A Robotics-Based Behavioral Paradigm to Measure Anxiety-Related Responses in Zebrafish
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{"title"=>"A Robotics-Based Behavioral Paradigm to Measure Anxiety-Related Responses in Zebrafish", "type"=>"journal", "authors"=>[{"first_name"=>"Valentina", "last_name"=>"Cianca", "scopus_author_id"=>"55805046400"}, {"first_name"=>"Tiziana", "last_name"=>"Bartolini", "scopus_author_id"=>"55258551100"}, {"first_name"=>"Maurizio", "last_name"=>"Porfiri", "scopus_author_id"=>"6701357619"}, {"first_name"=>"Simone", "last_name"=>"Macrì", "scopus_author_id"=>"23103354600"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"369442787", "sgr"=>"84880817866", "issn"=>"19326203", "pmid"=>"23922773", "scopus"=>"2-s2.0-84880817866", "doi"=>"10.1371/journal.pone.0069661", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)"}, "id"=>"af743e01-a09e-335d-ad95-c9c04a4c5486", "abstract"=>"Zebrafish are gaining momentum as a laboratory animal species for the study of anxiety-related disorders in translational research, whereby they serve a fundamental complement to laboratory rodents. Several anxiety-related behavioral paradigms, which rest upon the presentation of live predatorial stimuli, may yield inconsistent results due to fatigue, habituation, or idiosyncratic responses exhibited by the stimulus itself. To overcome these limitations, we designed and manufactured a fully controllable robot inspired by a natural aquatic predator (Indian leaf fish, Nandus nandus) of zebrafish. We report that this robot elicits aversive antipredatorial reactions in a preference test and that data obtained therein correlate with data observed in traditional anxiety- and fear-related tests (light/dark preference and shelter-seeking). Finally, ethanol administration (0.25; 0.50; 1.00%) exerts anxiolytic effects, thus supporting the view that robotic stimuli can be used in the analysis of anxiety-related behaviors in zebrafish.", "link"=>"http://www.mendeley.com/research/roboticsbased-behavioral-paradigm-measure-anxietyrelated-responses-zebrafish", "reader_count"=>47, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>9, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>11, "Student > Postgraduate"=>2, "Student > Master"=>9, "Other"=>2, "Student > Bachelor"=>6, "Lecturer"=>2, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>9, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>11, "Student > Postgraduate"=>2, "Student > Master"=>9, "Other"=>2, "Student > Bachelor"=>6, "Lecturer"=>2, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>5, "Agricultural and Biological Sciences"=>21, "Philosophy"=>1, "Computer Science"=>1, "Engineering"=>5, "Biochemistry, Genetics and Molecular Biology"=>2, "Mathematics"=>1, "Medicine and Dentistry"=>3, "Neuroscience"=>3, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Sports and Recreations"=>2, "Psychology"=>1, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Social Sciences"=>{"Social Sciences"=>1}, "Sports and Recreations"=>{"Sports and Recreations"=>2}, "Psychology"=>{"Psychology"=>1}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>5}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "Engineering"=>{"Engineering"=>5}, "Neuroscience"=>{"Neuroscience"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>21}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Philosophy"=>{"Philosophy"=>1}}, "reader_count_by_country"=>{"United States"=>2, "United Kingdom"=>1, "Germany"=>2}, "group_count"=>3}

