Cerebral Blood Flow Modulation by Basal Forebrain or Whisker Stimulation Can Occur Independently of Large Cytosolic Ca2+ Signaling in Astrocytes
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{"title"=>"Cerebral Blood Flow Modulation by Basal Forebrain or Whisker Stimulation Can Occur Independently of Large Cytosolic Ca2+ Signaling in Astrocytes", "type"=>"journal", "authors"=>[{"first_name"=>"Norio", "last_name"=>"Takata", "scopus_author_id"=>"17342916100"}, {"first_name"=>"Terumi", "last_name"=>"Nagai", "scopus_author_id"=>"55765577500"}, {"first_name"=>"Katsuya", "last_name"=>"Ozawa", "scopus_author_id"=>"55308680700"}, {"first_name"=>"Yuki", "last_name"=>"Oe", "scopus_author_id"=>"56992922400"}, {"first_name"=>"Katsuhiko", "last_name"=>"Mikoshiba", "scopus_author_id"=>"35415007100"}, {"first_name"=>"Hajime", "last_name"=>"Hirase", "scopus_author_id"=>"6603752796"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84879066305", "sgr"=>"84879066305", "pui"=>"369122419", "isbn"=>"1932-6203", "pmid"=>"23785506", "doi"=>"10.1371/journal.pone.0066525"}, "id"=>"ef489ba5-96eb-37d7-8ff7-d27cfd546ca0", "abstract"=>"We report that a brief electrical stimulation of the nucleus basalis of Meynert (NBM), the primary source of cholinergic projection to the cerebral cortex, induces a biphasic cerebral cortical blood flow (CBF) response in the somatosensory cortex of C57BL/6J mice. This CBF response, measured by laser Doppler flowmetry, was attenuated by the muscarinic type acetylcholine receptor antagonist atropine, suggesting a possible involvement of astrocytes in this type of CBF modulation. However, we find that IP3R2 knockout mice, which lack cytosolic Ca2+ surges in astrocytes, show similar CBF changes. Moreover, whisker stimulation resulted in similar degrees of CBF increase in IP3R2 knockout mice and the background strain C57BL/6J. Our results show that neural activity-driven CBF modulation could occur without large cytosolic increases of Ca2+ in astrocytes.", "link"=>"http://www.mendeley.com/research/cerebral-blood-flow-modulation-basal-forebrain-whisker-stimulation-occur-independently-large-cytosol", "reader_count"=>70, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>6, "Researcher"=>23, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>18, "Student > Postgraduate"=>2, "Student > Master"=>6, "Student > Bachelor"=>6, "Lecturer"=>2, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>6, "Researcher"=>23, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>18, "Student > Postgraduate"=>2, "Student > Master"=>6, "Student > Bachelor"=>6, "Lecturer"=>2, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>6, "Engineering"=>4, "Biochemistry, Genetics and Molecular Biology"=>1, "Mathematics"=>1, "Agricultural and Biological Sciences"=>27, "Medicine and Dentistry"=>11, "Neuroscience"=>19, "Business, Management and Accounting"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>4}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>11}, "Neuroscience"=>{"Neuroscience"=>19}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>27}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>6}}, "reader_count_by_country"=>{"Canada"=>1, "South Korea"=>1, "Norway"=>1, "Japan"=>2, "France"=>1, "Germany"=>1, "Spain"=>1}, "group_count"=>1}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1551915"], "description"=>"<p>(<b>A</b>) Sketch for experimental set up. A laser Doppler probe is placed above the thinned skull at the primary somatosensory cortex. A bipolar stimulation electrode is inserted to target the nucleus basalis of Meynert (NBM) in the ipsilateral side. (<b>B</b>) An example trace of laser Doppler flowmetry from a wild type mouse in response to a single train NBM stimulation (stNBM, arrow). (<b>C</b>) <i>In vivo</i> two-photon imaging of Fluo-4 AM loaded astrocytes in the somatosensory cortex of C57BL/6J (WT, upper panels) and IP<sub>3</sub>R2-KO (lower panels). (<b>D</b>) Proportion of barrel cortex astrocytes that elicited Ca<sup>2+</sup> elevations upon stNBM.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "electrophysiology", "Model organisms", "Animal models", "mouse", "Molecular cell biology", "Signal transduction", "Signaling cascades", "Calcium signaling cascade", "Signaling in cellular processes", "Calcium signaling", "neuroscience", "neuroimaging", "stnbm"], "article_id"=>1072109, "categories"=>["Biological Sciences"], "users"=>["Norio Takata", "Terumi Nagai", "Katsuya Ozawa", "Yuki Oe", "Katsuhiko Mikoshiba", "Hajime Hirase"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0066525.g001", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Overview_of_the_stNBM_experiment_/1072109", "title"=>"Overview of the stNBM experiment.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-13 09:33:08"}
