Gene-Metabolite Expression in Blood Can Discriminate Allergen-Induced Isolated Early from Dual Asthmatic Responses
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Gene-Metabolite Expression in Blood Can Discriminate Allergen-Induced Isolated Early from Dual Asthmatic Responses", "type"=>"journal", "authors"=>[{"first_name"=>"Amrit", "last_name"=>"Singh", "scopus_author_id"=>"56130501300"}, {"first_name"=>"Masatsugu", "last_name"=>"Yamamoto", "scopus_author_id"=>"35308213500"}, {"first_name"=>"Sarah H.Y.", "last_name"=>"Kam", "scopus_author_id"=>"55290784500"}, {"first_name"=>"Jian", "last_name"=>"Ruan", "scopus_author_id"=>"35238047700"}, {"first_name"=>"Gail M.", "last_name"=>"Gauvreau", "scopus_author_id"=>"6701538782"}, {"first_name"=>"Paul M.", "last_name"=>"O'Byrne", "scopus_author_id"=>"7102156248"}, {"first_name"=>"J. Mark", "last_name"=>"FitzGerald", "scopus_author_id"=>"7402450845"}, {"first_name"=>"Robert", "last_name"=>"Schellenberg", "scopus_author_id"=>"7005774922"}, {"first_name"=>"Louis Philippe", "last_name"=>"Boulet", "scopus_author_id"=>"7101845311"}, {"first_name"=>"Gabriella", "last_name"=>"Wojewodka", "scopus_author_id"=>"23101768100"}, {"first_name"=>"Cynthia", "last_name"=>"Kanagaratham", "scopus_author_id"=>"35336615300"}, {"first_name"=>"Juan B.", "last_name"=>"De Sanctis", "scopus_author_id"=>"7004639650"}, {"first_name"=>"Danuta", "last_name"=>"Radzioch", "scopus_author_id"=>"7007012582"}, {"first_name"=>"Scott J.", "last_name"=>"Tebbutt", "scopus_author_id"=>"6701561071"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"isbn"=>"1932-6203", "pui"=>"369253053", "scopus"=>"2-s2.0-84879773580", "pmid"=>"23844124", "doi"=>"10.1371/journal.pone.0067907", "sgr"=>"84879773580", "issn"=>"19326203"}, "id"=>"9c3d255c-4373-37cb-803a-5c702bfbf604", "abstract"=>"Some asthmatic individuals undergoing allergen inhalation challenge develop an isolated early response whereas others develop a dual response (early plus late response). In the present study we have used transcriptomics (microarrays) and metabolomics (mass spectrometry) of peripheral blood to identify molecular patterns that can discriminate allergen-induced isolated early from dual asthmatic responses. Peripheral blood was obtained prior to (pre-) and 2 hours post allergen inhalation challenge from 33 study participants. In an initial cohort of 14 participants, complete blood counts indicated significant differences in neutrophil and lymphocyte counts at pre-challenge between early and dual responders. At post-challenge, significant genes (ALOX15, FADS2 and LPCAT2) and metabolites (lysolipids) were enriched in lipid metabolism pathways. Enzymes encoding for these genes are involved in membrane biogenesis and metabolism of fatty acids into pro-inflammatory and anti-inflammatory mediators. Correlation analysis indicated a strong negative correlation between ALOX15, FADS2, and IL5RA expression with 2-arachidonoylglycerophosphocholine levels in dual responders. However, measuring arachidonic acid and docosahexaenoic acid levels in a validation cohort of 19 participants indicated that the free form of DHA (nmoles/µg of protein) was significantly (p = 0.03) different between early and dual responders after allergen challenge. Collectively these results may suggest an imbalance in lipid metabolism which dictates pro- (anti-) inflammatory and pro-resolving mechanisms. Future studies with larger sample sizes may reveal novel mechanisms and therapeutic targets of the late phase asthmatic response.", "link"=>"http://www.mendeley.com/research/genemetabolite-expression-blood-discriminate-allergeninduced-isolated-early-dual-asthmatic-responses", "reader_count"=>26, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>3, "Researcher"=>4, "Student > Ph. D. Student"=>5, "Other"=>6, "Student > Master"=>4, "Student > Bachelor"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>3, "Researcher"=>4, "Student > Ph. D. Student"=>5, "Other"=>6, "Student > Master"=>4, "Student > Bachelor"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Mathematics"=>1, "Agricultural and Biological Sciences"=>11, "Medicine and Dentistry"=>4, "Chemistry"=>1, "Social Sciences"=>1, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Chemistry"=>{"Chemistry"=>1}, "Social Sciences"=>{"Social Sciences"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>11}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>4}, "Environmental Science"=>{"Environmental Science"=>1}}, "reader_count_by_country"=>{"United States"=>1}, "group_count"=>0}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84879773580"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84879773580?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84879773580&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84879773580&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84879773580", "dc:identifier"=>"SCOPUS_ID:84879773580", "eid"=>"2-s2.0-84879773580", "dc:title"=>"Gene-Metabolite Expression in Blood Can Discriminate Allergen-Induced Isolated Early from Dual Asthmatic Responses", "dc:creator"=>"Singh A.