Scopus | Further Information

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/1135052"], "description"=>"<p>* p<0.05 significantly different from EtOH 0.00%.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Musculoskeletal system", "robotics", "Evolutionary biology", "Animal behavior", "Model organisms", "Animal models", "zebrafish", "neuroscience", "Behavioral neuroscience", "Zoology", "Mental health", "psychiatry", "Anxiety disorders", "latency", "simulated", "heron", "prototype", "exhibited", "etoh"], "article_id"=>758242, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Valentina Cianca", "Tiziana Bartolini", "Maurizio Porfiri", "Simone Macrì"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0069661.g004", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mean_SEM_latency_s_to_retreat_to_the_shelter_following_the_simulated_attack_of_the_heron_prototype_exhibited_by_EtOH_0_00_EtOH_0_25_EtOH_0_50_and_EtOH_1_00_/758242", "title"=>"Mean (+SEM) latency (s) to retreat to the shelter following the simulated attack of the heron prototype exhibited by EtOH 0.00%, EtOH 0.25%, EtOH 0.50%, and EtOH 1.00%.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-07-29 02:08:51"}
  • {"files"=>["https://ndownloader.figshare.com/files/1135054"], "description"=>"<p>Correlation between the latency to retreat to the shelter in the shelter-seeking test and the time spent near the robot side in the robot avoidance test (lower panel).</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Musculoskeletal system", "robotics", "Evolutionary biology", "Animal behavior", "Model organisms", "Animal models", "zebrafish", "neuroscience", "Behavioral neuroscience", "Zoology", "Mental health", "psychiatry", "Anxiety disorders", "spent", "compartment", "avoidance"], "article_id"=>758244, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Valentina Cianca", "Tiziana Bartolini", "Maurizio Porfiri", "Simone Macrì"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0069661.g005", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Correlation_between_the_time_spent_in_the_dark_compartment_of_the_L_D_test_and_the_time_spent_near_the_robot_side_in_the_robot_avoidance_test_upper_panel_/758244", "title"=>"Correlation between the time spent in the dark compartment of the L/D test and the time spent near the robot side in the robot avoidance test (upper panel).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-07-29 02:08:51"}
  • {"files"=>["https://ndownloader.figshare.com/files/1135055"], "description"=>"<p>Behavioral ethogram exhibited by the four experimental groups in the L/D and robotics-based predator avoidance test. In the two rightmost columns, we report the F and p values observed in the general ANOVA.</p>*<p>p<0.05 significantly different from EtOH in post-hoc comparisons.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Musculoskeletal system", "robotics", "Evolutionary biology", "Animal behavior", "Model organisms", "Animal models", "zebrafish", "neuroscience", "Behavioral neuroscience", "Zoology", "Mental health", "psychiatry", "Anxiety disorders", "exhibited", "robotics-based", "avoidance"], "article_id"=>758245, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Valentina Cianca", "Tiziana Bartolini", "Maurizio Porfiri", "Simone Macrì"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0069661.t001", "stats"=>{"downloads"=>2, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Behaviors_exhibited_in_the_L_D_and_robotics_based_predator_avoidance_test_/758245", "title"=>"Behaviors exhibited in the L/D and robotics-based predator avoidance test.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-07-29 02:08:51"}
  • {"files"=>["https://ndownloader.figshare.com/files/1135064", "https://ndownloader.figshare.com/files/1135065", "https://ndownloader.figshare.com/files/1135066", "https://ndownloader.figshare.com/files/1135067", "https://ndownloader.figshare.com/files/1135068", "https://ndownloader.figshare.com/files/1135069", "https://ndownloader.figshare.com/files/1135071", "https://ndownloader.figshare.com/files/1135072"], "description"=>"<div><p>Zebrafish are gaining momentum as a laboratory animal species for the study of anxiety-related disorders in translational research, whereby they serve a fundamental complement to laboratory rodents. Several anxiety-related behavioral paradigms, which rest upon the presentation of live predatorial stimuli, may yield inconsistent results due to fatigue, habituation, or idiosyncratic responses exhibited by the stimulus itself. To overcome these limitations, we designed and manufactured a fully controllable robot inspired by a natural aquatic predator (Indian leaf fish, <i>Nandus nandus</i>) of zebrafish. We report that this robot elicits aversive antipredatorial reactions in a preference test and that data obtained therein correlate with data observed in traditional anxiety- and fear-related tests (light/dark preference and shelter-seeking). Finally, ethanol administration (0.25; 0.50; 1.00%) exerts anxiolytic effects, thus supporting the view that robotic stimuli can be used in the analysis of anxiety-related behaviors in zebrafish.