Comparative Study of the Cytokine/Chemokine Response in Children with Differing Disease Severity in Enterovirus 71-Induced Hand, Foot, and Mouth Disease
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Comparative Study of the Cytokine/Chemokine Response in Children with Differing Disease Severity in Enterovirus 71-Induced Hand, Foot, and Mouth Disease", "type"=>"journal", "authors"=>[{"first_name"=>"Yan", "last_name"=>"Zhang", "scopus_author_id"=>"56295386500"}, {"first_name"=>"Haiying", "last_name"=>"Liu", "scopus_author_id"=>"14018295900"}, {"first_name"=>"Linghang", "last_name"=>"Wang", "scopus_author_id"=>"54796236200"}, {"first_name"=>"Fan", "last_name"=>"Yang", "scopus_author_id"=>"56883461400"}, {"first_name"=>"Yongfeng", "last_name"=>"Hu", "scopus_author_id"=>"55695316500"}, {"first_name"=>"Xianwen", "last_name"=>"Ren", "scopus_author_id"=>"7401875552"}, {"first_name"=>"Guojun", "last_name"=>"Li", "scopus_author_id"=>"55778013000"}, {"first_name"=>"Yang", "last_name"=>"Yu", "scopus_author_id"=>"57197520066"}, {"first_name"=>"Shaoxia", "last_name"=>"Sun", "scopus_author_id"=>"48761988200"}, {"first_name"=>"Yufen", "last_name"=>"Li", "scopus_author_id"=>"7502078027"}, {"first_name"=>"Xinchun", "last_name"=>"Chen", "scopus_author_id"=>"55109589100"}, {"first_name"=>"Xingwang", "last_name"=>"Li", "scopus_author_id"=>"7501697688"}, {"first_name"=>"Qi", "last_name"=>"Jin", "scopus_author_id"=>"26030966000"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84879537715", "pmid"=>"23840697", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "scopus"=>"2-s2.0-84879537715", "issn"=>"19326203", "pui"=>"369209062", "doi"=>"10.1371/journal.pone.0067430"}, "id"=>"f2c1beaa-043b-35dc-a765-44c51da87c44", "abstract"=>"BACKGROUND: Enterovirus 71 (EV71) infection can lead to a rapidly progressing, life-threatening, and severe neurological disease in young children, including the development of human hand, foot, and mouth disease (HFMD). This study aims to further characterize the specific immunological features in EV71-mediated HFMD patients presenting with differing degrees of disease severity.\\n\\nMETHODOLOGY: Comprehensive cytokine and chemokine expression were broadly evaluated by cytokine antibody array in EV71-infected patients hospitalized for HFMD compared to Coxsackievirus A16-infected patients and age-matched healthy controls. More detailed analysis using Luminex-based cytokine bead array was performed in EV71-infected patients stratified into diverse clinic outcomes. Additionally, immune cell frequencies in peripheral blood and EV71-specific antibodies in plasma were also examined.\\n\\nPRINCIPAL FINDINGS: Expression of several cytokines and chemokines were significantly increased in plasma from EV71-infected patients compared to healthy controls, which further indicated that: (1) GM-CSF, MIP-1β, IL-2, IL-33, and IL-23 secretion was elevated in patients who rapidly developed disease and presented with uncomplicated neurological damage; (2) G-CSF and MCP-1 were distinguishably secreted in EV71 infected very severe patients presenting with acute respiratory failure; (3) IP-10, MCP-1, IL-6, IL-8, and G-CSF levels were much higher in cerebrospinal fluid than in plasma from patients with neurological damage; (4) FACS analysis revealed that the frequency of CD19(+)HLADR(+) mature B cells dynamically changed over time during the course of hospitalization and was accompanied by dramatically increased EV71-specific antibodies. Our data provide a panoramic view of specific immune mediator and cellular immune responses of HFMD and may provide useful immunological profiles for monitoring the progress of EV71-induced fatal neurological symptoms with acute respiratory failure.", "link"=>"http://www.mendeley.com/research/comparative-study-cytokinechemokine-response-children-differing-disease-severity-enterovirus-71induc", "reader_count"=>18, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>2, "Student > Doctoral Student"=>1, "Researcher"=>5, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>4, "Student > Master"=>2, "Other"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>2, "Student > Doctoral Student"=>1, "Researcher"=>5, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>4, "Student > Master"=>2, "Other"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>4, "Medicine and Dentistry"=>7, "Arts and Humanities"=>1, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>7}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>4}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>3}, "Arts and Humanities"=>{"Arts and Humanities"=>1}}, "reader_count_by_country"=>{"United Kingdom"=>1}, "group_count"=>1}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84879537715"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84879537715?