Optic Neuritis Is Associated with Inner Nuclear Layer Thickening and Microcystic Macular Edema Independently of Multiple Sclerosis
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{"title"=>"Optic Neuritis Is Associated with Inner Nuclear Layer Thickening and Microcystic Macular Edema Independently of Multiple Sclerosis", "type"=>"journal", "authors"=>[{"first_name"=>"Falko", "last_name"=>"Kaufhold", "scopus_author_id"=>"6505988877"}, {"first_name"=>"Hanna", "last_name"=>"Zimmermann", "scopus_author_id"=>"48663100000"}, {"first_name"=>"Elisa", "last_name"=>"Schneider", "scopus_author_id"=>"55771479400"}, {"first_name"=>"Klemens", "last_name"=>"Ruprecht", "scopus_author_id"=>"7004466220"}, {"first_name"=>"Friedemann", "last_name"=>"Paul", "scopus_author_id"=>"12766456100"}, {"first_name"=>"Timm", "last_name"=>"Oberwahrenbrock", "scopus_author_id"=>"44861672100"}, {"first_name"=>"Alexander U.", "last_name"=>"Brandt", "scopus_author_id"=>"22950037300"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84881137559", "sgr"=>"84881137559", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0071145", "pmid"=>"23940706", "pui"=>"369507767"}, "id"=>"37065dfc-6d3f-3e95-830e-442a600f05f0", "abstract"=>"BACKGROUND: Microcystic macular edema (MME) and inner nuclear layer thickening (INL) were described in multiple sclerosis (MS) and neuromyelitis optica (NMO) patients using optical coherence tomography (OCT). The cause of these findings is currently unknown and a relation to inflammatory or degenerative processes in the optic nerve is discussed.\\n\\nOBJECTIVE: The aim of our study was to investigate whether INL thickening and MME are related to optic neuritis (ON) in various neuro-inflammatory disorders causingON: MS, NMO and chronic inflammatory optic neuropathy.\\n\\nMETHODS: We retrospectively analyzed data from 216 MS patients, 39 patients with a clinically isolated syndrome, 20 NMO spectrum disorder patients, 9 patients with chronic inflammatory optic neuropathy and 121 healthy subjects. Intra-retinal layer segmentation was performed for the eyes of patients with unilateral ON. Scanning laser ophthalmoscopy (SLO) images were reviewed for characteristic ocular fundus changes.\\n\\nRESULTS: Intra-retinal layer segmentation showed that eyes with a history of ON displayed MME independent INL thickening compared to contralateral eyes without previous ON. MME was detected in 22 eyes from 15 patients (5.3% of all screened patients), including 7 patients with bilateral edema. Of these, 21 had a prior history of ON (95%). The SLO images of all 22 MME-affected eyes showed crescent-shaped texture changes which were visible in the perifoveal region. A second grader who was blinded to the results of the OCT classified all SLO images for the presence of these characteristic fundus changes. All MME eyes were correctly classified (sensitivity = 100%) with high specificity (95.2%).\\n\\nCONCLUSION: This study shows that both MME and INL thickening occur in various neuro-inflammatory disorders associated with ON. We also demonstrate that detection and analysis of MME by OCT is not limited to B-scans, but also possible using SLO images.", "link"=>"http://www.mendeley.com/research/optic-neuritis-associated-inner-nuclear-layer-thickening-microcystic-macular-edema-independently-mul", "reader_count"=>48, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>4, "Librarian"=>1, "Researcher"=>9, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>4, "Other"=>6, "Student > Master"=>5, "Student > Bachelor"=>4, "Lecturer > Senior Lecturer"=>1, "Professor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>4, "Librarian"=>1, "Researcher"=>9, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>4, "Other"=>6, "Student > Master"=>5, "Student > Bachelor"=>4, "Lecturer > Senior Lecturer"=>1, "Professor"=>3}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Unspecified"=>4, "Biochemistry, Genetics and Molecular Biology"=>1, "Nursing and Health Professions"=>3, "Medicine and Dentistry"=>27, "Agricultural and Biological Sciences"=>3, "Neuroscience"=>6, "Physics and Astronomy"=>1, "Psychology"=>2}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>27}, "Neuroscience"=>{"Neuroscience"=>6}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Psychology"=>{"Psychology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>4}}, "reader_count_by_country"=>{"Germany"=>1, "Spain"=>2}, "group_count"=>5}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1144639"], "description"=>"<p><b>Abbreviations:</b> MME = microcystic macular edema; MS = multiple sclerosis ON = optic neuritis; SD = standard deviation; Min = minimum value; Max = maximum value; EDSS = Expanded Disability Status Scale; MSSS = Multiple Sclerosis Severity Score.