Default-Mode Network Changes in Huntington’s Disease: An Integrated MRI Study of Functional Connectivity and Morphometry
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{"title"=>"Default-mode network changes in Huntington's disease: An integrated MRI study of functional connectivity and morphometry", "type"=>"journal", "authors"=>[{"first_name"=>"Mario", "last_name"=>"Quarantelli", "scopus_author_id"=>"7004524756"}, {"first_name"=>"Elena", "last_name"=>"Salvatore", "scopus_author_id"=>"6603590758"}, {"first_name"=>"Sara Maria", "last_name"=>"Delle Acque Giorgio", "scopus_author_id"=>"56688609900"}, {"first_name"=>"Alessandro", "last_name"=>"Filla", "scopus_author_id"=>"55411798200"}, {"first_name"=>"Amedeo", "last_name"=>"Cervo", "scopus_author_id"=>"56397091800"}, {"first_name"=>"Cinzia Valeria", "last_name"=>"Russo", "scopus_author_id"=>"26039372000"}, {"first_name"=>"Sirio", "last_name"=>"Cocozza", "scopus_author_id"=>"56396408700"}, {"first_name"=>"Marco", "last_name"=>"Massarelli", "scopus_author_id"=>"25927380400"}, {"first_name"=>"Arturo", "last_name"=>"Brunetti", "scopus_author_id"=>"7103100891"}, {"first_name"=>"Giuseppe", "last_name"=>"De Michele", "scopus_author_id"=>"7005917994"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84904699367", "sgr"=>"84904699367", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0072159", "pmid"=>"23977239", "isbn"=>"1932-6203", "pui"=>"604820731"}, "id"=>"b5ea6214-920e-3c8b-8430-44213b29c607", "abstract"=>"Previous MRI studies of functional connectivity in pre-symptomatic mutation carriers of Huntington's disease (HD) have shown dysfunction of the Default-Mode Network (DMN). No data however are currently available on the DMN alterations in the symptomatic stages of the disease, which are characterized by cortical atrophy involving several DMN nodes. We assessed DMN integrity and its possible correlations with motor and cognitive symptoms in 26 symptomatic HD patients as compared to 22 normal volunteers, by analyzing resting state functional MRI data, using the Precuneal Cortex/Posterior Cingulate Cortices (PC/PCC) as seed, controlling at voxel level for the effect of atrophy by co-varying for gray matter volume. Direct correlation with PC/PCC was decreased, without correlation with atrophy, in the ventral medial prefrontal cortex (including anterior cingulate and subgenual cortex), right dorso-medial prefrontal cortex, and in the right inferior parietal cortex (mainly involving the angular gyrus). Negative correlations with PC/PCC were decreased bilaterally in the inferior parietal cortices, while a cluster in the right middle occipital gyrus presented increased correlation with PC/PCC. DMN changes in the ventral medial prefrontal cortex significantly correlated with the performance at the Stroop test (p = .0002). Widespread DMN changes, not correlating with the atrophy of the involved nodes, are present in symptomatic HD patients, and correlate with cognitive disturbances.", "link"=>"http://www.mendeley.com/research/defaultmode-network-changes-huntingtons-disease-integrated-mri-study-functional-connectivity-morphom", "reader_count"=>33, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Researcher"=>10, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>7, "Student > Postgraduate"=>3, "Student > Master"=>5, "Other"=>2, "Student > Bachelor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Researcher"=>10, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>7, "Student > Postgraduate"=>3, "Student > Master"=>5, "Other"=>2, "Student > Bachelor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>5, "Engineering"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Medicine and Dentistry"=>9, "Agricultural and Biological Sciences"=>3, "Neuroscience"=>5, "Psychology"=>8, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>9}, "Neuroscience"=>{"Neuroscience"=>5}, "Social Sciences"=>{"Social Sciences"=>1}, "Psychology"=>{"Psychology"=>8}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>5}}, "reader_count_by_country"=>{"United States"=>2, "Germany"=>1, "Russia"=>1}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1173956"], "description"=>"<p>Clusters resulting from the NV>HD (yellow) and HD>NV (cyan) between-group contrasts, corrected for differences in GM volume. Results are superimposed for anatomical reference to a single subject T1-weighted volume in the standard Montreal Neurological Institute stereotactic space. Significance for all clusters is p<.05 FWE-corrected at cluster level. Patient’s right is at the observer’s right. Axial planes are sampled every 7 mm, starting at Z = −30 mm.