Neuronal Activation in the Central Nervous System of Rats in the Initial Stage of Chronic Kidney Disease-Modulatory Effects of Losartan and Moxonidine
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{"title"=>"Neuronal Activation in the Central Nervous System of Rats in the Initial Stage of Chronic Kidney Disease-Modulatory Effects of Losartan and Moxonidine", "type"=>"journal", "authors"=>[{"first_name"=>"Miklós", "last_name"=>"Palkovits", "scopus_author_id"=>"7102519482"}, {"first_name"=>"Katarína", "last_name"=>"Šebeková", "scopus_author_id"=>"7004131233"}, {"first_name"=>"Kristina Simon", "last_name"=>"Klenovics", "scopus_author_id"=>"54585469500"}, {"first_name"=>"Anton", "last_name"=>"Kebis", "scopus_author_id"=>"7801322758"}, {"first_name"=>"Gholamreza", "last_name"=>"Fazeli", "scopus_author_id"=>"26423671400"}, {"first_name"=>"Udo", "last_name"=>"Bahner", "scopus_author_id"=>"7005832384"}, {"first_name"=>"August", "last_name"=>"Heidland", "scopus_author_id"=>"55422380800"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"369158052", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0066543", "scopus"=>"2-s2.0-84879251057", "pmid"=>"23818940", "sgr"=>"84879251057"}, "id"=>"1d6e921c-8caa-3afb-902e-fba99fb03ba3", "abstract"=>"The effect of mild chronic renal failure (CRF) induced by 4/6-nephrectomy (4/6NX) on central neuronal activations was investigated by c-Fos immunohistochemistry staining and compared to sham-operated rats. In the 4/6 NX rats also the effect of the angiotensin receptor blocker, losartan, and the central sympatholyticum moxonidine was studied for two months. In serial brain sections Fos-immunoreactive neurons were localized and classified semiquantitatively. In 37 brain areas/nuclei several neurons with different functional properties were strongly affected in 4/6NX. It elicited a moderate to high Fos-activity in areas responsible for the monoaminergic innervation of the cerebral cortex, the limbic system, the thalamus and hypothalamus (e.g. noradrenergic neurons of the locus coeruleus, serotonergic neurons in dorsal raphe, histaminergic neurons in the tuberomamillary nucleus). Other monoaminergic cell groups (A5 noradrenaline, C1 adrenaline, medullary raphe serotonin neurons) and neurons in the hypothalamic paraventricular nucleus (innervating the sympathetic preganglionic neurons and affecting the peripheral sympathetic outflow) did not show Fos-activity. Stress- and pain-sensitive cortical/subcortical areas, neurons in the limbic system, the hypothalamus and the circumventricular organs were also affected by 4/6NX. Administration of losartan and more strongly moxonidine modulated most effects and particularly inhibited Fos-activity in locus coeruleus neurons. In conclusion, 4/6NX elicits high activity in central sympathetic, stress- and pain-related brain areas as well as in the limbic system, which can be ameliorated by losartan and particularly by moxonidine. These changes indicate a high sensitivity of CNS in initial stages of CKD which could be causative in clinical disturbances.", "link"=>"http://www.mendeley.com/research/neuronal-activation-central-nervous-system-rats-initial-stage-chronic-kidney-diseasemodulatory-effec-5", "reader_count"=>8, "reader_count_by_academic_status"=>{"Researcher"=>2, "Student > Ph. D. Student"=>2, "Student > Master"=>1, "Student > Bachelor"=>2, "Professor"=>1}, "reader_count_by_user_role"=>{"Researcher"=>2, "Student > Ph. D. Student"=>2, "Student > Master"=>1, "Student > Bachelor"=>2, "Professor"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>2, "Medicine and Dentistry"=>1, "Neuroscience"=>2, "Arts and Humanities"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Neuroscience"=>{"Neuroscience"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Arts and Humanities"=>{"Arts and Humanities"=>1}}, "group_count"=>0}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1094608"], "description"=>"<p>P: placebo; Grade: grading of c-fos expression (as given in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0066543#s2\" target=\"_blank\">Methods</a> section); Δ: change; Sh: sham-operated; NA: noradrenaline; A: adrenaline; VTA: ventral tegmental area; PVN: paraventricular nucleus; OVLT: organum vasculosum laminae terminalis; PAG: periaqueductal gray matter; dorsolat.: dorsolateral; CAs: anterior commissure; DG: dentate gyrus.