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"8", "prism:issueIdentifier"=>"7", "prism:pageRange"=>nil, "prism:coverDate"=>"2013-07-02", "prism:coverDisplayDate"=>"2 July 2013", "prism:doi"=>"10.1371/journal.pone.0067907", "citedby-count"=>"10", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"The University of British Columbia", "affiliation-city"=>"Vancouver", "affiliation-country"=>"Canada"}, {"@_fa"=>"true", "affilname"=>"Centre for Heart Lung Innovation", "affiliation-city"=>"Vancouver", "affiliation-country"=>"Canada"}, {"@_fa"=>"true", "affilname"=>"NCE CECR PROOF Centre of Excellence", "affiliation-city"=>"Vancouver", "affiliation-country"=>"Canada"}], "pubmed-id"=>"23844124", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e67907", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0067907", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"37", "xml_views"=>"9", "html_views"=>"247"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"49"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"44"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"2", "html_views"=>"31"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"3", "xml_views"=>"2", "html_views"=>"25"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"3", "html_views"=>"26"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"9", "xml_views"=>"2", "html_views"=>"23"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"45"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"52"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"56"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"47"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"57"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"62"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"58"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"25"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"12"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"17"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"14", "xml_views"=>"2", "html_views"=>"33"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"17"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"2", "html_views"=>"22"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"55"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"25"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"2"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"6", "html_views"=>"12"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"7"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"4"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"20", "xml_views"=>"3", "html_views"=>"8"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"1"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1109246"], "description"=>"<p>ND - Not determined; all study participants were challenged with cat allergen.</p>a<p>: geometric mean (PC<sub>20</sub> values are measured on a log scale);</p>b<p>: [PC<sub>20</sub>]<sub>pre</sub>/[PC<sub>20</sub>]<sub>post.</sub></p>c<p>p<0.05 versus ER group.</p>", "links"=>[], "tags"=>["Computational biology", "Molecular genetics", "gene expression", "microarrays", "genetics", "Gene function", "Gene networks", "Human genetics", "genomics", "Functional genomics", "algebra", "Linear algebra", "Clinical genetics", "Pulmonology", "asthma"], "article_id"=>737933, "categories"=>["Mathematics", "Medicine", "Biological Sciences"], "users"=>["Amrit Singh", "Masatsugu Yamamoto", "Sarah H. Y. Kam", "Jian Ruan", "Gail M. Gauvreau", "Paul M. O'Byrne", "J. Mark FitzGerald", "Robert Schellenberg", "Louis-Philippe Boulet", "Gabriella Wojewodka", "Cynthia Kanagaratham", "Juan B. De Sanctis", "Danuta Radzioch", "Scott J. Tebbutt"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0067907.t001", "stats"=>{"downloads"=>6, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Demographics_of_study_participants_of_the_discovery_cohort_/737933", "title"=>"Demographics of study participants of the discovery cohort.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-07-02 03:55:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/1109245"], "description"=>"a<p>geometric mean (PC20 values are measured on a log scale);</p>b<p>[PC<sub>20</sub>]pre/[PC<sub>20</sub>]post;</p>c<p>p<0.001 versus ER group.</p>", "links"=>[], "tags"=>["Computational biology", "Molecular genetics", "gene expression", "microarrays", "genetics", "Gene function", "Gene networks", "Human genetics", "genomics", "Functional genomics", "algebra", "Linear algebra", "Clinical genetics", "Pulmonology", "asthma", "validation"], "article_id"=>737932, "categories"=>["Mathematics", "Medicine", "Biological Sciences"], "users"=>["Amrit Singh", "Masatsugu Yamamoto", "Sarah H. Y. Kam", "Jian Ruan", "Gail M. Gauvreau", "Paul M. O'Byrne", "J. Mark FitzGerald", "Robert Schellenberg", "Louis-Philippe Boulet", "Gabriella Wojewodka", "Cynthia Kanagaratham", "Juan B. De Sanctis", "Danuta Radzioch", "Scott J. Tebbutt"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0067907.t002", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Demographics_of_study_participants_of_the_validation_cohort_/737932", "title"=>"Demographics of study participants of the validation cohort.