Antidiabetic and Antioxidant Effects and Phytochemicals of Mulberry Fruit (Morus alba L.) Polyphenol Enhanced Extract
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{"title"=>"Antidiabetic and Antioxidant Effects and Phytochemicals of Mulberry Fruit (Morus alba L.) Polyphenol Enhanced Extract", "type"=>"journal", "authors"=>[{"first_name"=>"Yihai", "last_name"=>"Wang", "scopus_author_id"=>"36912783600"}, {"first_name"=>"Limin", "last_name"=>"Xiang", "scopus_author_id"=>"55261140100"}, {"first_name"=>"Chunhua", "last_name"=>"Wang", "scopus_author_id"=>"56482427600"}, {"first_name"=>"Chao", "last_name"=>"Tang", "scopus_author_id"=>"55804742200"}, {"first_name"=>"Xiangjiu", "last_name"=>"He", "scopus_author_id"=>"8518308600"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84880838317", "pui"=>"369443164", "doi"=>"10.1371/journal.pone.0071144", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "sgr"=>"84880838317", "pmid"=>"23936259"}, "id"=>"fbde109d-c84e-3c95-94d5-f1825a68d2a4", "abstract"=>"The antidiabetic and antioxidant activities of the ethyl acetate-soluble extract (MFE) of mulberry fruit (Morus alba L.) were investigated. In vitro, MFE showed potent α-glucosidase inhibitory activity and radical-scavenging activities against DPPH and superoxide anion radicals. In vivo, MFE could significantly decrease fasting blood glucose (FBG) and glycosylated serum protein (GSP), and increase antioxidant enzymatic activities (SOD, CAT, GSH-Px) in streptozotocin (STZ)-induced diabetic mice. Bioactivity-guided fractionation of the MFE led to the isolation of 25 phenolic compounds, and their structures were identified on the basis of MS and NMR data. All the 25 compounds were isolated from mulberry fruit for the first time. Also, the α-glucosidase inhibitory activity and antioxidant activity of the phenolics were evaluated. Potent α-glucosidase inhibitory and radical-scavenging activities of these phenolics suggested that they may be partially responsible for the antidiabetic and antioxidant activities of mulberry fruit.", "link"=>"http://www.mendeley.com/research/antidiabetic-antioxidant-effects-phytochemicals-mulberry-fruit-morus-alba-l-polyphenol-enhanced-extr", "reader_count"=>72, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>3, "Librarian"=>1, "Researcher"=>7, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>16, "Student > Postgraduate"=>8, "Student > Master"=>16, "Other"=>3, "Student > Bachelor"=>7, "Lecturer"=>3, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>3, "Librarian"=>1, "Researcher"=>7, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>16, "Student > Postgraduate"=>8, "Student > Master"=>16, "Other"=>3, "Student > Bachelor"=>7, "Lecturer"=>3, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Agricultural and Biological Sciences"=>31, "Veterinary Science and Veterinary Medicine"=>2, "Chemistry"=>10, "Computer Science"=>1, "Economics, Econometrics and Finance"=>1, "Engineering"=>3, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Nursing and Health Professions"=>2, "Medicine and Dentistry"=>7, "Pharmacology, Toxicology and Pharmaceutical Science"=>8, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>7}, "Social Sciences"=>{"Social Sciences"=>1}, "Unspecified"=>{"Unspecified"=>4}, "Environmental Science"=>{"Environmental Science"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>8}, "Engineering"=>{"Engineering"=>3}, "Chemistry"=>{"Chemistry"=>10}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>31}, "Computer Science"=>{"Computer Science"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>2}}, "reader_count_by_country"=>{"Israel"=>1, "Portugal"=>1}, "group_count"=>0}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1137439"], "description"=>"<p>Chemical structure of compounds 1−24 isolated from mulberry fruit (<i>Morus alba</i> L.)</p>", "links"=>[], "tags"=>["Biochemistry", "drug discovery", "biotechnology", "Model organisms", "Animal models", "mouse", "Plant science", "plants", "fruits", "medicinal chemistry", "phytochemistry", "Clinical research design", "Animal models of disease", "Drugs and devices", "Drug research and development", "Endocrinology", "Diabetic endocrinology", "Diabetes mellitus type 1", "compounds", "mulberry"], "article_id"=>760096, "categories"=>["Medicine", "Chemistry", "Biological Sciences"], "users"=>["Yihai Wang", "Limin Xiang", "Chunhua Wang", "Chao Tang", "Xiangjiu He"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0071144.g001", "stats"=>{"downloads"=>4, "page_views"=>125, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Chemical_structure_of_compounds_1_24_isolated_from_mulberry_fruit_Morus_alba_L_/760096", "title"=>"Chemical structure of compounds 1−24 isolated from mulberry fruit (<i>Morus alba</i> L.)", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-07-30 11:06:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/1137448"], "description"=>"a<p>Values are the mean ± SD; n = 8. <sup>b</sup> p<0.05 versus the control group. <sup>c</sup> p<0.01 versus the control group.