Metabolic Adaption of Ethanol-Tolerant Clostridium thermocellum
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{"title"=>"Metabolic Adaption of Ethanol-Tolerant Clostridium thermocellum", "type"=>"journal", "authors"=>[{"first_name"=>"Xinshu", "last_name"=>"Zhu", "scopus_author_id"=>"55806546400"}, {"first_name"=>"Jiatao", "last_name"=>"Cui", "scopus_author_id"=>"55557745200"}, {"first_name"=>"Yingang", "last_name"=>"Feng", "scopus_author_id"=>"7404544513"}, {"first_name"=>"Yun", "last_name"=>"Fa", "scopus_author_id"=>"55805109500"}, {"first_name"=>"Jingtao", "last_name"=>"Zhang", "scopus_author_id"=>"35235923300"}, {"first_name"=>"Qiu", "last_name"=>"Cui", "scopus_author_id"=>"7103080117"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84880852460", "pmid"=>"23936233", "sgr"=>"84880852460", "doi"=>"10.1371/journal.pone.0070631", "isbn"=>"1932-6203", "issn"=>"19326203", "pui"=>"369443185"}, "id"=>"62816ea4-a9a0-3028-8dfd-ce0a70241671", "abstract"=>"Clostridium thermocellum is a major candidate for bioethanol production via consolidated bioprocessing. However, the low ethanol tolerance of the organism dramatically impedes its usage in industry. To explore the mechanism of ethanol tolerance in this microorganism, systematic metabolomics was adopted to analyse the metabolic phenotypes of a C. thermocellum wild-type (WT) strain and an ethanol-tolerant strain cultivated without (ET0) or with (ET3) 3% (v/v) exogenous ethanol. Metabolomics analysis elucidated that the levels of numerous metabolites in different pathways were changed for the metabolic adaption of ethanol-tolerant C. thermocellum. The most interesting phenomenon was that cellodextrin was significantly more accumulated in the ethanol-tolerant strain compared with the WT strain, although cellobiose was completely consumed in both the ethanol-tolerant and wild-type strains. These results suggest that the cellodextrin synthesis was active, which might be a potential mechanism for stress resistance. Moreover, the overflow of many intermediate metabolites, which indicates the metabolic imbalance, in the ET0 cultivation was more significant than in the WT and ET3 cultivations. This indicates that the metabolic balance of the ethanol-tolerant strain was adapted better to the condition of ethanol stress. This study provides additional insight into the mechanism of ethanol tolerance and is valuable for further metabolic engineering aimed at higher bioethanol production.", "link"=>"http://www.mendeley.com/research/metabolic-adaption-ethanoltolerant-clostridium-thermocellum", "reader_count"=>38, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>3, "Researcher"=>10, "Student > Ph. D. Student"=>9, "Student > Master"=>6, "Student > Bachelor"=>4, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>3, "Unspecified"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>3, "Researcher"=>10, "Student > Ph. D. Student"=>9, "Student > Master"=>6, "Student > Bachelor"=>4, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>3, "Unspecified"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>2, "Environmental Science"=>2, "Biochemistry, Genetics and Molecular Biology"=>7, "Materials Science"=>1, "Agricultural and Biological Sciences"=>22, "Chemical Engineering"=>1, "Chemistry"=>1, "Immunology and Microbiology"=>1, "Unspecified"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>2}, "Materials Science"=>{"Materials Science"=>1}, "Chemistry"=>{"Chemistry"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>22}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>7}, "Environmental Science"=>{"Environmental Science"=>2}, "Unspecified"=>{"Unspecified"=>1}, "Chemical Engineering"=>{"Chemical Engineering"=>1}}, "reader_count_by_country"=>{"Belgium"=>1, "United States"=>1, "South Africa"=>1}, "group_count"=>3}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1137696", "https://ndownloader.figshare.com/files/1137697", "https://ndownloader.figshare.com/files/1137699", "https://ndownloader.figshare.com/files/1137700", "https://ndownloader.figshare.com/files/1137701"], "description"=>"<div><p><i>Clostridium thermocellum</i> is a major candidate for bioethanol production via consolidated