The Functional Significance of MicroRNA-29c in Patients with Colorectal Cancer: A Potential Circulating Biomarker for Predicting Early Relapse
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{"title"=>"The Functional Significance of MicroRNA-29c in Patients with Colorectal Cancer: A Potential Circulating Biomarker for Predicting Early Relapse", "type"=>"journal", "authors"=>[{"first_name"=>"I. Ping", "last_name"=>"Yang", "scopus_author_id"=>"36646974700"}, {"first_name"=>"Hsiang Lin", "last_name"=>"Tsai", "scopus_author_id"=>"12446730400"}, {"first_name"=>"Ching Wen", "last_name"=>"Huang", "scopus_author_id"=>"8146991300"}, {"first_name"=>"Ming Yii", "last_name"=>"Huang", "scopus_author_id"=>"35083663900"}, {"first_name"=>"Ming Feng", "last_name"=>"Hou", "scopus_author_id"=>"7201437333"}, {"first_name"=>"Suh Hang Hank", "last_name"=>"Juo", "scopus_author_id"=>"7003867375"}, {"first_name"=>"Jaw Yuan", "last_name"=>"Wang", "scopus_author_id"=>"8422011200"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"23840538", "doi"=>"10.1371/journal.pone.0066842", "sgr"=>"84879543880", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "scopus"=>"2-s2.0-84879543880", "issn"=>"19326203", "pui"=>"369209031"}, "id"=>"8e06a8cd-7e87-3f78-a2a2-07fdacbaeabe", "abstract"=>"BACKGROUND: The recurrence of colorectal cancer (CRC) is frequent within the first year of curative resection surgery and may be unavoidable. microRNAs have been suggested to play roles in carcinogenesis and cancer recurrence. We recently identified microRNA-29c (miRNA-29c) as a predictor of early recurrence in CRC. In the present study, we further investigated the functions and serum level of miRNA-29c in relation to early recurrence of CRC.\\n\\nMETHODS: First we further confirmed overexpression of miRNA-29c in non-early relapse subjects. Gain-of-function in vitro studies were used to evaluate the effect of miRNA-29c on cell proliferation, migration, invasion, and cell cycle progression. The colon cancer cell line Caco2 and a stable clone overexpressing miRNA-29c were xenografted to evaluate the in vivo effect of miRNA-29c in null mice. Finally, circulating miRNA-29c was investigated as a potential biomarker for identifying early relapse.\\n\\nRESULTS: miRNA-29c expression significantly decreased during early relapse compared to non-early relapse in UICC stage II and III CRC patients (P = 0.021). In vitro studies showed that overexpression of miRNA-29c inhibited cell proliferation and migration. The cell cycle studies also revealed that miRNA-29c caused an accumulation of the G1 and G2 population. In vivo, miRNA-29c suppressed tumor growth in null mice. The serum miRNA-29c increased significantly in early relapsed patients compared to non-early elapsed patients (P = 0.012).\\n\\nCONCLUSIONS: miRNA-29c shows anti-tumorigenesis activity, and preoperative circulating miRNA-29c levels can be used to predict postoperative early relapse of CRC.", "link"=>"http://www.mendeley.com/research/functional-significance-microrna29c-patients-colorectal-cancer-potential-circulating-biomarker-predi-2", "reader_count"=>3, "reader_count_by_academic_status"=>{"Researcher"=>1, "Professor"=>1, "Unspecified"=>1}, "reader_count_by_user_role"=>{"Researcher"=>1, "Professor"=>1, "Unspecified"=>1}, "reader_count_by_subject_area"=>{"Medicine and Dentistry"=>1, "Unspecified"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Unspecified"=>{"Unspecified"=>2}}, "group_count"=>0}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1105239", "https://ndownloader.figshare.com/files/1105240", "https://ndownloader.figshare.com/files/1105242"], "description"=>"<div><p>Background</p><p>The recurrence of colorectal cancer (CRC) is frequent within the first year of curative resection surgery and may be unavoidable. microRNAs have been suggested to play roles in carcinogenesis and cancer recurrence. We recently identified microRNA-29c <b>(</b>miRNA-29c<b>)</b> as a predictor of early recurrence in CRC. In the present study, we further investigated the functions and serum level of miRNA-29c in relation to early recurrence of CRC.</p><p>Methods</p><p>First we further confirmed overexpression of miRNA-29c in non-early relapse subjects. Gain-of-function <i>in vitro</i> studies were used to evaluate the effect of miRNA-29c on cell proliferation, migration, invasion, and cell cycle progression. The colon cancer cell line Caco2 and a stable clone overexpressing miRNA-29c were xenografted to evaluate the <i>in vivo</i> effect of miRNA-29c in null mice. Finally, circulating miRNA-29c was investigated as a potential biomarker for identifying early relapse.