</p>", "links"=>[], "tags"=>["Biochemistry", "drug discovery", "biotechnology", "Model organisms", "Animal models", "mouse", "Plant science", "plants", "fruits", "medicinal chemistry", "phytochemistry", "Clinical research design", "Animal models of disease", "Drugs and devices", "Drug research and development", "Endocrinology", "Diabetic endocrinology", "Diabetes mellitus type 1", "mfe", "antioxidant", "enzyme", "activities", "stz-induced", "diabetic"], "article_id"=>760105, "categories"=>["Medicine", "Chemistry", "Biological Sciences"], "users"=>["Yihai Wang", "Limin Xiang", "Chunhua Wang", "Chao Tang", "Xiangjiu He"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0071144.t004", "stats"=>{"downloads"=>3, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_the_MFE_on_Antioxidant_Enzyme_Activities_of_STZ_induced_Diabetic_Mice_a_/760105", "title"=>"Effect of the MFE on Antioxidant Enzyme Activities of STZ-induced Diabetic Mice.<sup>a</sup>", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-07-30 11:06:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/1137446"], "description"=>"a<p>Values are the mean ± SD; n = 3. <sup>b</sup> Compounds <b>17</b>−<b>25</b> did not show α-glucosidase inhibitory activity (IC50 >1000 <i>μ</i>M).</p>", "links"=>[], "tags"=>["Biochemistry", "drug discovery", "biotechnology", "Model organisms", "Animal models", "mouse", "Plant science", "plants", "fruits", "medicinal chemistry", "phytochemistry", "Clinical research design", "Animal models of disease", "Drugs and devices", "Drug research and development", "Endocrinology", "Diabetic endocrinology", "Diabetes mellitus type 1", "inhibitory", "activities", "compounds"], "article_id"=>760103, "categories"=>["Medicine", "Chemistry", "Biological Sciences"], "users"=>["Yihai Wang", "Limin Xiang", "Chunhua Wang", "Chao Tang", "Xiangjiu He"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0071144.t006", "stats"=>{"downloads"=>3, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Glucosidase_Inhibitory_Activities_of_the_Isolated_Compounds_1_25_a_/760103", "title"=>"α-Glucosidase Inhibitory Activities of the Isolated Compounds 1−25.<sup>a</sup>", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-07-30 11:06:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/1137447"], "description"=>"a<p>Values are the mean ± SD; n = 3.</p>b<p>Compounds <b>17</b>, <b>19</b>, <b>22</b> and <b>23</b> did not show DPPH radical-scavenging or superoxide anion radical-scavenging activity (EC50 >500 <i>μ</i>M).</p>", "links"=>[], "tags"=>["Biochemistry", "drug discovery", "biotechnology", "Model organisms", "Animal models", "mouse", "Plant science", "plants", "fruits", "medicinal chemistry", "phytochemistry", "Clinical research design", "Animal models of disease", "Drugs and devices", "Drug research and development", "Endocrinology", "Diabetic endocrinology", "Diabetes mellitus type 1", "radical-scavenging", "superoxide", "anion", "activities", "compounds"], "article_id"=>760104, "categories"=>["Medicine", "Chemistry", "Biological Sciences"], "users"=>["Yihai Wang", "Limin Xiang", "Chunhua Wang", "Chao Tang", "Xiangjiu He"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0071144.t005", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_DPPH_Radical_scavenging_and_Superoxide_anion_Radical_scavenging_Activities_of_The_Isolated_Compounds_1_25_a_/760104", "title"=>"DPPH Radical-scavenging and Superoxide anion Radical-scavenging Activities of The Isolated Compounds 1–25.<sup>a</sup>", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-07-30 11:06:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/1137445"], "description"=>"a<p>Values are the mean ± SD; n = 3. <sup>b</sup> DPPH used in the DPPH radical-scavenging assay of the extracts was 2,2-Di(4-tert-octylphenyl)-1-picrylhydrazyl (Sigma-Aldrich). NA, no assay.