High Levels of Both n-3 and n-6 Long-Chain Polyunsaturated Fatty Acids in Cord Serum Phospholipids Predict Allergy Development
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{"title"=>"High Levels of Both n-3 and n-6 Long-Chain Polyunsaturated Fatty Acids in Cord Serum Phospholipids Predict Allergy Development", "type"=>"journal", "authors"=>[{"first_name"=>"Malin", "last_name"=>"Barman", "scopus_author_id"=>"55790347700"}, {"first_name"=>"Sara", "last_name"=>"Johansson", "scopus_author_id"=>"57197177504"}, {"first_name"=>"Bill", "last_name"=>"Hesselmar", "scopus_author_id"=>"6602135967"}, {"first_name"=>"Agnes E.", "last_name"=>"Wold", "scopus_author_id"=>"7005145529"}, {"first_name"=>"Ann Sofie", "last_name"=>"Sandberg", "scopus_author_id"=>"57200562956"}, {"first_name"=>"Anna", "last_name"=>"Sandin", "scopus_author_id"=>"6701662820"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84880016564", "doi"=>"10.1371/journal.pone.0067920", "sgr"=>"84880016564", "isbn"=>"1932-6203 (Electronic) 1932-6203 (Linking)", "pmid"=>"23874467", "issn"=>"19326203", "pui"=>"369294482"}, "id"=>"180eeada-9543-3fa6-a8ec-f311c99e22f9", "abstract"=>"BACKGROUND: Long-chain polyunsaturated fatty acids (LCPUFAs) reduce T-cell activation and dampen inflammation. They might thereby counteract the neonatal immune activation and hamper normal tolerance development to harmless environmental antigens. We investigated whether fatty acid composition of cord serum phospholipids affects allergy development up to age 13 years.\\n\\nMETHODS: From a population-based birth-cohort born in 1996/7 and followed until 13 years of age (n = 794), we selected cases with atopic eczema (n = 37) or respiratory allergy (n = 44), as well as non-allergic non-sensitized controls (n = 48) based on diagnosis at 13 years of age. Cord and maternal sera obtained at delivery from cases and controls were analysed for proportions of saturated, monounsaturated and polyunsaturated fatty acids among serum phospholipids.\\n\\nRESULTS: The cord serum phospholipids from subject who later developed either respiratory allergy or atopic eczema had significantly higher proportions of 5/8 LCPUFA species, as well as total n-3 LCPUFA, total n-6 LCPUFA and total LCPUFA compared to cord serum phospholipids from controls who did not develop allergy (P<0.001 for all comparisons). Conversely, individuals later developing allergy had lower proportion of the monounsaturated fatty acid 18∶1n-9 as well as total MUFA (p<0.001) among cord serum phospholipids. The risk of respiratory allergy at age 13 increased linearly with the proportion of n-3 LCPUFA (Ptrend<0.001), n-6 LCPUFA (Ptrend = 0.001), and total LCPUFA (Ptrend<0.001) and decreased linearly with the proportions of total MUFA (Ptrend = 0.025) in cord serum phospholipids. Furthermore, Kaplan-Meier estimates of allergy development demonstrated that total LCPUFA proportion in cord serum phospholipids was significantly associated with respiratory allergy (P = 0.008) and sensitization (P = 0.002), after control for sex and parental allergy.\\n\\nCONCLUSION: A high proportion of long-chain PUFAs among cord serum phospholipids may predispose to allergy development. The mechanism is unknown, but may involve dampening of the physiologic immune activation in infancy needed for proper maturation of the infant's immune system.", "link"=>"http://www.mendeley.com/research/high-levels-both-n3-n6-longchain-polyunsaturated-fatty-acids-cord-serum-phospholipids-predict-allerg", "reader_count"=>37, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>2, "Researcher"=>11, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>3, "Student > Master"=>2, "Other"=>2, "Student > Bachelor"=>4, "Lecturer"=>3, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>2, "Researcher"=>11, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>3, "Student > Master"=>2, "Other"=>2, "Student > Bachelor"=>4, "Lecturer"=>3, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_subject_area"=>{"Nursing and Health Professions"=>2, "Biochemistry, Genetics and Molecular Biology"=>1, "Mathematics"=>1, "Medicine and Dentistry"=>16, "Agricultural and Biological Sciences"=>11, "Chemistry"=>1, "Social Sciences"=>1, "Immunology and Microbiology"=>4}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>16}, "Chemistry"=>{"Chemistry"=>1}, "Social Sciences"=>{"Social Sciences"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>4}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>11}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Mathematics"=>{"Mathematics"=>1}}, "group_count"=>1}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1116395"], "description"=>"<p>The 129 investigated individuals were divided into quartiles (Q1–Q4) according to their proportions of total n-3 (a–c), total n-6 (d–f), and total long-chain PUFAs (g–i) among cord serum phospholipids, Q1 representing the lowest and Q4 the highest proportion. Allergy was diagnosed at 1, 4, 7 and 13 years of age and sensitization to a panel of 10 allergens was measured by skin prick test at 1, 4 and 13 years of age. Cox regression was performed and P values were adjusted for the following confounders: sex, and parental history of allergy.