Disruption of the Circadian Clock in Mice Increases Intestinal Permeability and Promotes Alcohol-Induced Hepatic Pathology and Inflammation
- Publication Date
- June 18, 2013
- Journal
- PLOS ONE
- Authors
- Keith C. Summa, Robin M. Voigt, Christopher B. Forsyth, Maliha Shaikh, et al
- Volume
- 8
- Issue
- 6
- Pages
- e67102
- DOI
- https://dx.plos.org/10.1371/journal.pone.0067102
- Publisher URL
- http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0067102
- PubMed
- http://www.ncbi.nlm.nih.gov/pubmed/23825629
- PubMed Central
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688973
- Europe PMC
- http://europepmc.org/abstract/MED/23825629
- Web of Science
- 000320576400176
- Scopus
- 84879190606
- Mendeley
- http://www.mendeley.com/research/disruption-circadian-clock-mice-increases-intestinal-permeability-promotes-alcoholinduced-hepatic-pa
Loading … 

Events
Loading … 

Mendeley | Further Information
{"title"=>"Disruption of the Circadian Clock in Mice Increases Intestinal Permeability and Promotes Alcohol-Induced Hepatic Pathology and Inflammation", "type"=>"journal", "authors"=>[{"first_name"=>"Keith C.", "last_name"=>"Summa", "scopus_author_id"=>"39262490900"}, {"first_name"=>"Robin M.", "last_name"=>"Voigt", "scopus_author_id"=>"36471324700"}, {"first_name"=>"Christopher B.", "last_name"=>"Forsyth", "scopus_author_id"=>"7102647425"}, {"first_name"=>"Maliha", "last_name"=>"Shaikh", "scopus_author_id"=>"7102079209"}, {"first_name"=>"Kate", "last_name"=>"Cavanaugh", "scopus_author_id"=>"55768361400"}, {"first_name"=>"Yueming", "last_name"=>"Tang", "scopus_author_id"=>"56161703200"}, {"first_name"=>"Martha Hotz", "last_name"=>"Vitaterna", "scopus_author_id"=>"6601932969"}, {"first_name"=>"Shiwen", "last_name"=>"Song", "scopus_author_id"=>"55768980900"}, {"first_name"=>"Fred W.", "last_name"=>"Turek", "scopus_author_id"=>"7102799347"}, {"first_name"=>"Ali", "last_name"=>"Keshavarzian", "scopus_author_id"=>"7006447140"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84879190606", "sgr"=>"84879190606", "pui"=>"369142448", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pmid"=>"23825629", "doi"=>"10.1371/journal.pone.0067102"}, "id"=>"24cc23bc-2414-31b3-bb15-b7355e52ee76", "abstract"=>"The circadian clock orchestrates temporal patterns of physiology and behavior relative to the environmental light:dark cycle by generating and organizing transcriptional and biochemical rhythms in cells and tissues throughout the body. Circadian clock genes have been shown to regulate the physiology and function of the gastrointestinal tract. Disruption of the intestinal epithelial barrier enables the translocation of proinflammatory bacterial products, such as endotoxin, across the intestinal wall and into systemic circulation; a process that has been linked to pathologic inflammatory states associated with metabolic, hepatic, cardiovascular and neurodegenerative diseases - many of which are commonly reported in shift workers. Here we report, for the first time, that circadian disorganization, using independent genetic and environmental strategies, increases permeability of the intestinal epithelial barrier (i.e., gut leakiness) in mice. Utilizing chronic alcohol consumption as a well-established model of induced intestinal hyperpermeability, we also found that both genetic and environmental circadian disruption promote alcohol-induced gut leakiness, endotoxemia and steatohepatitis, possibly through a mechanism involving the tight junction protein occludin. Circadian organization thus appears critical for the maintenance of intestinal barrier integrity, especially in the context of injurious agents, such as alcohol. Circadian disruption may therefore represent a previously unrecognized risk factor underlying the susceptibility to or development of alcoholic liver disease, as well as other conditions associated with intestinal hyperpermeability and an