A Genome-Wide Association Study of Total Serum and Mite-Specific IgEs in Asthma Patients
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{"title"=>"A Genome-Wide Association Study of Total Serum and Mite-Specific IgEs in Asthma Patients", "type"=>"journal", "authors"=>[{"first_name"=>"Jeong-Hyun", "last_name"=>"Kim"}, {"first_name"=>"Hyun Sub", "last_name"=>"Cheong"}, {"first_name"=>"Jong Sook", "last_name"=>"Park"}, {"first_name"=>"An-Soo", "last_name"=>"Jang"}, {"first_name"=>"Soo-Taek", "last_name"=>"Uh"}, {"first_name"=>"Yong-Hoon", "last_name"=>"Kim"}, {"first_name"=>"Mi-Kyeong", "last_name"=>"Kim"}, {"first_name"=>"Inseon S.", "last_name"=>"Choi"}, {"first_name"=>"Sang Heon", "last_name"=>"Cho"}, {"first_name"=>"Byoung Whui", "last_name"=>"Choi"}, {"first_name"=>"Joon Seol", "last_name"=>"Bae"}, {"first_name"=>"Choon-Sik", "last_name"=>"Park"}, {"first_name"=>"Hyoung Doo", "last_name"=>"Shin"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"1932-6203", "doi"=>"10.1371/journal.pone.0071958", "pmid"=>"23967269"}, "id"=>"87f59f26-90fc-3adf-86c9-7f7152814338", "abstract"=>"Immunoglobulin E (IgE) is one of the central players in asthma and allergic diseases. Although the serum IgE level, a useful endophenotype, is generally increased in patients with asthma, genetic factors influencing IgE regulation in asthma are still not fully understood. To identify the genetic variations associated with total serum and mite-specific IgEs in asthmatics, a genome-wide association study (GWAS) of 657,366 single nucleotide polymorphisms (SNPs) was performed in 877 Korean asthmatics. This study found that several new genes might be associated with total IgE in asthmatics, such as CRIM1 (rs848512, P = 1.18×10(-6); rs711254, P = 6.73×10(-6)), ZNF71 (rs10404342, P = 7.60×10(-6)), TLN1 (rs4879926, P = 7.74×10(-6)), and SYNPO2 (rs1472066, P = 8.36×10(-6); rs1038770, P = 8.66×10(-6)). Regarding the association of specific IgE to house dust mites, it was observed that intergenic SNPs nearby to OPRK1 and LOC730217 might be associated with Dermatophagoides pteronyssinus (D.p.) and Dermatophagoides farinae (D.f.) in asthmatics, respectively. In further pathway analysis, the phosphatidylinositol signaling system and adherens junction pathways were estimated to play a role in the regulation of total IgE levels in asthma. Although functional evaluations and replications of these results in other populations are needed, this GWAS of serum IgE in asthmatics could facilitate improved understanding of the role of the newly identified genetic variants in asthma and its related phenotypes.", "link"=>"http://www.mendeley.com/research/genomewide-association-study-total-serum-mitespecific-iges-asthma-patients-3", "reader_count"=>12, "reader_count_by_academic_status"=>{"Researcher"=>5, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Student > Master"=>1, "Other"=>1}, "reader_count_by_user_role"=>{"Researcher"=>5, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Student > Master"=>1, "Other"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Agricultural and Biological Sciences"=>5, "Medicine and Dentistry"=>6}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>6}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>5}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"Canada"=>1, "Korea (South)"=>2, "United States"=>1}, "group_count"=>1}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1168112"], "description"=>"<p>The y-axis represents -log<sub>10</sub><i>P</i> (linear regression analysis) from 442,117 SNPs in 877 patients with asthma, correcting for age, gender, and smoking status as covariates; the x-axis indicates its physical position on successive chromosomes.</p>", "links"=>[], "tags"=>["genetics", "Genome-wide association studies", "presenting", "serum", "ige", "asthma"], "article_id"=>771188, "categories"=>["Biological Sciences"], "users"=>["Jeong-Hyun Kim", "Hyun Sub Cheong", "Jong Sook Park", "An-Soo Jang", "Soo-Taek Uh", "Yong-Hoon Kim", "Mi-Kyeong Kim", "Inseon S. Choi", "Sang Heon Cho", "Byoung Whui Choi", "Joon Seol Bae", "Choon-Sik Park", "Hyoung Doo Shin"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0071958.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Graphical_summary_Manhattan_plot_presenting_P_values_for_the_association_with_total_serum_IgE_in_asthma_patients_/771188", "title"=>"Graphical summary (Manhattan plot) presenting <i>P</i>-values for the association with total serum IgE in asthma patients.