</p>", "links"=>[], "tags"=>["Biochemistry", "lipids", "Fatty acids", "immunology", "Allergy and hypersensitivity", "Clinical immunology", "Diagnostic medicine", "pathology", "General pathology", "biomarkers", "epidemiology", "Biomarker epidemiology", "pediatrics", "Child development", "Public health", "Child health", "Pulmonology", "asthma", "allergy", "sensitization", "lcpufa", "proportions", "serum"], "article_id"=>743597, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Malin Barman", "Sara Johansson", "Bill Hesselmar", "Agnes E. Wold", "Ann-Sofie Sandberg", "Anna Sandin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0067920.g003", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cumulative_proportion_of_allergy_and_sensitization_in_relation_to_LCPUFA_proportions_in_cord_serum_phospholipids_/743597", "title"=>"Cumulative proportion of allergy and sensitization in relation to LCPUFA proportions in cord serum phospholipids.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-07-10 02:46:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/1116394"], "description"=>"<p>The 129 investigated individuals were divided into quartiles according to their proportions of(a) n-3 long-chain polyunsaturated fatty acids (LCPUFAs), (b) n-6 LCPUFAs, (c) total LCPUFAs and (d) total MUFAs in cord serum phospholipids and the proportion within each quartile that had respiratory allergy (filled), atopic eczema (hatched) or were non-allergic (unfilled) is depicted. P value for trend analysis (P<sub>trend</sub>) is shown for each allergic manifestation.</p>", "links"=>[], "tags"=>["Biochemistry", "lipids", "Fatty acids", "immunology", "Allergy and hypersensitivity", "Clinical immunology", "Diagnostic medicine", "pathology", "General pathology", "biomarkers", "epidemiology", "Biomarker epidemiology", "pediatrics", "Child development", "Public health", "Child health", "Pulmonology", "asthma", "allergic", "manifestations", "fatty", "proportions", "serum"], "article_id"=>743596, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Malin Barman", "Sara Johansson", "Bill Hesselmar", "Agnes E. Wold", "Ann-Sofie Sandberg", "Anna Sandin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0067920.g002", "stats"=>{"downloads"=>0, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Developing_different_allergic_manifestations_as_a_function_of_fatty_acid_proportions_in_cord_serum_phospholipids_/743596", "title"=>"Developing different allergic manifestations as a function of fatty acid proportions in cord serum phospholipids.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-07-10 02:46:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/1116391"], "description"=>"<p>The figure shows the proportion of (a) n-3 long-chain polyunsaturated fatty acids (LCPUFAs), (b) n-6 LCPUFAs, and (c) total MUFAs in cord serum phospholipids in the three groups, respiratory allergy (filled), atopic eczema (hatched) or non-allergic (unfilled), for all subjects (n = 129, left), subjects born to non-allergic mothers (n = 54, middle) as wells as subjects born to allergic mothers (n = 75, right). Mann-Whitney U test were used to test for significant differences between the allergic groups and the non-allergic group, *P<0.05, **P<0.01, ***P<0.001.</p>", "links"=>[], "tags"=>["Biochemistry", "lipids", "Fatty acids", "immunology", "Allergy and hypersensitivity", "Clinical immunology", "Diagnostic medicine", "pathology", "General pathology", "biomarkers", "epidemiology", "Biomarker epidemiology", "pediatrics", "Child development", "Public health", "Child health", "Pulmonology", "asthma", "serum", "phospholipid", "proportions", "n-3", "n-6", "lcpufa", "mufa", "allergy", "13"], "article_id"=>743593, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Malin Barman", "Sara Johansson", "Bill Hesselmar", "Agnes E. Wold", "Ann-Sofie Sandberg", "Anna Sandin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0067920.g001", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cord_serum_phospholipid_proportions_of_n_3_LCPUFA_n_6_LCPUFA_and_MUFA_and_allergy_at_13_years_/743593", "title"=>"Cord serum phospholipid proportions of n-3 LCPUFA, n-6 LCPUFA and MUFA and allergy at 13 years.