endotoxin-triggered inflammatory state.", "link"=>"http://www.mendeley.com/research/disruption-circadian-clock-mice-increases-intestinal-permeability-promotes-alcoholinduced-hepatic-pa", "reader_count"=>80, "reader_count_by_academic_status"=>{"Unspecified"=>4, "Professor > Associate Professor"=>4, "Researcher"=>15, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>19, "Student > Postgraduate"=>7, "Student > Master"=>13, "Other"=>5, "Student > Bachelor"=>6, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>4, "Professor > Associate Professor"=>4, "Researcher"=>15, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>19, "Student > Postgraduate"=>7, "Student > Master"=>13, "Other"=>5, "Student > Bachelor"=>6, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>7, "Agricultural and Biological Sciences"=>30, "Chemistry"=>1, "Engineering"=>1, "Biochemistry, Genetics and Molecular Biology"=>3, "Nursing and Health Professions"=>1, "Mathematics"=>1, "Medicine and Dentistry"=>25, "Neuroscience"=>3, "Pharmacology, Toxicology and Pharmaceutical Science"=>2, "Psychology"=>1, "Social Sciences"=>1, "Immunology and Microbiology"=>4}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>25}, "Social Sciences"=>{"Social Sciences"=>1}, "Psychology"=>{"Psychology"=>1}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>7}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>2}, "Engineering"=>{"Engineering"=>1}, "Chemistry"=>{"Chemistry"=>1}, "Neuroscience"=>{"Neuroscience"=>3}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>4}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>30}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}}, "reader_count_by_country"=>{"Sweden"=>1, "United States"=>5, "United Kingdom"=>3, "Kazakhstan"=>1}, "group_count"=>1}CrossRef
- http://doi.org/10.1016/j.molmet.2016.10.003
- http://doi.org/10.3389/fphys.2018.00009
- http://doi.org/10.1016/j.intimp.2019.05.005
- http://doi.org/10.1111/nmo.12706
- http://doi.org/10.3389/fmed.2019.00103
- http://doi.org/10.1002/jcp.24946
- http://doi.org/10.5056/jnm14084
- http://doi.org/10.1016/j.alcohol.2017.10.006
- http://doi.org/10.1002/hep.29878
- http://doi.org/10.1038/nrgastro.2016.8
- http://doi.org/10.1016/j.cbi.2020.109132
- http://doi.org/10.1016/j.ceb.2014.06.010
- http://doi.org/10.1016/j.trsl.2018.12.001
- http://doi.org/10.1097/MIB.0000000000000108
- http://doi.org/10.1152/ajpgi.00002.2015
- http://doi.org/10.3390/biom8010003
- http://doi.org/10.1111/acer.12834
- http://doi.org/10.1016/j.jcmgh.2019.10.011
- http://doi.org/10.1016/j.livres.2017.12.004
- http://doi.org/10.1111/acer.13612
- http://doi.org/10.1152/ajpgi.00245.2016
- http://doi.org/10.3389/fonc.2020.01029
- http://doi.org/10.1016/j.stem.2020.05.002
- http://doi.org/10.3390/nu10060681
- http://doi.org/10.1007/s11655-017-2969-8
- http://doi.org/10.3389/fphar.2020.573074
- http://doi.org/10.1111/acer.12483
- http://doi.org/10.1038/srep16896
- http://doi.org/10.1038/srep14424
- http://doi.org/10.1016/j.jhep.2018.10.037
- http://doi.org/10.1038/s41577-018-0008-4
- http://doi.org/10.1016/j.jmb.2019.12.036
- http://doi.org/10.1210/endocr/bqaa167
- http://doi.org/10.1111/acer.13519
- http://doi.org/10.1016/S2468-1253(19)30412-1
- http://doi.org/10.1111/acer.13257
- http://doi.org/10.1016/j.redox.2014.10.002
- http://doi.org/10.1111/ejn.14253
- http://doi.org/10.1080/17474124.2019.1595588
- http://doi.org/10.1080/10408398.2020.1719473
- http://doi.org/10.3390/biology9120417
- http://doi.org/10.1093/ecco-jcc/jjy049
- http://doi.org/10.1038/nrgastro.2016.85
- http://doi.org/10.1016/j.alcohol.2014.07.021
- http://doi.org/10.1016/j.cmet.2017.08.015
- http://doi.org/10.1152/ajpgi.00103.2017
- http://doi.org/10.1152/ajpgi.00207.2015
- http://doi.org/10.1093/carcin/bgv034
- http://doi.org/10.1016/j.neuropharm.2017.04.013
- http://doi.org/10.1016/j.tips.2018.07.003
- http://doi.org/10.1016/j.nbscr.2020.100058
- http://doi.org/10.1111/acer.13351