</p>", "links"=>[], "tags"=>["immunology", "immunity", "inflammation", "microbiology", "Clinical immunology", "Autoimmune diseases", "Multiple sclerosis", "neurology", "Demyelinating disorders", "Neuro-ophthalmology", "ophthalmology", "severity", "ms"], "article_id"=>765767, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Falko Kaufhold", "Hanna Zimmermann", "Elisa Schneider", "Klemens Ruprecht", "Friedemann Paul", "Timm Oberwahrenbrock", "Alexander U. Brandt"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0071145.t003", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Disease_severity_in_MS_patients_/765767", "title"=>"Disease severity in MS patients.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-08-06 02:10:06"}
  • {"files"=>["https://ndownloader.figshare.com/files/1144640"], "description"=>"<p><b>Abbreviations:</b> MME = microcystic macular edema; ON = optic neuritis; mRNFL = macular retinal nerve fiber layer; GCIPL = ganglion cell and inner plexiform layer; INL = inner nuclear layer; SD = standard deviation; GEE = generalized estimation equation.</p>", "links"=>[], "tags"=>["immunology", "immunity", "inflammation", "microbiology", "Clinical immunology", "Autoimmune diseases", "Multiple sclerosis", "neurology", "Demyelinating disorders", "Neuro-ophthalmology", "ophthalmology", "retinal", "segmentation", "patients", "unilateral", "eyes", "mme"], "article_id"=>765768, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Falko Kaufhold", "Hanna Zimmermann", "Elisa Schneider", "Klemens Ruprecht", "Friedemann Paul", "Timm Oberwahrenbrock", "Alexander U. Brandt"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0071145.t004", "stats"=>{"downloads"=>0, "page_views"=>21, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Results_of_the_retinal_segmentation_for_patients_with_a_history_of_unilateral_ON_patients_8217_eyes_with_MME_and_controls_/765768", "title"=>"Results of the retinal segmentation for patients with a history of unilateral ON, patients’ eyes with MME and controls.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-08-06 02:10:06"}
  • {"files"=>["https://ndownloader.figshare.com/files/1144638"], "description"=>"a)<p>The contralateral eyes of unilateral MME eyes were excluded.</p><p><b>Abbreviations:</b> MME = microcystic macular edema; MS = multiple sclerosis; NMO = neuromyelitis optica spectrum diseases; CRION = chronic relapsing inflammatory optic neuropathy; ON = optic neuritis; pRNFL = peripapillary retinal nerve fiber layer; TMV = total macular volume; SD = standard deviation; Min = minimum value; Max = maximum value.</p>", "links"=>[], "tags"=>["immunology", "immunity", "inflammation", "microbiology", "Clinical immunology", "Autoimmune diseases", "Multiple sclerosis", "neurology", "Demyelinating disorders", "Neuro-ophthalmology", "ophthalmology", "mme", "non-mme"], "article_id"=>765766, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Falko Kaufhold", "Hanna Zimmermann", "Elisa Schneider", "Klemens Ruprecht", "Friedemann Paul", "Timm Oberwahrenbrock", "Alexander U. Brandt"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0071145.t002", "stats"=>{"downloads"=>0, "page_views"=>31, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Ocular_key_data_of_MME_and_non_MME_eyes_/765766", "title"=>"Ocular key data of MME and non-MME eyes.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-08-06 02:10:06"}
  • {"files"=>["https://ndownloader.figshare.com/files/1144631"], "description"=>"<p>A) Differences in inner nuclear layer (INL) thickness between affected and unaffected eyes of patients with a unilateral history of optic neuritis categorized by diagnosis. Eyes belonging to one patient are connected by lines. Lines in blue indicate eyes, which the INL of the optic neuritis eyes was thicker compared to the contralateral unaffected eyes, whereas red lines show the contrary. B) Correlation of inter-eye INL thickness differences with inter-eye macular retinal nerve fiber layer (mRNFL) thickness differences (LR: P<0.001). C) Correlation of inter-eye INL thickness differences with inter-eye ganglion cell and inner plexiform layer (GCIPL) thickness differences (LR: P = 0.011).</p>", "links"=>[], "tags"=>["immunology", "immunity", "inflammation", "microbiology", "Clinical immunology", "Autoimmune diseases", "Multiple sclerosis", "neurology", "Demyelinating disorders", "Neuro-ophthalmology", "ophthalmology", "differences", "patients", "unilateral", "optic"], "article_id"=>765763, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Falko Kaufhold", "Hanna Zimmermann", "Elisa Schneider", "Klemens Ruprecht", "Friedemann Paul", "Timm Oberwahrenbrock", "Alexander U. Brandt"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0071145.g002", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Inter_eye_differences_in_patients_with_unilateral_history_of_optic_neuritis_/765763", "title"=>"Inter-eye differences in patients with unilateral history of optic neuritis.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-08-06 02:10:06"}
