Curcumin Inhibits Imiquimod-Induced Psoriasis-Like Inflammation by Inhibiting IL-1beta and IL-6 Production in Mice
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{"title"=>"Curcumin Inhibits Imiquimod-Induced Psoriasis-Like Inflammation by Inhibiting IL-1beta and IL-6 Production in Mice", "type"=>"journal", "authors"=>[{"first_name"=>"Jun", "last_name"=>"Sun", "scopus_author_id"=>"55566644800"}, {"first_name"=>"Yi", "last_name"=>"Zhao", "scopus_author_id"=>"56528597700"}, {"first_name"=>"Jinhong", "last_name"=>"Hu", "scopus_author_id"=>"55798233000"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84879388555", "doi"=>"10.1371/journal.pone.0067078", "sgr"=>"84879388555", "pmid"=>"23825622", "issn"=>"19326203", "pui"=>"369184579"}, "id"=>"ff4e4dea-d8ed-3b9a-9f04-ebc872395007", "abstract"=>"Curcumin, a selective phosphorylase kinase inhibitor, is a naturally occurring phytochemical present in turmeric. Curcumin has been confirmed to have anti-inflammatory properties in addition to the ability to decrease the expression of pro-inflammatory cytokines in keratinocytes. The interleukin-23 (IL-23)/IL-17A cytokine axis plays a critical role in the pathogenesis of psoriasis. Here, we report that topical use of a curcumin gel formulation strongly inhibited imiquimod (IMQ)-induced psoriasis-like inflammation, the development of which was based on the IL-23/IL-17A axis. IMQ-induced epidermal hyperplasia and inflammation in BALB/c mouse ear was significantly inhibited following curcumin treatment. Real-time PCR showed that mRNA levels of IL-17A, IL-17F, IL-22, IL-1β, IL-6 and TNF-α cytokines were decreased significantly by curcumin in ear skin, an effect similar to that of clobetasol. In addition, we found that curcumin may enhance the proliferation of epidermis γδ T cells but inhibit dermal γδ T cell proliferation. We inferred that curcumin was capable of impacting the IL-23/IL-17A axis by inhibiting IL-1β/IL-6 and then indirectly down-regulating IL-17A/IL-22 production. In conclusion, curcumin can relieve the IMQ-induced psoriasis-like inflammation in a mouse model, similar to the effects of clobetasol. Therefore, we have every reason to expect that curcumin will be used in the treatment of psoriasis in the future.", "link"=>"http://www.mendeley.com/research/curcumin-inhibits-imiquimodinduced-psoriasislike-inflammation-inhibiting-il1beta-il6-production-mice", "reader_count"=>99, "reader_count_by_academic_status"=>{"Unspecified"=>4, "Professor > Associate Professor"=>5, "Student > Doctoral Student"=>9, "Researcher"=>17, "Student > Ph. D. Student"=>19, "Student > Postgraduate"=>8, "Student > Master"=>13, "Other"=>10, "Student > Bachelor"=>12, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>4, "Professor > Associate Professor"=>5, "Student > Doctoral Student"=>9, "Researcher"=>17, "Student > Ph. D. Student"=>19, "Student > Postgraduate"=>8, "Student > Master"=>13, "Other"=>10, "Student > Bachelor"=>12, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>6, "Agricultural and Biological Sciences"=>37, "Philosophy"=>1, "Chemistry"=>5, "Economics, Econometrics and Finance"=>1, "Engineering"=>1, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>3, "Nursing and Health Professions"=>3, "Medicine and Dentistry"=>23, "Neuroscience"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>9, "Psychology"=>1, "Social Sciences"=>1, "Immunology and Microbiology"=>6}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>23}, "Social Sciences"=>{"Social Sciences"=>1}, "Psychology"=>{"Psychology"=>1}, "Unspecified"=>{"Unspecified"=>6}, "Environmental Science"=>{"Environmental Science"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>9}, "Engineering"=>{"Engineering"=>1}, "Chemistry"=>{"Chemistry"=>5}, "Neuroscience"=>{"Neuroscience"=>1}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>6}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>37}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Philosophy"=>{"Philosophy"=>1}}, "reader_count_by_country"=>{"Hungary"=>1, "Brazil"=>1, "Malaysia"=>1, "India"=>1}, "group_count"=>2}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1100265"], "description"=>"<p>AS, antisense; S, sense;</p>", "links"=>[], "tags"=>["immunology", "immunity", "immunotherapy", "autoimmunity", "immunomodulation", "Model organisms", "Animal models", "mouse", "Clinical immunology", "Autoimmune diseases", "psoriasis", "Drugs and devices", "Drug research and development", "drug discovery", "Pharmacodynamics", "sequences", "genes", "examined", "quantitative", "Real-time"], "article_id"=>730848, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Jun Sun", "Yi Zhao", "Jinhong Hu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0067078.t001", "stats"=>{"downloads"=>14, "page_views"=>28, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Primer_sequences_of_mouse_genes_examined_by_quantitative_real_time_PCR_/730848", "title"=>"Primer sequences of mouse genes examined by quantitative real-time PCR.