- http://doi.org/10.1039/C4FO00739E
- http://doi.org/10.3390/biom5042504
- http://doi.org/10.3389/fmicb.2020.01975
- http://doi.org/10.1007/s10620-019-05675-7
- http://doi.org/10.1371/journal.pone.0098016
- http://doi.org/10.1111/imm.13166
- http://doi.org/10.3389/fimmu.2020.01237
- http://doi.org/10.1186/s12981-020-00273-4
- http://doi.org/10.1016/j.trsl.2020.11.007
- http://doi.org/10.1152/ajpgi.00010.2018
- http://doi.org/10.1016/j.nbd.2018.12.012
- http://doi.org/10.1016/j.foodres.2020.109437
- http://doi.org/10.1111/dom.12400
- http://doi.org/10.1152/ajpendo.00270.2016
- http://doi.org/10.15252/embr.201847129
- http://doi.org/10.1016/j.smrv.2020.101340
- http://doi.org/10.1053/j.gastro.2014.10.042
- http://doi.org/10.1002/mnfr.202000375
- http://doi.org/10.1111/acer.12813
- http://doi.org/10.1111/acer.12943
- http://doi.org/10.3390/ijms17122017
- http://doi.org/10.3389/fphys.2020.01048
- http://doi.org/10.3390/cancers10020038
- http://doi.org/10.1152/ajpgi.00152.2020
- http://doi.org/10.1530/JOE-14-0200
- http://doi.org/10.3390/biom5042573
- http://doi.org/10.3389/fpsyt.2018.00669
- http://doi.org/10.1016/j.trsl.2020.04.004
- http://doi.org/10.3389/fimmu.2020.01783
- http://doi.org/10.1097/MCG.0000000000000965
- http://doi.org/10.1111/acer.13513
- http://doi.org/10.1038/s41598-019-42760-3
- http://doi.org/10.1016/j.sleep.2020.08.032
- http://doi.org/10.1007/s00592-016-0923-4
- http://doi.org/10.3389/fnut.2020.00116
- http://doi.org/10.18632/oncotarget.7065
- http://doi.org/10.1152/ajpgi.00066.2017
- http://doi.org/10.1111/acer.14141
- http://doi.org/10.1016/j.jhep.2019.03.020
- http://doi.org/10.1186/1880-6805-33-22
- http://doi.org/10.3389/fmicb.2018.02013
- http://doi.org/10.1371/journal.pone.0097500
- http://doi.org/10.1016/j.pbb.2018.08.009
- http://doi.org/10.1002/art.39090
- http://doi.org/10.1158/1055-9965.EPI-14-1292
- http://doi.org/10.1152/ajpgi.00087.2016
- http://doi.org/10.1016/j.physbeh.2018.04.017
- http://doi.org/10.1155/2017/4723836
- http://doi.org/10.1093/advances/nmy078
- http://doi.org/10.1073/pnas.1911189116
Europe PMC Database Citations | Further Information
{"UNIPROT"=>7}Scopus | Further Information
{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84879190606"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84879190606?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84879190606&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84879190606&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84879190606", "dc:identifier"=>"SCOPUS_ID:84879190606", "eid"=>"2-s2.0-84879190606", "dc:title"=>"Disruption of the Circadian Clock in Mice Increases Intestinal Permeability and Promotes Alcohol-Induced Hepatic Pathology and Inflammation", "dc:creator"=>"Summa K.C.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"8", "prism:issueIdentifier"=>"6", "prism:pageRange"=>nil, "prism:coverDate"=>"2013-06-18", "prism:coverDisplayDate"=>"18 June 2013", "prism:doi"=>"10.1371/journal.pone.0067102", "citedby-count"=>"126", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Northwestern University Feinberg School of Medicine", "affiliation-city"=>"Chicago", "affiliation-country"=>"United States"}, {"@_fa"=>"true", "affilname"=>"Northwestern University", "affiliation-city"=>"Evanston", "affiliation-country"=>"United States"}], "pubmed-id"=>"23825629", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e67102", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true, "freetoread"=>{"value"=>[{"$"=>"all"}, {"$"=>"publisherfullgold"}, {"$"=>"repository"}, {"$"=>"repositoryvor"}, {"$"=>"repositoryam"}]}, "freetoreadLabel"=>{"value"=>[{"$"=>"All Open Access"}, {"$"=>"Gold"}, {"$"=>"Green"}]}}- {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0067102", "share_count"=>3, "like_count"=>1, "comment_count"=>0, "click_count"=>0, "total_count"=>4}
