Resveratrol Treatment Delays Growth Plate Fusion and Improves Bone Growth in Female Rabbits
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{"title"=>"Resveratrol Treatment Delays Growth Plate Fusion and Improves Bone Growth in Female Rabbits", "type"=>"journal", "authors"=>[{"first_name"=>"Elham", "last_name"=>"Karimian", "scopus_author_id"=>"24476225500"}, {"first_name"=>"Chen", "last_name"=>"Tamm", "scopus_author_id"=>"55777086600"}, {"first_name"=>"Andrei S.", "last_name"=>"Chagin", "scopus_author_id"=>"8676551100"}, {"first_name"=>"Karin", "last_name"=>"Samuelsson", "scopus_author_id"=>"57198362459"}, {"first_name"=>"Kristín Rós", "last_name"=>"Kjartansdóttir", "scopus_author_id"=>"26658430800"}, {"first_name"=>"Claes", "last_name"=>"Ohlsson", "scopus_author_id"=>"56386930400"}, {"first_name"=>"Lars", "last_name"=>"Sävendahl", "scopus_author_id"=>"6603950210"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84879527248", "sgr"=>"84879527248", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0067859", "pmid"=>"23840780", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pui"=>"369209139"}, "id"=>"477fede4-91d3-36a7-8c52-f41b81f87e49", "abstract"=>"Trans-resveratrol (RES), naturally produced by many plants, has a structure similar to synthetic estrogen diethylstilbestrol, but any effect on bone growth has not yet been clarified. Pre-pubertal ovary-intact New Zealand white rabbits received daily oral administration of either vehicle (control) or RES (200 mg/kg) until growth plate fusion occurred. Bone growth and growth plate size were longitudinally monitored by X-ray imaging, while at the endpoint, bone length was assessed by a digital caliper. In addition, pubertal ovariectomized (OVX) rabbits were treated with vehicle, RES or estradiol cypionate (positive control) for 7 or 10 weeks and fetal rat metatarsal bones were cultured in vitro with RES (0.03 µM-50 µM) and followed for up to 19 days. In ovary-intact rabbits, sixteen-week treatment with RES increased tibiae and vertebrae bone growth and subsequently improved final length. In OVX rabbits, RES delayed fusion of the distal tibia, distal femur and proximal tibia epiphyses and femur length and vertebral bone growth increased when compared with controls. Histomorphometrical analysis showed that RES-treated OVX rabbits had a wider distal femur growth plate, enlarged resting zone, increased number/size of hypertrophic chondrocytes, increased height of the hypertrophic zone, and suppressed chondrocyte expression of VEGF and laminin. In cultured fetal rat metatarsal bones, RES stimulated growth at 0.3 µM while at higher concentrations (10 μM and 50 μM) growth was inhibited. We conclude that RES has the potential to improve longitudinal bone growth. The effect was associated with a delay of growth plate fusion resulting in increased final length. These effects were accompanied by a profound suppression of VEGF and laminin expression suggesting that impairment of growth plate vascularization might be an underlying mechanism.", "link"=>"http://www.mendeley.com/research/resveratrol-treatment-delays-growth-plate-fusion-improves-bone-growth-female-rabbits", "reader_count"=>12, "reader_count_by_academic_status"=>{"Researcher"=>3, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>4, "Other"=>1, "Student > Bachelor"=>1, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_user_role"=>{"Researcher"=>3, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>4, "Other"=>1, "Student > Bachelor"=>1, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>5, "Medicine and Dentistry"=>2, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Chemistry"=>2, "Nursing and Health Professions"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Chemistry"=>{"Chemistry"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>5}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "group_count"=>0}

Scopus | Further Information