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84879537715&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84879537715&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84879537715", "dc:identifier"=>"SCOPUS_ID:84879537715", "eid"=>"2-s2.0-84879537715", "dc:title"=>"Comparative Study of the Cytokine/Chemokine Response in Children with Differing Disease Severity in Enterovirus 71-Induced Hand, Foot, and Mouth Disease", "dc:creator"=>"Zhang Y.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"8", "prism:issueIdentifier"=>"6", "prism:pageRange"=>nil, "prism:coverDate"=>"2013-06-28", "prism:coverDisplayDate"=>"28 June 2013", "prism:doi"=>"10.1371/journal.pone.0067430", "citedby-count"=>"28", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Chinese Academy of Medical Sciences", "affiliation-city"=>"Beijing", "affiliation-country"=>"China"}], "pubmed-id"=>"23840697", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e67430", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0067430", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"2", "html_views"=>"20"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"92", "xml_views"=>"3", "html_views"=>"194"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"49", "xml_views"=>"0", "html_views"=>"59"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"27", "xml_views"=>"0", "html_views"=>"64"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"32", "xml_views"=>"3", "html_views"=>"88"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"28"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"88"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"29", "xml_views"=>"1", "html_views"=>"86"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"26", "xml_views"=>"2", "html_views"=>"71"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"22", "xml_views"=>"2", "html_views"=>"103"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"75"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"62"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"53"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"13", "xml_views"=>"4", "html_views"=>"52"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"35"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"45"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"41"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"24", "xml_views"=>"1", "html_views"=>"44"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"29"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"57"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"38"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"16"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"28"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"19"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"32"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"68"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"2", "html_views"=>"36"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"13"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"11"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"6", "html_views"=>"15"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"1", "html_views"=>"8"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"6"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"5"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1104779"], "description"=>"<p>Cytokine antibody array screened 120 immune factors in 4 mild patients (no neurological syndromes), 5 severe patients (with neurological syndromes), and 2 healthy controls. Data are presented as ratios of the normalized signals for each factor in each of the nine individual patients to the mean concentration obtained from the healthy controls. Data were analyzed by EXCEL and Matlab software.</p>", "links"=>[], "tags"=>["immunology", "Immune cells", "Immune response", "Clinical immunology", "Immune system", "Infectious diseases", "Infectious diseases of the nervous system", "Viral diseases", "antibody", "broadly", "screened", "120", "mediators", "ev71-positive", "hfmd"], "article_id"=>734332, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Yan Zhang", "Haiying Liu", "Linghang Wang", "Fan Yang", "Yongfeng Hu", "Xianwen Ren", "Guojun Li", "Yang Yu", "Shaoxia Sun", "Yufen Li", "Xinchun Chen", "Xingwang Li", "Qi Jin"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0067430.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cytokine_antibody_array_broadly_screened_for_changes_in_120_immune_mediators_in_EV71_positive_HFMD_patients_/734332", "title"=>"Cytokine antibody array broadly screened for changes in 120 immune mediators in EV71-positive HFMD patients.