- {"id"=>"771502516152381440", "text"=>"Study: #circadian disruption ? ?intestinal permeability & alcohol-induced liver damage https://t.co/rBcbx88Cih ?\n\nhttps://t.co/YxDrrqRz1G ?", "created_at"=>"2016-09-02T00:18:28Z", "user"=>"CaloriesProper", "user_name"=>"Bill Lagakos", "user_profile_image"=>"http://pbs.twimg.com/profile_images/740718720864026624/l4EWWpyw_normal.jpg"}
- {"id"=>"771505352340680704", "text"=>"RT @CaloriesProper: Study: #circadian disruption ? ?intestinal permeability & alcohol-induced liver damage https://t.co/rBcbx88Cih ?\n\nhttps…", "created_at"=>"2016-09-02T00:29:44Z", "user"=>"DrDeaRoberts", "user_name"=>"Dr Dea Roberts", "user_profile_image"=>"http://pbs.twimg.com/profile_images/644762685389737984/BaONbQks_normal.jpg"}
- {"id"=>"771736425016340480", "text"=>"RT @CaloriesProper: Study: #circadian disruption ? ?intestinal permeability & alcohol-induced liver damage https://t.co/rBcbx88Cih ?\n\nhttps…", "created_at"=>"2016-09-02T15:47:56Z", "user"=>"arenelopez1", "user_name"=>"Ren? Louri", "user_profile_image"=>"http://pbs.twimg.com/profile_images/755089650901929984/mM39ergG_normal.jpg"}
Counter
- {"month"=>"6", "year"=>"2013", "pdf_views"=>"25", "xml_views"=>"4", "html_views"=>"213"}
- {"month"=>"7", "year"=>"2013", "pdf_views"=>"113", "xml_views"=>"3", "html_views"=>"570"}
- {"month"=>"8", "year"=>"2013", "pdf_views"=>"44", "xml_views"=>"0", "html_views"=>"208"}
- {"month"=>"9", "year"=>"2013", "pdf_views"=>"46", "xml_views"=>"0", "html_views"=>"267"}
- {"month"=>"10", "year"=>"2013", "pdf_views"=>"30", "xml_views"=>"3", "html_views"=>"218"}
- {"month"=>"11", "year"=>"2013", "pdf_views"=>"33", "xml_views"=>"1", "html_views"=>"196"}
- {"month"=>"12", "year"=>"2013", "pdf_views"=>"28", "xml_views"=>"1", "html_views"=>"214"}
- {"month"=>"1", "year"=>"2014", "pdf_views"=>"29", "xml_views"=>"1", "html_views"=>"238"}
- {"month"=>"2", "year"=>"2014", "pdf_views"=>"15", "xml_views"=>"3", "html_views"=>"160"}
- {"month"=>"3", "year"=>"2014", "pdf_views"=>"27", "xml_views"=>"2", "html_views"=>"217"}
- {"month"=>"4", "year"=>"2014", "pdf_views"=>"23", "xml_views"=>"2", "html_views"=>"218"}
- {"month"=>"5", "year"=>"2014", "pdf_views"=>"26", "xml_views"=>"0", "html_views"=>"179"}
- {"month"=>"6", "year"=>"2014", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"144"}
- {"month"=>"7", "year"=>"2014", "pdf_views"=>"20", "xml_views"=>"2", "html_views"=>"159"}
- {"month"=>"8", "year"=>"2014", "pdf_views"=>"12", "xml_views"=>"2", "html_views"=>"81"}
- {"month"=>"9", "year"=>"2014", "pdf_views"=>"25", "xml_views"=>"1", "html_views"=>"152"}
- {"month"=>"10", "year"=>"2014", "pdf_views"=>"16", "xml_views"=>"1", "html_views"=>"104"}
- {"month"=>"11", "year"=>"2014", "pdf_views"=>"21", "xml_views"=>"1", "html_views"=>"122"}
- {"month"=>"12", "year"=>"2014", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"94"}
- {"month"=>"1", "year"=>"2015", "pdf_views"=>"28", "xml_views"=>"0", "html_views"=>"77"}
- {"month"=>"2", "year"=>"2015", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"89"}
- {"month"=>"3", "year"=>"2015", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"110"}
- {"month"=>"4", "year"=>"2015", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"92"}
- {"month"=>"5", "year"=>"2015", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"114"}
- {"month"=>"6", "year"=>"2015", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"82"}
- {"month"=>"7", "year"=>"2015", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"58"}
- {"month"=>"8", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"71"}
- {"month"=>"9", "year"=>"2015", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"105"}
- {"month"=>"10", "year"=>"2015", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"130"}
- {"month"=>"11", "year"=>"2015", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"150"}
- {"month"=>"12", "year"=>"2015", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"139"}
- {"month"=>"1", "year"=>"2016", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"123"}