</p>", "links"=>[], "tags"=>["Biochemistry", "drug discovery", "biotechnology", "Model organisms", "Animal models", "mouse", "Plant science", "plants", "fruits", "medicinal chemistry", "phytochemistry", "Clinical research design", "Animal models of disease", "Drugs and devices", "Drug research and development", "Endocrinology", "Diabetic endocrinology", "Diabetes mellitus type 1", "superoxide", "anion", "radical-scavenging", "activities", "inhibitory", "extracts", "mulberry"], "article_id"=>760102, "categories"=>["Medicine", "Chemistry", "Biological Sciences"], "users"=>["Yihai Wang", "Limin Xiang", "Chunhua Wang", "Chao Tang", "Xiangjiu He"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0071144.t001", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_DPPH_Radical_scavenging_Superoxide_anion_Radical_scavenging_Activities_and_glucosidase_Inhibitory_Activity_of_the_Extracts_from_Mulberry_Fruit_a_b_/760102", "title"=>"DPPH Radical-scavenging, Superoxide anion Radical-scavenging Activities and α-glucosidase Inhibitory Activity of the Extracts from Mulberry Fruit.<sup>a, b</sup>", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-07-30 11:06:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/1137442"], "description"=>"<p>HPLC-PDA chromatogram of mulberry fruit (<i>Morus alba</i> L.) polyphenol enhanced extract.</p>", "links"=>[], "tags"=>["Biochemistry", "drug discovery", "biotechnology", "Model organisms", "Animal models", "mouse", "Plant science", "plants", "fruits", "medicinal chemistry", "phytochemistry", "Clinical research design", "Animal models of disease", "Drugs and devices", "Drug research and development", "Endocrinology", "Diabetic endocrinology", "Diabetes mellitus type 1", "chromatogram", "mulberry", "polyphenol", "enhanced"], "article_id"=>760099, "categories"=>["Medicine", "Chemistry", "Biological Sciences"], "users"=>["Yihai Wang", "Limin Xiang", "Chunhua Wang", "Chao Tang", "Xiangjiu He"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0071144.g002", "stats"=>{"downloads"=>3, "page_views"=>28, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_HPLC_PDA_chromatogram_of_mulberry_fruit_Morus_alba_L_polyphenol_enhanced_extract_/760099", "title"=>"HPLC-PDA chromatogram of mulberry fruit (<i>Morus alba</i> L.) polyphenol enhanced extract.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-07-30 11:06:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/1137444"], "description"=>"a<p>Values are the mean ± SD; n = 3. GAE, gallic acid equivalent. RE, rutin equivalent; NA, no assay.</p>", "links"=>[], "tags"=>["Biochemistry", "drug discovery", "biotechnology", "Model organisms", "Animal models", "mouse", "Plant science", "plants", "fruits", "medicinal chemistry", "phytochemistry", "Clinical research design", "Animal models of disease", "Drugs and devices", "Drug research and development", "Endocrinology", "Diabetic endocrinology", "Diabetes mellitus type 1", "phenolic", "flavonoid", "extracts", "mulberry"], "article_id"=>760101, "categories"=>["Medicine", "Chemistry", "Biological Sciences"], "users"=>["Yihai Wang", "Limin Xiang", "Chunhua Wang", "Chao Tang", "Xiangjiu He"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0071144.t002", "stats"=>{"downloads"=>1, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Total_Phenolic_Content_TPC_and_Total_Flavonoid_Content_TFC_of_the_Extracts_from_Mulberry_Fruit_a_/760101", "title"=>"Total Phenolic Content (TPC) and Total Flavonoid Content (TFC) of the Extracts from Mulberry Fruit.<sup>a</sup>", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-07-30 11:06:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/1137443"], "description"=>"a<p>Values are the mean ± SD; n = 8. <sup>b</sup> p<0.05 versus the control group. <sup>c</sup> p<0.01 versus the control group.</p>", "links"=>[], "tags"=>["Biochemistry", "drug discovery", "biotechnology", "Model organisms", "Animal models", "mouse", "Plant science", "plants", "fruits", "medicinal chemistry", "phytochemistry", "Clinical research design", "Animal models of disease", "Drugs and devices", "Drug research and development", "Endocrinology", "Diabetic endocrinology", "Diabetes mellitus type 1", "mfe", "fasting", "glucose", "glucosylated", "serum", "stz-induced", "diabetic"], "article_id"=>760100, "categories"=>["Medicine", "Chemistry", "Biological Sciences"], "users"=>["Yihai Wang", "Limin Xiang", "Chunhua Wang", "Chao Tang", "Xiangjiu He"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0071144.t003", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_the_MFE_on_the_Fasting_Blood_Glucose_FBG_and_Glucosylated_Serum_Protein_GSP_of_STZ_induced_Diabetic_Mice_a_/760100", "title"=>"Effect of the MFE on the Fasting Blood Glucose (FBG) and Glucosylated Serum Protein (GSP) of STZ-induced Diabetic Mice.<sup>a</sup>", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-07-30 11:06:49"}

PMC Usage Stats | Further Information

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Relative Metric

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