Regulated Expression of PTPRJ/CD148 and an Antisense Long Noncoding RNA in Macrophages by Proinflammatory Stimuli
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{"title"=>"Regulated Expression of PTPRJ/CD148 and an Antisense Long Noncoding RNA in Macrophages by Proinflammatory Stimuli", "type"=>"journal", "authors"=>[{"first_name"=>"Richa K.", "last_name"=>"Dave", "scopus_author_id"=>"36924164800"}, {"first_name"=>"Marcel E.", "last_name"=>"Dinger", "scopus_author_id"=>"15759402200"}, {"first_name"=>"Megan", "last_name"=>"Andrew", "scopus_author_id"=>"55317020100"}, {"first_name"=>"Marjan", "last_name"=>"Askarian-Amiri", "scopus_author_id"=>"6506617535"}, {"first_name"=>"David A.", "last_name"=>"Hume", "scopus_author_id"=>"26032966400"}, {"first_name"=>"Stuart", "last_name"=>"Kellie", "scopus_author_id"=>"7007064612"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84879541699", "pui"=>"369209155", "doi"=>"10.1371/journal.pone.0068306", "isbn"=>"1932-6203", "sgr"=>"84879541699", "pmid"=>"23840844"}, "id"=>"5154f272-db6d-352d-ac2c-d166548ef1e1", "abstract"=>"PTPRJ/CD148 is a tyrosine phosphatase that has tumour suppressor-like activity. Quantitative PCR of various cells and tissues revealed that it is preferentially expressed in macrophage-enriched tissues. Within lymphoid tissues immunohistochemistry revealed that PTPRJ/CD148 co-localised with F4/80, indicating that macrophages most strongly express the protein. Macrophages express the highest basal level of ptprj, and this is elevated further by treatment with LPS and other Toll-like receptor ligands. In contrast, CSF-1 treatment reduced basal and stimulated Ptprj expression in human and mouse cells, and interferon also repressed Ptprj expression. We identified a 1006 nucleotide long noncoding RNA species, Ptprj-as1 that is transcribed antisense to Ptprj. Ptprj-as1 was highly expressed in macrophage-enriched tissue and was transiently induced by Toll-like receptor ligands with a similar time course to Ptprj. Finally, putative transcription factor binding sites in the promoter region of Ptprj were identified.", "link"=>"http://www.mendeley.com/research/regulated-expression-ptprjcd148-antisense-long-noncoding-rna-macrophages-proinflammatory-stimuli", "reader_count"=>20, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>4, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>1, "Student > Master"=>3, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>4, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>1, "Student > Master"=>3, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>3, "Agricultural and Biological Sciences"=>9, "Medicine and Dentistry"=>2, "Neuroscience"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Immunology and Microbiology"=>3}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Neuroscience"=>{"Neuroscience"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>9}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "group_count"=>2}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1105465"], "description"=>"<p>A–C: Regulation of <i>Ptprj</i> expression by CSF-1 and LPS in mouse bone marrow-derived macrophages (BMMs). BMMs were maintained overnight in the presence or absence of CSF-1 (1×10<sup>4</sup> U/mL) before treatment with LPS (10 ng/mL) (A, B). RAW 264.7 cells were maintained overnight in the absence of CSF-1 before treatment with LPS (10 ng/mL) (C). <i>Ptprj</i> (A, C) and <i>c-fms</i> (B) expression profiles were assessed by quantitative real-time PCR. Profiles are representative of two independent experiments. D: Regulation of <i>Ptprj</i> expression by CSF-1 and LPS in mouse thioglycollate-elicited peritoneal macrophages (TEPMs). TEPMs were maintained overnight in the presence or absence of CSF-1 (1×10<sup>4</sup> U/mL) before treatment with LPS (10 ng/mL). <i>Ptprj</i> expression profile was assessed by quantitative real-time PCR. E: IFNγ treatment of bone marrow derived macrophages suppresses the LPS mediated induction of <i>ptprj</i>. BMMs were maintained overnight in the presence of CSF-1 (1×10<sup>4</sup> U/mL) and presence or absence of IFNγ (500 pg/mL) before treatment with LPS (10 ng/mL). RNA was extracted at each time point and used for the synthesis of cDNA. <i>Ptprj</i> expression profile was assessed by quantitative real-time PCR. Datapoints (+/− SD) represent the average of triplicate samples each from triplicate independent experiments. Significance values were determined by one-way analysis of variance (ANOVA). *denotes p<0.05; **denotes p<0.005; n = 3. F: Regulation of <i>PTPRJ</i> protein in response to LPS, CpG DNA and CSF-1. BMMs were maintained overnight in the presence or absence of CSF-1 (1×10<sup>4</sup> U/mL) before treatment with LPS (10 ng/mL) [top panel] or CpG DNA (0.1 µM) [bottom panel]. Protein lysates were separated by SDS-PAGE, transferred to PVDF membranes and immunoblotted for PTPRJ. The membrane was then stripped, and reprobed for total Akt as a loading control. Profiles are representative of two independent experiments.