- {"month"=>"2", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"117"}
- {"month"=>"3", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"114"}
- {"month"=>"4", "year"=>"2016", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"90"}
- {"month"=>"5", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"66"}
- {"month"=>"6", "year"=>"2016", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"44"}
- {"month"=>"7", "year"=>"2016", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"53"}
- {"month"=>"8", "year"=>"2016", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"61"}
- {"month"=>"9", "year"=>"2016", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"460"}
- {"month"=>"10", "year"=>"2016", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"278"}
- {"month"=>"11", "year"=>"2016", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"237"}
- {"month"=>"12", "year"=>"2016", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"303"}
- {"month"=>"1", "year"=>"2017", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"323"}
- {"month"=>"2", "year"=>"2017", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"244"}
- {"month"=>"3", "year"=>"2017", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"267"}
- {"month"=>"4", "year"=>"2017", "pdf_views"=>"24", "xml_views"=>"0", "html_views"=>"274"}
- {"month"=>"5", "year"=>"2017", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"272"}
- {"month"=>"6", "year"=>"2017", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"221"}
- {"month"=>"7", "year"=>"2017", "pdf_views"=>"41", "xml_views"=>"8", "html_views"=>"234"}
- {"month"=>"8", "year"=>"2017", "pdf_views"=>"34", "xml_views"=>"1", "html_views"=>"224"}
- {"month"=>"9", "year"=>"2017", "pdf_views"=>"20", "xml_views"=>"2", "html_views"=>"208"}
- {"month"=>"10", "year"=>"2017", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"206"}
- {"month"=>"11", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"237"}
- {"month"=>"12", "year"=>"2017", "pdf_views"=>"22", "xml_views"=>"1", "html_views"=>"192"}
- {"month"=>"1", "year"=>"2018", "pdf_views"=>"11", "xml_views"=>"2", "html_views"=>"82"}
- {"month"=>"2", "year"=>"2018", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"45"}
- {"month"=>"3", "year"=>"2018", "pdf_views"=>"25", "xml_views"=>"0", "html_views"=>"65"}
- {"month"=>"4", "year"=>"2018", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"48"}
- {"month"=>"5", "year"=>"2018", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"53"}
- {"month"=>"6", "year"=>"2018", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"34"}
- {"month"=>"7", "year"=>"2018", "pdf_views"=>"24", "xml_views"=>"5", "html_views"=>"59"}
- {"month"=>"8", "year"=>"2018", "pdf_views"=>"17", "xml_views"=>"1", "html_views"=>"26"}
- {"month"=>"9", "year"=>"2018", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"36"}
- {"month"=>"10", "year"=>"2018", "pdf_views"=>"19", "xml_views"=>"3", "html_views"=>"58"}
- {"month"=>"11", "year"=>"2018", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"49"}
- {"month"=>"12", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"27"}
- {"month"=>"1", "year"=>"2019", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"39"}
- {"month"=>"2", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"46"}
- {"month"=>"3", "year"=>"2019", "pdf_views"=>"31", "xml_views"=>"0", "html_views"=>"41"}
- {"month"=>"4", "year"=>"2019", "pdf_views"=>"27", "xml_views"=>"0", "html_views"=>"42"}
- {"month"=>"5", "year"=>"2019", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"61"}
- {"month"=>"6", "year"=>"2019", "pdf_views"=>"26", "xml_views"=>"0", "html_views"=>"65"}
- {"month"=>"7", "year"=>"2019", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"50"}
- {"month"=>"8", "year"=>"2019", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"39"}
- {"month"=>"9", "year"=>"2019", "pdf_views"=>"25", "xml_views"=>"0", "html_views"=>"29"}
