The Dual Effect of Cannabinoid Receptor-1 Deficiency on the Murine Postoperative Ileus
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{"title"=>"The Dual Effect of Cannabinoid Receptor-1 Deficiency on the Murine Postoperative Ileus", "type"=>"journal", "authors"=>[{"first_name"=>"Yong yu", "last_name"=>"Li", "scopus_author_id"=>"27168218200"}, {"first_name"=>"Ming hua", "last_name"=>"Cao", "scopus_author_id"=>"55540616600"}, {"first_name"=>"Brigitte", "last_name"=>"Goetz", "scopus_author_id"=>"55364095600"}, {"first_name"=>"Chun qiu", "last_name"=>"Chen", "scopus_author_id"=>"56190380400"}, {"first_name"=>"Ya jing", "last_name"=>"Feng", "scopus_author_id"=>"49663323900"}, {"first_name"=>"Chang Jie", "last_name"=>"Chen", "scopus_author_id"=>"57192216683"}, {"first_name"=>"Michael S.", "last_name"=>"Kasparek", "scopus_author_id"=>"6701715284"}, {"first_name"=>"Andrej", "last_name"=>"Sibaev", "scopus_author_id"=>"6508123149"}, {"first_name"=>"Martin", "last_name"=>"Storr", "scopus_author_id"=>"7004471341"}, {"first_name"=>"Martin E.", "last_name"=>"Kreis", "scopus_author_id"=>"16836746900"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"23844009", "sgr"=>"84879746214", "doi"=>"10.1371/journal.pone.0067427", "scopus"=>"2-s2.0-84879746214", "pui"=>"369253388", "issn"=>"19326203"}, "id"=>"0560102b-363f-36b9-9644-b4ac3342690a", "abstract"=>"INTRODUCTION: Intestinal inflammatory responses play a critical role in the pathogenesis of postoperative ileus (POI). As cannabinoid receptor-1 (CB1) is involved in inhibiting gastrointestinal (GI) motility and anti-inflammation, we aimed to explore its contribution to POI.\\n\\nMETHODS: Experimental POI was induced in adult female CB1-deficient (CB1-/-) mice and wild-type littermates (C57BL/6N) by standardized small bowel manipulation. Twenty-four hours after surgery, GI transit was assessed by charcoal transport. FITC avidin, F4/80, and myeloperoxidase immunohistochemistry techniques were used to evaluate the inflammatory response in the muscularis of ileum and colon. Expressions of p38MAPK and its phosphorylated form (pp38) in the intestine were determined. Plasma levels of proinflammatory cytokines and chemokines were measured by ELISA as well.\\n\\nRESULTS: POI was characterized by decreased GI transit (p<0.01) and accompanied by a marked intestinal and systematic inflammatory response in wild-type and CB1-/- mice. Increased numbers of inflammatory cells, including macrophages, neutrophils, and mast cells were observed in the muscularis of ileum and colon (p<0.01, or p<0.05). Plasma levels of interleukin-6 (IL-6), cytokine-induced neutrophil chemoattractant-1 (CINC-1/KC), and monocyte chemoattractant protein-1 (MCP-1) were elevated (p<0.01, or p<0.05). Expression of p38 and pp38 increased in the intestine (p<0.01, or p<0.05). CB1-/- mice showed an increased inflammatory response during POI, especially the systemic inflammatory markers, such as IL-6, KC, CINC1, and pp38 expression were increased as compared to those in WT mice (p<0.05).\\n\\nCONCLUSIONS: Intestinal motility was inhibited during POI. In this condition, inhibition of motility did not seem to be altered by the absence of CB1 receptors, however, an increased inflammatory response was observed in CB1-/- mice. Hence, CB1 receptor activation rather than inhibition may reduce the inflammatory response in POI, which has a remote potential to relate into reduced inhibition of intestinal motility during POI.", "link"=>"http://www.mendeley.com/research/dual-effect-cannabinoid-receptor1-deficiency-murine-postoperative-ileus", "reader_count"=>14, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>4, "Student > Doctoral Student"=>2, "Student > Postgraduate"=>1, "Student > Master"=>1, "Other"=>2, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>4, "Student > Doctoral Student"=>2, "Student > Postgraduate"=>1, "Student > Master"=>1, "Other"=>2, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>1, "Medicine and Dentistry"=>4, "Agricultural and Biological Sciences"=>3, "Psychology"=>1, "Social Sciences"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Social Sciences"=>{"Social Sciences"=>1}, "Psychology"=>{"Psychology"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>3}}, "reader_count_by_country"=>{"United States"=>1, "United Kingdom"=>1}, "group_count"=>2}

