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{"title"=>"Patient Factors Influencing the Prescribing of Lipid Lowering Drugs for Primary Prevention of Cardiovascular Disease in UK General Practice: A National Retrospective Cohort Study", "type"=>"journal", "authors"=>[{"first_name"=>"Jianhua", "last_name"=>"Wu", "scopus_author_id"=>"55552058000"}, {"first_name"=>"Shihua", "last_name"=>"Zhu", "scopus_author_id"=>"55812056000"}, {"first_name"=>"Guiqing Lily", "last_name"=>"Yao", "scopus_author_id"=>"8552708100"}, {"first_name"=>"Mohammed A.", "last_name"=>"Mohammed", "scopus_author_id"=>"7005737551"}, {"first_name"=>"Tom", "last_name"=>"Marshall", "scopus_author_id"=>"7201537704"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84880813036", "doi"=>"10.1371/journal.pone.0067611", "pui"=>"369439464", "sgr"=>"84880813036", "issn"=>"19326203", "pmid"=>"23922649"}, "id"=>"b4a30c07-cb2d-3719-b47b-7ef6a2969994", "abstract"=>"BACKGROUND: Guidelines indicate eligibility for lipid lowering drugs, but it is not known to what extent GPs' follow guidelines in routine clinical practice or whether additional clinical factors systematically influence their prescribing decisions.\\n\\nMETHODS: A retrospective cohort analysis was undertaken using electronic primary care records from 421 UK general practices. At baseline (May 2008) patients were aged 30 to 74 years, free from cardiovascular disease and not taking lipid lowering drugs. The outcome was prescription of a lipid lowering drug within the next two years. The proportions of eligible and ineligible patients prescribed lipid lowering drugs were reported and multivariable logistic regression models were used to investigate associations between age, sex, cardiovascular risk factors and prescribing.\\n\\nRESULTS: Of 365,718 patients with complete data, 13.8% (50,558) were prescribed lipid lowering drugs: 28.5% (21,101/74,137) of those eligible and 10.1% (29,457/291,581) of those ineligible. Only 41.7% (21,101/50,558) of those prescribed lipid lowering drugs were eligible. In multivariable analysis prescribing was most strongly associated with increasing age (OR for age ≥ 65 years 4.21; 95% CI 4.05-4.39); diabetes (OR 4.49; 95% CI 4.35-4.64); total cholesterol level ≥ 7 mmol/L (OR 2.20; 95% CI 2.12-2.29); and ≥ 4 blood pressure measurements in the past year (OR 4.24; 95% CI 4.06-4.42). The predictors were similar in eligible and ineligible patients.\\n\\nCONCLUSIONS: Most lipid lowering drugs for primary prevention are prescribed to ineligible patients. There is underuse of lipid lowering drugs in eligible patients.", "link"=>"http://www.mendeley.com/research/patient-factors-influencing-prescribing-lipid-lowering-drugs-primary-prevention-cardiovascular-disea-3", "reader_count"=>26, "reader_count_by_academic_status"=>{"Researcher"=>6, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>4, "Student > Master"=>5, "Other"=>3, "Student > Bachelor"=>4, "Lecturer"=>1}, "reader_count_by_user_role"=>{"Researcher"=>6, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>4, "Student > Master"=>5, "Other"=>3, "Student > Bachelor"=>4, "Lecturer"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Agricultural and Biological Sciences"=>1, "Medicine and Dentistry"=>20, "Psychology"=>1, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>20}, "Social Sciences"=>{"Social Sciences"=>1}, "Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Unspecified"=>{"Unspecified"=>3}}, "reader_count_by_country"=>{"Netherlands"=>1, "Philippines"=>1}, "group_count"=>3}

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• http://doi.org/10.1371/journal.pone.0190688
• http://doi.org/10.3399/bjgp15X684205
• http://doi.org/10.1016/j.ypmed.2015.05.022
• http://doi.org/10.3390/jcm9113719
• http://doi.org/10.3389/fphar.2016.00066
• http://doi.org/10.1371/journal.pone.0138092
• http://doi.org/10.1136/bmjdrc-2018-000639
• http://doi.org/10.1177/2047487317698585
• http://doi.org/10.1186/s12913-018-3707-4
• http://doi.org/10.1371/journal.pone.0131318
• http://doi.org/10.1186/s13012-016-0479-2
• http://doi.org/10.1186/1472-6963-14-414
• http://doi.org/10.1136/bmjopen-2017-021137
• http://doi.org/10.3399/bjgpopen20X101087
• http://doi.org/10.3399/bjgp20X713057
• http://doi.org/10.1093/eurheartj/ehv393
• http://doi.org/10.1371/journal.pone.0123112
• http://doi.org/10.3399/bjgp18X699833
• http://doi.org/10.1111/bcp.14463
• http://doi.org/10.3399/bjgp15X686113
• http://doi.org/10.1136/bmjopen-2014-004812
• http://doi.org/10.1016/j.therap.2019.01.004
• http://doi.org/10.3399/bjgp17X693485
• http://doi.org/10.1371/journal.pone.0189599
• http://doi.org/10.1007/s00103-014-2104-3
• http://doi.org/10.3399/bjgp16X687481
• http://doi.org/10.1161/STROKEAHA.117.020080
• http://doi.org/10.1177/2047487315595583
• http://doi.org/10.3399/bjgp16X686629
• http://doi.org/10.1007/s40274-013-0641-x
• http://doi.org/10.1136/heartjnl-2019-316217