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-08-13 02:18:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/1168114"], "description"=>"<p>GWAS associations (-log<sub>10</sub><i>P</i>) of SNPs across approximately 768 kb region around <i>SYNPO4</i> in the chromosome 4q26 are shown. Relatively strong associations are shown as large black circles; relatively less significances as small gray diamonds.</p>", "links"=>[], "tags"=>["genetics", "Genome-wide association studies", "ld", "ige"], "article_id"=>771190, "categories"=>["Biological Sciences"], "users"=>["Jeong-Hyun Kim", "Hyun Sub Cheong", "Jong Sook Park", "An-Soo Jang", "Soo-Taek Uh", "Yong-Hoon Kim", "Mi-Kyeong Kim", "Inseon S. Choi", "Sang Heon Cho", "Byoung Whui Choi", "Joon Seol Bae", "Choon-Sik Park", "Hyoung Doo Shin"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0071958.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Regional_association_plot_and_LD_of_SYNPO2_for_the_total_IgE_in_asthmatics_/771190", "title"=>"Regional association plot and LD of <i>SYNPO2</i> for the total IgE in asthmatics.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-08-13 02:18:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/1168115"], "description"=>"<p>Association analyses were adjusted by age, sex, and smoking status as covariates.</p>*<p><i>P</i>-value of Hardy-Weinberg equilibrium (HWE).</p>**<p>Genotype represents number of subjects (mean of log[Total IgE (IU/ml)]).</p>†<p>M/M, M/m, and m/m indicate homozygote for common allele, heterozygote, and homozygote for rare allele, respectively.</p><p>Chr, chromosome; MAF, minor allele frequency.</p>", "links"=>[], "tags"=>["genetics", "Genome-wide association studies", "snps", "ige", "asthmatics"], "article_id"=>771191, "categories"=>["Biological Sciences"], "users"=>["Jeong-Hyun Kim", "Hyun Sub Cheong", "Jong Sook Park", "An-Soo Jang", "Soo-Taek Uh", "Yong-Hoon Kim", "Mi-Kyeong Kim", "Inseon S. Choi", "Sang Heon Cho", "Byoung Whui Choi", "Joon Seol Bae", "Choon-Sik Park", "Hyoung Doo Shin"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0071958.t002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Top_6_SNPs_P_8722_5_associated_with_total_IgE_of_asthmatics_in_the_GWAS_/771191", "title"=>"Top 6 SNPs (<i>P</i><1.0×10<sup>−5</sup>) associated with total IgE of asthmatics in the GWAS.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-08-13 02:18:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/1168116"], "description"=>"<p>Ex indicates ex-smoker.</p><p>D.p., Dermatophagoides pteronyssinus; D.f., Dermatophagoides farinae.</p>*<p><i>P</i><0.001.</p>", "links"=>[], "tags"=>["genetics", "Genome-wide association studies", "profiles"], "article_id"=>771192, "categories"=>["Biological Sciences"], "users"=>["Jeong-Hyun Kim", "Hyun Sub Cheong", "Jong Sook Park", "An-Soo Jang", "Soo-Taek Uh", "Yong-Hoon Kim", "Mi-Kyeong Kim", "Inseon S. Choi", "Sang Heon Cho", "Byoung Whui Choi", "Joon Seol Bae", "Choon-Sik Park", "Hyoung Doo Shin"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0071958.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Clinical_profiles_of_study_subjects_/771192", "title"=>"Clinical profiles of study subjects.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-08-13 02:18:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/1168124", "https://ndownloader.figshare.com/files/1168126", "https://ndownloader.figshare.com/files/1168130", "https://ndownloader.figshare.com/files/1168134", "https://ndownloader.figshare.com/files/1168137", "https://ndownloader.figshare.com/files/1168141", "https://ndownloader.figshare.com/files/1168144", "https://ndownloader.figshare.com/files/1168145", "https://ndownloader.figshare.com/files/1168150", "https://ndownloader.figshare.com/files/1168154", "https://ndownloader.figshare.com/files/1168159", "https://ndownloader.figshare.com/files/1168166", "https://ndownloader.figshare.com/files/1168170", "https://ndownloader.figshare.com/files/1168172", "https://ndownloader.figshare.com/files/1168175"], "description"=>"<div><p>Immunoglobulin E (IgE) is one of the central players in asthma and allergic diseases. Although the serum IgE level, a useful endophenotype, is generally increased in patients with asthma, genetic factors influencing IgE