</p>", "links"=>[], "tags"=>["immunology", "Immune cells", "monocytes", "immunity", "inflammation", "Immunologic techniques", "Immunohistochemical analysis", "Molecular cell biology", "Signal transduction", "Membrane receptor signaling", "Immunologic receptor signaling", "Signaling cascades", "Protein kinase signaling cascade", "Tyrosine kinase signaling cascade", "Signaling in cellular processes", "Transcriptional signaling", "Signaling in selected disciplines", "Immunological signaling", "gene expression", "macrophages", "proinflammatory"], "article_id"=>734912, "categories"=>["Biological Sciences"], "users"=>["Richa K. Dave", "Marcel E. Dinger", "Megan Andrew", "Marjan Askarian-Amiri", "David A. Hume", "Stuart Kellie"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0068306.g002", "stats"=>{"downloads"=>0, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Regulation_of_Ptprj_expression_in_mouse_macrophages_by_proinflammatory_stimuli_/734912", "title"=>"Regulation of <i>Ptprj</i> expression in mouse macrophages by proinflammatory stimuli.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-28 02:43:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/1105474"], "description"=>"<p>Consensus transcription factor binding sites conserved in sequence and position between mouse and human were predicted using RVista browser and TRANSFAC. Only the myeloid-specific transcription factors have been shown in this figure. Evolutionary conserved region (ECR1) lies within the blue brackets. Blue line marks the region of transcription start site (TSS) cluster represented in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0068306#pone-0068306-g006\" target=\"_blank\">Figure 6</a>. mTSS refers to the transcription start site for mouse <i>ptprj</i> and hTSS to the transcription start site for human <i>Ptprj</i> predicted by CAGE analysis. The four uAUG codons are highlighted within grey boxes and the stop codons within red boxes. Asterisk (*) represents the translation start site. The boxes represent the conserved sequences between mouse and human. N represents any nucleotide.</p>", "links"=>[], "tags"=>["immunology", "Immune cells", "monocytes", "immunity", "inflammation", "Immunologic techniques", "Immunohistochemical analysis", "Molecular cell biology", "Signal transduction", "Membrane receptor signaling", "Immunologic receptor signaling", "Signaling cascades", "Protein kinase signaling cascade", "Tyrosine kinase signaling cascade", "Signaling in cellular processes", "Transcriptional signaling", "Signaling in selected disciplines", "Immunological signaling", "gene expression", "alignment", "putative"], "article_id"=>734921, "categories"=>["Biological Sciences"], "users"=>["Richa K. Dave", "Marcel E. Dinger", "Megan Andrew", "Marjan Askarian-Amiri", "David A. Hume", "Stuart Kellie"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0068306.g006", "stats"=>{"downloads"=>1, "page_views"=>24, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Clustal_W_alignment_of_the_mouse_and_human_Ptprj_putative_promoters_/734921", "title"=>"Clustal W alignment of the mouse and human <i>Ptprj</i> putative promoters.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-28 02:43:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/1105472"], "description"=>"<p>A: Expression of <i>Ptprj-as1</i> in murine tissues. B, C: <i>Ptprj</i> and <i>Ptprj-as1</i> mRNA expression in BMMs in response to LPS (B) or Pam3Cys (C). mRNA expression was quantified by qRT-PCR and expressed as fold change compared with untreated (0h). Plots represent mean fold change +/− SD; n = 3. Significance values were determined by one-way analysis of variance (ANOVA). *denotes p<0.05; **denotes p<0.005; n = 3. *denotes p<0.05; **denotes p<0.005; n = 3.</p>", "links"=>[], "tags"=>["immunology", "Immune cells", "monocytes", "immunity", "inflammation", "Immunologic techniques", "Immunohistochemical analysis", "Molecular cell biology", "Signal transduction", "Membrane receptor signaling", "Immunologic receptor signaling", "Signaling cascades", "Protein kinase signaling cascade", "Tyrosine kinase signaling cascade", "Signaling in cellular processes", "Transcriptional signaling", "Signaling in selected disciplines", "Immunological signaling", "gene expression", "murine", "tissues", "trl"], "article_id"=>734919, "categories"=>["Biological Sciences"], "users"=>["Richa K. Dave", "Marcel E. Dinger", "Megan Andrew", "Marjan Askarian-Amiri", "David A. Hume", "Stuart Kellie"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0068306.g005", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Expression_of_Ptprj_as1_in_murine_tissues_and_in_response_to_TRL_ligands_/734919", "title"=>"Expression of <i>Ptprj-as1</i> in murine tissues and in response to TRL ligands.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-28 02:43:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/1105470"], "description"=>"<p>A–B: <i>Ptprj-as1</i> maps to the reverse strand within the boundaries of the murine <i>Ptprj</i> gene. Comparison of the mouse Ptprj (A) and human PTPRJ (B) loci. Protein coding transcript isoforms of Ptprj/PTPRJ are shown in red and long noncoding transcripts are shown in blue. Arrows indicate the direction of transcription. The human microRNA miR-3161 is shown in green. Position of PCR primers used for qRT-PCR for mouse Ptprj-as1 are indicated. C-D: Mapping (C) and expression (D) of a splice variant of murine <i>Ptprj-as1</i> in brain, kidney and testis. E: Predicted secondary structure of <i>Ptprj-as1</i> splice variant.