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-28 01:33:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/1104782"], "description"=>"<p>(A, B, C) The profiles of 12 cytokines/chemokines were significantly elevated in plasma samples from recruited EV71-positive HFMD patients: VS = severe patients with pulmonary edema, n = 8; S = severe patients with uncomplicated neurological manifestations, n = 23; M = mild patients without neurological syndromes, n = 19; and H = healthy controls, n = 10. (A) G-CSF and MCP-1 were significantly increased in plasma from very severe patients with acute respiratory failure. (B) Cytokines/chemokines were markedly elevated in plasma of both very severe and severe patients. (C) Cytokines/chemokines were significantly enhanced in all HFMD patients compared to healthy controls. The unpaired Student’s <i>t</i>-test and non-parametric ANOVA test were used to compare variables between any two groups and <i>P</i> value from unpaired Student’s <i>t</i>-test analysis was presented in figures. *<i>P</i><0.05, **<i>P</i><0.01,***<i>P</i><0.001. Each assay was performed duplicate and data are representative of at least 2 independent experiments.</p>", "links"=>[], "tags"=>["immunology", "Immune cells", "Immune response", "Clinical immunology", "Immune system", "Infectious diseases", "Infectious diseases of the nervous system", "Viral diseases", "compared", "ev71-positive", "hfmd", "groups", "stratified"], "article_id"=>734335, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Yan Zhang", "Haiying Liu", "Linghang Wang", "Fan Yang", "Yongfeng Hu", "Xianwen Ren", "Guojun Li", "Yang Yu", "Shaoxia Sun", "Yufen Li", "Xinchun Chen", "Xingwang Li", "Qi Jin"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0067430.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Peripheral_cytokine_chemokine_expression_was_compared_between_EV71_positive_HFMD_patient_groups_stratified_by_disease_severity_/734335", "title"=>"Peripheral cytokine/chemokine expression was compared between EV71-positive HFMD patient groups stratified by disease severity.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-28 01:33:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/1104784"], "description"=>"<p>A panel of 12 immune mediators was evaluated in plasma samples from CA16–positive patients with neurological manifestations: S = 4; M = 6. (A) The expression pattern of G-CSF and MCP-1 was consistent between EV71– and CA16–mediated mild and severe HFMD patients, and G-CSF and MCP-1 were significantly higher in EV71–mediated very severe HFMD patients with respiratory failure as compared to all other groups. (B) The expression pattern of GM-CSF, IL-2, and MIP-1β were consistent in both EV71– and CA16–positive mild and severe patients. The unpaired Student’s <i>t</i>-test and non-parametric ANOVA test was used to compare variables between the indicated 2 groups. *<i>P</i><0.05, **<i>P</i><0.01,***<i>P</i><0.001. Data are representative of at least 2 experiments.</p>", "links"=>[], "tags"=>["immunology", "Immune cells", "Immune response", "Clinical immunology", "Immune system", "Infectious diseases", "Infectious diseases of the nervous system", "Viral diseases", "compared"], "article_id"=>734337, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Yan Zhang", "Haiying Liu", "Linghang Wang", "Fan Yang", "Yongfeng Hu", "Xianwen Ren", "Guojun Li", "Yang Yu", "Shaoxia Sun", "Yufen Li", "Xinchun Chen", "Xingwang Li", "Qi Jin"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0067430.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Plasma_cytokine_chemokine_expression_pattern_was_compared_between_EV71_8211_and_CA16_8211_positive_patients_/734337", "title"=>"Plasma cytokine/chemokine expression pattern was compared between EV71– and CA16–positive patients.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-28 01:33:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/1104785"], "description"=>"<p>Cytokine/chemokine expression was evaluated in CSF samples from 9 severe patients with neurological manifestations. Five cytokines/chemokines levels were significantly higher in CSF as compared to plasma. Absolute cytokine/chemokine concentration in plasma (open circles) and CSF (solid circles) (upper panel); ratio of CSF:plasma concentrations >1 (lower panel). Data are expressed as mean ± SEM, and are representative of at least 2 experiments.</p>", "links"=>[], "tags"=>["immunology", "Immune cells", "Immune response", "Clinical immunology", "Immune system", "Infectious diseases", "Infectious diseases of the nervous system", "Viral diseases", "mediators", "elevated", "csf", "compared", "plasma", "ev71-positive", "patients", "neurological"], "article_id"=>734338, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Yan Zhang", "Haiying Liu", "Linghang Wang", "Fan Yang", "Yongfeng Hu", "Xianwen Ren", "Guojun Li", "Yang Yu", "Shaoxia Sun", "Yufen Li", "Xinchun Chen", "Xingwang Li", "Qi Jin"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0067430.g004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Five_immune_mediators_are_elevated_in_CSF_as_compared_to_plasma_in_EV71_positive_patients_with_neurological_complications_/734338", "title"=>"Five immune mediators are elevated in CSF as compared to plasma in EV71-positive patients with neurological complications.