Delta-9-Tetrahydrocannabinol-Induced Dopamine Release as a Function of Psychosis Risk: 18F-Fallypride Positron Emission Tomography Study
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{"title"=>"Delta-9-Tetrahydrocannabinol-Induced Dopamine Release as a Function of Psychosis Risk: 18F-Fallypride Positron Emission Tomography Study", "type"=>"journal", "authors"=>[{"first_name"=>"Rebecca", "last_name"=>"Kuepper", "scopus_author_id"=>"25521596000"}, {"first_name"=>"Jenny", "last_name"=>"Ceccarini", "scopus_author_id"=>"37092670800"}, {"first_name"=>"Johan", "last_name"=>"Lataster", "scopus_author_id"=>"21934260000"}, {"first_name"=>"Jim", "last_name"=>"van Os", "scopus_author_id"=>"7102358027"}, {"first_name"=>"Marinus", "last_name"=>"van Kroonenburgh", "scopus_author_id"=>"7004024896"}, {"first_name"=>"Joop M.A.", "last_name"=>"van Gerven", "scopus_author_id"=>"7003882119"}, {"first_name"=>"Machteld", "last_name"=>"Marcelis", "scopus_author_id"=>"6603325363"}, {"first_name"=>"Koen", "last_name"=>"van Laere", "scopus_author_id"=>"8076202000"}, {"first_name"=>"Cécile", "last_name"=>"Henquet", "scopus_author_id"=>"6701333430"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84880810573", "pmid"=>"23936196", "pui"=>"369439032", "isbn"=>"1932-6203", "scopus"=>"2-s2.0-84880810573", "doi"=>"10.1371/journal.pone.0070378", "issn"=>"19326203"}, "id"=>"b353e74c-d606-3601-a144-ccd5c6d23221", "abstract"=>"Cannabis use is associated with psychosis, particularly in those with expression of, or vulnerability for, psychotic illness. The biological underpinnings of these differential associations, however, remain largely unknown. We used Positron Emission Tomography and (18)F-fallypride to test the hypothesis that genetic risk for psychosis is expressed by differential induction of dopamine release by Δ(9)-THC (delta-9-tetrahydrocannabinol, the main psychoactive ingredient of cannabis). In a single dynamic PET scanning session, striatal dopamine release after pulmonary administration of Δ(9)-THC was measured in 9 healthy cannabis users (average risk psychotic disorder), 8 patients with psychotic disorder (high risk psychotic disorder) and 7 un-related first-degree relatives (intermediate risk psychotic disorder). PET data were analyzed applying the linear extension of the simplified reference region model (LSRRM), which accounts for time-dependent changes in (18)F-fallypride displacement. Voxel-based statistical maps, representing specific D2/3 binding changes, were computed to localize areas with increased ligand displacement after Δ(9)-THC administration, reflecting dopamine release. While Δ(9)-THC was not associated with dopamine release in the control group, significant ligand displacement induced by Δ(9)-THC in striatal subregions, indicative of dopamine release, was detected in both patients and relatives. This was most pronounced in caudate nucleus. This is the first study to demonstrate differential sensitivity to Δ(9)-THC in terms of increased endogenous dopamine release in individuals at risk for psychosis.", "link"=>"http://www.mendeley.com/research/delta9tetrahydrocannabinolinduced-dopamine-release-function-psychosis-risk-18ffallypride-positron-em", "reader_count"=>54, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>1, "Researcher"=>7, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>7, "Student > Postgraduate"=>9, "Student > Master"=>10, "Other"=>2, "Student > Bachelor"=>9, "Lecturer"=>1, "Professor"=>4}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>1, "Researcher"=>7, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>7, "Student > Postgraduate"=>9, "Student > Master"=>10, "Other"=>2, "Student > Bachelor"=>9, "Lecturer"=>1, "Professor"=>4}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Biochemistry, Genetics and Molecular Biology"=>3, "Agricultural and Biological Sciences"=>7, "Medicine and Dentistry"=>13, "Neuroscience"=>6, "Pharmacology, Toxicology and Pharmaceutical Science"=>2, "Physics and Astronomy"=>1, "Psychology"=>16, "Social Sciences"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>13}, "Neuroscience"=>{"Neuroscience"=>6}, "Social Sciences"=>{"Social Sciences"=>2}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Psychology"=>{"Psychology"=>16}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>7}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>4}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>2}}, "reader_count_by_country"=>{"Denmark"=>1, "Germany"=>1}, "group_count"=>3}