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-07-02 03:55:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/1109242"], "description"=>"<p>A. Gene-metabolite clusters for early responders (ΔG<sub>25,8</sub> and ΔM<sub>11,8</sub>). B. Gene-metabolite clusters for dual responders (ΔG<sub>25,6</sub> and ΔM<sub>11,6</sub>). A correlation coefficient cut-off of 0.5 is applied to both networks.</p>", "links"=>[], "tags"=>["Computational biology", "Molecular genetics", "gene expression", "microarrays", "genetics", "Gene function", "Gene networks", "Human genetics", "genomics", "Functional genomics", "algebra", "Linear algebra", "Clinical genetics", "Pulmonology", "asthma", "highlighting", "dual"], "article_id"=>737929, "categories"=>["Mathematics", "Medicine", "Biological Sciences"], "users"=>["Amrit Singh", "Masatsugu Yamamoto", "Sarah H. Y. Kam", "Jian Ruan", "Gail M. Gauvreau", "Paul M. O'Byrne", "J. Mark FitzGerald", "Robert Schellenberg", "Louis-Philippe Boulet", "Gabriella Wojewodka", "Cynthia Kanagaratham", "Juan B. De Sanctis", "Danuta Radzioch", "Scott J. Tebbutt"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0067907.g004", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Network_plots_highlighting_the_correlation_between_916_G_and_916_M_for_early_and_dual_responders_/737929", "title"=>"Network plots highlighting the correlation between ΔG and ΔM for early and dual responders.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-07-02 03:55:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/1109241"], "description"=>"<p>Ingenuity Pathway Analysis network of differentially expressed genes at post-challenge comparing ERs and DRs. Dash lines indicate indirect relationships, whereas solid lines indicate direct relationships. The red colour indicates significant genes at an FDR of 10%. The grey colour indicates non-significant genes at an FDR of 10%.</p>", "links"=>[], "tags"=>["Computational biology", "Molecular genetics", "gene expression", "microarrays", "genetics", "Gene function", "Gene networks", "Human genetics", "genomics", "Functional genomics", "algebra", "Linear algebra", "Clinical genetics", "Pulmonology", "asthma"], "article_id"=>737928, "categories"=>["Mathematics", "Medicine", "Biological Sciences"], "users"=>["Amrit Singh", "Masatsugu Yamamoto", "Sarah H. Y. Kam", "Jian Ruan", "Gail M. Gauvreau", "Paul M. O'Byrne", "J. Mark FitzGerald", "Robert Schellenberg", "Louis-Philippe Boulet", "Gabriella Wojewodka", "Cynthia Kanagaratham", "Juan B. De Sanctis", "Danuta Radzioch", "Scott J. Tebbutt"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0067907.g003", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Gene_network_/737928", "title"=>"Gene network.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-07-02 03:55:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/1109236"], "description"=>"<p>Forced expiratory volume in 1 second (FEV<sub>1</sub>) measurements at 0.2 h, 0.3 h, 0.5 h, 0.8 h, 1 h, 1.5 h, 2 h, 3 h, 4 h, 5 h, 6 h and 7 h for eight early and six dual responders. FEV<sub>1</sub> measurements are statistically different (*p<0.05) between early and dual responders at each of the time points between three and seven hours inclusive. The p-value for each time point comparing ERs and DRs was computed using a robust linear model (see Methods).</p>", "links"=>[], "tags"=>["Computational biology", "Molecular genetics", "gene expression", "microarrays", "genetics", "Gene function", "Gene networks", "Human genetics", "genomics", "Functional genomics", "algebra", "Linear algebra", "Clinical genetics", "Pulmonology", "asthma", "allergen", "inhalation"], "article_id"=>737923, "categories"=>["Mathematics", "Medicine", "Biological Sciences"], "users"=>["Amrit Singh", "Masatsugu Yamamoto", "Sarah H. Y. Kam", "Jian Ruan", "Gail M. Gauvreau", "Paul M. O'Byrne", "J. Mark FitzGerald", "Robert Schellenberg", "Louis-Philippe Boulet", "Gabriella Wojewodka", "Cynthia Kanagaratham", "Juan B. De Sanctis", "Danuta Radzioch", "Scott J. Tebbutt"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0067907.g001", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Lung_function_during_allergen_inhalation_challenge_/737923", "title"=>"Lung function during allergen inhalation challenge.