Passive Immunization with Hypochlorite-oxLDL Specific Antibodies Reduces Plaque Volume in LDL Receptor-Deficient Mice
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{"title"=>"Passive Immunization with Hypochlorite-oxLDL Specific Antibodies Reduces Plaque Volume in LDL Receptor-Deficient Mice", "type"=>"journal", "authors"=>[{"first_name"=>"Marcella", "last_name"=>"van Leeuwen", "scopus_author_id"=>"23101328400"}, {"first_name"=>"Michael J.", "last_name"=>"Kemna", "scopus_author_id"=>"55799462400"}, {"first_name"=>"Menno P.J.", "last_name"=>"de Winther", "scopus_author_id"=>"6701795528"}, {"first_name"=>"Louis", "last_name"=>"Boon", "scopus_author_id"=>"7005688644"}, {"first_name"=>"Adriaan M.", "last_name"=>"Duijvestijn", "scopus_author_id"=>"7004311104"}, {"first_name"=>"Darius", "last_name"=>"Henatsch", "scopus_author_id"=>"36463529700"}, {"first_name"=>"Nico A.", "last_name"=>"Bos", "scopus_author_id"=>"7006530227"}, {"first_name"=>"Marion J.J.", "last_name"=>"Gijbels", "scopus_author_id"=>"35512381800"}, {"first_name"=>"Jan Willem Cohen", "last_name"=>"Tervaert", "scopus_author_id"=>"7003559165"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84880474367", "pmid"=>"23874490", "sgr"=>"84880474367", "doi"=>"10.1371/journal.pone.0068039", "issn"=>"19326203", "pui"=>"369369145"}, "id"=>"fcbc7a0e-19da-3f36-a4dc-f5f0b490b33f", "abstract"=>"AIMS: New strategies to overcome complications of cardiovascular diseases are needed. Since it has been demonstrated that atherosclerosis is an inflammatory disease, modulation of the immune system may be a promising approach. Previously, it was suggested that antibodies may confer protective effects on the development of atherosclerosis. In this study, we hypothesised that passive immunization with anti-oxLDL IgM antibodies specific for hypochlorite (HOCl) may be athero-protective in mice.\\n\\nMETHODS AND RESULTS: Monoclonal mouse IgM antibodies were produced and the antibody with specificity for hypochlorite-oxLDL (HOCl-oxLDL) (Moab A7S8) was selected. VH sequence determination revealed that Moab A7S8 is a natural IgM antibody. Atherosclerosis in LDLr(-/-) mice was induced by a perivascular collar placement around the right carotid artery in combination with feeding a high-fat diet. Subsequently, the mice were treated every six days with 500 µg Moab A7S8, non-relevant IgM or with PBS and the carotid arteries and aortic roots were studied for atherosclerosis. Passive immunization with this Moab A7S8 resulted in a significant reduced plaque volume formation in LDLr(-/-) mice when compared with PBS treatment (P = 0.002 and P = 0.035). Cholesterol levels decreased by 20% when mice were treated with Moab A7S8 compared to PBS. Furthermore, anti-oxLDL specific IgM and IgG antibody production increased significantly in the Moab A7S8 treated mice in comparison with PBS treated mice.\\n\\nCONCLUSION: Our data show that passive immunization with a natural IgM antibody, directed to HOCl-oxLDL, can reduce atherosclerotic plaque development. We postulate that specific antibody therapy may be developed for use in human cardiovascular diseases.", "link"=>"http://www.mendeley.com/research/passive-immunization-hypochloriteoxldl-specific-antibodies-reduces-plaque-volume-ldl-receptordeficie", "reader_count"=>15, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>2, "Student > Ph. D. Student"=>3, "Student > Master"=>5, "Student > Bachelor"=>2, "Professor"=>1, "Unspecified"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>2, "Student > Ph. D. Student"=>3, "Student > Master"=>5, "Student > Bachelor"=>2, "Professor"=>1, "Unspecified"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>4, "Medicine and Dentistry"=>3, "Agricultural and Biological Sciences"=>6, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Unspecified"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>6}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"Netherlands"=>1, "United Kingdom"=>1}, "group_count"=>2}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1120346"], "description"=>"<p>A. Atherosclerotic lesions develop caudal to the collar, cross-sections were made of the common right carotid artery in a caudal direction from the collar and collected in a parallel series of slides, B. Time schedule of the experiment to study the effect of passive immunization using Moab A7S8 or PBS on atherosclerotic plaque development.</p>", "links"=>[], "tags"=>["Model organisms", "Animal models", "mouse", "cardiovascular", "atherosclerosis", "Clinical immunology", "immunity", "immunizations", "inflammation", "immunoglobulins"], "article_id"=>746599, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Marcella van Leeuwen", "Michael J. Kemna", "Menno P. J. de Winther", "Louis Boon", "Adriaan M. Duijvestijn", "Darius Henatsch", "Nico A. Bos", "Marion J. J. Gijbels", "Jan Willem Cohen Tervaert"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0068039.g001", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Schematic_representation_of_the_collar_model_and_the_experimental_design_/746599", "title"=>"Schematic representation of the collar model and the experimental design.