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  • {"files"=>["https://ndownloader.figshare.com/files/1106265"], "description"=>"<p><sup>*</sup>p<0.05 and <sup>***</sup>p<0.001 vs. controls.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Musculoskeletal system", "bone", "developmental biology", "morphogenesis", "Skeletal development", "Organism development", "Model organisms", "Animal models", "organic chemistry", "Organic compounds", "Small molecules", "res", "longitudinal", "fetal", "metatarsal", "bones", "cultured"], "article_id"=>735589, "categories"=>["Medicine", "Chemistry", "Biological Sciences"], "users"=>["Elham Karimian", "Chen Tamm", "Andrei S. Chagin", "Karin Samuelsson", "Kristín Rós Kjartansdóttir", "Claes Ohlsson", "Lars Sävendahl"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0067859.g006", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Dose_dependent_effect_of_RES_on_longitudinal_bone_growth_of_fetal_rat_metatarsal_bones_cultured_ex_vivo_/735589", "title"=>"Dose-dependent effect of RES on longitudinal bone growth of fetal rat metatarsal bones cultured <i>ex vivo.</i>", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-28 04:06:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/1106266"], "description"=>"1<p>Growth plate morphometry was performed after 7 weeks' treatment.</p>*<p>p<0.05, <sup>**</sup>p<0.01 and <sup>***</sup>p<0.001 compared to vehicle-treated animals.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Musculoskeletal system", "bone", "developmental biology", "morphogenesis", "Skeletal development", "Organism development", "Model organisms", "Animal models", "organic chemistry", "Organic compounds", "Small molecules", "osteoclasts", "uterus", "serum", "igf-i", "ovariectomized"], "article_id"=>735590, "categories"=>["Medicine", "Chemistry", "Biological Sciences"], "users"=>["Elham Karimian", "Chen Tamm", "Andrei S. Chagin", "Karin Samuelsson", "Kristín Rós Kjartansdóttir", "Claes Ohlsson", "Lars Sävendahl"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0067859.t001", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Femur_growth_plate_morphometry_osteoclasts_number_uterus_weight_and_serum_IGF_I_levels_in_ovariectomized_rabbits_1_/735590", "title"=>"Femur growth plate morphometry, osteoclasts number, uterus weight and serum IGF-I levels in ovariectomized rabbits<sup>1</sup>.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-06-28 04:06:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/1106267"], "description"=>"<div><p><i>Trans</i>-resveratrol (RES), naturally produced by many plants, has a structure similar to synthetic estrogen diethylstilbestrol, but any effect on bone growth has not yet been clarified. Pre-pubertal ovary-intact New Zealand white rabbits received daily oral administration of either vehicle (control) or RES (200 mg/kg) until growth plate fusion occurred. Bone growth and growth plate size were longitudinally monitored by X-ray imaging, while at the endpoint, bone length was assessed by a digital caliper. In addition, pubertal ovariectomized (OVX) rabbits were treated with vehicle, RES or estradiol cypionate (positive control) for 7 or 10 weeks and fetal rat metatarsal bones were cultured <i>in vitro</i> with RES (0.03 µM–50 µM) and followed for up to 19 days. In ovary-intact rabbits, sixteen-week treatment with RES increased tibiae and vertebrae bone growth and subsequently improved final length. In OVX rabbits, RES delayed fusion of the distal tibia, distal femur and proximal tibia epiphyses and femur length and vertebral bone growth increased when compared with controls. Histomorphometrical analysis showed that RES-treated OVX rabbits had a wider distal femur growth plate, enlarged resting zone, increased number/size of hypertrophic chondrocytes, increased height of the hypertrophic zone, and suppressed chondrocyte expression of VEGF and laminin. In cultured fetal rat metatarsal bones, RES stimulated growth at 0.3 µM while at higher concentrations (10 μM and 50 μM) growth was inhibited. We conclude that RES has the potential to improve longitudinal bone growth. The effect was associated with a delay of growth plate fusion resulting in increased final length. These effects were accompanied by a profound suppression of VEGF and laminin expression suggesting that impairment of growth plate vascularization might be an underlying mechanism.