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Neurological system", "neuroanatomy", "neuroscience", "neuroimaging", "fmri", "neurology", "Huntington disease", "Neurodegenerative diseases", "radiology", "Diagnostic radiology", "Magnetic resonance imaging", "resting-state", "corrected"], "article_id"=>775643, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Mario Quarantelli", "Elena Salvatore", "Sara Maria Delle Acque Giorgio", "Alessandro Filla", "Amedeo Cervo", "Cinzia Valeria Russo", "Sirio Cocozza", "Marco Massarelli", "Arturo Brunetti", "Giuseppe De Michele"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0072159.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Results_of_resting_state_fMRI_analysis_corrected_for_atrophy_/775643", "title"=>"Results of resting-state fMRI analysis, corrected for atrophy.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-08-19 02:06:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/1173958"], "description"=>"<p>For each cluster the size before and after correction for atrophy using BPM is reported. For each involved structure, the maximum T-value and the corresponding coordinates (distances from the anterior commissure in mm) in the MNI space are reported.</p><p><b>VMPFC</b>: Ventral Medial PreFrontal Cortex; <b>rDMPFC</b>: right Dorso-Medial PreFrontal Cortex; <b>rANG</b>: right Angular Gyrus.</p><p>Structures involved by each cluster are reported with the corresponding MNI X/Y/Z coordinates and maximum T value.</p><p>Anatomical labeling is according to <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0072159#pone.0072159-TzourioMazoyer1\" target=\"_blank\">[40]</a>.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Neurological system", "neuroanatomy", "neuroscience", "neuroimaging", "fmri", "neurology", "Huntington disease", "Neurodegenerative diseases", "radiology", "Diagnostic radiology", "Magnetic resonance imaging", "between-group"], "article_id"=>775645, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Mario Quarantelli", "Elena Salvatore", "Sara Maria Delle Acque Giorgio", "Alessandro Filla", "Amedeo Cervo", "Cinzia Valeria Russo", "Sirio Cocozza", "Marco Massarelli", "Arturo Brunetti", "Giuseppe De Michele"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0072159.t002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Results_of_the_NV_gt_HD_between_group_contrast_/775645", "title"=>"Results of the NV>HD between-group contrast.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-08-19 02:06:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/1173959"], "description"=>"<p>For each cluster the size before and after correction for atrophy using BPM is reported. For each involved structure, the maximum T-value and the corresponding coordinates (distances from the anterior commissure in mm) in the MNI space are reported.</p><p><b>lSMG</b> and <b>rSMG</b>: left and right SupraMarginal Gyrus, respectively; <b>rOCC</b> and <b>lOCC</b>: right and left Occipital cortex, respectively; <b>lINS</b>: left Insula; <b>SMA</b>: Supplementary Motor Area.</p><p>Structures involved by each cluster are reported with the corresponding maximum T value.</p><p>Anatomical labeling is according to <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0072159#pone.0072159-TzourioMazoyer1\" target=\"_blank\">[40]</a>.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Neurological system", "neuroanatomy", "neuroscience", "neuroimaging", "fmri", "neurology", "Huntington disease", "Neurodegenerative diseases", "radiology", "Diagnostic radiology", "Magnetic resonance imaging", "between-group"], "article_id"=>775646, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Mario Quarantelli", "Elena Salvatore", "Sara Maria Delle Acque Giorgio", "Alessandro Filla", "Amedeo Cervo", "Cinzia Valeria Russo", "Sirio Cocozza", "Marco Massarelli", "Arturo Brunetti", "Giuseppe De Michele"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0072159.t003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Results_of_the_HD_gt_NV_between_group_contrast_/775646", "title"=>"Results of the HD>NV between-group contrast.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-08-19 02:06:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/1173960"], "description"=>"<p>SD: standard deviation.</p><p>N.A.: not applicable.</p>*<p>at Student’s t-test.</p>#<p>at Chi-squared test.