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-07-16 03:11:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/1120347"], "description"=>"<p>A. Reactivity to native, HOCL-oxLDL and MDA-oxLDL. Measured by ELISA, OD 405 at different concentrations (100, 50, 25, 10 and 1 µg/ml IgM concentration). B. Sequence IgM hybridoma. The sequence of Moab A7S8 was compared with germline VH genes by using the international ImMunoGeneTics information system/−QUEry and Standardization (IMGT/V-Quest). Moab A7S8 is composed of IgHV1–78*01, IGHJ3*01 and IGHD1-1*02 alleles, with 100% identity and no gaps. Except for the N-addition, the alleles are in frame germline sequences.</p>", "links"=>[], "tags"=>["Model organisms", "Animal models", "mouse", "cardiovascular", "atherosclerosis", "Clinical immunology", "immunity", "immunizations", "inflammation", "immunoglobulins", "monoclonal", "antibody"], "article_id"=>746600, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Marcella van Leeuwen", "Michael J. Kemna", "Menno P. J. de Winther", "Louis Boon", "Adriaan M. Duijvestijn", "Darius Henatsch", "Nico A. Bos", "Marion J. J. Gijbels", "Jan Willem Cohen Tervaert"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0068039.g002", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_IgM_Monoclonal_antibody_Moab_A7S8_/746600", "title"=>"IgM Monoclonal antibody (Moab A7S8).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-07-16 03:11:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/1120349"], "description"=>"<p>A. Representative lesions of PBS and Moab A7S8 treated mice of collar-induce atherosclerosis in LDLr<sup>−/−</sup> mice. Scale bar, 100µm (haematoxylin-eosin). B. Percentage mice with atherosclerotic plaque formation after certain distances from collar. Closed bars: PBS treated mice. Grey bars: control IgM treated mice. Open bars: Moab A7S8 treated mice. C. Representative lesions in the aortic root of PBS and Moab A7S8 treated LDLr<sup>−/−</sup> mice. Scale bar, 100 µm (toluidin blue). D. Atherosclerotic plaque volume in the aortic root. Plaque volume, expressed in mm2. E. Collar-induced atherosclerotic plaque volume, measured at every 50 µm from collar, in PBS (▪), control IgM (○) and Moab A7S8 (□) treated mice. A dot represents the mean ± SEM.</p>", "links"=>[], "tags"=>["Model organisms", "Animal models", "mouse", "cardiovascular", "atherosclerosis", "Clinical immunology", "immunity", "immunizations", "inflammation", "immunoglobulins", "plaque", "aortic"], "article_id"=>746602, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Marcella van Leeuwen", "Michael J. Kemna", "Menno P. J. de Winther", "Louis Boon", "Adriaan M. Duijvestijn", "Darius Henatsch", "Nico A. Bos", "Marion J. J. Gijbels", "Jan Willem Cohen Tervaert"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0068039.g003", "stats"=>{"downloads"=>2, "page_views"=>39, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Atherosclerotic_plaque_volume_at_the_collar_and_aortic_root_/746602", "title"=>"Atherosclerotic plaque volume at the collar and aortic root.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-07-16 03:11:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/1120350"], "description"=>"<p>Percentage positive collagen of the total plaque area. In PBS (▪) and Moab A7S8 (□) treated mice.</p>", "links"=>[], "tags"=>["Model organisms", "Animal models", "mouse", "cardiovascular", "atherosclerosis", "Clinical immunology", "immunity", "immunizations", "inflammation", "immunoglobulins", "atherosclerotic"], "article_id"=>746603, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Marcella van Leeuwen", "Michael J. Kemna", "Menno P. J. de Winther", "Louis Boon", "Adriaan M. Duijvestijn", "Darius Henatsch", "Nico A. Bos", "Marion J. J. Gijbels", "Jan Willem Cohen Tervaert"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0068039.g004", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Collagen_content_in_the_atherosclerotic_plaque_/746603", "title"=>"Collagen content in the atherosclerotic plaque.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-07-16 03:11:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/1120351"], "description"=>"<p>Serum cholesterol levels are expressed as mM (± SEM). Closed bars: PBS treated mice. Grey bars: control IgM treated mice. Open bars: Moab A7S8 treated mice.</p>", "links"=>[], "tags"=>["Model organisms", "Animal models", "mouse", "cardiovascular", "atherosclerosis", "Clinical immunology", "immunity", "immunizations", "inflammation", "immunoglobulins"], "article_id"=>746604, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Marcella van Leeuwen", "Michael J. Kemna", "Menno P. J. de Winther", "Louis Boon", "Adriaan M. Duijvestijn", "Darius Henatsch", "Nico A. Bos", "Marion J. J. Gijbels", "Jan Willem Cohen Tervaert"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0068039.g005", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cholesterol_levels_/746604", "title"=>"Cholesterol levels.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-07-16 03:11:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/1120352"], "description"=>"<p>A. Total IgM titers, B. anti-HOCl oxLDL IgM titers and C. anti-MDA oxLDL IgM in PBS treated mice (▪), control IgM treated mice (o) and Moab A7S8 treated mice (□).