</p><p>Results</p><p>miRNA-29c expression significantly decreased during early relapse compared to non-early relapse in UICC stage II and III CRC patients (<i>P</i> = 0.021). <i>In vitro</i> studies showed that overexpression of miRNA-29c inhibited cell proliferation and migration. The cell cycle studies also revealed that miRNA-29c caused an accumulation of the G1 and G2 population. <i>In vivo</i>, miRNA-29c suppressed tumor growth in null mice. The serum miRNA-29c increased significantly in early relapsed patients compared to non-early elapsed patients (<i>P = </i>0.012).</p><p>Conclusions</p><p>miRNA-29c shows anti-tumorigenesis activity, and preoperative circulating miRNA-29c levels can be used to predict postoperative early relapse of CRC.</p></div>", "links"=>[], "tags"=>["genetics", "gene expression", "RNA interference", "Molecular genetics", "Gene regulation", "oncology", "Cancer detection and diagnosis", "Cancer screening", "Cancers and neoplasms", "Gastrointestinal tumors", "Colon adenocarcinoma", "Colonic polyps", "Rectal cancer", "microrna-29c", "patients", "colorectal", "circulating", "biomarker", "predicting"], "article_id"=>734738, "categories"=>["Medicine", "Biological Sciences"], "users"=>["I-Ping Yang", "Hsiang-Lin Tsai", "Ching-Wen Huang", "Ming-Yii Huang", "Ming-Feng Hou", "Suh-Hang Hank Juo", "Jaw-Yuan Wang"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0066842.s001", "https://dx.doi.org/10.1371/journal.pone.0066842.s002", "https://dx.doi.org/10.1371/journal.pone.0066842.s003"], "stats"=>{"downloads"=>4, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_Functional_Significance_of_MicroRNA_29c_in_Patients_with_Colorectal_Cancer_A_Potential_Circulating_Biomarker_for_Predicting_Early_Relapse_/734738", "title"=>"The Functional Significance of MicroRNA-29c in Patients with Colorectal Cancer: A Potential Circulating Biomarker for Predicting Early Relapse", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-06-28 02:17:07"}
  • {"files"=>["https://ndownloader.figshare.com/files/1105225"], "description"=>"<p>(A) miRNA-29c expression levels in 56 non-early and 51 early relapse CRC tumor samples. The expression level is significantly decreased in the early-relapse tumors (<i>P = </i>0.021). (B) WST-1 assay showing that miRNA-29c suppresses tumor cell proliferation (<i>P = </i>0.006). OmiR-29c indicates the Caco2 cell clone stably overexpressing miRNA-29c, and NC indicates the negative control stable clone. (C) Overexpression of miRNA-29c causes a significant accumulation of cells in the G2 phase (<i>P = </i>0.02). Black: G1/G0 phase; light gray: S phase; and dark gray: G2 phase. (D) Transwell assay showing that overexpression of miRNA-29c suppresses tumor-cell migration (<i>P</i><0.0001). (E) Overexpression of miRNA-29c does not affect tumor-cell invasion (<i>P = </i>0.349). (F) Overexpression of miRNA-29c decreases cell migration, as indicated by a gap of increased width in O miRNA-29c compared to NC at 24 and 48 h. The photographs showing the inhibition of tumor cell migration were obtained from the wounding healing assay.</p>", "links"=>[], "tags"=>["genetics", "gene expression", "RNA interference", "Molecular genetics", "Gene regulation", "oncology", "Cancer detection and diagnosis", "Cancer screening", "Cancers and neoplasms", "Gastrointestinal tumors", "Colon adenocarcinoma", "Colonic polyps", "Rectal cancer", "mirna-29c", "deregulated", "crc", "overexpression", "caco2", "cells"], "article_id"=>734724, "categories"=>["Medicine", "Biological Sciences"], "users"=>["I-Ping Yang", "Hsiang-Lin Tsai", "Ching-Wen Huang", "Ming-Yii Huang", "Ming-Feng Hou", "Suh-Hang Hank Juo", "Jaw-Yuan Wang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0066842.g001", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_expression_levels_of_miRNA_29c_are_deregulated_in_human_CRC_tumors_and_overexpression_of_miRNA_29c_in_Caco2_cells_affects_cell_proliferation_cell_cycle_progression_and_cell_migration_/734724", "title"=>"The expression levels of miRNA-29c are deregulated in human CRC tumors, and overexpression of miRNA-29c in Caco2 cells affects cell proliferation, cell cycle progression, and cell migration.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-28 02:17:07"}