Scopus | Further Information

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/1110659"], "description"=>"<p>A and C show the representative images and summarizing histograms of p38 in mouse ileum, and B and D show pp38 in mouse ileum of WT and <i>CB1–/–</i> mice. Data are given as mean ± SEM (n = 4/group). **<i>P</i><0.01 vs.normal, ##<i>P</i><0.01 vs.sham, and && <i>P</i><0.01 vs. the identically-treated groups in WT mice. SMI means small intestine. Scale bar  = 50 µm.</p>", "links"=>[], "tags"=>["Molecular cell biology", "Signal transduction", "Membrane receptor signaling", "Diagnostic medicine", "pathology", "anatomical pathology", "Surgical pathology", "Gastroenterology and hepatology", "Infectious diseases", "Gastrointestinal infections", "surgery", "Gastrointestinal surgery", "ileum"], "article_id"=>739047, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Yong-yu Li", "Ming-hua Cao", "Brigitte Goetz", "Chun-qiu Chen", "Ya-jing Feng", "Chang-Jie Chen", "Michael S. Kasparek", "Andrej Sibaev", "Martin Storr", "Martin E. Kreis"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0067427.g007", "stats"=>{"downloads"=>2, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_p38MAPK_expression_in_the_ileum_of_mice_/739047", "title"=>"p38MAPK expression in the ileum of mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-07-03 03:16:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/1110641"], "description"=>"<p>Gastrointestinal transit is determined as the distance travelled by orally-administered charcoal and presented as the percentage of total length of small intestine. Data are mean ± SD (n = 6/group). **<i>P</i><0.01 vs. Control; <sup>##</sup><i>P</i><0.01 vs. Sham group; and & <i>P</i><0.05, CB1–/– vs. identically-treated groups in WT mice.</p>", "links"=>[], "tags"=>["Molecular cell biology", "Signal transduction", "Membrane receptor signaling", "Diagnostic medicine", "pathology", "anatomical pathology", "Surgical pathology", "Gastroenterology and hepatology", "Infectious diseases", "Gastrointestinal infections", "surgery", "Gastrointestinal surgery", "gi", "wt"], "article_id"=>739029, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Yong-yu Li", "Ming-hua Cao", "Brigitte Goetz", "Chun-qiu Chen", "Ya-jing Feng", "Chang-Jie Chen", "Michael S. Kasparek", "Andrej Sibaev", "Martin Storr", "Martin E. Kreis"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0067427.g001", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Upper_GI_transit_in_WT_and_CB1_8211_8211_CB1_KO_mice_/739029", "title"=>"Upper GI transit in WT and <i>CB1–/–</i> (CB1-KO) mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-07-03 03:16:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/1110655"], "description"=>"<p>A and B show representative staining figures of MPO positive cells in small intestine (SMI) (A) and in colon (B) from WT or <i>CB1–/–</i> mice. C and D show statistical histograms of MPO positive cells in SMI (C) and in colon(D). Cell counts are given as positive cells per square millimeter (mean±SEM, n = 6). *<i>P</i><0.05 vs.normal, **<i>P</i><0.01 vs. normal; and #<i>P</i><0.05 vs. sham group. Scale bar  = 10 µm.</p>", "links"=>[], "tags"=>["Molecular cell biology", "Signal transduction", "Membrane receptor signaling", "Diagnostic medicine", "pathology", "anatomical pathology", "Surgical pathology", "Gastroenterology and hepatology", "Infectious diseases", "Gastrointestinal infections", "surgery", "Gastrointestinal surgery", "neutrophils", "mounts", "intestinal", "muscularis"], "article_id"=>739043, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Yong-yu Li", "Ming-hua Cao", "Brigitte Goetz", "Chun-qiu Chen", "Ya-jing Feng", "Chang-Jie Chen", "Michael S. Kasparek", "Andrej Sibaev", "Martin Storr", "Martin E. Kreis"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0067427.g005", "stats"=>{"downloads"=>1, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_MPO_staining_for_neutrophils_in_whole_mounts_of_intestinal_muscularis_of_mice_/739043", "title"=>"MPO-staining for neutrophils in whole mounts of intestinal muscularis of mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-07-03 03:16:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/1110662"], "description"=>"<p>A and C display images and histograms for p38 in colon, and B and D for pp38 in colon of WT and <i>CB1–/–</i> mice. Data are given as mean±SEM (n = 4/group). *<i>P</i><0.05, **<i>P</i><0.01 vs.normal; ##<i>P</i><0.01 vs.sham; and && <i>P</i><0.01 vs. the identically-treated groups in WT mice. Scale bar  = 50 µm.