Population Genomics of Cardiometabolic Traits: Design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium
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Nevertheless, gaps in knowledge remain and new questions have arisen regarding the population relevance, mechanisms, and applications for healthcare. 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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1175751"], "description"=>"<p>Total incident CHD =  incident non-fatal MI or revascularization plus fatal CHD (ICD codes I20–I25, I516).</p><p>Total prevalent CHD  =  prevalent non-fatal MI or revascularization.</p><p>Total incident stroke  =  incident non-fatal stroke (ischaemic & haemorrhagic combined, but excluding TIA) plus fatal stroke (ICD codes I60×, I61×, I62, I629 I63×, I64× I65× I66×, I67, I672, I678, I679, I69×, G46×, G450, G451, G452, G453).</p><p>Total diabetes defined by a combination of self-report, medical history review, use of glucose lowering medication, or fasting glucose >7 mmol/L.</p>*<p>1958BC are currently undertaking case ascertainment.</p>", "links"=>[], "tags"=>["Computational biology", "population genetics", "Evolutionary biology", "genetics", "Population biology", "epidemiology", "Genetic epidemiology", "cardiovascular", "Cardiovascular disease epidemiology", "prevalent", "ucleb"], "article_id"=>777013, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Tina Shah", "Jorgen Engmann", "Caroline Dale", "Sonia Shah", "Jon White", "Claudia Giambartolomei", "Stela McLachlan", "Delilah Zabaneh", "Alana Cavadino", "Chris Finan", "Andrew Wong", "Antoinette Amuzu", "Ken Ong", "Tom Gaunt", "Michael V. Holmes", "Helen Warren", "Teri-Louise Davies", "Fotios Drenos", "Jackie Cooper", "Reecha Sofat", "Mark Caulfield", "Shah Ebrahim", "Debbie A. Lawlor", "Philippa J. Talmud", "Steve E. Humphries", "Christine Power", "Elina Hyppönen", "Marcus Richards", "Rebecca Hardy", "Diana Kuh", "Nicholas Wareham", "Yoav Ben-Shlomo", "Ian N. Day", "Peter Whincup", "Richard Morris", "Mark W. J. Strachan", "Jacqueline Price", "Meena Kumari", "Mika Kivimäki", "Vincent Plagnol", "Frank Dudbridge", "John C. Whittaker", "Juan P. Casas", "Aroon D. Hingorani"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0071345.t003", "stats"=>{"downloads"=>1, "page_views"=>35, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Disease_event_definitions_incident_and_prevalent_events_by_disease_and_medication_use_in_the_UCLEB_consortium_/777013", "title"=>"Disease event definitions, incident and prevalent events by disease and medication use in the UCLEB consortium.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-08-20 01:36:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/1175752"], "description"=>"*<p>DNA extraction/standardisation in progress <sup>†</sup>DNA extracted at baseline <sup>††</sup>DNA extracted at subsequent resurvey.</p>", "links"=>[], "tags"=>["Computational biology", "population genetics", "Evolutionary biology", "genetics", "Population biology", "epidemiology", "Genetic epidemiology", "cardiovascular", "Cardiovascular disease epidemiology", "inclusion", "assessments", "ucleb"], "article_id"=>777014, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Tina Shah", "Jorgen Engmann", "Caroline Dale", "Sonia Shah", "Jon White", "Claudia Giambartolomei", "Stela McLachlan", "Delilah Zabaneh", "Alana Cavadino", "Chris Finan", "Andrew Wong", "Antoinette Amuzu", "Ken Ong", "Tom Gaunt", "Michael V. Holmes", "Helen Warren", "Teri-Louise Davies", "Fotios Drenos", "Jackie Cooper", "Reecha Sofat", "Mark Caulfield", "Shah Ebrahim", "Debbie A. Lawlor", "Philippa J. Talmud", "Steve E. Humphries", "Christine Power", "Elina Hyppönen", "Marcus Richards", "Rebecca Hardy", "Diana Kuh", "Nicholas Wareham", "Yoav Ben-Shlomo", "Ian N. Day", "Peter Whincup", "Richard Morris", "Mark W. J. Strachan", "Jacqueline Price", "Meena Kumari", "Mika Kivimäki", "Vincent Plagnol", "Frank Dudbridge", "John C. Whittaker", "Juan P. Casas", "Aroon D. Hingorani"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0071345.t001", "stats"=>{"downloads"=>1, "page_views"=>47, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Summary_of_recruitment_inclusion_criteria_and_clinical_assessments_in_the_UCLEB_studies_/777014", "title"=>"Summary of recruitment, inclusion criteria and clinical assessments in the UCLEB studies.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-08-20 01:36:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/1175750"], "description"=>"<p>Measures available in the UCLEB consortium.</p>", "links"=>[], "tags"=>["Computational biology", "population genetics", "Evolutionary biology", "genetics", "Population biology", "epidemiology", "Genetic epidemiology", "cardiovascular", "Cardiovascular disease epidemiology", "ucleb"], "article_id"=>777012, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Tina Shah", "Jorgen Engmann", "Caroline Dale", "Sonia Shah", "Jon White", "Claudia Giambartolomei", "Stela McLachlan", "Delilah Zabaneh", "Alana Cavadino", "Chris Finan", "Andrew Wong", "Antoinette Amuzu", "Ken Ong", "Tom Gaunt", "Michael V. Holmes", "Helen Warren", "Teri-Louise Davies", "Fotios Drenos", "Jackie Cooper", "Reecha Sofat", "Mark Caulfield", "Shah Ebrahim", "Debbie A. Lawlor", "Philippa J. Talmud", "Steve E. Humphries", "Christine Power", "Elina Hyppönen", "Marcus Richards", "Rebecca Hardy", "Diana Kuh", "Nicholas Wareham", "Yoav Ben-Shlomo", "Ian N. Day", "Peter Whincup", "Richard Morris", "Mark W. J. Strachan", "Jacqueline Price", "Meena Kumari", "Mika Kivimäki", "Vincent Plagnol", "Frank Dudbridge", "John C. Whittaker", "Juan P. Casas", "Aroon D. Hingorani"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0071345.t002", "stats"=>{"downloads"=>6, "page_views"=>81, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Measures_available_in_the_UCLEB_consortium_/777012", "title"=>"Measures available in the UCLEB consortium.