  • {"files"=>["https://ndownloader.figshare.com/files/1105226"], "description"=>"<p>OmiR-29c is the Caco2 clone stably overexpressing miRNA-29c, and NC is the control stable clone. (A) Photographs of null mice subcutaneously injected with NC cells (<i>N = </i>4, upper panel) or with OmiR-29c cells (<i>N = </i>4, lower panel) were taken 21 days post-injection. (B) The tumor lumps were smaller in the OmiR-29c group (lower panel) than in the NC group (upper panel) after 21 days. (C) The tumor (cm<sup>3</sup>) growth curves for OmiR-29c (- - -; gray) and NC cells (–-; black) over 21 days (<i>P = </i>0.018). (D) Using the Ultra Sensitive Molecular Imaging Strategy, the luciferase activity in the lumps can be scanned without invasion from photographs of null mice subcutaneously injected with OmiR-29c cells taken 21 days post-injection.</p>", "links"=>[], "tags"=>["genetics", "gene expression", "RNA interference", "Molecular genetics", "Gene regulation", "oncology", "Cancer detection and diagnosis", "Cancer screening", "Cancers and neoplasms", "Gastrointestinal tumors", "Colon adenocarcinoma", "Colonic polyps", "Rectal cancer", "mirna-29c"], "article_id"=>734725, "categories"=>["Medicine", "Biological Sciences"], "users"=>["I-Ping Yang", "Hsiang-Lin Tsai", "Ching-Wen Huang", "Ming-Yii Huang", "Ming-Feng Hou", "Suh-Hang Hank Juo", "Jaw-Yuan Wang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0066842.g002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effects_of_miRNA_29c_on_tumor_growth_in_an_animal_model_in_vivo_/734725", "title"=>"Effects of miRNA-29c on tumor growth in an animal model (<i>in vivo</i>).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-28 02:17:07"}
  • {"files"=>["https://ndownloader.figshare.com/files/1105228"], "description"=>"<p>(A) The expression levels of circulating miRNA-29c are deregulated in the serum samples from 23 healthy subjects, 41 non-early and 20 early-relapse CRC patients. Serum miRNA-29c levels were not significantly different between healthy subjects group and non-early-relapse group (<i>P</i> = 0.256). The expression level is significantly increased in the serum samples of early-relapse patients comparing to the healthy subjects group (<i>P</i><0.0001) and non-early-relapse group (<i>P = </i>0.012). (B) The recurrence analysis in CRC patients was assessed by the Kaplan-Meier method and the patterns of early relapsed (blank line) and non-early relapsed (gray line) groups were shown.</p>", "links"=>[], "tags"=>["genetics", "gene expression", "RNA interference", "Molecular genetics", "Gene regulation", "oncology", "Cancer detection and diagnosis", "Cancer screening", "Cancers and neoplasms", "Gastrointestinal tumors", "Colon adenocarcinoma", "Colonic polyps", "Rectal cancer", "circulating", "mirna-29c", "recurrence", "107", "patients", "colorectal", "cancer"], "article_id"=>734727, "categories"=>["Medicine", "Biological Sciences"], "users"=>["I-Ping Yang", "Hsiang-Lin Tsai", "Ching-Wen Huang", "Ming-Yii Huang", "Ming-Feng Hou", "Suh-Hang Hank Juo", "Jaw-Yuan Wang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0066842.g003", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_expression_levels_of_circulating_miRNA_29c_and_recurrence_analysis_of_the_107_patients_with_colorectal_cancer_CRC_/734727", "title"=>"The expression levels of circulating miRNA-29c and recurrence analysis of the 107 patients with colorectal cancer (CRC).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-28 02:17:07"}
  • {"files"=>["https://ndownloader.figshare.com/files/1105230"], "description"=>"1<p>UICC: Union for International Cancer Control;</p>2<p>OR: Odds ratio;</p>3<p>CI: Confidence interval.</p>4<p>WD:Well differentiated; MD: Moderately differentiated; PD: Poorly differentiated.</p>5<p>Ac: Adneocarcinoma; M: Mucinous carcinoma; S: Signet-ring cell carcinoma.</p>6<p>The relative expression level of miRNA-29c is represented by log<sub>10</sub> (2<sup>−ΔCt</sup>). ΔCt = (Ct<sub>miRNA-29c</sub> - Ct<sub>U6b</sub>), with U6b as the internal control for normalization.</p>7<p>SD: Standard deviation.</p>", "links"=>[], "tags"=>["genetics", "gene expression", "RNA interference", "Molecular genetics", "Gene regulation", "oncology", "Cancer detection and diagnosis", "Cancer screening", "Cancers and neoplasms", "Gastrointestinal tumors", "Colon adenocarcinoma", "Colonic polyps", "Rectal cancer", "multivariate", "predictors", "postoperative", "relapse", "107", "ii-iii", "colorectal", "cancer", "patients", "undergoing", "curative"], "article_id"=>734729, "categories"=>["Medicine", "Biological Sciences"], "users"=>["I-Ping Yang", "Hsiang-Lin Tsai", "Ching-Wen Huang", "Ming-Yii Huang", "Ming-Feng Hou", "Suh-Hang Hank Juo", "Jaw-Yuan Wang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0066842.t002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Univariate_and_multivariate_analysis_of_predictors_on_postoperative_early_relapse_for_107_UICC_1_stage_II_III_colorectal_cancer_patients_undergoing_curative_resection_/734729", "title"=>"Univariate and multivariate analysis of predictors on postoperative early relapse for 107 UICC<sup>1</sup> stage II-III colorectal cancer patients undergoing curative resection.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-06-28 02:17:07"}