</p>", "links"=>[], "tags"=>["Anatomy and physiology", "Neurological system", "neuroanatomy", "neuroscience", "neuroimaging", "fmri", "neurology", "Huntington disease", "Neurodegenerative diseases", "radiology", "Diagnostic radiology", "Magnetic resonance imaging", "demographics"], "article_id"=>775647, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Mario Quarantelli", "Elena Salvatore", "Sara Maria Delle Acque Giorgio", "Alessandro Filla", "Amedeo Cervo", "Cinzia Valeria Russo", "Sirio Cocozza", "Marco Massarelli", "Arturo Brunetti", "Giuseppe De Michele"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0072159.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Subject_demographics_and_clinical_variables_/775647", "title"=>"Subject demographics and clinical variables.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-08-19 02:06:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/1173962", "https://ndownloader.figshare.com/files/1173963", "https://ndownloader.figshare.com/files/1173964", "https://ndownloader.figshare.com/files/1173965", "https://ndownloader.figshare.com/files/1173966", "https://ndownloader.figshare.com/files/1173967"], "description"=>"<div><p>Previous MRI studies of functional connectivity in pre-symptomatic mutation carriers of Huntington’s disease (HD) have shown dysfunction of the Default-Mode Network (DMN). No data however are currently available on the DMN alterations in the symptomatic stages of the disease, which are characterized by cortical atrophy involving several DMN nodes. We assessed DMN integrity and its possible correlations with motor and cognitive symptoms in 26 symptomatic HD patients as compared to 22 normal volunteers, by analyzing resting state functional MRI data, using the Precuneal Cortex/Posterior Cingulate Cortices (PC/PCC) as seed, controlling at voxel level for the effect of atrophy by co-varying for gray matter volume. Direct correlation with PC/PCC was decreased, without correlation with atrophy, in the ventral medial prefrontal cortex (including anterior cingulate and subgenual cortex), right dorso-medial prefrontal cortex, and in the right inferior parietal cortex (mainly involving the angular gyrus). Negative correlations with PC/PCC were decreased bilaterally in the inferior parietal cortices, while a cluster in the right middle occipital gyrus presented increased correlation with PC/PCC. DMN changes in the ventral medial prefrontal cortex significantly correlated with the performance at the Stroop test (p = .0002). Widespread DMN changes, not correlating with the atrophy of the involved nodes, are present in symptomatic HD patients, and correlate with cognitive disturbances.</p></div>", "links"=>[], "tags"=>["Anatomy and physiology", "Neurological system", "neuroanatomy", "neuroscience", "neuroimaging", "fmri", "neurology", "Huntington disease", "Neurodegenerative diseases", "radiology", "Diagnostic radiology", "Magnetic resonance imaging", "mri", "connectivity"], "article_id"=>775649, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Mario Quarantelli", "Elena Salvatore", "Sara Maria Delle Acque Giorgio", "Alessandro Filla", "Amedeo Cervo", "Cinzia Valeria Russo", "Sirio Cocozza", "Marco Massarelli", "Arturo Brunetti", "Giuseppe De Michele"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0072159.s001", "https://dx.doi.org/10.1371/journal.pone.0072159.s002", "https://dx.doi.org/10.1371/journal.pone.0072159.s003", "https://dx.doi.org/10.1371/journal.pone.0072159.s004", "https://dx.doi.org/10.1371/journal.pone.0072159.s005", "https://dx.doi.org/10.1371/journal.pone.0072159.s006"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Default_Mode_Network_Changes_in_Huntington_8217_s_Disease_An_Integrated_MRI_Study_of_Functional_Connectivity_and_Morphometry_/775649", "title"=>"Default-Mode Network Changes in Huntington’s Disease: An Integrated MRI Study of Functional Connectivity and Morphometry", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-08-19 02:06:34"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}

Relative Metric

{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[269, 466, 588, 697, 800, 896, 988, 1076, 1165, 1254, 1340, 1417]}, {"subject_area"=>"/Biology and life sciences/Anatomy and physiology", "average_usage"=>[256, 428]}, {"subject_area"=>"/Biology and life sciences/Neuroscience", "average_usage"=>[261, 444, 554, 655, 748, 834, 923, 1004, 1089, 1170, 1244, 1315, 1380]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[264, 460, 584, 692, 794, 887, 978, 1067, 1154, 1241, 1328, 1408, 1474]}, {"subject_area"=>"/Medicine and health sciences/Anatomy and physiology", "average_usage"=>[253, 430]}, {"subject_area"=>"/Medicine and health sciences/Health care", "average_usage"=>[278, 463, 587, 692, 804, 897, 984, 1068, 1165, 1254, 1339, 1429, 1490]}]}
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