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-07-02 03:55:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/1109247", "https://ndownloader.figshare.com/files/1109249", "https://ndownloader.figshare.com/files/1109264", "https://ndownloader.figshare.com/files/1109268", "https://ndownloader.figshare.com/files/1109270", "https://ndownloader.figshare.com/files/1109271"], "description"=>"<div><p>Some asthmatic individuals undergoing allergen inhalation challenge develop an isolated early response whereas others develop a dual response (early plus late response). In the present study we have used transcriptomics (microarrays) and metabolomics (mass spectrometry) of peripheral blood to identify molecular patterns that can discriminate allergen-induced isolated early from dual asthmatic responses. Peripheral blood was obtained prior to (pre-) and 2 hours post allergen inhalation challenge from 33 study participants. In an initial cohort of 14 participants, complete blood counts indicated significant differences in neutrophil and lymphocyte counts at pre-challenge between early and dual responders. At post-challenge, significant genes (<i>ALOX15</i>, <i>FADS2</i> and <i>LPCAT2</i>) and metabolites (lysolipids) were enriched in lipid metabolism pathways. Enzymes encoding for these genes are involved in membrane biogenesis and metabolism of fatty acids into pro-inflammatory and anti-inflammatory mediators. Correlation analysis indicated a strong negative correlation between <i>ALOX15</i>, <i>FADS2</i>, and <i>IL5RA</i> expression with 2-arachidonoylglycerophosphocholine levels in dual responders. However, measuring arachidonic acid and docosahexaenoic acid levels in a validation cohort of 19 participants indicated that the free form of DHA (nmoles/µg of protein) was significantly (p = 0.03) different between early and dual responders after allergen challenge. Collectively these results may suggest an imbalance in lipid metabolism which dictates pro- (anti-) inflammatory and pro-resolving mechanisms. Future studies with larger sample sizes may reveal novel mechanisms and therapeutic targets of the late phase asthmatic response.</p></div>", "links"=>[], "tags"=>["Computational biology", "Molecular genetics", "gene expression", "microarrays", "genetics", "Gene function", "Gene networks", "Human genetics", "genomics", "Functional genomics", "algebra", "Linear algebra", "Clinical genetics", "Pulmonology", "asthma", "discriminate", "allergen-induced", "dual", "asthmatic"], "article_id"=>737934, "categories"=>["Mathematics", "Medicine", "Biological Sciences"], "users"=>["Amrit Singh", "Masatsugu Yamamoto", "Sarah H. Y. Kam", "Jian Ruan", "Gail M. Gauvreau", "Paul M. O'Byrne", "J. Mark FitzGerald", "Robert Schellenberg", "Louis-Philippe Boulet", "Gabriella Wojewodka", "Cynthia Kanagaratham", "Juan B. De Sanctis", "Danuta Radzioch", "Scott J. Tebbutt"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0067907.s001", "https://dx.doi.org/10.1371/journal.pone.0067907.s002", "https://dx.doi.org/10.1371/journal.pone.0067907.s003", "https://dx.doi.org/10.1371/journal.pone.0067907.s004", "https://dx.doi.org/10.1371/journal.pone.0067907.s005", "https://dx.doi.org/10.1371/journal.pone.0067907.s006"], "stats"=>{"downloads"=>23, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Gene_Metabolite_Expression_in_Blood_Can_Discriminate_Allergen_Induced_Isolated_Early_from_Dual_Asthmatic_Responses_/737934", "title"=>"Gene-Metabolite Expression in Blood Can Discriminate Allergen-Induced Isolated Early from Dual Asthmatic Responses", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-07-02 03:55:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/1109243"], "description"=>"<p>Levels of DHA (left) decrease in early responders from pre to post-challenge whereas no consistent change is observed in dual responders following allergen challenge. At post-challenge (scaled to pre-challenge levels), DHA was differentially expressed (p = 0.033) between ERs and DRs (right). The p-value was computed using a robust linear model (see Methods).</p>", "links"=>[], "tags"=>["Computational biology", "Molecular genetics", "gene expression", "microarrays", "genetics", "Gene function", "Gene networks", "Human genetics", "genomics", "Functional genomics", "algebra", "Linear algebra", "Clinical genetics", "Pulmonology", "asthma", "docosahexaenoic", "plasma", "dual", "responders", "undergoing", "allergen", "inhalation"], "article_id"=>737930, "categories"=>["Mathematics", "Medicine", "Biological Sciences"], "users"=>["Amrit Singh", "Masatsugu Yamamoto", "Sarah H. Y. Kam", "Jian Ruan", "Gail M. Gauvreau", "Paul M. O'Byrne", "J. Mark FitzGerald", "Robert Schellenberg", "Louis-Philippe Boulet", "Gabriella Wojewodka", "Cynthia Kanagaratham", "Juan B. De Sanctis", "Danuta Radzioch", "Scott J. Tebbutt"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0067907.g005", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Levels_of_free_docosahexaenoic_acid_in_the_plasma_of_early_and_dual_responders_undergoing_allergen_inhalation_challenge_/737930", "title"=>"Levels of free docosahexaenoic acid in the plasma of early and dual responders undergoing allergen inhalation challenge.