bioprocessing. However, the low ethanol tolerance of the organism dramatically impedes its usage in industry. To explore the mechanism of ethanol tolerance in this microorganism, systematic metabolomics was adopted to analyse the metabolic phenotypes of a <i>C. thermocellum</i> wild-type (WT) strain and an ethanol-tolerant strain cultivated without (ET<sub>0</sub>) or with (ET<sub>3</sub>) 3% (v/v) exogenous ethanol. Metabolomics analysis elucidated that the levels of numerous metabolites in different pathways were changed for the metabolic adaption of ethanol-tolerant <i>C. thermocellum</i>. The most interesting phenomenon was that cellodextrin was significantly more accumulated in the ethanol-tolerant strain compared with the WT strain, although cellobiose was completely consumed in both the ethanol-tolerant and wild-type strains. These results suggest that the cellodextrin synthesis was active, which might be a potential mechanism for stress resistance. Moreover, the overflow of many intermediate metabolites, which indicates the metabolic imbalance, in the ET<sub>0</sub> cultivation was more significant than in the WT and ET<sub>3</sub> cultivations. This indicates that the metabolic balance of the ethanol-tolerant strain was adapted better to the condition of ethanol stress. This study provides additional insight into the mechanism of ethanol tolerance and is valuable for further metabolic engineering aimed at higher bioethanol production.</p></div>", "links"=>[], "tags"=>["Biochemistry", "metabolism", "biotechnology", "Environmental biotechnology", "biodegradation", "Applied microbiology", "microbiology", "Industrial microbiology", "Microbial metabolism", "Microbial physiology", "Energy and power", "Alternative energy", "bioenergy", "metabolic", "adaption", "ethanol-tolerant"], "article_id"=>760300, "categories"=>["Biological Sciences", "Earth and Environmental Sciences"], "users"=>["Xinshu Zhu", "Jiatao Cui", "Yingang Feng", "Yun Fa", "Jingtao Zhang", "Qiu Cui"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0070631.s001", "https://dx.doi.org/10.1371/journal.pone.0070631.s002", "https://dx.doi.org/10.1371/journal.pone.0070631.s003", "https://dx.doi.org/10.1371/journal.pone.0070631.s004", "https://dx.doi.org/10.1371/journal.pone.0070631.s005"], "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Metabolic_Adaption_of_Ethanol_Tolerant_Clostridium_thermocellum_/760300", "title"=>"Metabolic Adaption of Ethanol-Tolerant <i>Clostridium thermocellum</i>", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-07-30 11:31:14"}
  • {"files"=>["https://ndownloader.figshare.com/files/1137693"], "description"=>"a<p>Metabolites that were not detected among all three cultivations and control medium are not listed in the table. These metabolites included tryptophan, arabinose, galactose, lactose, malonic acid, isocitric acid, and α-ketoglutarate.</p>b<p>Positive and negative values indicate amount of the released and absorbed metabolites, respectively.</p>c<p>The significant differences were derived from a one-way ANOVA analysis (p<0.05).</p>d<p>No significant difference was derived from a one-way ANOVA analysis (p<0.05).</p>", "links"=>[], "tags"=>["Biochemistry", "metabolism", "biotechnology", "Environmental biotechnology", "biodegradation", "Applied microbiology", "microbiology", "Industrial microbiology", "Microbial metabolism", "Microbial physiology", "Energy and power", "Alternative energy", "bioenergy", "extracellular", "metabolites", "cultivations"], "article_id"=>760297, "categories"=>["Biological Sciences", "Earth and Environmental Sciences"], "users"=>["Xinshu Zhu", "Jiatao Cui", "Yingang Feng", "Yun Fa", "Jingtao Zhang", "Qiu Cui"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0070631.t003", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_extracellular_metabolites_of_the_WT_ET_0_and_ET_3_cultivations_of_C_thermocellum_/760297", "title"=>"The extracellular metabolites of the WT, ET<sub>0</sub> and ET<sub>3</sub> cultivations of <i>C. thermocellum</i>.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-07-30 11:31:14"}