  • {"files"=>["https://ndownloader.figshare.com/files/1551922"], "description"=>"<p><a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0066525#s2\" target=\"_blank\">Results</a> for C57BL/6J and IP<sub>3</sub>R2-KO mice are represented in blue and red traces, respectively. Each experimental condition has N>5 animals. Upon 200 µA stNBM, the cerebral blood flow (CBF) showed an immediate increase, followed by a transient decrease that overshot the baseline both in WT (<b>A</b>) and KO (<b>E</b>). CBF change by the stNBM is attenuated by the muscarinic receptor antagonist atropine (ATR) (<b>B</b>). Weak stNBM stimulation (50 µA) resulted in negative laser Doppler flowmetry signal (<b>C</b>) and similar changes were observed in KO (<b>F</b>). Stimulation outside the NBM failed to induce CBF increase (<b>D</b>). Shaded areas represent s.e.m.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "electrophysiology", "Model organisms", "Animal models", "mouse", "Molecular cell biology", "Signal transduction", "Signaling cascades", "Calcium signaling cascade", "Signaling in cellular processes", "Calcium signaling", "neuroscience", "neuroimaging", "traces", "doppler", "flowmetry"], "article_id"=>1072116, "categories"=>["Biological Sciences"], "users"=>["Norio Takata", "Terumi Nagai", "Katsuya Ozawa", "Yuki Oe", "Katsuhiko Mikoshiba", "Hajime Hirase"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0066525.g002", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Averaged_traces_of_laser_Doppler_flowmetry_in_C57BL_6J_and_IP_3_R2_KO_mice_/1072116", "title"=>"Averaged traces of laser Doppler flowmetry in C57BL/6J and IP<sub>3</sub>R2-KO mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-13 09:33:08"}
  • {"files"=>["https://ndownloader.figshare.com/files/1551927"], "description"=>"<p>(<b>A</b>) Single example trace of 10 Hz air puff stimulation experiment. The recording was made from a WT mouse. (<b>B</b>) Proportion of barrel cortex astrocytes that elicited Ca<sup>2+</sup> elevations after whisker stimulation (10 Hz, 20 s) for WT (n = 3) and IP<sub>3</sub>R2 KO (n = 3). (<b>C</b>) Mean CBF of WT (black) and IP<sub>3</sub>R2 mice (white) during 20 s whisker stimulation was compared. The number of tested animal for each stimulation paradigm is shown in parenthesis. Whisker stimulation with 5 or 10 Hz significantly increased cerebral blood flow in WT and KO when compared with prestimulus period. No significant differences in CBF response were observed between WT and KO in any of the stimulation paradigms.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "electrophysiology", "Model organisms", "Animal models", "mouse", "Molecular cell biology", "Signal transduction", "Signaling cascades", "Calcium signaling cascade", "Signaling in cellular processes", "Calcium signaling", "neuroscience", "neuroimaging", "cbf", "doppler", "flowmetry"], "article_id"=>1072121, "categories"=>["Biological Sciences"], "users"=>["Norio Takata", "Terumi Nagai", "Katsuya Ozawa", "Yuki Oe", "Katsuhiko Mikoshiba", "Hajime Hirase"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0066525.g004", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Whisker_evoked_CBF_changes_measured_by_laser_Doppler_flowmetry_from_the_barrel_cortex_/1072121", "title"=>"Whisker-evoked CBF changes measured by laser Doppler flowmetry from the barrel cortex.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-13 09:33:08"}
  • {"files"=>["https://ndownloader.figshare.com/files/1551925"], "description"=>"<p>(<b>A</b>) <i>In vivo</i> two-photon imaging of an arteriole in the somatosensory cortex upon stNBM. The arteriole is imaged at the pial depth of 200 µm. Arrows point to the region where constriction is evident. (<b>B</b>) Distribution of responses of arteriole area to stNBM. Shallower (pial depth <100 µm) arteriole were less susceptible to diameter changes than deeper arterioles (pial depth: 100∼300 µm). Numbers are in percent. (<b>C</b>) The time course of vessel area change in response to stNBM for the vessel eliciting constriction. Shaded area represents s.e.m. (<b>D</b>) Horizontal movement of imaged vessels associated with stNBM is quantified by plotting a histogram of the maximum displacement within 3 s after stNBM for each imaged arteriole.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "electrophysiology", "Model organisms", "Animal models", "mouse", "Molecular cell biology", "Signal transduction", "Signaling cascades", "Calcium signaling cascade", "Signaling in cellular processes", "Calcium signaling", "neuroscience", "neuroimaging", "cortical", "arterioles"], "article_id"=>1072119, "categories"=>["Biological Sciences"], "users"=>["Norio Takata", "Terumi Nagai", "Katsuya Ozawa", "Yuki Oe", "Katsuhiko Mikoshiba", "Hajime Hirase"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0066525.g003", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Dynamical_changes_of_cortical_arterioles_by_stNBM_/1072119", "title"=>"Dynamical changes of cortical arterioles by stNBM.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-13 09:33:08"}

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