</p></div>", "links"=>[], "tags"=>["Anatomy and physiology", "Musculoskeletal system", "bone", "developmental biology", "morphogenesis", "Skeletal development", "Organism development", "Model organisms", "Animal models", "organic chemistry", "Organic compounds", "Small molecules", "delays", "fusion", "improves"], "article_id"=>735591, "categories"=>["Medicine", "Chemistry", "Biological Sciences"], "users"=>["Elham Karimian", "Chen Tamm", "Andrei S. Chagin", "Karin Samuelsson", "Kristín Rós Kjartansdóttir", "Claes Ohlsson", "Lars Sävendahl"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0067859", "stats"=>{"downloads"=>2, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Resveratrol_Treatment_Delays_Growth_Plate_Fusion_and_Improves_Bone_Growth_in_Female_Rabbits_/735591", "title"=>"Resveratrol Treatment Delays Growth Plate Fusion and Improves Bone Growth in Female Rabbits", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-28 04:06:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/1106249"], "description"=>"<p><sup>*</sup>p<0.05 vs. control.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Musculoskeletal system", "bone", "developmental biology", "morphogenesis", "Skeletal development", "Organism development", "Model organisms", "Animal models", "organic chemistry", "Organic compounds", "Small molecules", "tibia", "vertebrae", "ovary-intact", "rabbits", "treated", "resveratrol", "16", "weeks"], "article_id"=>735573, "categories"=>["Medicine", "Chemistry", "Biological Sciences"], "users"=>["Elham Karimian", "Chen Tamm", "Andrei S. Chagin", "Karin Samuelsson", "Kristín Rós Kjartansdóttir", "Claes Ohlsson", "Lars Sävendahl"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0067859.g001", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mean_tibia_A_and_vertebrae_B_growth_from_treatment_start_in_ovary_intact_rabbits_treated_with_resveratrol_RES_or_vehicle_Control_for_16_weeks_n_8202_8202_24_/735573", "title"=>"Mean tibia (A) and vertebrae (B) growth from treatment start in ovary-intact rabbits treated with resveratrol (RES) or vehicle (Control) for 16 weeks (n = 24).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-28 04:06:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/1106251"], "description"=>"<p><sup>*</sup>p<0.05 and <sup>**</sup>p<0.01 vs. controls.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Musculoskeletal system", "bone", "developmental biology", "morphogenesis", "Skeletal development", "Organism development", "Model organisms", "Animal models", "organic chemistry", "Organic compounds", "Small molecules", "res", "e2", "tibiae", "vertebrae", "ovx"], "article_id"=>735575, "categories"=>["Medicine", "Chemistry", "Biological Sciences"], "users"=>["Elham Karimian", "Chen Tamm", "Andrei S. Chagin", "Karin Samuelsson", "Kristín Rós Kjartansdóttir", "Claes Ohlsson", "Lars Sävendahl"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0067859.g002", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_RES_and_E2_on_tibiae_A_and_vertebrae_B_growth_in_OVX_rabbits_/735575", "title"=>"Effect of RES and E2 on tibiae (A) and vertebrae (B) growth in OVX rabbits.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-28 04:06:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/1106253"], "description"=>"<p>Growth plates were considered to be fused if 50% or more of the growth plate cartilage was replaced by bone bridges. <sup>*</sup>p<0.05 vs. control.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Musculoskeletal system", "bone", "developmental biology", "morphogenesis", "Skeletal development", "Organism development", "Model organisms", "Animal models", "organic chemistry", "Organic compounds", "Small molecules", "ovx", "rabbits", "unfused", "distal", "tibia", "femur", "proximal"], "article_id"=>735577, "categories"=>["Medicine", "Chemistry", "Biological Sciences"], "users"=>["Elham Karimian", "Chen Tamm", "Andrei S. Chagin", "Karin Samuelsson", "Kristín Rós Kjartansdóttir", "Claes Ohlsson", "Lars Sävendahl"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0067859.g003", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Percent_of_OVX_rabbits_with_unfused_growth_plates_in_the_distal_tibia_A_distal_femur_B_and_proximal_tibia_C_/735577", "title"=>"Percent of OVX rabbits with unfused growth plates; in the distal tibia (A), distal femur (B) and proximal tibia (C).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-28 04:06:33"}

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Relative Metric

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