  • {"files"=>["https://ndownloader.figshare.com/files/1137691"], "description"=>"<p>Keys: 1, cis-13-eicosenoic acid (20:1); 2, 10-methyl-undecanoic acid (i-11:0); 3, 12-methyl-tridecanoic acid (i-13:0); 4, tetradecanoic acid (14:0); 5, plasmalogen n-14:0 (P n-14:0); 6, 13-methyl-tetradecanoic acid (i-14:0); 7, plasmalogen n-15:0 (P n-15:0); 8, pentadecanoic acid (15:0); 9, plasmalogen n-16:0 (P n-16:0); 10, 14-methyl-pentadecanoic acid (i-15:0); 11, plasmalogen i-17:0 (P i-17:0); 12, n-hexadecanoic acid (16:0); 13, 15-methyl-hexadecanoic acid (i-16:0); 14, 14-methyl-hexadecanoic acid (i-16:0); 15, heptadecanoic acid (17:0); 16, 16-methyl-heptadecanoic acid (i-17:0); 17, octadecanoic acid (18:0); 18, nonadecanoic acid (C19:0).</p>", "links"=>[], "tags"=>["Biochemistry", "metabolism", "biotechnology", "Environmental biotechnology", "biodegradation", "Applied microbiology", "microbiology", "Industrial microbiology", "Microbial metabolism", "Microbial physiology", "Energy and power", "Alternative energy", "bioenergy", "fatty", "metabolites"], "article_id"=>760296, "categories"=>["Biological Sciences", "Earth and Environmental Sciences"], "users"=>["Xinshu Zhu", "Jiatao Cui", "Yingang Feng", "Yun Fa", "Jingtao Zhang", "Qiu Cui"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0070631.g003", "stats"=>{"downloads"=>0, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_GC_MS_spectrum_of_C_thermocellum_for_fatty_phase_metabolites_assignment_/760296", "title"=>"GC-MS spectrum of <i>C. thermocellum</i> for fatty phase metabolites assignment.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-07-30 11:31:14"}
  • {"files"=>["https://ndownloader.figshare.com/files/1137690"], "description"=>"<p>Significantly changed intramolecular polar metabolites in <i>C. thermocellum</i> wild-type strain (WT) and ethanol-tolerant strain without additional ethanol (ET<sub>0</sub>) and with 3% ethanol (ET<sub>3</sub>) were mapped on the existing metabolic pathways. The red and green symbols indicate significantly increased and decreased metabolites, respectively. Metabolites: G1P, glucose 1-phosphate; G6P, glucose 6-phosphate; F6P, fructose 6-phosphate; G3P, glyceraldehyde 3-phosphate; E4P, erythrose 4-phosphate; R5P, ribose 5-phosphate; PEP, phosphoenolpyruvate; OAA, oxaloacetic acid; α-KG, α-ketoglutaric acid; Glu, glutamic acid; Gln, glutamine; Arg, arginine; Citru, citrulline; Orn, ornithine; Put, putrescine; Nors, norspermidine; FA, fatty acid. Enzymes: ACK, acetate kinase; ALDH/ADH, acetaldehyde dehydrogenase/alcohol dehydrogenase; CDPase, cellodextrin phosphorylase; CBPase, cellobiose phosphorylase; HK, hexokinase; PGM, phosphoglucomutase; LDH, lactate dehydrogenase; MDH, malate dehydrogenase; PTA, phosphotransacetylase; PFL, pyruvate:formate lyase; PFO, pyruvate:ferredoxin oxidoreductase; Fd H2ase, ferredoxin hydrogenase; NAD(P)H H2ase, NAD(P)H hydrogenase.</p>", "links"=>[], "tags"=>["Biochemistry", "metabolism", "biotechnology", "Environmental biotechnology", "biodegradation", "Applied microbiology", "microbiology", "Industrial microbiology", "Microbial metabolism", "Microbial physiology", "Energy and power", "Alternative energy", "bioenergy", "pathway", "intramolecular", "metabolite"], "article_id"=>760294, "categories"=>["Biological Sciences", "Earth and Environmental Sciences"], "users"=>["Xinshu Zhu", "Jiatao Cui", "Yingang Feng", "Yun Fa", "Jingtao Zhang", "Qiu Cui"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0070631.g002", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Metabolic_pathway_representation_of_intramolecular_metabolite_change_/760294", "title"=>"Metabolic pathway representation of intramolecular metabolite change.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-07-30 11:31:14"}