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Neurological system", "neuroanatomy", "Biochemistry", "Neurochemistry", "neuromodulation", "Model organisms", "Animal models", "mouse", "neuroscience", "Neurobiology of disease and regeneration", "Clinical research design", "Animal models of disease", "Nephrology", "Chronic kidney disease", "neurology", "Pain management", "Sleep disorders", "areas", "losartan"], "article_id"=>726413, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Miklós Palkovits", "Katarína Šebeková", "Kristína Simon Klenovics", "Anton Kebis", "Gholamreza Fazeli", "Udo Bahner", "August Heidland"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0066543.t002", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Fos_expression_in_various_brain_areas_after_4_6NX_and_its_treatment_with_losartan_and_moxonidine_/726413", "title"=>"Fos expression in various brain areas after 4/6NX and its treatment with losartan and moxonidine.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-06-20 01:46:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/1094609"], "description"=>"<p>Cl: clearance; AGE: advanced glycation end products-associated fluorescence of plasma; AU: arbitrary units; AOPPs: plasma advanced oxidation protein products; K-W: Kruskal-Wallis test;</p><p>+: p<0.05 vs. SHAM-PLAC;</p>*<p>: p<0.05 vs. 4/6NX-PLAC (Exact 2-sided Man-Whitney U-test with Bonferonni correction).</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Neurological system", "neuroanatomy", "Biochemistry", "Neurochemistry", "neuromodulation", "Model organisms", "Animal models", "mouse", "neuroscience", "Neurobiology of disease and regeneration", "Clinical research design", "Animal models of disease", "Nephrology", "Chronic kidney disease", "neurology", "Pain management", "Sleep disorders", "sham-operated", "rats"], "article_id"=>726414, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Miklós Palkovits", "Katarína Šebeková", "Kristína Simon Klenovics", "Anton Kebis", "Gholamreza Fazeli", "Udo Bahner", "August Heidland"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0066543.t001", "stats"=>{"downloads"=>1, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characteristics_of_sham_operated_and_4_6_nephrectomized_4_6NX_rats_at_sacrifice_/726414", "title"=>"Characteristics of sham-operated and 4/6-nephrectomized (4/6NX) rats at sacrifice.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-06-20 01:46:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/1094606"], "description"=>"<p>The rostro-caudal levels of the coronal sections are indicated on Fig. A). <i>Dark blue</i> = highly, <i>light blue = </i>moderately <i>elevated</i> Fos activation, <i>red = </i>highly, <i>light red</i> = moderately <i>depleted</i> Fos activation. (For the level of numerical changes <i>see </i><a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0066543#pone-0066543-t002\" target=\"_blank\">Table 2</a>.) <i>Abbreviations and numbers: see</i> Fig. 1.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Neurological system", "neuroanatomy", "Biochemistry", "Neurochemistry", "neuromodulation", "Model organisms", "Animal models", "mouse", "neuroscience", "Neurobiology of disease and regeneration", "Clinical research design", "Animal models of disease", "Nephrology", "Chronic kidney disease", "neurology", "Pain management", "Sleep disorders", "coronal", "drawings", "topography", "nuclei", "areas", "responded", "expressions", "fos", "compared"], "article_id"=>726411, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Miklós Palkovits", "Katarína Šebeková", "Kristína Simon Klenovics", "Anton Kebis", "Gholamreza Fazeli", "Udo Bahner", "August Heidland"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0066543.g002", "stats"=>{"downloads"=>28, "page_views"=>485, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Sagittal_A_and_coronal_B_and_C_drawings_of_the_rat_brain_with_the_topography_of_brain_nuclei_and_areas_where_nephrectomized_rats_responded_with_losartan_treatment_with_moderate_to_high_expressions_of_Fos_as_compared_to_placebo_treated_nephrectomized_anim/726411", "title"=>"Sagittal (A) and coronal (B and C) drawings of the rat brain with the topography of brain nuclei and areas where <i>nephrectomized rats</i> responded with <i>losartan treatment</i> with moderate to high expressions of Fos as compared to <i>placebo-treated nephrectomized</i> animals.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-20 01:46:51"}
