The Combination of SMAD4 Expression and Histological Grade of Dysplasia Is a Better Predictor for the Malignant Transformation of Oral Leukoplakia
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{"title"=>"The Combination of SMAD4 Expression and Histological Grade of Dysplasia Is a Better Predictor for the Malignant Transformation of Oral Leukoplakia", "type"=>"journal", "authors"=>[{"first_name"=>"Rong Hui", "last_name"=>"Xia", "scopus_author_id"=>"54421697300"}, {"first_name"=>"Xiao Meng", "last_name"=>"Song", "scopus_author_id"=>"55566194200"}, {"first_name"=>"Xiao Jing", "last_name"=>"Wang", "scopus_author_id"=>"56469844900"}, {"first_name"=>"Jiang", "last_name"=>"Li", "scopus_author_id"=>"56011623200"}, {"first_name"=>"Li", "last_name"=>"Mao", "scopus_author_id"=>"35227692000"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84879497126", "pmid"=>"23826135", "sgr"=>"84879497126", "doi"=>"10.1371/journal.pone.0066794", "issn"=>"19326203", "pui"=>"369200009"}, "id"=>"902c8b59-fb33-3b9d-b29b-9e2d88ecf496", "abstract"=>"Oral leukoplakia (OL) is the most common premalignancy in the oral cavity and can progress to oral squamous cell carcinoma (OSCC). SMAD4 is a tumor suppressor implicated in multiple cancer types including OSCC. To assess the role of SMAD4 in oral leukoplakia malignant transformation, the authors investigated SMAD4 expression patterns in OL and OSCC using a highly specific antibody and correlated the patterns with the risk of malignant transformation oral leukoplakia. Immunohistochemistry and a quantitative imaging system were used to measure SMAD4 expression in OL from 88 OL patients, including 22 who later went through malignant transformation, and their OSCC counterpart. Forty-three (48.9%) of the 88 OL patients had strong SMAD4 expression. SMAD4 expression had no significant correlation with patients' clinicopathological parameters. Interestingly, 17 (39.5%) of the 43 OL lesions with strong SMAD4 expression went through malignant transformation whereas only 5 (11.1%) of the 45 OL lesions with weak SMAD4 expression did so (p = 0.002). The SMAD4 expression in OL was much higher than that in their OSCC counterpart. Kaplan-Meier analysis revealed that the combination of SMAD4 expression and histological grade of dysplasia (p = 0.007) is a better predictor for the malignant transformation of oral leukoplakia. In the multivariate analysis, both SMAD4 expression and grade of dysplasia were identified as independent factors for OL malignant transformation risk (p = 0.013 and 0.021, respectively). It was concluded that high SMAD4 expression may be indicative of an early carcinogenic process in OL and serve as an independent biomarker in assessing malignant transformation risk in patients with OL, and the combination of SMAD4 expression and histological grade of dysplasia is a better predictor for the malignant transformation of oral leukoplakia.", "link"=>"http://www.mendeley.com/research/combination-smad4-expression-histological-grade-dysplasia-better-predictor-malignant-transformation", "reader_count"=>11, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Student > Doctoral Student"=>2, "Researcher"=>1, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>2, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Student > Doctoral Student"=>2, "Researcher"=>1, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>2, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Medicine and Dentistry"=>5, "Agricultural and Biological Sciences"=>3}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Unspecified"=>{"Unspecified"=>3}}, "reader_count_by_country"=>{"Argentina"=>1}, "group_count"=>1}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1099381"], "description"=>"<p>CI: confidence interval.</p>*<p>L–M: low and moderate-grade dysplasia, H: high-grade dysplasia.</p><p>Bold indicates values that are statistically significant (p<0.05).</p>", "links"=>[], "tags"=>["immunology", "Immunologic techniques", "Immunohistochemical analysis", "Diagnostic medicine", "pathology", "General pathology", "biomarkers", "oncology", "Cancers and neoplasms", "Head and neck tumors", "Oral leukoplakia", "Cancer risk factors", "proportional", "regression", "analyzing", "ol", "malignant"], "article_id"=>730189, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Rong-Hui Xia", "Xiao-Meng Song", "Xiao-Jing Wang", "Jiang Li", "Li Mao"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0066794.t002", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cox_proportional_hazard_regression_models_in_analyzing_OL_malignant_transformation_risk_/730189", "title"=>"Cox proportional hazard regression models in analyzing OL malignant transformation risk.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-06-24 03:47:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/1099382"], "description"=>"<div><p>Oral leukoplakia (OL) is the most common premalignancy in the oral cavity and can progress to oral squamous cell carcinoma (OSCC). SMAD4 is a tumor suppressor implicated in multiple cancer types including OSCC. To assess the role of SMAD4 in oral leukoplakia malignant transformation, the authors investigated SMAD4 expression patterns in OL and OSCC using a highly specific antibody and correlated the patterns with the risk of malignant transformation oral leukoplakia. Immunohistochemistry and a quantitative imaging system were used to measure SMAD4 expression in OL from 88 OL patients, including 22 who later went through malignant transformation, and their OSCC counterpart. Forty-three (48.9%) of the 88 OL patients had strong SMAD4 expression. SMAD4 expression had no significant correlation with patients' clinicopathological parameters. Interestingly, 17 (39.5%) of the 43 OL lesions with strong SMAD4 expression went through malignant transformation whereas only 5 (11.1%) of the 45 OL lesions with weak SMAD4 expression did so (p = 0.002). The SMAD4 expression in OL was much higher than that in their OSCC counterpart. Kaplan-Meier analysis revealed that the combination of SMAD4 expression and histological grade of dysplasia (p = 0.007) is a better predictor for the malignant transformation of oral leukoplakia. In the multivariate analysis, both SMAD4 expression and grade of dysplasia were identified as independent factors for OL malignant transformation risk (p = 0.013 and 0.021, respectively). It was concluded that high SMAD4 expression may be indicative of an early carcinogenic process in OL and serve as an independent biomarker in assessing malignant transformation risk in patients with OL, and the combination of SMAD4 expression and histological grade of dysplasia is a better predictor for the malignant transformation of oral leukoplakia.