</p></div>", "links"=>[], "tags"=>["Anatomy and physiology", "Musculoskeletal system", "robotics", "Evolutionary biology", "Animal behavior", "Model organisms", "Animal models", "zebrafish", "neuroscience", "Behavioral neuroscience", "Zoology", "Mental health", "psychiatry", "Anxiety disorders", "robotics-based", "paradigm", "anxiety-related", "responses"], "article_id"=>758253, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Valentina Cianca", "Tiziana Bartolini", "Maurizio Porfiri", "Simone Macrì"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0069661.s001", "https://dx.doi.org/10.1371/journal.pone.0069661.s002", "https://dx.doi.org/10.1371/journal.pone.0069661.s003", "https://dx.doi.org/10.1371/journal.pone.0069661.s004", "https://dx.doi.org/10.1371/journal.pone.0069661.s005", "https://dx.doi.org/10.1371/journal.pone.0069661.s006", "https://dx.doi.org/10.1371/journal.pone.0069661.s007", "https://dx.doi.org/10.1371/journal.pone.0069661.s008"], "stats"=>{"downloads"=>4, "page_views"=>44, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_A_Robotics_Based_Behavioral_Paradigm_to_Measure_Anxiety_Related_Responses_in_Zebrafish_/758253", "title"=>"A Robotics-Based Behavioral Paradigm to Measure Anxiety-Related Responses in Zebrafish", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-07-29 02:08:51"}
  • {"files"=>["https://ndownloader.figshare.com/files/1135048"], "description"=>"<p>* p<0.05 significant preference for the bright compartment; # p<0.05 significantly different from EtOH in post-hoc comparisons.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Musculoskeletal system", "robotics", "Evolutionary biology", "Animal behavior", "Model organisms", "Animal models", "zebrafish", "neuroscience", "Behavioral neuroscience", "Zoology", "Mental health", "psychiatry", "Anxiety disorders", "spent", "compartment", "etoh"], "article_id"=>758238, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Valentina Cianca", "Tiziana Bartolini", "Maurizio Porfiri", "Simone Macrì"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0069661.g002", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Percent_time_mean_SEM_spent_in_the_dark_compartment_of_the_L_D_test_by_EtOH_0_00_EtOH_0_25_EtOH_0_50_and_EtOH_1_00_/758238", "title"=>"Percent time (mean+SEM) spent in the dark compartment of the L/D test by EtOH 0.00%, EtOH 0.25%, EtOH 0.50%, and EtOH 1.00%.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-07-29 02:08:51"}
  • {"files"=>["https://ndownloader.figshare.com/files/1135047"], "description"=>"<p>Illustration of the robotic fish (left) and heron (right) used in the robot avoidance and shelter-seeking tests.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Musculoskeletal system", "robotics", "Evolutionary biology", "Animal behavior", "Model organisms", "Animal models", "zebrafish", "neuroscience", "Behavioral neuroscience", "Zoology", "Mental health", "psychiatry", "Anxiety disorders", "robotic", "heron", "avoidance", "shelter-seeking"], "article_id"=>758237, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Valentina Cianca", "Tiziana Bartolini", "Maurizio Porfiri", "Simone Macrì"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0069661.g001", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Illustration_of_the_robotic_fish_left_and_heron_right_used_in_the_robot_avoidance_and_shelter_seeking_tests_/758237", "title"=>"Illustration of the robotic fish (left) and heron (right) used in the robot avoidance and shelter-seeking tests.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-07-29 02:08:51"}

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  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"7", "full-text"=>"45", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}

Relative Metric

{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[269, 466, 588, 697, 800, 896, 988, 1076, 1165, 1254, 1340, 1417]}, {"subject_area"=>"/Biology and life sciences/Organisms", "average_usage"=>[281, 484, 611, 728, 835, 934, 1030, 1123, 1214, 1299, 1383, 1464]}, {"subject_area"=>"/Biology and life sciences/Physiology", "average_usage"=>[256, 449, 572, 676, 775, 866, 955, 1041, 1127, 1213, 1290, 1370, 1437]}, {"subject_area"=>"/Engineering and technology", "average_usage"=>[254, 440, 558, 675, 785, 883, 972, 1061, 1154, 1248, 1336, 1414, 1489]}, {"subject_area"=>"/Physical sciences", "average_usage"=>[254, 431, 547, 651, 748, 842, 932, 1017, 1098, 1178, 1259, 1336, 1404]}]}
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