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-07-02 03:55:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/1109237"], "description"=>"<p>Relative frequencies of various leukocytes obtained at pre and post-challenge. The relative neutrophil counts were significantly (p = 0.01) elevated in ERs compared to DRs, whereas the relative lymphocyte counts were significantly reduced (p = 0.02) in ERs compared to DRs at pre-challenge. The p-value was computed using a robust linear model (see Methods); * denotes p<0.05.</p>", "links"=>[], "tags"=>["Computational biology", "Molecular genetics", "gene expression", "microarrays", "genetics", "Gene function", "Gene networks", "Human genetics", "genomics", "Functional genomics", "algebra", "Linear algebra", "Clinical genetics", "Pulmonology", "asthma"], "article_id"=>737924, "categories"=>["Mathematics", "Medicine", "Biological Sciences"], "users"=>["Amrit Singh", "Masatsugu Yamamoto", "Sarah H. Y. Kam", "Jian Ruan", "Gail M. Gauvreau", "Paul M. O'Byrne", "J. Mark FitzGerald", "Robert Schellenberg", "Louis-Philippe Boulet", "Gabriella Wojewodka", "Cynthia Kanagaratham", "Juan B. De Sanctis", "Danuta Radzioch", "Scott J. Tebbutt"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0067907.g002", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Complete_blood_counts_/737924", "title"=>"Complete blood counts.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-07-02 03:55:34"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"23", "full-text"=>"24", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"15", "full-text"=>"14", "pdf"=>"8", "abstract"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"24", "full-text"=>"17", "pdf"=>"7", "abstract"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"20", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"11", "full-text"=>"13", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"11", "full-text"=>"15", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"17", "full-text"=>"21", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"15", "full-text"=>"11", "pdf"=>"5", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"11", "full-text"=>"19", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"10", "full-text"=>"12", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"16", "full-text"=>"20", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"6", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"4", "cited-by"=>"1", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"12", "full-text"=>"9", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"17", "full-text"=>"10", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"8", "full-text"=>"4", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"21", "full-text"=>"13", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"19", "full-text"=>"14", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"13", "full-text"=>"6", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"4", "cited-by"=>"2", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"8", "full-text"=>"10", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"13", "full-text"=>"10", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"3", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"13", "full-text"=>"10", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"16", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"8", "full-text"=>"10", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"1", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"5", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"2"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"18", "full-text"=>"26", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"8", "full-text"=>"34", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"16", "full-text"=>"25", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"44", "full-text"=>"56", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"15", "supp-data"=>"6", "cited-by"=>"1", "year"=>"2019", "month"=>"8"}

Relative Metric

{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[269, 466, 588, 697, 800, 896, 988, 1076, 1165, 1254, 1340, 1417]}, {"subject_area"=>"/Biology and life sciences/Anatomy and physiology", "average_usage"=>[256, 428]}, {"subject_area"=>"/Biology and life sciences/Biochemistry", "average_usage"=>[266, 468, 593, 703, 804, 903, 993, 1084, 1171, 1256, 1339, 1422, 1492]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[264, 460, 584, 692, 794, 887, 978, 1067, 1154, 1241, 1328, 1408, 1474]}, {"subject_area"=>"/Medicine and health sciences/Anatomy and physiology", "average_usage"=>[253, 430]}, {"subject_area"=>"/Medicine and health sciences/Hematology", "average_usage"=>[238, 424, 545, 650, 749, 839, 926, 1006, 1090, 1167, 1243, 1316, 1380]}]}
Loading … Spinner
There are currently no alerts