</p></div>", "links"=>[], "tags"=>["immunology", "Immunologic techniques", "Immunohistochemical analysis", "Diagnostic medicine", "pathology", "General pathology", "biomarkers", "oncology", "Cancers and neoplasms", "Head and neck tumors", "Oral leukoplakia", "Cancer risk factors", "smad4", "histological", "dysplasia", "predictor", "malignant"], "article_id"=>730190, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Rong-Hui Xia", "Xiao-Meng Song", "Xiao-Jing Wang", "Jiang Li", "Li Mao"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0066794", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_Combination_of_SMAD4_Expression_and_Histological_Grade_of_Dysplasia_Is_a_Better_Predictor_for_the_Malignant_Transformation_of_Oral_Leukoplakia_/730190", "title"=>"The Combination of SMAD4 Expression and Histological Grade of Dysplasia Is a Better Predictor for the Malignant Transformation of Oral Leukoplakia", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-06-24 03:47:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/1099379"], "description"=>"<p>C, The combination of strong SMAD4 expression and high grade of dysplasia predicted the malignant transformation of oral leukoplakia better than either single factor did (p = 0.007, log-rank test).</p>", "links"=>[], "tags"=>["immunology", "Immunologic techniques", "Immunohistochemical analysis", "Diagnostic medicine", "pathology", "General pathology", "biomarkers", "oncology", "Cancers and neoplasms", "Head and neck tumors", "Oral leukoplakia", "Cancer risk factors", "showed", "stronger", "smad4", "higher", "ol", "malignant", "transformed", "log-rank", "high-grade", "dysplasia"], "article_id"=>730187, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Rong-Hui Xia", "Xiao-Meng Song", "Xiao-Jing Wang", "Jiang Li", "Li Mao"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0066794.g002", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Kaplan_8211_Meier_analysis_showed_that_A_Stronger_expression_of_SMAD4_was_associated_with_higher_OL_malignant_transformed_rate_p_8202_8202_0_012_log_rank_test_B_High_grade_of_dysplasia_was_associated_with_higher_OL_malignant_transformed_rate_p_8202_8202_/730187", "title"=>"Kaplan–Meier analysis showed that A, Stronger expression of SMAD4 was associated with higher OL malignant transformed rate (p = 0.012, log-rank test); B, High-grade of dysplasia was associated with higher OL malignant transformed rate (p = 0.026, log-rank test).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-24 03:47:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/1099380"], "description"=>"<p>Abbreviations: MT, malignant-transformed oral leukoplakia; UT: untransformed oral leukoplakia.</p><p>Bold indicates values that are statistically significant (p<0.05).</p>", "links"=>[], "tags"=>["immunology", "Immunologic techniques", "Immunohistochemical analysis", "Diagnostic medicine", "pathology", "General pathology", "biomarkers", "oncology", "Cancers and neoplasms", "Head and neck tumors", "Oral leukoplakia", "Cancer risk factors", "smad4", "patients"], "article_id"=>730188, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Rong-Hui Xia", "Xiao-Meng Song", "Xiao-Jing Wang", "Jiang Li", "Li Mao"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0066794.t001", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Clinicopathologic_characteristics_and_SMAD4_expression_of_patients_with_OL_/730188", "title"=>"Clinicopathologic characteristics and SMAD4 expression of patients with OL.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-06-24 03:47:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/1099377"], "description"=>"<p>A, case 31: weak expression of SMAD4 in OL lesion which did not go through malignant transformation (x20). B, case 59:strong expression of SMAD4 in OL lesion which later went through malignant transformation (x20). C, OSCC samples which derived from OL lesion: weak expression of SMAD4 in OSCC samples. D, The frequency of strong SMAD4 expression is 39.4% in untransformed OL and 77.3% in malignant transformed OL. * indicated that p = 0.002.</p>", "links"=>[], "tags"=>["immunology", "Immunologic techniques", "Immunohistochemical analysis", "Diagnostic medicine", "pathology", "General pathology", "biomarkers", "oncology", "Cancers and neoplasms", "Head and neck tumors", "Oral leukoplakia", "Cancer risk factors", "smad4", "ol", "oscc"], "article_id"=>730185, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Rong-Hui Xia", "Xiao-Meng Song", "Xiao-Jing Wang", "Jiang Li", "Li Mao"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0066794.g001", "stats"=>{"downloads"=>1, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Expression_pattern_of_SMAD4_in_OL_and_OSCC_samples_/730185", "title"=>"Expression pattern of SMAD4 in OL and OSCC samples.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-24 03:47:21"}

PMC Usage Stats | Further Information

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Relative Metric

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