  • {"files"=>["https://ndownloader.figshare.com/files/1105231"], "description"=>"1<p>International Union Against Cancer.</p>2<p>WD: well differentiated; MD: moderately well differentiated; PD: poorly differentiated.</p>3<p>A: adenocarcinoma; M, mucinous; S: signet-ring cell carcinoma.</p>4<p>Early relapse means recurrence of cancer within 12 months after surgery.</p>*<p>P value was considered statistically significant.</p>", "links"=>[], "tags"=>["genetics", "gene expression", "RNA interference", "Molecular genetics", "Gene regulation", "oncology", "Cancer detection and diagnosis", "Cancer screening", "Cancers and neoplasms", "Gastrointestinal tumors", "Colon adenocarcinoma", "Colonic polyps", "Rectal cancer", "colorectal", "cancer"], "article_id"=>734730, "categories"=>["Medicine", "Biological Sciences"], "users"=>["I-Ping Yang", "Hsiang-Lin Tsai", "Ching-Wen Huang", "Ming-Yii Huang", "Ming-Feng Hou", "Suh-Hang Hank Juo", "Jaw-Yuan Wang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0066842.t003", "stats"=>{"downloads"=>3, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_miRNA_29c_expression_levels_in_colorectal_cancer_tumor_samples_/734730", "title"=>"miRNA-29c expression levels in colorectal cancer tumor samples.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-06-28 02:17:07"}
  • {"files"=>["https://ndownloader.figshare.com/files/1105233"], "description"=>"1<p>UICC: Union for International Cancer Control.</p>2<p>WD:Well differentiated; MD: Moderately differentiated; PD: Poorly differentiated.</p>3<p>Ac: Adneocarcinoma; M: Mucinous carcinoma; S: Signet-ring cell carcinoma.</p>4<p>It means local recurrence or distant metastases within 12 months after surgery.</p>", "links"=>[], "tags"=>["genetics", "gene expression", "RNA interference", "Molecular genetics", "Gene regulation", "oncology", "Cancer detection and diagnosis", "Cancer screening", "Cancers and neoplasms", "Gastrointestinal tumors", "Colon adenocarcinoma", "Colonic polyps", "Rectal cancer", "107", "ii-iii", "colorectal", "cancer"], "article_id"=>734732, "categories"=>["Medicine", "Biological Sciences"], "users"=>["I-Ping Yang", "Hsiang-Lin Tsai", "Ching-Wen Huang", "Ming-Yii Huang", "Ming-Feng Hou", "Suh-Hang Hank Juo", "Jaw-Yuan Wang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0066842.t001", "stats"=>{"downloads"=>7, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Demographic_data_in_107_UICC_1_stage_II_III_colorectal_cancer_patients_/734732", "title"=>"Demographic data in 107 UICC<sup>1</sup> stage II-III colorectal cancer patients.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-06-28 02:17:07"}

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  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
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  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
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  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}

Relative Metric

{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Cell biology", "average_usage"=>[272, 472, 600, 713, 815, 911, 1004, 1094, 1185, 1273, 1358, 1441]}, {"subject_area"=>"/Biology and life sciences/Developmental biology", "average_usage"=>[275, 472, 605, 720, 822, 921, 1013, 1106, 1200, 1289, 1378, 1459, 1531]}, {"subject_area"=>"/Biology and life sciences/Genetics", "average_usage"=>[284, 491, 620, 738, 843, 945, 1043, 1137, 1225, 1315, 1400, 1479, 1555]}]}
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Net::HTTPUnauthorized

Source
CrossRef
Time
2020-05-28 02:17:53 UTC
Target URL
http://doi.crossref.org/servlet/getForwardLinks?usr=plos&pwd=plos1&doi=10.1371%2Fjournal.pone.0066842
Trace

/app/models/concerns/networkable.rb:21:in `get_result'
/app/models/source.rb:165:in `get_data'
/app/models/retrieval_status.rb:47:in `perform_get_data'
/app/jobs/source_job.rb:52:in `block (2 levels) in perform'
/app/jobs/source_job.rb:51:in `block in perform'
/app/jobs/source_job.rb:35:in `each'
/app/jobs/source_job.rb:35:in `perform'