Influence of a Polyphenol-Enriched Protein Powder on Exercise-Induced Inflammation and Oxidative Stress in Athletes: A Randomized Trial Using a Metabolomics Approach
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{"title"=>"Influence of a Polyphenol-Enriched Protein Powder on Exercise-Induced Inflammation and Oxidative Stress in Athletes: A Randomized Trial Using a Metabolomics Approach", "type"=>"journal", "authors"=>[{"first_name"=>"David C.", "last_name"=>"Nieman", "scopus_author_id"=>"7102429071"}, {"first_name"=>"Nicholas D.", "last_name"=>"Gillitt", "scopus_author_id"=>"57032468500"}, {"first_name"=>"Amy M.", "last_name"=>"Knab", "scopus_author_id"=>"26664637800"}, {"first_name"=>"R. Andrew", "last_name"=>"Shanely", "scopus_author_id"=>"6602448272"}, {"first_name"=>"Kirk L.", "last_name"=>"Pappan", "scopus_author_id"=>"6602559060"}, {"first_name"=>"Fuxia", "last_name"=>"Jin", "scopus_author_id"=>"7201785075"}, {"first_name"=>"Mary Ann", "last_name"=>"Lila", "scopus_author_id"=>"6603252874"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84881598681", "issn"=>"19326203", "pui"=>"369579632", "sgr"=>"84881598681", "isbn"=>"1932-6203", "pmid"=>"23967286", "doi"=>"10.1371/journal.pone.0072215"}, "id"=>"f0225590-ed0e-3670-b064-50305e19fbae", "abstract"=>"OBJECTIVES: Polyphenol supplementation was tested as a countermeasure to inflammation and oxidative stress induced by 3-d intensified training. METHODS: Water soluble polyphenols from blueberry and green tea extracts were captured onto a polyphenol soy protein complex (PSPC). Subjects were recruited, and included 38 long-distance runners ages 19-45 years who regularly competed in road races. Runners successfully completing orientation and baseline testing (N = 35) were randomized to 40 g/d PSPC (N = 17) (2,136 mg/d gallic acid equivalents) or placebo (N = 18) for 17 d using double-blinded methods and a parallel group design, with a 3-d running period inserted at day 14 (2.5 h/d, 70% VO2max). Blood samples were collected pre- and post-14 d supplementation, and immediately and 14 h after the third day of running in subjects completing all aspects of the study (N = 16 PSPC, N = 15 placebo), and analyzed using a metabolomics platform with GC-MS and LC-MS. RESULTS: Metabolites characteristic of gut bacteria metabolism of polyphenols were increased with PSPC and 3 d running (e.g., hippurate, 4-hydroxyhippurate, 4-methylcatechol sulfate, 1.8-, 1.9-, 2.5-fold, respectively, P<0.05), an effect which persisted for 14-h post-exercise. Fatty acid oxidation and ketogenesis were induced by exercise in both groups, with more ketones at 14-h post-exercise in PSPC (3-hydroxybutyrate, 1.8-fold, P<0.05). Established biomarkers for inflammation (CRP, cytokines) and oxidative stress (protein carbonyls) did not differ between groups. CONCLUSIONS: PSPC supplementation over a 17-d period did not alter established biomarkers for inflammation and oxidative stress but was linked to an enhanced gut-derived phenolic signature and ketogenesis in runners during recovery from 3-d heavy exertion. TRIAL REGISTRATION: ClinicalTrials.gov, U.S. National Institutes of Health, identifier: NCT01775384.", "link"=>"http://www.mendeley.com/research/influence-polyphenolenriched-protein-powder-exerciseinduced-inflammation-oxidative-stress-athletes-r", "reader_count"=>92, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>17, "Student > Doctoral Student"=>9, "Student > Ph. D. Student"=>17, "Student > Postgraduate"=>8, "Other"=>9, "Student > Master"=>18, "Student > Bachelor"=>6, "Lecturer"=>4, "Lecturer > Senior Lecturer"=>2, "Unspecified"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>17, "Student > Doctoral Student"=>9, "Student > Ph. D. Student"=>17, "Student > Postgraduate"=>8, "Other"=>9, "Student > Master"=>18, "Student > Bachelor"=>6, "Lecturer"=>4, "Lecturer > Senior