</p>", "links"=>[], "tags"=>["Model organisms", "Animal models", "mouse", "cardiovascular", "atherosclerosis", "Clinical immunology", "immunity", "immunizations", "inflammation", "immunoglobulins", "igm", "hocl", "mda", "anti-oxldl"], "article_id"=>746605, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Marcella van Leeuwen", "Michael J. Kemna", "Menno P. J. de Winther", "Louis Boon", "Adriaan M. Duijvestijn", "Darius Henatsch", "Nico A. Bos", "Marion J. J. Gijbels", "Jan Willem Cohen Tervaert"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0068039.g006", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Total_IgM_and_HOCl_and_MDA_anti_oxLDL_IgM_titers_/746605", "title"=>"Total IgM and HOCl and MDA anti-oxLDL IgM titers.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-07-16 03:11:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/1120353"], "description"=>"<p>A. Anti-Cu-oxLDL IgM titers, B. T15/EO6 IgM antibodies and C. IgM-apoB immune complexes expressed as IgM/apoB. Mice treated with PBS (▪), control IgM treated mice (o) and in mice treated with Moab A7S8 (□).</p>", "links"=>[], "tags"=>["Model organisms", "Animal models", "mouse", "cardiovascular", "atherosclerosis", "Clinical immunology", "immunity", "immunizations", "inflammation", "immunoglobulins", "igm", "antibodies", "igm-apob"], "article_id"=>746606, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Marcella van Leeuwen", "Michael J. Kemna", "Menno P. J. de Winther", "Louis Boon", "Adriaan M. Duijvestijn", "Darius Henatsch", "Nico A. Bos", "Marion J. J. Gijbels", "Jan Willem Cohen Tervaert"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0068039.g007", "stats"=>{"downloads"=>1, "page_views"=>44, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cu_anti_oxLDL_IgM_titers_T15_EO6_IgM_antibodies_and_IgM_apoB_immune_complexes_/746606", "title"=>"Cu-anti-oxLDL IgM titers, T15/EO6 IgM antibodies and IgM-apoB immune complexes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-07-16 03:11:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/1120355"], "description"=>"<p>A. Anti-HOCl-oxLDL IgG titers, B. anti-MDA-oxLDL IgG titers and C. anti-Cu-oxLDL IgG titers in mice treated with PBS (▪), control IgM treated mice (o) and in mice treated with Moab A7S8 (□).</p>", "links"=>[], "tags"=>["Model organisms", "Animal models", "mouse", "cardiovascular", "atherosclerosis", "Clinical immunology", "immunity", "immunizations", "inflammation", "immunoglobulins", "mda", "cu-oxldl", "igg"], "article_id"=>746607, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Marcella van Leeuwen", "Michael J. Kemna", "Menno P. J. de Winther", "Louis Boon", "Adriaan M. Duijvestijn", "Darius Henatsch", "Nico A. Bos", "Marion J. J. Gijbels", "Jan Willem Cohen Tervaert"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0068039.g008", "stats"=>{"downloads"=>1, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Anti_HOCl_MDA_and_Cu_oxLDL_IgG_titers_/746607", "title"=>"Anti-HOCl, MDA and Cu-oxLDL IgG titers.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-07-16 03:11:16"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"13", "full-text"=>"7", "pdf"=>"9", "abstract"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
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  • {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
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  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"14", "full-text"=>"12", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"6", "full-text"=>"11", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
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  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
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  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"7", "full-text"=>"3", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
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  • {"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
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  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"8", "full-text"=>"18", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"15", "full-text"=>"18", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"2", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
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  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
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  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}

Relative Metric

{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Biochemistry", "average_usage"=>[266, 468, 593, 703, 804, 903, 993, 1084, 1171, 1256, 1339, 1422, 1492]}, {"subject_area"=>"/Biology and life sciences/Immunology", "average_usage"=>[266, 466, 591, 701, 799, 887, 982, 1067, 1155, 1237, 1317, 1395, 1458]}, {"subject_area"=>"/Medicine and health sciences/Public and occupational health", "average_usage"=>[291, 491, 610, 723, 817, 906, 991, 1071, 1153, 1238, 1324, 1411, 1478]}, {"subject_area"=>"/Medicine and health sciences/Vascular medicine", "average_usage"=>[222, 394, 496, 593, 683, 762, 835, 910, 980, 1047, 1116, 1184, 1244]}]}
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