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-28 01:33:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/1104787"], "description"=>"<p>(A) IgG and IgM antibodies were rapidly increased and were markedly higher in plasma from severe patients (n = 13) compared with normal controls (n = 7). The differences between two time points of every individuals were determined by Wilcoxon’s Sign Rank Test. *<i>P</i><0.05. (B) Very severe patients with acute respiratory failure (n = 8) have lower IgG secretion as compared to patients with uncomplicated neurological manifestations (n = 13), which were both examined before treatment. The unpaired Student’s <i>t</i>-test and non-parametric ANOVA test were used to compare variables between the indicated 2 groups. **<i>P</i><0.01. (C) Frequency of CD19<sup>+</sup>HLA-DR<sup>+</sup> lymphocytes in peripheral blood of severe patients (n = 13) and healthy controls (n = 3). Data are expressed as the percentage of the examined cell subset within gated lymphocytes. The lower panel showing representative data from a severe patient indicated that CD19<sup>+</sup>HLADR<sup>+</sup> frequency increased during the course of hospitalization. (D) Representative FACS data examining CD19<sup>+</sup> cells from a healthy control and a mild patient with no neurological manifestations.</p>", "links"=>[], "tags"=>["immunology", "Immune cells", "Immune response", "Clinical immunology", "Immune system", "Infectious diseases", "Infectious diseases of the nervous system", "Viral diseases", "ev71", "igg", "igm", "antibodies", "patients"], "article_id"=>734340, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Yan Zhang", "Haiying Liu", "Linghang Wang", "Fan Yang", "Yongfeng Hu", "Xianwen Ren", "Guojun Li", "Yang Yu", "Shaoxia Sun", "Yufen Li", "Xinchun Chen", "Xingwang Li", "Qi Jin"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0067430.g005"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Production_of_EV71_VP_1_specific_IgG_and_IgM_antibodies_in_patients_with_increased_frequency_of_CD19_HLA_DR_cells_/734340", "title"=>"Production of EV71 VP-1–specific IgG and IgM antibodies in patients with increased frequency of CD19<sup>+</sup>HLA-DR<sup>+</sup> cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-28 01:33:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/1104789"], "description"=>"*<p>AOA = Average of age.</p>*<p>ATD = Average of therapy duration.</p><p>Among 153 recruit patients, blood samples from 59 EV71-positive HFMD patients, 10 CA16-positive HFMD patients and 19 healthy controls were successfully obtained and used for immunological examination.</p>", "links"=>[], "tags"=>["immunology", "Immune cells", "Immune response", "Clinical immunology", "Immune system", "Infectious diseases", "Infectious diseases of the nervous system", "Viral diseases", "immunological"], "article_id"=>734342, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Yan Zhang", "Haiying Liu", "Linghang Wang", "Fan Yang", "Yongfeng Hu", "Xianwen Ren", "Guojun Li", "Yang Yu", "Shaoxia Sun", "Yufen Li", "Xinchun Chen", "Xingwang Li", "Qi Jin"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0067430.t002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Patient_Characteristics_for_immunological_examination_/734342", "title"=>"Patient Characteristics for immunological examination.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-06-28 01:33:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/1104791"], "description"=>"<p>Thirty cytokines/chemokines of various functional groups were analyzed by Luminex-based cytokine bead array.</p>", "links"=>[], "tags"=>["immunology", "Immune cells", "Immune response", "Clinical immunology", "Immune system", "Infectious diseases", "Infectious diseases of the nervous system", "Viral diseases", "groups", "luminex-based", "cytokine", "bead"], "article_id"=>734344, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Yan Zhang", "Haiying Liu", "Linghang Wang", "Fan Yang", "Yongfeng Hu", "Xianwen Ren", "Guojun Li", "Yang Yu", "Shaoxia Sun", "Yufen Li", "Xinchun Chen", "Xingwang Li", "Qi Jin"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0067430.t003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Thirty_cytokines_chemokines_of_various_functional_groups_were_analyzed_by_Luminex_based_cytokine_bead_array_/734344", "title"=>"Thirty cytokines/chemokines of various functional groups were analyzed by Luminex-based cytokine bead array.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-06-28 01:33:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/1104792"], "description"=>"*<p>AOA = Average of age.</p>*<p>ATD = Average of therapy duration.</p><p>One hundred and fifty-three clinically diagnosed HFMD patients were recruited and classified into 3 groups depending on the clinical severity of disease and degrees of neurological damage.