- {"month"=>"10", "year"=>"2019", "pdf_views"=>"16", "xml_views"=>"1", "html_views"=>"34"}
- {"month"=>"11", "year"=>"2019", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"30"}
- {"month"=>"12", "year"=>"2019", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"27"}
- {"month"=>"1", "year"=>"2020", "pdf_views"=>"25", "xml_views"=>"0", "html_views"=>"28"}
- {"month"=>"2", "year"=>"2020", "pdf_views"=>"16", "xml_views"=>"1", "html_views"=>"36"}
- {"month"=>"3", "year"=>"2020", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"27"}
- {"month"=>"4", "year"=>"2020", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"22"}
- {"month"=>"5", "year"=>"2020", "pdf_views"=>"49", "xml_views"=>"1", "html_views"=>"24"}
- {"month"=>"6", "year"=>"2020", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"20"}
- {"month"=>"7", "year"=>"2020", "pdf_views"=>"34", "xml_views"=>"0", "html_views"=>"15"}
- {"month"=>"8", "year"=>"2020", "pdf_views"=>"20", "xml_views"=>"1", "html_views"=>"18"}
- {"month"=>"9", "year"=>"2020", "pdf_views"=>"41", "xml_views"=>"0", "html_views"=>"35"}
- {"month"=>"10", "year"=>"2020", "pdf_views"=>"57", "xml_views"=>"0", "html_views"=>"19"}
- {"month"=>"11", "year"=>"2020", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"23"}
- {"month"=>"12", "year"=>"2020", "pdf_views"=>"84", "xml_views"=>"3", "html_views"=>"20"}
- {"month"=>"1", "year"=>"2021", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"11"}
PMC Usage Stats | Further Information
- {"unique-ip"=>"70", "full-text"=>"76", "pdf"=>"60", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"39", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
- {"unique-ip"=>"46", "full-text"=>"44", "pdf"=>"28", "abstract"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
- {"unique-ip"=>"43", "full-text"=>"50", "pdf"=>"39", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"16", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
- {"unique-ip"=>"30", "full-text"=>"28", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"25", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
- {"unique-ip"=>"34", "full-text"=>"38", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
- {"unique-ip"=>"29", "full-text"=>"42", "pdf"=>"20", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"22", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
- {"unique-ip"=>"37", "full-text"=>"36", "pdf"=>"23", "abstract"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
- {"unique-ip"=>"33", "full-text"=>"28", "pdf"=>"7", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
- {"unique-ip"=>"26", "full-text"=>"24", "pdf"=>"7", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
- {"unique-ip"=>"76", "full-text"=>"79", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
- {"unique-ip"=>"22", "full-text"=>"16", "pdf"=>"7", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"27", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
- {"unique-ip"=>"22", "full-text"=>"28", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2014", "month"=>"4"}
- {"unique-ip"=>"48", "full-text"=>"55", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
- {"unique-ip"=>"27", "full-text"=>"34", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"5"}
- {"unique-ip"=>"23", "full-text"=>"47", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
- {"unique-ip"=>"37", "full-text"=>"38", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"3", "year"=>"2015", "month"=>"7"}
- {"unique-ip"=>"41", "full-text"=>"51", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
- {"unique-ip"=>"33", "full-text"=>"32", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"2"}
- {"unique-ip"=>"21", "full-text"=>"19", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
- {"unique-ip"=>"15", "full-text"=>"18", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
- {"unique-ip"=>"42", "full-text"=>"41", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"10"}