  • {"files"=>["https://ndownloader.figshare.com/files/1144637"], "description"=>"<p><b>Abbreviations:</b> MME = microcystic macular edema; MS = multiple sclerosis; NMO = neuromyelitis optica spectrum diseases; CRION = chronic relapsing inflammatory optic neuropathy; HC = healthy control; RRMS = relapsing-remitting multiple sclerosis; SPMS = secondary-progressive multiple sclerosis; PPMS = primary-progressive multiple sclerosis; CIS = Clinical isolated syndrome; SD = standard deviation; Min = minimum value; Max = maximum value.</p>", "links"=>[], "tags"=>["immunology", "immunity", "inflammation", "microbiology", "Clinical immunology", "Autoimmune diseases", "Multiple sclerosis", "neurology", "Demyelinating disorders", "Neuro-ophthalmology", "ophthalmology", "overview"], "article_id"=>765765, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Falko Kaufhold", "Hanna Zimmermann", "Elisa Schneider", "Klemens Ruprecht", "Friedemann Paul", "Timm Oberwahrenbrock", "Alexander U. Brandt"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0071145.t001", "stats"=>{"downloads"=>0, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Demographic_overview_of_the_study_cohort_/765765", "title"=>"Demographic overview of the study cohort.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-08-06 02:10:06"}
  • {"files"=>["https://ndownloader.figshare.com/files/1144634"], "description"=>"<p>A) Quantification of the MME-affected area of a sample eye in a SLO image with ImageJ. B) The microcysts in OCT B-scans of the same sample eye mapped onto the SLO image. The yellow lines correspond to the spread of the macular edema in the two example B-scans at the bottom.</p>", "links"=>[], "tags"=>["immunology", "immunity", "inflammation", "microbiology", "Clinical immunology", "Autoimmune diseases", "Multiple sclerosis", "neurology", "Demyelinating disorders", "Neuro-ophthalmology", "ophthalmology", "quantification", "slo", "mme"], "article_id"=>765764, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Falko Kaufhold", "Hanna Zimmermann", "Elisa Schneider", "Klemens Ruprecht", "Friedemann Paul", "Timm Oberwahrenbrock", "Alexander U. Brandt"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0071145.g003", "stats"=>{"downloads"=>0, "page_views"=>33, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Sample_quantification_of_SLO_MME_area_/765764", "title"=>"Sample quantification of SLO MME area.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-08-06 02:10:06"}
  • {"files"=>["https://ndownloader.figshare.com/files/1144627"], "description"=>"<p>Sample SLO images (on the left) and sample OCT B-scan images (on the right) from A) MS patient’s eye with a history of ON but without MME, B) an MS patient’s eye with history of ON and MME, C) an NMO patient’s eye with history of ON and MME and D) an eye from a patient with CRION and MME. Whereas the eye from A does not show any signs of MME in either the SLO or OCT B-scan image, all eyes in B-D show similar findings. The SLO images were mirrored where necessary to standardize orientation.</p>", "links"=>[], "tags"=>["immunology", "immunity", "inflammation", "microbiology", "Clinical immunology", "Autoimmune diseases", "Multiple sclerosis", "neurology", "Demyelinating disorders", "Neuro-ophthalmology", "ophthalmology", "scans", "mme", "slo", "oct"], "article_id"=>765761, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Falko Kaufhold", "Hanna Zimmermann", "Elisa Schneider", "Klemens Ruprecht", "Friedemann Paul", "Timm Oberwahrenbrock", "Alexander U. Brandt"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0071145.g001", "stats"=>{"downloads"=>0, "page_views"=>43, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Sample_scans_showing_MME_in_SLO_and_OCT_images_/765761", "title"=>"Sample scans showing MME in SLO and OCT images.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-08-06 02:10:06"}

PMC Usage Stats | Further Information

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Relative Metric

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