  • {"files"=>["https://ndownloader.figshare.com/files/1094607"], "description"=>"<p>The rostro-caudal levels of the coronal sections are indicated on Fig. A). <i>Dark blue</i> = highly, <i>light blue = </i>moderately <i>elevated</i> Fos activation, <i>red = </i>highly, <i>light red</i> = moderately <i>depleted</i> Fos activation. (For the level of numerical changes <i>see </i><a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0066543#pone-0066543-t002\" target=\"_blank\">Table 2</a>.) <i>Abbreviations and numbers: see</i> Fig. 1.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Neurological system", "neuroanatomy", "Biochemistry", "Neurochemistry", "neuromodulation", "Model organisms", "Animal models", "mouse", "neuroscience", "Neurobiology of disease and regeneration", "Clinical research design", "Animal models of disease", "Nephrology", "Chronic kidney disease", "neurology", "Pain management", "Sleep disorders", "coronal", "drawings", "topography", "nuclei", "areas", "neurons", "responded", "expressions", "fos", "compared"], "article_id"=>726412, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Miklós Palkovits", "Katarína Šebeková", "Kristína Simon Klenovics", "Anton Kebis", "Gholamreza Fazeli", "Udo Bahner", "August Heidland"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0066543.g003", "stats"=>{"downloads"=>10, "page_views"=>407, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Sagittal_A_and_coronal_B_and_C_drawings_of_the_rat_brain_with_the_topography_of_brain_nuclei_and_areas_where_neurons_in_nephrectomized_rats_responded_to_moxodinine_treatment_with_moderate_to_high_expressions_of_Fos_as_compared_to_placebo_treated_nephrect/726412", "title"=>"Sagittal (A) and coronal (B and C) drawings of the rat brain with the topography of brain nuclei and areas where neurons in <i>nephrectomized rats</i> responded to <i>moxodinine treatment</i> with moderate to high expressions of Fos as compared to <i>placebo-treated nephrectomized</i> animals.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-20 01:46:52"}
  • {"files"=>["https://ndownloader.figshare.com/files/1094605"], "description"=>"<p>The rostro-caudal levels of the coronal sections are indicated on Fig. A). <i>Dark blue</i> = highly, <i>light blue = </i>moderately <i>elevated</i> Fos activation, <i>red = </i>highly, <i>light red</i> = moderately <i>depleted</i> Fos activation. (For the level of numerical changes <i>see </i><a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0066543#pone-0066543-t002\" target=\"_blank\">Table 2</a>.) <i>Abbreviations:</i> CA – anterior commissure, CC – corpus callosum, F – fornix. <i>Brain nuclei and areas:</i> 1 – locus coeruleus, 2 – A1 noradrenaline cell group, 3 – A5 noradrenaline cell group, 4 – C1 adrenaline cell group, 5 – dorsal raphe nucleus, 6 – medullary raphe nuclei, 7 – supraoptic nucleus, 8 – hypothalamic paraventricular nucleus (magnocellular portion), 9 – preoptic AV3V area, 10 – organum vasculosum laminae terminalis (OVLT), 11 – subfornical organ, 12 – area postrema, 13 – hypothalamic paraventricular nucleus (parvocellular portion), 14 – hypothalamic dorsomedial nucleus, 15 – supramamillary nucleus, 16 – lateral hypothalamic area, 17 – lateral septum, 18 – central amygdala nucleus, 19 – somatosensory cortex, 20 – viscerosensory cortex (insula), 21 – nucleus of the solitary tract, 22 – periaqueductal gray matter (PAG), 23 – prefrontal cortex, 24 – piriform cortex, 25 – anterior cingulate cortex, 26 – hippocampus (CA1-3), 27 – subiculum, 28 – olfactory tubercle, 29 – substantia nigra/VTA dopamine neurons.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Neurological system", "neuroanatomy", "Biochemistry", "Neurochemistry", "neuromodulation", "Model organisms", "Animal models", "mouse", "neuroscience", "Neurobiology of disease and regeneration", "Clinical research design", "Animal models of disease", "Nephrology", "Chronic kidney disease", "neurology", "Pain management", "Sleep disorders", "coronal", "drawings", "topography", "nuclei", "areas", "neurons", "responded", "renal", "expressions", "fos", "compared", "sham-operated"], "article_id"=>726410, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Miklós Palkovits", "Katarína Šebeková", "Kristína Simon Klenovics", "Anton Kebis", "Gholamreza Fazeli", "Udo Bahner", "August Heidland"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0066543.g001", "stats"=>{"downloads"=>12, "page_views"=>417, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Sagittal_A_and_coronal_B_and_C_drawings_of_the_rat_brain_with_the_topography_of_brain_nuclei_and_areas_where_neurons_responded_to_experimental_chronic_renal_failure_4_6_nephrectomy_with_moderate_to_high_expressions_of_Fos_as_compared_to_sham_operated_ani/726410", "title"=>"Sagittal (A) and coronal (B and C) drawings of the rat brain with the topography of brain nuclei and areas where neurons responded to experimental chronic renal failure (<i>4/6 nephrectomy)</i> with moderate to high expressions of Fos as compared to sham-operated animals.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-20 01:46:50"}

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Relative Metric

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