- {"unique-ip"=>"27", "full-text"=>"22", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
- {"unique-ip"=>"9", "full-text"=>"6", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
- {"unique-ip"=>"37", "full-text"=>"33", "pdf"=>"37", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2014", "month"=>"9"}
- {"unique-ip"=>"22", "full-text"=>"18", "pdf"=>"5", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2014", "month"=>"10"}
- {"unique-ip"=>"38", "full-text"=>"33", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"42", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
- {"unique-ip"=>"20", "full-text"=>"20", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
- {"unique-ip"=>"22", "full-text"=>"17", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
- {"unique-ip"=>"26", "full-text"=>"35", "pdf"=>"20", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
- {"unique-ip"=>"29", "full-text"=>"22", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"3", "year"=>"2015", "month"=>"11"}
- {"unique-ip"=>"39", "full-text"=>"30", "pdf"=>"18", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"19", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
- {"unique-ip"=>"36", "full-text"=>"46", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2016", "month"=>"1"}
- {"unique-ip"=>"28", "full-text"=>"27", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
- {"unique-ip"=>"32", "full-text"=>"37", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
- {"unique-ip"=>"21", "full-text"=>"20", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"16", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
- {"unique-ip"=>"26", "full-text"=>"20", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
- {"unique-ip"=>"23", "full-text"=>"25", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
- {"unique-ip"=>"23", "full-text"=>"27", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
- {"unique-ip"=>"25", "full-text"=>"23", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
- {"unique-ip"=>"30", "full-text"=>"31", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
- {"unique-ip"=>"32", "full-text"=>"39", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2016", "month"=>"11"}
- {"unique-ip"=>"20", "full-text"=>"24", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
- {"unique-ip"=>"16", "full-text"=>"12", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2017", "month"=>"1"}
- {"unique-ip"=>"26", "full-text"=>"29", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
- {"unique-ip"=>"20", "full-text"=>"23", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
- {"unique-ip"=>"10", "full-text"=>"16", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
- {"unique-ip"=>"88", "full-text"=>"96", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
- {"unique-ip"=>"16", "full-text"=>"16", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
- {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
- {"unique-ip"=>"20", "full-text"=>"23", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
- {"unique-ip"=>"22", "full-text"=>"25", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"16", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2017", "month"=>"9"}
- {"unique-ip"=>"34", "full-text"=>"29", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
- {"unique-ip"=>"33", "full-text"=>"38", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
- {"unique-ip"=>"34", "full-text"=>"32", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
- {"unique-ip"=>"38", "full-text"=>"47", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
- {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"2"}
- {"unique-ip"=>"44", "full-text"=>"49", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2018", "month"=>"3"}
- {"unique-ip"=>"20", "full-text"=>"25", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