</p>", "links"=>[], "tags"=>["immunology", "Immune cells", "Immune response", "Clinical immunology", "Immune system", "Infectious diseases", "Infectious diseases of the nervous system", "Viral diseases", "153", "recruited"], "article_id"=>734345, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Yan Zhang", "Haiying Liu", "Linghang Wang", "Fan Yang", "Yongfeng Hu", "Xianwen Ren", "Guojun Li", "Yang Yu", "Shaoxia Sun", "Yufen Li", "Xinchun Chen", "Xingwang Li", "Qi Jin"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0067430.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Patient_Characteristics_of_153_recruited_patients_/734345", "title"=>"Patient Characteristics of 153 recruited patients.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-06-28 01:33:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/1104793", "https://ndownloader.figshare.com/files/1104794", "https://ndownloader.figshare.com/files/1104795", "https://ndownloader.figshare.com/files/1104796", "https://ndownloader.figshare.com/files/1104797"], "description"=>"<div><p>Background</p><p>Enterovirus 71 (EV71) infection can lead to a rapidly progressing, life-threatening, and severe neurological disease in young children, including the development of human hand, foot, and mouth disease (HFMD). This study aims to further characterize the specific immunological features in EV71–mediated HFMD patients presenting with differing degrees of disease severity.</p><p>Methodology</p><p>Comprehensive cytokine and chemokine expression were broadly evaluated by cytokine antibody array in EV71–infected patients hospitalized for HFMD compared to Coxsackievirus A16-infected patients and age-matched healthy controls. More detailed analysis using Luminex-based cytokine bead array was performed in EV71–infected patients stratified into diverse clinic outcomes. Additionally, immune cell frequencies in peripheral blood and EV71–specific antibodies in plasma were also examined.</p><p>Principal Findings</p><p>Expression of several cytokines and chemokines were significantly increased in plasma from EV71–infected patients compared to healthy controls, which further indicated that: (1) GM-CSF, MIP-1β, IL-2, IL-33, and IL-23 secretion was elevated in patients who rapidly developed disease and presented with uncomplicated neurological damage; (2) G-CSF and MCP-1 were distinguishably secreted in EV71 infected very severe patients presenting with acute respiratory failure; (3) IP-10, MCP-1, IL-6, IL-8, and G-CSF levels were much higher in cerebrospinal fluid than in plasma from patients with neurological damage; (4) FACS analysis revealed that the frequency of CD19<sup>+</sup>HLADR<sup>+</sup> mature B cells dynamically changed over time during the course of hospitalization and was accompanied by dramatically increased EV71–specific antibodies. Our data provide a panoramic view of specific immune mediator and cellular immune responses of HFMD and may provide useful immunological profiles for monitoring the progress of EV71–induced fatal neurological symptoms with acute respiratory failure.</p></div>", "links"=>[], "tags"=>["immunology", "Immune cells", "Immune response", "Clinical immunology", "Immune system", "Infectious diseases", "Infectious diseases of the nervous system", "Viral diseases", "children", "differing", "severity", "enterovirus", "71-induced"], "article_id"=>734346, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Yan Zhang", "Haiying Liu", "Linghang Wang", "Fan Yang", "Yongfeng Hu", "Xianwen Ren", "Guojun Li", "Yang Yu", "Shaoxia Sun", "Yufen Li", "Xinchun Chen", "Xingwang Li", "Qi Jin"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0067430.s001", "https://dx.doi.org/10.1371/journal.pone.0067430.s002", "https://dx.doi.org/10.1371/journal.pone.0067430.s003", "https://dx.doi.org/10.1371/journal.pone.0067430.s004", "https://dx.doi.org/10.1371/journal.pone.0067430.s005"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparative_Study_of_the_Cytokine_Chemokine_Response_in_Children_with_Differing_Disease_Severity_in_Enterovirus_71_Induced_Hand_Foot_and_Mouth_Disease_/734346", "title"=>"Comparative Study of the Cytokine/Chemokine Response in Children with Differing Disease Severity in Enterovirus 71-Induced Hand, Foot, and Mouth Disease", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-06-28 01:33:47"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"69", "full-text"=>"67", "pdf"=>"39", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"17", "supp-data"=>"15", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"46", "full-text"=>"66", "pdf"=>"29", "abstract"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"44", "full-text"=>"41", "pdf"=>"27", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"23", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"27", "full-text"=>"31", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"20", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"21", "full-text"=>"23", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"31", "full-text"=>"31", "pdf"=>"18", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"33", "full-text"=>"34", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"28", "full-text"=>"26", "pdf"=>"23", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"29", "full-text"=>"31", "pdf"=>"9", "abstract"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"33", "full-text"=>"30", "pdf"=>"253", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"28", "full-text"=>"37", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"60", "full-text"=>"61", "pdf"=>"262", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"2", "cited-by"=>"2", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"22", "full-text"=>"19", "pdf"=>"50", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"24", "full-text"=>"20", "pdf"=>"27", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"16", "full-text"=>"17", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"16", "full-text"=>"19", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"46", "full-text"=>"36", "pdf"=>"212", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"20", "full-text"=>"17", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"18", "full-text"=>"21", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"18", "full-text"=>"18", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"27", "full-text"=>"28", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"19", "full-text"=>"17", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"28", "full-text"=>"22", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"1", "cited-by"=>"1", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"25", "full-text"=>"19", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"14", "full-text"=>"18", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"22", "full-text"=>"22", "pdf"=>"5", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"15", "full-text"=>"20", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"1", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"17", "full-text"=>"17", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"13", "full-text"=>"11", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"18", "full-text"=>"14", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"21", "full-text"=>"23", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"13", "full-text"=>"15", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"12", "full-text"=>"17", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"15", "full-text"=>"13", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"10", "full-text"=>"7", "pdf"=>"28", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"27", "full-text"=>"30", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"13", "full-text"=>"10", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"13", "full-text"=>"11", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"5", "full-text"=>"9", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"2"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"10", "full-text"=>"12", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"18", "full-text"=>"14", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"11", "full-text"=>"29", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"12", "full-text"=>"14", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"9", "full-text"=>"11", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"7", "full-text"=>"9", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"10", "full-text"=>"24", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"11", "full-text"=>"9", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"10", "full-text"=>"7", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}

Relative Metric

{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Anatomy", "average_usage"=>[248, 440, 562, 666, 765, 856, 944, 1028, 1112, 1198, 1282, 1362, 1430]}, {"subject_area"=>"/Biology and life sciences/Biochemistry", "average_usage"=>[266, 468, 593, 703, 804, 903, 993, 1084, 1171, 1256, 1339, 1422, 1492]}, {"subject_area"=>"/Biology and life sciences/Cell biology", "average_usage"=>[272, 472, 600, 713, 815, 911, 1004, 1094, 1185, 1273, 1358, 1441]}, {"subject_area"=>"/Biology and life sciences/Developmental biology", "average_usage"=>[275, 472, 605, 720, 822, 921, 1013, 1106, 1200, 1289, 1378, 1459, 1531]}, {"subject_area"=>"/Biology and life sciences/Immunology", "average_usage"=>[266, 466, 591, 701, 799, 887, 982, 1067, 1155, 1237, 1317, 1395, 1458]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[264, 460, 584, 692, 794, 887, 978, 1067, 1154, 1241, 1328, 1408, 1474]}, {"subject_area"=>"/Medicine and health sciences/Anatomy", "average_usage"=>[248, 441, 564, 668, 769, 859, 948, 1034, 1117, 1202, 1290, 1368, 1437]}, {"subject_area"=>"/Medicine and health sciences/Anatomy and physiology", "average_usage"=>[253, 430]}, {"subject_area"=>"/Medicine and health sciences/Hematology", "average_usage"=>[238, 424, 545, 650, 749, 839, 926, 1006, 1090, 1167, 1243, 1316, 1380]}, {"subject_area"=>"/Medicine and health sciences/Physiology", "average_usage"=>[258, 449, 572, 679, 775, 866, 956, 1041, 1124, 1211, 1291, 1371, 1437]}]}
Loading … Spinner
There are currently no alerts