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-08-20 01:36:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/1175755", "https://ndownloader.figshare.com/files/1175756", "https://ndownloader.figshare.com/files/1175757", "https://ndownloader.figshare.com/files/1175758"], "description"=>"<div><p>Substantial advances have been made in identifying common genetic variants influencing cardiometabolic traits and disease outcomes through genome wide association studies. Nevertheless, gaps in knowledge remain and new questions have arisen regarding the population relevance, mechanisms, and applications for healthcare. Using a new high-resolution custom single nucleotide polymorphism (SNP) array (Metabochip) incorporating dense coverage of genomic regions linked to cardiometabolic disease, the University College-London School-Edinburgh-Bristol (UCLEB) consortium of highly-phenotyped population-based prospective studies, aims to: (1) fine map functionally relevant SNPs; (2) precisely estimate individual absolute and population attributable risks based on individual SNPs and their combination; (3) investigate mechanisms leading to altered risk factor profiles and CVD events; and (4) use Mendelian randomisation to undertake studies of the causal role in CVD of a range of cardiovascular biomarkers to inform public health policy and help develop new preventative therapies.</p></div>", "links"=>[], "tags"=>["Computational biology", "population genetics", "Evolutionary biology", "genetics", "Population biology", "epidemiology", "Genetic epidemiology", "cardiovascular", "Cardiovascular disease epidemiology", "genomics", "cardiometabolic", "london-london", "hygiene", "medicine-edinburgh-bristol"], "article_id"=>777017, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Tina Shah", "Jorgen Engmann", "Caroline Dale", "Sonia Shah", "Jon White", "Claudia Giambartolomei", "Stela McLachlan", "Delilah Zabaneh", "Alana Cavadino", "Chris Finan", "Andrew Wong", "Antoinette Amuzu", "Ken Ong", "Tom Gaunt", "Michael V. Holmes", "Helen Warren", "Teri-Louise Davies", "Fotios Drenos", "Jackie Cooper", "Reecha Sofat", "Mark Caulfield", "Shah Ebrahim", "Debbie A. Lawlor", "Philippa J. Talmud", "Steve E. Humphries", "Christine Power", "Elina Hyppönen", "Marcus Richards", "Rebecca Hardy", "Diana Kuh", "Nicholas Wareham", "Yoav Ben-Shlomo", "Ian N. Day", "Peter Whincup", "Richard Morris", "Mark W. J. Strachan", "Jacqueline Price", "Meena Kumari", "Mika Kivimäki", "Vincent Plagnol", "Frank Dudbridge", "John C. Whittaker", "Juan P. Casas", "Aroon D. Hingorani"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0071345.s001", "https://dx.doi.org/10.1371/journal.pone.0071345.s002", "https://dx.doi.org/10.1371/journal.pone.0071345.s003", "https://dx.doi.org/10.1371/journal.pone.0071345.s004"], "stats"=>{"downloads"=>3, "page_views"=>76, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Population_Genomics_of_Cardiometabolic_Traits_Design_of_the_University_College_London_London_School_of_Hygiene_and_Tropical_Medicine_Edinburgh_Bristol_UCLEB_Consortium_/777017", "title"=>"Population Genomics of Cardiometabolic Traits: Design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-08-20 01:36:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/1175753"], "description"=>"*<p>The WHII study was typed at two centres with different array readers, which were compared and shown to be concordant.</p>", "links"=>[], "tags"=>["Computational biology", "population genetics", "Evolutionary biology", "genetics", "Population biology", "epidemiology", "Genetic epidemiology", "cardiovascular", "Cardiovascular disease epidemiology", "genotyped", "imputed"], "article_id"=>777015, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Tina Shah", "Jorgen Engmann", "Caroline Dale", "Sonia Shah", "Jon White", "Claudia Giambartolomei", "Stela McLachlan", "Delilah Zabaneh", "Alana Cavadino", "Chris Finan", "Andrew Wong", "Antoinette Amuzu", "Ken Ong", "Tom Gaunt", "Michael V. Holmes", "Helen Warren", "Teri-Louise Davies", "Fotios Drenos", "Jackie Cooper", "Reecha Sofat", "Mark Caulfield", "Shah Ebrahim", "Debbie A. Lawlor", "Philippa J. Talmud", "Steve E. Humphries", "Christine Power", "Elina Hyppönen", "Marcus Richards", "Rebecca Hardy", "Diana Kuh", "Nicholas Wareham", "Yoav Ben-Shlomo", "Ian N. Day", "Peter Whincup", "Richard Morris", "Mark W. J. Strachan", "Jacqueline Price", "Meena Kumari", "Mika Kivimäki", "Vincent Plagnol", "Frank Dudbridge", "John C. Whittaker", "Juan P. Casas", "Aroon D. Hingorani"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0071345.t004", "stats"=>{"downloads"=>3, "page_views"=>40, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Information_on_genotyped_and_imputed_SNPs_/777015", "title"=>"Information on genotyped and imputed SNPs.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-08-20 01:36:43"}

PMC Usage Stats | Further Information

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Relative Metric

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