</p>", "links"=>[], "tags"=>["immunology", "Immune cells", "monocytes", "immunity", "inflammation", "Immunologic techniques", "Immunohistochemical analysis", "Molecular cell biology", "Signal transduction", "Membrane receptor signaling", "Immunologic receptor signaling", "Signaling cascades", "Protein kinase signaling cascade", "Tyrosine kinase signaling cascade", "Signaling in cellular processes", "Transcriptional signaling", "Signaling in selected disciplines", "Immunological signaling", "gene expression"], "article_id"=>734917, "categories"=>["Biological Sciences"], "users"=>["Richa K. Dave", "Marcel E. Dinger", "Megan Andrew", "Marjan Askarian-Amiri", "David A. Hume", "Stuart Kellie"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0068306.g004", "stats"=>{"downloads"=>0, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characterisation_of_Ptprj_as1_/734917", "title"=>"Characterisation of <i>Ptprj-as1.</i>", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-28 02:43:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/1105466"], "description"=>"<p>THP-1 cells were maintained for 24 hours in the presence or absence of PMA (10<sup>−7</sup> M) to induce differentiation, before treatment with LPS (10 ng/mL) (A, B). Human dendritic cells were treated with LPS (10 ng/mL) over a time course (C, D). <i>Ptprj</i> (A, C) and <i>c-fms</i> (B, D) expression profiles were assessed by quantitative real-time PCR. Datapoints (+/− SD) represent the average of triplicate samples. Significance values were determined by one-way analysis of variance (ANOVA). *denotes p<0.05; **denotes p<0.005; n = 3. *denotes p<0.05; **denotes p<0.005; n = 3.</p>", "links"=>[], "tags"=>["immunology", "Immune cells", "monocytes", "immunity", "inflammation", "Immunologic techniques", "Immunohistochemical analysis", "Molecular cell biology", "Signal transduction", "Membrane receptor signaling", "Immunologic receptor signaling", "Signaling cascades", "Protein kinase signaling cascade", "Tyrosine kinase signaling cascade", "Signaling in cellular processes", "Transcriptional signaling", "Signaling in selected disciplines", "Immunological signaling", "gene expression", "lps", "mononuclear", "phagocytic"], "article_id"=>734913, "categories"=>["Biological Sciences"], "users"=>["Richa K. Dave", "Marcel E. Dinger", "Megan Andrew", "Marjan Askarian-Amiri", "David A. Hume", "Stuart Kellie"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0068306.g003", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Ptprj_expression_in_response_to_LPS_in_human_mononuclear_phagocytic_cells_/734913", "title"=>"<i>Ptprj</i> expression in response to LPS in human mononuclear phagocytic cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-28 02:43:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/1105464"], "description"=>"<p>(A). qPCR of <i>Ptprj</i> from RNA extracted from mouse tissues. (B) qPCR of <i>Ptprj</i> from RNA from pre-B lymphoid cell line WEHI-231, osteoclast-like cell line (RAW 264.7, C4), TEPM, macrophage-like cell line (RAW 264.7), BMM, myeloid cell line M1 and fibroblasts (NIH3T3 and mouse embryonic). (C). Immunohistochemistry of cell-specific expression of PTPRJ in mouse spleen sections. Sections were immunostained for CD148 (A1, B1) or F4/80 (A2, B2) and with CD148 (C1) and F4/80 (C2) isotype control antibodies. All sections were counterstained with haematoxylin. RP, red pulp; WP, white pulp. Original magnification: x100 (A), x200 (B, C). Bar, 100µm.</p>", "links"=>[], "tags"=>["immunology", "Immune cells", "monocytes", "immunity", "inflammation", "Immunologic techniques", "Immunohistochemical analysis", "Molecular cell biology", "Signal transduction", "Membrane receptor signaling", "Immunologic receptor signaling", "Signaling cascades", "Protein kinase signaling cascade", "Tyrosine kinase signaling cascade", "Signaling in cellular processes", "Transcriptional signaling", "Signaling in selected disciplines", "Immunological signaling", "gene expression", "mrna", "murine"], "article_id"=>734911, "categories"=>["Biological Sciences"], "users"=>["Richa K. Dave", "Marcel E. Dinger", "Megan Andrew", "Marjan Askarian-Amiri", "David A. Hume", "Stuart Kellie"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0068306.g001", "stats"=>{"downloads"=>0, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Ptprj_mRNA_expression_in_murine_tissues_/734911", "title"=>"Ptprj mRNA expression in murine tissues.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-06-28 02:43:35"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
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  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"7", "full-text"=>"11", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"10", "full-text"=>"6", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"7", "full-text"=>"11", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
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Relative Metric

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