Lecturer"=>2, "Unspecified"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Agricultural and Biological Sciences"=>26, "Veterinary Science and Veterinary Medicine"=>1, "Chemistry"=>4, "Engineering"=>1, "Environmental Science"=>2, "Biochemistry, Genetics and Molecular Biology"=>7, "Nursing and Health Professions"=>1, "Medicine and Dentistry"=>25, "Neuroscience"=>1, "Sports and Recreations"=>16, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Psychology"=>2, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>25}, "Sports and Recreations"=>{"Sports and Recreations"=>16}, "Psychology"=>{"Psychology"=>2}, "Unspecified"=>{"Unspecified"=>4}, "Environmental Science"=>{"Environmental Science"=>2}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "Engineering"=>{"Engineering"=>1}, "Chemistry"=>{"Chemistry"=>4}, "Neuroscience"=>{"Neuroscience"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>26}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>7}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"Belgium"=>1, "United States"=>1, "United Kingdom"=>1, "Spain"=>2}, "group_count"=>6}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1171564"], "description"=>"<p>Subject flow diagram.</p>", "links"=>[], "tags"=>["Biochemistry", "lipids", "Lipid metabolism", "metabolism", "Protein metabolism", "Clinical immunology", "immunity", "inflammation", "Clinical research design", "clinical trials", "Diagnostic medicine", "pathology", "General pathology", "biomarkers", "Drugs and devices", "pharmacokinetics", "Drug metabolism", "nutrition", "Sports and exercise medicine"], "article_id"=>773930, "categories"=>["Medicine", "Biological Sciences"], "users"=>["David C. Nieman", "Nicholas D. Gillitt", "Amy M. Knab", "R. Andrew Shanely", "Kirk L. Pappan", "Fuxia Jin", "Mary Ann Lila"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0072215.g001", "stats"=>{"downloads"=>4, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Subject_flow_diagram_/773930", "title"=>"Subject flow diagram.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-08-15 03:35:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/1171565"], "description"=>"<p>For all figures: PSPC = red bars; placebo = gray;+ = mean; <sup>____</sup> = median; ○ = extreme data points; box = upper and lower quartiles; whiskers = maximum and minimum of distribution; * = group contrast difference P<0.05. The vertical axis represents the median scaled intensity.</p>", "links"=>[], "tags"=>["Biochemistry", "lipids", "Lipid metabolism", "metabolism", "Protein metabolism", "Clinical immunology", "immunity", "inflammation", "Clinical research design", "clinical trials", "Diagnostic medicine", "pathology", "General pathology", "biomarkers", "Drugs and devices", "pharmacokinetics", "Drug metabolism", "nutrition", "Sports and exercise medicine"], "article_id"=>773931, "categories"=>["Medicine", "Biological Sciences"], "users"=>["David C. Nieman", "Nicholas D. Gillitt", "Amy M. Knab", "R. Andrew Shanely", "Kirk L. Pappan", "Fuxia Jin", "Mary Ann Lila"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0072215.g002", "stats"=>{"downloads"=>2, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Serum_12_13_hydroxyoctadec_9_Z_enoate_DHOME_time_effect_P_lt_0_001_interaction_effect_P_8202_8202_0_9272_/773931", "title"=>"Serum 12,13-hydroxyoctadec-9(Z)-enoate (DHOME) (time effect, P<0.001; interaction effect, P = 0.9272).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-08-15 03:35:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/1171566"], "description"=>"<p>Serum cortisol (time effect, P<0.001; interaction effect, P = 0.466).