio calculated using fixed or random* effects meta-analysis.</p>ß<p>Power calculation based on these results assuming 1% disease prevalence in the population.</p>", "links"=>[], "tags"=>["genetics", "Human genetics", "Genetic association studies", "Genome-wide association studies", "population genetics", "Genetic polymorphism", "Genetics of disease", "Clinical research design", "meta-analyses", "rheumatology", "rheumatoid arthritis", "published", "associations", "ra", "susceptibility", "meta-analysis", "been"], "article_id"=>727145, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Joanna E. Cobb", "Darren Plant", "Edward Flynn", "Meriem Tadjeddine", "Philippe Dieudé", "François Cornelis", "Lisbeth Ärlestig", "Solbritt Rantapää Dahlqvist", "George Goulielmos", "Dimitrios T. Boumpas", "Prodromos Sidiropoulos", "Sophine B. Krintel", "Lykke M. Ørnbjerg", "Merete L. Hetland", "Lars Klareskog", "Thomas Haeupl", "Andrew Filer", "Christopher D. Buckley", "Karim Raza", "Torsten Witte", "Reinhold E. Schmidt", "Oliver FitzGerald", "Douglas Veale", "Stephen Eyre", "Jane Worthington"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0066456.t002", "stats"=>{"downloads"=>6, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_SNP_results_from_previously_published_associations_of_RA_susceptibility_and_the_meta_analysis_results_now_GRACE_AutoCure_data_has_been_added_/727145", "title"=>"SNP results from previously published associations of RA susceptibility and the meta-analysis results now GRACE (AutoCure) data has been added.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-06-20 01:59:05"}
  • {"files"=>["https://ndownloader.figshare.com/files/1095637"], "description"=>"<p>SNPs allocated to group 1, 2 or 3 based on previously published evidence. The SNPs<sup>†</sup> in group 2 do not reach genome-wide significance in Stahl et al used in meta-analysis <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0066456#pone.0066456-Stahl1\" target=\"_blank\">[6]</a> (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0066456#pone-0066456-t002\" target=\"_blank\">Table 2</a>), but have in prior publications <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0066456#pone.0066456-Gregersen1\" target=\"_blank\">[4]</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0066456#pone.0066456-Raychaudhuri1\" target=\"_blank\">[5]</a>. Het <i>P</i> = meta-analysis heterogeneity χ<sup>2</sup><i>P</i> value, OR = odds ratio calculated using fixed or random* effects meta-analysis.</p>", "links"=>[], "tags"=>["genetics", "Human genetics", "Genetic association studies", "Genome-wide association studies", "population genetics", "Genetic polymorphism", "Genetics of disease", "Clinical research design", "meta-analyses", "rheumatology", "rheumatoid arthritis"], "article_id"=>727146, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Joanna E. Cobb", "Darren Plant", "Edward Flynn", "Meriem Tadjeddine", "Philippe Dieudé", "François Cornelis", "Lisbeth Ärlestig", "Solbritt Rantapää Dahlqvist", "George Goulielmos", "Dimitrios T. Boumpas", "Prodromos Sidiropoulos", "Sophine B. Krintel", "Lykke M. Ørnbjerg", "Merete L. Hetland", "Lars Klareskog", "Thomas Haeupl", "Andrew Filer", "Christopher D. Buckley", "Karim Raza", "Torsten Witte", "Reinhold E. Schmidt", "Oliver FitzGerald", "Douglas Veale", "Stephen Eyre", "Jane Worthington"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0066456.t001", "stats"=>{"downloads"=>4, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Results_from_initial_GRACE_only_meta_analysis_/727146", "title"=>"Results from initial (GRACE only) meta-analysis.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-06-20 01:59:06"}

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Relative Metric

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