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-06-25 01:58:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/1100261"], "description"=>"<p>A, The thickness of the right ear skin was measured on the days indicated (Mean±SD). B, Erythema, scaling and thickness of the right ear skin was scored on the indicated days with a scale from 0 to 4. The cumulative score is presented (Mean±SD). C, H&E staining of the mouse ear skin of different treatment groups (200×). Arrowheads denote the inside of the ear skin. CUR, curcumin; CLO, clobetasol.</p>", "links"=>[], "tags"=>["immunology", "immunity", "immunotherapy", "autoimmunity", "immunomodulation", "Model organisms", "Animal models", "mouse", "Clinical immunology", "Autoimmune diseases", "psoriasis", "Drugs and devices", "Drug research and development", "drug discovery", "Pharmacodynamics", "inhibited", "imq-induced", "psoriasis-like", "inflammation"], "article_id"=>730844, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Jun Sun", "Yi Zhao", "Jinhong Hu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0067078.g001", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Curcumin_inhibited_IMQ_induced_psoriasis_like_inflammation_N_8202_8202_6_/730844", "title"=>"Curcumin inhibited IMQ-induced psoriasis-like inflammation (N = 6).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-25 01:58:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/1100262"], "description"=>"<p>The figures show the mean value ± SD (fold) of the measured mRNA in mouse ear tissue of different treatment groups at 60 h, 84 h, and 240 h (N = 6). A, IL-1β. The level of IL-1β mRNA in the IMQ-treated group was sharply increased and was inhibited in the CUR-/CLO-treated groups. B, TNF-α. The level of TNF-α mRNA in the IMQ-treated group was increased and was inhibited in the CUR-/CLO-treated groups. C, IL-6. The level of IL-6 mRNA in the IMQ-treated group was increased and was inhibited in the CLO-treated group. D, STAT3. The level of STAT3 mRNA in all groups except control was increased at 240 h. CUR, curcumin; CLO, clobetasol.</p>", "links"=>[], "tags"=>["immunology", "immunity", "immunotherapy", "autoimmunity", "immunomodulation", "Model organisms", "Animal models", "mouse", "Clinical immunology", "Autoimmune diseases", "psoriasis", "Drugs and devices", "Drug research and development", "drug discovery", "Pharmacodynamics", "mrna", "Real-time", "pcr"], "article_id"=>730845, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Jun Sun", "Yi Zhao", "Jinhong Hu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0067078.g003", "stats"=>{"downloads"=>0, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_levels_of_mRNA_measured_using_real_time_PCR_Part_2_/730845", "title"=>"The levels of mRNA measured using real-time PCR (Part 2).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-25 01:58:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/1100263"], "description"=>"<p>A, TCR γδ, CCR6 and RORγ immunohistochemical staining was examined in samples of differently treated mouse ear skin (N = 6). B, The mean number of TCR γδ-positive cells per high power field (N = 6). The differences between groups and between any two groups were significant (Kruskal-Wallis test/Wilcoxon Scores test, <i>P</i><0.05). C, CCR6 and RORγ expression was detected using western blotting. CCR6 expression was increased in IMQ-treated mice and was inhibited by both curcumin and clobetasol. The results shown are representative of 3 independent experiments. CUR, curcumin; CLO, clobetasol.</p>", "links"=>[], "tags"=>["immunology", "immunity", "immunotherapy", "autoimmunity", "immunomodulation", "Model organisms", "Animal models", "mouse", "Clinical immunology", "Autoimmune diseases", "psoriasis", "Drugs and devices", "Drug research and development", "drug discovery", "Pharmacodynamics", "staining", "tcr", "ccr6"], "article_id"=>730846, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Jun Sun", "Yi Zhao", "Jinhong Hu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0067078.g004", "stats"=>{"downloads"=>2, "page_views"=>22, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Immunohistochemical_staining_for_TCR_947_948_CCR6_and_ROR_947_in_skin_/730846", "title"=>"Immunohistochemical staining for TCR γδ, CCR6 and RORγ in skin.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-25 01:58:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/1100264"], "description"=>"<p><b>CUR, curcumin.</b></p>", "links"=>[], "tags"=>["immunology", "immunity", "immunotherapy", "autoimmunity", "immunomodulation", "Model organisms", "Animal models", "mouse", "Clinical immunology", "Autoimmune diseases", "psoriasis", "Drugs and devices", "Drug research and development", "drug discovery", "Pharmacodynamics", "targets", "impacted", "curcumin"], "article_id"=>730847, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Jun Sun", "Yi Zhao", "Jinhong Hu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0067078.g005", "stats"=>{"downloads"=>2, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_possible_targets_impacted_by_curcumin_in_the_IL_23_IL_17A_axis_/730847", "title"=>"The possible targets impacted by curcumin in the IL-23/IL-17A axis.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-25 01:58:01"}

PMC Usage Stats | Further Information

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Relative Metric

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