- {"unique-ip"=>"37", "full-text"=>"43", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
- {"unique-ip"=>"34", "full-text"=>"39", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
- {"unique-ip"=>"26", "full-text"=>"28", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
- {"unique-ip"=>"28", "full-text"=>"34", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
- {"unique-ip"=>"44", "full-text"=>"57", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2018", "month"=>"8"}
- {"unique-ip"=>"38", "full-text"=>"40", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
- {"unique-ip"=>"39", "full-text"=>"49", "pdf"=>"12", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
- {"unique-ip"=>"34", "full-text"=>"42", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
- {"unique-ip"=>"31", "full-text"=>"33", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
- {"unique-ip"=>"28", "full-text"=>"31", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
- {"unique-ip"=>"26", "full-text"=>"28", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
- {"unique-ip"=>"37", "full-text"=>"45", "pdf"=>"11", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
- {"unique-ip"=>"27", "full-text"=>"31", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
- {"unique-ip"=>"22", "full-text"=>"27", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
- {"unique-ip"=>"29", "full-text"=>"31", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
- {"unique-ip"=>"72", "full-text"=>"74", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"27", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2019", "month"=>"10"}
- {"unique-ip"=>"22", "full-text"=>"22", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
- {"unique-ip"=>"33", "full-text"=>"42", "pdf"=>"24", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2020", "month"=>"2"}
- {"unique-ip"=>"30", "full-text"=>"34", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
- {"unique-ip"=>"34", "full-text"=>"38", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
- {"unique-ip"=>"50", "full-text"=>"71", "pdf"=>"13", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}
- {"unique-ip"=>"30", "full-text"=>"39", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}
- {"unique-ip"=>"38", "full-text"=>"53", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"7"}
- {"unique-ip"=>"29", "full-text"=>"58", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"8"}
- {"unique-ip"=>"27", "full-text"=>"38", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"9"}
- {"unique-ip"=>"25", "full-text"=>"27", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2020", "month"=>"10"}
- {"unique-ip"=>"28", "full-text"=>"44", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"11"}
- {"unique-ip"=>"27", "full-text"=>"51", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2020", "month"=>"12"}
Relative Metric
{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Biochemistry", "average_usage"=>[266, 468, 593, 703, 804, 903, 993, 1084, 1171, 1256, 1339, 1422, 1492]}, {"subject_area"=>"/Biology and life sciences/Chronobiology", "average_usage"=>[239, 466, 586, 696, 781, 872, 958, 1041, 1118, 1201, 1282, 1354, 1422]}, {"subject_area"=>"/Biology and life sciences/Immunology", "average_usage"=>[266, 466, 591, 701, 799, 887, 982, 1067, 1155, 1237, 1317, 1395, 1458]}, {"subject_area"=>"/Biology and life sciences/Nutrition", "average_usage"=>[264, 463, 602, 708, 816, 908, 1015, 1103, 1200, 1297, 1389, 1476, 1538]}, {"subject_area"=>"/Ecology and environmental sciences", "average_usage"=>[284, 475, 603, 722, 826, 928, 1026, 1129, 1225, 1310, 1390, 1468, 1549]}, {"subject_area"=>"/Medicine and health sciences/Anatomy and physiology", "average_usage"=>[253, 430]}, {"subject_area"=>"/Medicine and health sciences/Pathology and laboratory medicine", "average_usage"=>[267, 466, 592, 709, 806, 901, 989, 1075, 1162, 1254, 1342, 1424, 1486]}]}Loading … 

There are currently no alerts