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• {"type"=>"COMMENT", "annotationUri"=>"info:doi/10.1371/annotation/ed054f91-7b81-4b84-8f2d-d7de38015db2", "title"=>"Reference error", "body"=>"In the paragraph headed \"Determining cardiovascular risk\" the sentence on estimation of ten-year cardiovascular risk has been incorrectly cross-referenced. It should be cross-referenced to reference 9, not to reference 8. \n\nTherefore it should read as follows:\n\n\"Ten-year cardiovascular risk was calculated from each patient's risk factors using the modified Framingham equation advocated in 2005 UK guidelines [9].\"\n\n\n\n\n\n", "isRemoved"=>false, "created"=>"2013-08-02T11:10:24Z", "lastModified"=>"2013-08-02T11:10:24Z", "creator"=>{"userId"=>"358347"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>true, "body"=>"I am the corresponding authors for this paper"}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pone.0067611", "state"=>"published", "journals"=>{"PLoSONE"=>{"journalKey"=>"PLoSONE", "eIssn"=>"1932-6203", "title"=>"PLOS ONE"}}}, "replyTreeSize"=>0, "mostRecentActivity"=>"2013-08-02T11:10:24Z", "replies"=>[]}
• {"type"=>"COMMENT", "annotationUri"=>"info:doi/10.1371/annotation/aa71f71a-5ee7-4e68-8542-b97e7f9e6632", "title"=>"Media coverage of this article", "body"=>"The following article represents some of the media coverage that has occurred for this paper:\n\nPublication: Express \nTitle: “GPs in a muddle over who gets heart drugs statins as chaos hits millions | Health | News | Daily Express”\nhttp://www.express.co.uk/news/health/421421/GPs-in-a-muddle-over-who-gets-heart-drugs-statins-as-chaos-hits-millions\n\nIf you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article. \n", "isRemoved"=>false, "created"=>"2013-08-16T18:34:53Z", "lastModified"=>"2013-08-16T18:34:53Z", "creator"=>{"userId"=>"80539"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>true, "body"=>"PLOS ONE Staff"}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pone.0067611", "state"=>"published", "journals"=>{"PLoSONE"=>{"journalKey"=>"PLoSONE", "eIssn"=>"1932-6203", "title"=>"PLOS ONE"}}}, "replyTreeSize"=>1, "mostRecentActivity"=>"2013-08-16T21:23:56Z", "replies"=>[{"type"=>"REPLY", "parentID"=>70469, "annotationUri"=>"info:doi/10.1371/reply/6852333f-d57e-4c01-a156-9a91880c67d0", "title"=>"RE: Media coverage of this article", "body"=>"http://www.pulsetoday.co.uk/clinical/therapy-areas/cardiovascular/one-in-ten-patients-on-statins-not-at-high-risk/20003905.article?msgid=13611#.Ug6X5WxwbIU \n\nMore coverage in the media", "isRemoved"=>false, "created"=>"2013-08-16T21:23:56Z", "lastModified"=>"2013-08-16T21:23:56Z", "creator"=>{"userId"=>"358347"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>true, "body"=>"Author"}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pone.0067611", "state"=>"published", "journals"=>{"PLoSONE"=>{"journalKey"=>"PLoSONE", "eIssn"=>"1932-6203", "title"=>"PLOS ONE"}}}, "replyTreeSize"=>0, "mostRecentActivity"=>"2013-08-16T21:23:56Z", "replies"=>[]}]}

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• {"id"=>"363224043345809408", "text"=>"Most Statins prescribed to the wrong patients - read our research published in PLoS One this week http://t.co/EuQH8S0m1w", "created_at"=>"2013-08-02T09:05:34Z", "user"=>"CLAHRC_BBC", "user_name"=>"CLAHRC Bham", "user_profile_image"=>"http://a0.twimg.com/profile_images/1276983041/New_Image_normal.JPG"}
• {"id"=>"365779203456630784", "text"=>"60% of patients on statins - low risk - classic treatment paradox !\nhttp://t.co/8KVx3ympe7", "created_at"=>"2013-08-09T10:18:52Z", "user"=>"des_spence1", "user_name"=>"Des Spence", "user_profile_image"=>"http://a0.twimg.com/profile_images/1675773758/image_normal.jpg"}
• {"id"=>"366869395592593408", "text"=>"For anyone interestng the free academic article referred to in newspapers re GP prescribing of statins - here it is:) http://t.co/xH8KxpigNQ", "created_at"=>"2013-08-12T10:30:54Z", "user"=>"Mistress_Fiona", "user_name"=>"Fiona ", "user_profile_image"=>"http://a0.twimg.com/profile_images/2832909466/e0200291d86cb16b0eb299383f067236_normal.jpeg"}
• {"id"=>"367382944044052480", "text"=>"La 1/2 de los casos en los que se usan estatinas en prevencion primaria no estan indicados en UK. Aqui?? http://t.co/L41phSKRxl", "created_at"=>"2013-08-13T20:31:34Z", "user"=>"JesusmRedondo", "user_name"=>"Jesus Redondo", "user_profile_image"=>"http://a0.twimg.com/profile_images/3607223188/488599293236a7b43f2280214c8d6926_normal.jpeg"}
• {"id"=>"367448365354594304", "text"=>"英国の後ろ向きコホート研究。心臓血管病の一次予防としてのスタチンが不適切に処方されている\n【PLoS ONE】\nhttp://t.co/D6QqwhNyzu", "created_at"=>"2013-08-14T00:51:31Z", "user"=>"kojima_aponet", "user_name"=>"小嶋 慎二＠アポネット", "user_profile_image"=>"http://a0.twimg.com/profile_images/1864221167/aponet_profile_normal.jpg"}

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Figshare

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PMC Usage Stats | Further Information

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Relative Metric

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F1000Prime