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/1131930"], "description"=>"<p>T maps are shown at the level of t >2.4 in transversal sections overlaid on a MRI template.</p>", "links"=>[], "tags"=>["Biochemistry", "Neurochemistry", "Neurochemicals", "dopamine", "neuroscience", "neuroimaging", "pet", "Drugs and devices", "Behavioral pharmacology", "Recreational drug use", "Neuropharmacology", "Mental health", "psychiatry", "psychoses", "schizophrenia", "Substance abuse", "parametric", "striatal", "voxels", "surviving", "controls", "relatives", "patients"], "article_id"=>755783, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Rebecca Kuepper", "Jenny Ceccarini", "Johan Lataster", "Jim van Os", "Marinus van Kroonenburgh", "Joop M. A. van Gerven", "Machteld Marcelis", "Koen Van Laere", "Cécile Henquet"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0070378.g003", "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mean_statistical_parametric_t_map_of_947_showing_only_the_striatal_voxels_that_show_significant_dopamine_release_surviving_the_t_gt_2_4_threshold_p_lt_0_01_in_controls_top_row_n_8202_8202_9_relatives_middle_row_n_8202_8202_8_and_patients_bottom_row_n_820/755783", "title"=>"Mean statistical parametric t map of γ showing only the striatal voxels that show significant dopamine release surviving the t >2.4 threshold (p<0.01) in controls (top row, n = 9), relatives (middle row, n = 8) and patients (bottom row, n = 7).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-07-25 03:30:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/1131932"], "description"=>"<p>Horizontal lines indicate the mean value for each group.</p>", "links"=>[], "tags"=>["Biochemistry", "Neurochemistry", "Neurochemicals", "dopamine", "neuroscience", "neuroimaging", "pet", "Drugs and devices", "Behavioral pharmacology", "Recreational drug use", "Neuropharmacology", "Mental health", "psychiatry", "psychoses", "schizophrenia", "Substance abuse", "voxels", "caudate", "putamen", "globus", "pallidus", "nucleus", "accumbens", "controls", "relatives", "patients", "excluded", "anomalous"], "article_id"=>755784, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Rebecca Kuepper", "Jenny Ceccarini", "Johan Lataster", "Jim van Os", "Marinus van Kroonenburgh", "Joop M. A. van Gerven", "Machteld Marcelis", "Koen Van Laere", "Cécile Henquet"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0070378.g004", "stats"=>{"downloads"=>0, "page_views"=>22, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Percentage_of_voxels_with_significant_9_THC_induced_dopamine_release_in_the_caudate_nucleus_putamen_top_row_globus_pallidus_and_nucleus_accumbens_bottom_row_for_controls_n_8202_8202_9_relatives_n_8202_8202_8_and_patients_n_8202_8202_7_one_subject_was_exc/755784", "title"=>"Percentage of voxels with significant Δ<sup>9</sup>-THC-induced dopamine release in the caudate nucleus, putamen (top row), globus pallidus and nucleus accumbens (bottom row) for controls (n = 9), relatives (n = 8) and patients (n = 7, one subject was excluded from this analysis due to anomalous (non)physiological values).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-07-25 03:30:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/1131925"], "description"=>"<p>PET emission protocol conform the one-day PET imaging protocol for <sup>18</sup>F-fallypride described and used previously by Christian and colleagues <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0070378#pone.0070378-Christian1\" target=\"_blank\">[34]</a>, modified according to simulation studies showing possible improvements in the experiment design that can increase the detection sensitivity of DA release in the striatum <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0070378#pone.0070378-Ceccarini1\" target=\"_blank\">[37]</a>.</p>", "links"=>[], "tags"=>["Biochemistry", "Neurochemistry", "Neurochemicals", "dopamine", "neuroscience", "neuroimaging", "pet", "Drugs and devices", "Behavioral pharmacology", "Recreational drug use", "Neuropharmacology", "Mental health", "psychiatry", "psychoses", "schizophrenia", "Substance abuse", "conform", "one-day", "imaging", "christian", "colleagues", "modified", "simulation", "studies", "improvements", "detection", "da", "striatum"], "article_id"=>755778, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Rebecca Kuepper", "Jenny Ceccarini", "Johan Lataster", "Jim van Os", "Marinus van Kroonenburgh", "Joop M. A. van Gerven", "Machteld Marcelis", "Koen Van Laere", "Cécile Henquet"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0070378.g001", "stats"=>{"downloads"=>5, "page_views"=>25, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_PET_emission_protocol_conform_the_one_day_PET_imaging_protocol_for_18_F_fallypride_described_and_used_previously_by_Christian_and_colleagues_34_modified_according_to_simulation_studies_showing_possible_improvements_in_the_experiment_design_that_can_incre/755778", "title"=>"PET emission protocol conform the one-day PET imaging protocol for <sup>18</sup>F-fallypride described and used previously by Christian and colleagues [34], modified according to simulation studies showing possible improvements in the experiment design that can increase the detection sensitivity of DA release in the striatum [37].", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-07-25 03:30:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/1131935"], "description"=>"<p><i>Note.</i> Percentages do not always total 100 due to rounding.</p>*<p>Refers to cannabis use in the last 12 months.