regulation in asthma are still not fully understood. To identify the genetic variations associated with total serum and mite-specific IgEs in asthmatics, a genome-wide association study (GWAS) of 657,366 single nucleotide polymorphisms (SNPs) was performed in 877 Korean asthmatics. This study found that several new genes might be associated with total IgE in asthmatics, such as <i>CRIM1</i> (rs848512, <i>P</i> = 1.18×10<sup>−6</sup>; rs711254, <i>P</i> = 6.73×10<sup>−6</sup>), <i>ZNF71</i> (rs10404342, <i>P</i> = 7.60×10<sup>−6</sup>), <i>TLN1</i> (rs4879926, <i>P</i> = 7.74×10<sup>−6</sup>), and <i>SYNPO2</i> (rs1472066, <i>P</i> = 8.36×10<sup>−6</sup>; rs1038770, <i>P</i> = 8.66×10<sup>−6</sup>). Regarding the association of specific IgE to house dust mites, it was observed that intergenic SNPs nearby to <i>OPRK1</i> and <i>LOC730217</i> might be associated with <i>Dermatophagoides pteronyssinus</i> (D.p.) and <i>Dermatophagoides farinae</i> (D.f.) in asthmatics, respectively. In further pathway analysis, the phosphatidylinositol signaling system and adherens junction pathways were estimated to play a role in the regulation of total IgE levels in asthma. Although functional evaluations and replications of these results in other populations are needed, this GWAS of serum IgE in asthmatics could facilitate improved understanding of the role of the newly identified genetic variants in asthma and its related phenotypes.</p></div>", "links"=>[], "tags"=>["genetics", "Genome-wide association studies", "genome-wide", "serum", "mite-specific", "iges", "asthma"], "article_id"=>771200, "categories"=>["Biological Sciences"], "users"=>["Jeong-Hyun Kim", "Hyun Sub Cheong", "Jong Sook Park", "An-Soo Jang", "Soo-Taek Uh", "Yong-Hoon Kim", "Mi-Kyeong Kim", "Inseon S. Choi", "Sang Heon Cho", "Byoung Whui Choi", "Joon Seol Bae", "Choon-Sik Park", "Hyoung Doo Shin"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0071958.s001", "https://dx.doi.org/10.1371/journal.pone.0071958.s002", "https://dx.doi.org/10.1371/journal.pone.0071958.s003", "https://dx.doi.org/10.1371/journal.pone.0071958.s004", "https://dx.doi.org/10.1371/journal.pone.0071958.s005", "https://dx.doi.org/10.1371/journal.pone.0071958.s006", "https://dx.doi.org/10.1371/journal.pone.0071958.s007", "https://dx.doi.org/10.1371/journal.pone.0071958.s008", "https://dx.doi.org/10.1371/journal.pone.0071958.s009", "https://dx.doi.org/10.1371/journal.pone.0071958.s010", "https://dx.doi.org/10.1371/journal.pone.0071958.s011", "https://dx.doi.org/10.1371/journal.pone.0071958.s012", "https://dx.doi.org/10.1371/journal.pone.0071958.s013", "https://dx.doi.org/10.1371/journal.pone.0071958.s014", "https://dx.doi.org/10.1371/journal.pone.0071958.s015"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_A_Genome_Wide_Association_Study_of_Total_Serum_and_Mite_Specific_IgEs_in_Asthma_Patients_/771200", "title"=>"A Genome-Wide Association Study of Total Serum and Mite-Specific IgEs in Asthma Patients", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-08-13 02:18:28"}

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  • {"unique-ip"=>"8", "full-text"=>"32", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"10"}
  • {"unique-ip"=>"11", "full-text"=>"30", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2020", "month"=>"11"}
  • {"unique-ip"=>"15", "full-text"=>"12", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"13", "cited-by"=>"0", "year"=>"2020", "month"=>"12"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2021", "month"=>"1"}

Relative Metric

{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Computational biology", "average_usage"=>[295, 511, 651, 775, 882, 992, 1100, 1201, 1304, 1400, 1486, 1570, 1650]}, {"subject_area"=>"/Biology and life sciences/Immunology", "average_usage"=>[266, 466, 591, 701, 799, 887, 982, 1067, 1155, 1237, 1317, 1395, 1458]}, {"subject_area"=>"/Biology and life sciences/Organisms", "average_usage"=>[281, 484, 611, 728, 835, 934, 1030, 1123, 1214, 1299, 1383, 1464]}, {"subject_area"=>"/Medicine and health sciences/Clinical medicine", "average_usage"=>[263, 451, 582, 699, 797, 889, 969, 1045, 1134, 1215, 1284, 1362, 1412]}, {"subject_area"=>"/Medicine and health sciences/Pulmonology", "average_usage"=>[241, 428, 552, 659, 752, 848, 934, 1028, 1106, 1183, 1267, 1350, 1401]}]}
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