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-07-10 02:46:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/1116399"], "description"=>"<p>Phospholipids were extracted from cord serum and analysed by gas chromatography. Fatty acids of chain length 20–22 carbon atoms were analysed in all samples, while 16–18 carbon atom long fatty acids were assayed in samples of sufficient remaining quantity. Adolescents were assigned to any of the three diagnostic groups based on clinical examination at 13 years of age. Adolescents with atopic eczema had no other allergic manifestation; the same was true of adolescents with respiratory allergy. Non-allergic adolescents had no symptoms and no skin-prick test positivity to a range of common aeroallergens and food allergens (see Methods). P values given in italics signify higher levels of the fatty acid species in the infants who did not develop allergy.</p>", "links"=>[], "tags"=>["Biochemistry", "lipids", "Fatty acids", "immunology", "Allergy and hypersensitivity", "Clinical immunology", "Diagnostic medicine", "pathology", "General pathology", "biomarkers", "epidemiology", "Biomarker epidemiology", "pediatrics", "Child development", "Public health", "Child health", "Pulmonology", "asthma", "fatty", "acids", "serum", "phospholipids"], "article_id"=>743601, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Malin Barman", "Sara Johansson", "Bill Hesselmar", "Agnes E. Wold", "Ann-Sofie Sandberg", "Anna Sandin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0067920.t002", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Proportions_of_long_chain_fatty_acids_in_cord_serum_phospholipids_of_cord_serum_phospholipids_mean_177_SEM_/743601", "title"=>"Proportions of long chain fatty acids in cord serum phospholipids (% of cord serum phospholipids, mean±SEM).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-07-10 02:46:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/1116397"], "description"=>"†<p>Fulfilling at least one of the following criteria; wheeze in the past year, asthma inhalation treatment, or an affirmative answer to the question: “Have you had any signs of pollen allergy or allergy to furred pets during the last 12 months?”, diagnosed at 13 years of age. <sup>*</sup>Defined as a pruritic, chronic or chronically relapsing non-infectious dermatitis with typical features and distribution and fulfilling at least three of the main criteria defined by Hanifin and Rajka <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0067920#pone.0067920-Hanifin1\" target=\"_blank\">[22]</a>, diagnosed at 13 years of age. <sup>¤</sup>Response to questionnaire distributed at 1 year of age. <sup>§</sup>Defined as an affirmative answer to the question “Has the child's mother/father ever had asthma, hay fever or eczema?” answered at 13 years of age. <sup>¥</sup>Answered at 4 years of age.</p>", "links"=>[], "tags"=>["Biochemistry", "lipids", "Fatty acids", "immunology", "Allergy and hypersensitivity", "Clinical immunology", "Diagnostic medicine", "pathology", "General pathology", "biomarkers", "epidemiology", "Biomarker epidemiology", "pediatrics", "Child development", "Public health", "Child health", "Pulmonology", "asthma", "individuals", "groups", "cohort"], "article_id"=>743599, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Malin Barman", "Sara Johansson", "Bill Hesselmar", "Agnes E. Wold", "Ann-Sofie Sandberg", "Anna Sandin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0067920.t001", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characteristics_of_the_individuals_in_the_selected_study_groups_the_clinical_groups_from_which_they_were_selected_and_the_cohort_from_which_they_derived_/743599", "title"=>"Characteristics of the individuals in the selected study groups, the clinical groups from which they were selected and the cohort from which they derived.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-07-10 02:46:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/1116396"], "description"=>"<p>At gestational week 18 the mothers were asked to specify how often they consumed fish. These answers were then converted to intake frequencies in times per month and three groups were formed; one group eating fish less than twice a month (white bars), one group eating fish twice a month (light grey bars) and one group eating fish more than twice a month (dark grey bars). This was then correlated to the levels of total n-3 LCPUFA in maternal and cord serum phospholipids at birth.