</p>**<p>Refers to the frequency of cannabis used in the most intensive period of use as assessed with the CIDI.</p>***<p>Cannabis dependence according to the Structured Clinical Interview for DSM Disorders, <i>lifetime</i> and <i>current</i> (i.e. present in the last month).</p>a<p>Refers to number of cigarettes per day.</p>b<p>Refers to grams per week. Standard drink/unit size in the Netherlands contains 9.9 g of ethanol.</p>c<p>Refers to other drug use in the last 12 months (incl. cocaine, opiates, psychostimulants, and sedatives).</p>", "links"=>[], "tags"=>["Biochemistry", "Neurochemistry", "Neurochemicals", "dopamine", "neuroscience", "neuroimaging", "pet", "Drugs and devices", "Behavioral pharmacology", "Recreational drug use", "Neuropharmacology", "Mental health", "psychiatry", "psychoses", "schizophrenia", "Substance abuse"], "article_id"=>755787, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Rebecca Kuepper", "Jenny Ceccarini", "Johan Lataster", "Jim van Os", "Marinus van Kroonenburgh", "Joop M. A. van Gerven", "Machteld Marcelis", "Koen Van Laere", "Cécile Henquet"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0070378.t001", "stats"=>{"downloads"=>6, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Participant_characteristics_/755787", "title"=>"Participant characteristics.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-07-25 03:30:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/1131934"], "description"=>"<p><i>Note.</i> Numbers are percentages (SD) of voxels within a region exceeding the significance threshold of <i>t</i> >2.4, relative to the total number of voxels within the mask of the respective region.</p>a<p>One subject was excluded from this analysis due to anomalous (non)physiological values.</p>#<p>Adjusted for age, gender, alcohol use, nicotine use, other drug use, use of other medication, and frequency of cannabis use.</p>*<p>Significant after Bonferroni correction for multiple comparisons (i.e. at a statistical significance level of <i>p</i> = 1/8*0.05).</p>", "links"=>[], "tags"=>["Biochemistry", "Neurochemistry", "Neurochemicals", "dopamine", "neuroscience", "neuroimaging", "pet", "Drugs and devices", "Behavioral pharmacology", "Recreational drug use", "Neuropharmacology", "Mental health", "psychiatry", "psychoses", "schizophrenia", "Substance abuse", "induced", "thc", "striatal"], "article_id"=>755786, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Rebecca Kuepper", "Jenny Ceccarini", "Johan Lataster", "Jim van Os", "Marinus van Kroonenburgh", "Joop M. A. van Gerven", "Machteld Marcelis", "Koen Van Laere", "Cécile Henquet"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0070378.t002", "stats"=>{"downloads"=>4, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Spatial_extent_of_estimated_dopamine_release_induced_by_THC_within_striatal_subregions_/755786", "title"=>"Spatial extent of estimated dopamine release induced by THC within striatal subregions.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-07-25 03:30:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/1131928"], "description"=>"<p>The image is thresholded for visualization purposes (maximum t obtained for controls, relatives and patients, respectively: 1.15, 2.6, and 2.7).</p>", "links"=>[], "tags"=>["Biochemistry", "Neurochemistry", "Neurochemicals", "dopamine", "neuroscience", "neuroimaging", "pet", "Drugs and devices", "Behavioral pharmacology", "Recreational drug use", "Neuropharmacology", "Mental health", "psychiatry", "psychoses", "schizophrenia", "Substance abuse", "parametric", "sagittal", "coronal", "sections", "overlaid", "mri", "displacement", "striatum", "controls", "relatives", "patients", "excluded", "anomalous"], "article_id"=>755781, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Rebecca Kuepper", "Jenny Ceccarini", "Johan Lataster", "Jim van Os", "Marinus van Kroonenburgh", "Joop M. A. van Gerven", "Machteld Marcelis", "Koen Van Laere", "Cécile Henquet"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0070378.g002", "stats"=>{"downloads"=>3, "page_views"=>31, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mean_statistical_parametric_t_map_of_in_sagittal_left_and_coronal_right_sections_overlaid_on_a_MRI_template_showing_9_THC_induced_18_F_fallypride_displacement_at_the_level_of_the_striatum_x_8202_8202_0_y_8202_8202_11_z_8202_8202_8722_4_for_controls_top_r/755781", "title"=>"Mean statistical parametric <i>t</i> map of γ in sagittal (left) and coronal (right) sections overlaid on a MRI template, showing Δ<sup>9</sup>-THC-induced <sup>18</sup>F-fallypride displacement at the level of the striatum (x = 0, y = 11, z = −4) for controls (top row, n = 9), relatives (middle row, n = 8) and patients (bottom row, n = 7, one subject was excluded from this analysis due to anomalous (non)physiological values).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-07-25 03:30:13"}

PMC Usage Stats | Further Information

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Relative Metric

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