</p>", "links"=>[], "tags"=>["Molecular cell biology", "Signal transduction", "Membrane receptor signaling", "Diagnostic medicine", "pathology", "anatomical pathology", "Surgical pathology", "Gastroenterology and hepatology", "Infectious diseases", "Gastrointestinal infections", "surgery", "Gastrointestinal surgery", "colon"], "article_id"=>739050, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Yong-yu Li", "Ming-hua Cao", "Brigitte Goetz", "Chun-qiu Chen", "Ya-jing Feng", "Chang-Jie Chen", "Michael S. Kasparek", "Andrej Sibaev", "Martin Storr", "Martin E. Kreis"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0067427.g008", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_p38MAPK_expression_in_the_colon_of_mice_/739050", "title"=>"p38MAPK expression in the colon of mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-07-03 03:16:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/1110643"], "description"=>"<p>A shows ileum tissue, and B shows colonic tissue sections from WT and <i>CB1–/–</i> (CB1-KO) mice. Excised ileum and colon segments were paraffin embedded, sliced, and stained with hematoxylin and eosin (HE), and observed under a microscope (original magnification 100×). Scale bar  = 50 µm.</p>", "links"=>[], "tags"=>["Molecular cell biology", "Signal transduction", "Membrane receptor signaling", "Diagnostic medicine", "pathology", "anatomical pathology", "Surgical pathology", "Gastroenterology and hepatology", "Infectious diseases", "Gastrointestinal infections", "surgery", "Gastrointestinal surgery", "intestinal", "tissues"], "article_id"=>739031, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Yong-yu Li", "Ming-hua Cao", "Brigitte Goetz", "Chun-qiu Chen", "Ya-jing Feng", "Chang-Jie Chen", "Michael S. Kasparek", "Andrej Sibaev", "Martin Storr", "Martin E. Kreis"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0067427.g002", "stats"=>{"downloads"=>2, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Histological_changes_in_intestinal_tissues_of_mice_/739031", "title"=>"Histological changes in intestinal tissues of mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-07-03 03:16:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/1110644"], "description"=>"<p>A and B show representative staining figures of FITC-avidin positive cells in small intestine (SMI) (A) and in colon (B) from WT or <i>CB1–/–</i> mice. C and D show statistical histograms of FITC-avidin positive cells in SMI (C) and in colon (D). The given cell counts are as positive cells per square millimeter (mean ± SEM, n = 6). **<i>P</i><0.01 vs. normal controls, #<i>P</i><0.05 vs. sham operated mice. Scale bar  = 10 µm.</p>", "links"=>[], "tags"=>["Molecular cell biology", "Signal transduction", "Membrane receptor signaling", "Diagnostic medicine", "pathology", "anatomical pathology", "Surgical pathology", "Gastroenterology and hepatology", "Infectious diseases", "Gastrointestinal infections", "surgery", "Gastrointestinal surgery", "avidin", "staining", "mast", "cells", "mounts", "intestinal", "muscularis"], "article_id"=>739032, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Yong-yu Li", "Ming-hua Cao", "Brigitte Goetz", "Chun-qiu Chen", "Ya-jing Feng", "Chang-Jie Chen", "Michael S. Kasparek", "Andrej Sibaev", "Martin Storr", "Martin E. Kreis"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0067427.g003", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_FITC_avidin_staining_for_mast_cells_in_whole_mounts_of_intestinal_muscularis_of_mice_/739032", "title"=>"FITC avidin staining for mast cells in whole mounts of intestinal muscularis of mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-07-03 03:16:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/1110656"], "description"=>"<p>A–B show the statistical histograms of cytokine-induced neutrophil chemoattractant-1 (CINC-1/KC) and monocyte chemoattractant protein-1 (MCP-1), C–D show the statistical histograms of interlukin (IL)-6 and tumor necrotic factor (TNF)-α. The data are expressed as pg/ml plasma (A–C) or as percentage of the control (D) (mean±SEM, n = 6).*<i>P</i><0.05 vs.normal, **<i>P</i><0.01 vs.normal; ##<i>P</i><0.01 vs.sham; and && <i>P</i><0.01 vs. the identically-treated groups in WT mice.</p>", "links"=>[], "tags"=>["Molecular cell biology", "Signal transduction", "Membrane receptor signaling", "Diagnostic medicine", "pathology", "anatomical pathology", "Surgical pathology", "Gastroenterology and hepatology", "Infectious diseases", "Gastrointestinal infections", "surgery", "Gastrointestinal surgery", "inflammatory", "chemokines", "cytokines"], "article_id"=>739044, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Yong-yu Li", "Ming-hua Cao", "Brigitte Goetz", "Chun-qiu Chen", "Ya-jing Feng", "Chang-Jie Chen", "Michael S. Kasparek", "Andrej Sibaev", "Martin Storr", "Martin E. Kreis"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0067427.g006", "stats"=>{"downloads"=>1, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Levels_of_inflammatory_chemokines_and_cytokines_in_mouse_plasma_/739044", "title"=>"Levels of inflammatory chemokines and cytokines in mouse plasma.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-07-03 03:16:59"}

PMC Usage Stats | Further Information

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Relative Metric

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