  • {"files"=>["https://ndownloader.figshare.com/files/1137695"], "description"=>"<p>Abbreviated metabolites: NAD, nicotinamide adenine dinucleotide; NADP, nicotinamide adenine dinucleotide phosphate; UDPG, uridine diphosphate glucose; Ery, L-erythrose; PEP, phosphoenolpyruvate; DMA, dimethylamine; α-KG, α-ketoglutaric acid.</p>a,b,c<p>Different letters indicated statistical significance (P<0.05) from one-way ANOVA with a Turkey post-test.</p>", "links"=>[], "tags"=>["Biochemistry", "metabolism", "biotechnology", "Environmental biotechnology", "biodegradation", "Applied microbiology", "microbiology", "Industrial microbiology", "Microbial metabolism", "Microbial physiology", "Energy and power", "Alternative energy", "bioenergy", "intracellular", "polar", "metabolites", "cultivations"], "article_id"=>760299, "categories"=>["Biological Sciences", "Earth and Environmental Sciences"], "users"=>["Xinshu Zhu", "Jiatao Cui", "Yingang Feng", "Yun Fa", "Jingtao Zhang", "Qiu Cui"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0070631.t001", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Quantification_of_the_intracellular_polar_metabolites_from_the_WT_ET_0_and_ET_3_cultivations_of_C_thermocellum_/760299", "title"=>"Quantification of the intracellular polar metabolites from the WT, ET<sub>0</sub> and ET<sub>3</sub> cultivations of <i>C. thermocellum</i>.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-07-30 11:31:14"}
  • {"files"=>["https://ndownloader.figshare.com/files/1137694"], "description"=>"*<p>The significant differences are derived from a one-way ANOVA analysis (p<0.05).</p>", "links"=>[], "tags"=>["Biochemistry", "metabolism", "biotechnology", "Environmental biotechnology", "biodegradation", "Applied microbiology", "microbiology", "Industrial microbiology", "Microbial metabolism", "Microbial physiology", "Energy and power", "Alternative energy", "bioenergy", "fatty", "metabolites", "cultivations"], "article_id"=>760298, "categories"=>["Biological Sciences", "Earth and Environmental Sciences"], "users"=>["Xinshu Zhu", "Jiatao Cui", "Yingang Feng", "Yun Fa", "Jingtao Zhang", "Qiu Cui"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0070631.t002", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_fatty_phase_metabolites_of_the_WT_ET_0_and_ET_3_cultivations_of_C_thermocellum_/760298", "title"=>"The fatty phase metabolites of the WT, ET<sub>0</sub> and ET<sub>3</sub> cultivations of <i>C. thermocellum</i>.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-07-30 11:31:14"}
  • {"files"=>["https://ndownloader.figshare.com/files/1137689"], "description"=>"<p>The spectra of the wild type strain (WT) and the ethanol-tolerant strain without additional ethanol (ET<sub>0</sub>) and with 3% ethanol (ET<sub>3</sub>) were shown from bottom to top. The left halves (4.90–9.50 ppm) of all spectra are magnified two times in the Y-axis for clarification. Keys: 1, valine; 2, lactic acid; 3, threonine; 4, acetic acid; 5, glutamate; 6, pyruvate; 7, succinate; 8, dimethylamine; 9, norspermidine; 10, malonate; 11, ethanol; 12, cellodextrin; 13, phosphoenolpyruvate; 14, L-erythrose; 15, uridine monophosphate; 16, adenosine; 17, nicotinate; 18, thymidylic acid; 19, Adenosine monophosphate; 20, nicotinamide adenine dinucleotide; 21, nicotinamide adenine dinucleotide phosphate; 22, uracil; 23, uridine monophosphate; 24, inosine; 25, formate; 26, adenosine diphosphate; 27, adenosine triphosphate; 28, tyrosine; 29, tryptophan; 30, aspartate; 31, α-arabinose; 32, methanol; 33, fumarate; 34, guanine; 35, cytosine; 36, acetamide; 37, p-aminobenzoic acid; 38, uridine diphosphate glucose; 39, α-D-galactose-1-phosphate.</p>", "links"=>[], "tags"=>["Biochemistry", "metabolism", "biotechnology", "Environmental biotechnology", "biodegradation", "Applied microbiology", "microbiology", "Industrial microbiology", "Microbial metabolism", "Microbial physiology", "Energy and power", "Alternative energy", "bioenergy", "nmr", "spectra", "intracellular", "polar", "metabolites"], "article_id"=>760293, "categories"=>["Biological Sciences", "Earth and Environmental Sciences"], "users"=>["Xinshu Zhu", "Jiatao Cui", "Yingang Feng", "Yun Fa", "Jingtao Zhang", "Qiu Cui"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0070631.g001", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_1_H_NMR_spectra_of_the_intracellular_polar_metabolites_of_C_thermocellum_/760293", "title"=>"<sup>1</sup>H NMR spectra of the intracellular polar metabolites of <i>C. thermocellum</i>.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-07-30 11:31:14"}

PMC Usage Stats | Further Information

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Relative Metric

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