</p>", "links"=>[], "tags"=>["Biochemistry", "lipids", "Fatty acids", "immunology", "Allergy and hypersensitivity", "Clinical immunology", "Diagnostic medicine", "pathology", "General pathology", "biomarkers", "epidemiology", "Biomarker epidemiology", "pediatrics", "Child development", "Public health", "Child health", "Pulmonology", "asthma", "intake", "n-3", "lcpufa", "maternal", "serum", "phospholipids"], "article_id"=>743598, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Malin Barman", "Sara Johansson", "Bill Hesselmar", "Agnes E. Wold", "Ann-Sofie Sandberg", "Anna Sandin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0067920.g004", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Correlation_between_fish_intake_in_pregnancy_and_n_3_LCPUFA_in_maternal_and_cord_serum_phospholipids_at_birth_/743598", "title"=>"Correlation between fish intake in pregnancy and n-3 LCPUFA in maternal and cord serum phospholipids at birth.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-07-10 02:46:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/1116400"], "description"=>"<div><p>Background</p><p>Long-chain polyunsaturated fatty acids (LCPUFAs) reduce T-cell activation and dampen inflammation. They might thereby counteract the neonatal immune activation and hamper normal tolerance development to harmless environmental antigens. We investigated whether fatty acid composition of cord serum phospholipids affects allergy development up to age 13 years.</p><p>Methods</p><p>From a population-based birth-cohort born in 1996/7 and followed until 13 years of age (n = 794), we selected cases with atopic eczema (n = 37) or respiratory allergy (n = 44), as well as non-allergic non-sensitized controls (n = 48) based on diagnosis at 13 years of age. Cord and maternal sera obtained at delivery from cases and controls were analysed for proportions of saturated, monounsaturated and polyunsaturated fatty acids among serum phospholipids.</p><p>Results</p><p>The cord serum phospholipids from subject who later developed either respiratory allergy or atopic eczema had significantly higher proportions of 5/8 LCPUFA species, as well as total n-3 LCPUFA, total n-6 LCPUFA and total LCPUFA compared to cord serum phospholipids from controls who did not develop allergy (P<0.001 for all comparisons). Conversely, individuals later developing allergy had lower proportion of the monounsaturated fatty acid 18∶1n-9 as well as total MUFA (p<0.001) among cord serum phospholipids. The risk of respiratory allergy at age 13 increased linearly with the proportion of n-3 LCPUFA (P<sub>trend</sub><0.001), n-6 LCPUFA (P<sub>trend</sub> = 0.001), and total LCPUFA (P<sub>trend</sub><0.001) and decreased linearly with the proportions of total MUFA (P<sub>trend</sub> = 0.025) in cord serum phospholipids. Furthermore, Kaplan-Meier estimates of allergy development demonstrated that total LCPUFA proportion in cord serum phospholipids was significantly associated with respiratory allergy (P = 0.008) and sensitization (P = 0.002), after control for sex and parental allergy.</p><p>Conclusion</p><p>A high proportion of long-chain PUFAs among cord serum phospholipids may predispose to allergy development. The mechanism is unknown, but may involve dampening of the physiologic immune activation in infancy needed for proper maturation of the infant's immune system.</p></div>", "links"=>[], "tags"=>["Biochemistry", "lipids", "Fatty acids", "immunology", "Allergy and hypersensitivity", "Clinical immunology", "Diagnostic medicine", "pathology", "General pathology", "biomarkers", "epidemiology", "Biomarker epidemiology", "pediatrics", "Child development", "Public health", "Child health", "Pulmonology", "asthma", "n-3", "n-6", "long-chain", "polyunsaturated", "fatty", "acids", "serum", "phospholipids", "allergy"], "article_id"=>743602, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Malin Barman", "Sara Johansson", "Bill Hesselmar", "Agnes E. Wold", "Ann-Sofie Sandberg", "Anna Sandin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0067920", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_High_Levels_of_Both_n_3_and_n_6_Long_Chain_Polyunsaturated_Fatty_Acids_in_Cord_Serum_Phospholipids_Predict_Allergy_Development_/743602", "title"=>"High Levels of Both n-3 and n-6 Long-Chain Polyunsaturated Fatty Acids in Cord Serum Phospholipids Predict Allergy Development", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-07-10 02:46:47"}

PMC Usage Stats | Further Information

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Relative Metric

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