</p>", "links"=>[], "tags"=>["Biochemistry", "lipids", "Lipid metabolism", "metabolism", "Protein metabolism", "Clinical immunology", "immunity", "inflammation", "Clinical research design", "clinical trials", "Diagnostic medicine", "pathology", "General pathology", "biomarkers", "Drugs and devices", "pharmacokinetics", "Drug metabolism", "nutrition", "Sports and exercise medicine", "cortisol"], "article_id"=>773932, "categories"=>["Medicine", "Biological Sciences"], "users"=>["David C. Nieman", "Nicholas D. Gillitt", "Amy M. Knab", "R. Andrew Shanely", "Kirk L. Pappan", "Fuxia Jin", "Mary Ann Lila"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0072215.g003", "stats"=>{"downloads"=>5, "page_views"=>20, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Serum_cortisol_time_effect_P_lt_0_001_interaction_effect_P_8202_8202_0_466_/773932", "title"=>"Serum cortisol (time effect, P<0.001; interaction effect, P = 0.466).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-08-15 03:35:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/1171570"], "description"=>"<p>Serum 3-hydroxybutyrate (group contrast at 14-h recovery, P = 0.005, Q = 0.246).</p>", "links"=>[], "tags"=>["Biochemistry", "lipids", "Lipid metabolism", "metabolism", "Protein metabolism", "Clinical immunology", "immunity", "inflammation", "Clinical research design", "clinical trials", "Diagnostic medicine", "pathology", "General pathology", "biomarkers", "Drugs and devices", "pharmacokinetics", "Drug metabolism", "nutrition", "Sports and exercise medicine", "3-hydroxybutyrate", "14-h"], "article_id"=>773934, "categories"=>["Medicine", "Biological Sciences"], "users"=>["David C. Nieman", "Nicholas D. Gillitt", "Amy M. Knab", "R. Andrew Shanely", "Kirk L. Pappan", "Fuxia Jin", "Mary Ann Lila"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0072215.g004", "stats"=>{"downloads"=>0, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Serum_3_hydroxybutyrate_group_contrast_at_14_h_recovery_P_8202_8202_0_005_Q_8202_8202_0_246_/773934", "title"=>"Serum 3-hydroxybutyrate (group contrast at 14-h recovery, P = 0.005, Q = 0.246).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-08-15 03:35:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/1171571"], "description"=>"<p>Serum acetoacetate (group contrast at 14-h recovery, P = 0.0105, Q = 0.265).</p>", "links"=>[], "tags"=>["Biochemistry", "lipids", "Lipid metabolism", "metabolism", "Protein metabolism", "Clinical immunology", "immunity", "inflammation", "Clinical research design", "clinical trials", "Diagnostic medicine", "pathology", "General pathology", "biomarkers", "Drugs and devices", "pharmacokinetics", "Drug metabolism", "nutrition", "Sports and exercise medicine", "acetoacetate", "14-h"], "article_id"=>773935, "categories"=>["Medicine", "Biological Sciences"], "users"=>["David C. Nieman", "Nicholas D. Gillitt", "Amy M. Knab", "R. Andrew Shanely", "Kirk L. Pappan", "Fuxia Jin", "Mary Ann Lila"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0072215.g005", "stats"=>{"downloads"=>2, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Serum_acetoacetate_group_contrast_at_14_h_recovery_P_8202_8202_0_0105_Q_8202_8202_0_265_/773935", "title"=>"Serum acetoacetate (group contrast at 14-h recovery, P = 0.0105, Q = 0.265).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-08-15 03:35:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/1171572"], "description"=>"<p>Serum hippurate (interaction effect, P = 0.0245; group contrasts immediately- and 14-h-post-exercise, P = 0.006 and 0.022, respectively; Q = 0.116 and 0.2648, respectively).</p>", "links"=>[], "tags"=>["Biochemistry", "lipids", "Lipid metabolism", "metabolism", "Protein metabolism", "Clinical immunology", "immunity", "inflammation", "Clinical research design", "clinical trials", "Diagnostic medicine", "pathology", "General pathology", "biomarkers", "Drugs and devices", "pharmacokinetics", "Drug metabolism", "nutrition", "Sports and exercise medicine", "hippurate", "contrasts", "immediately-"], "article_id"=>773936, "categories"=>["Medicine", "Biological Sciences"], "users"=>["David C. Nieman", "Nicholas D. Gillitt", "Amy M. Knab", "R. Andrew Shanely", "Kirk L. Pappan", "Fuxia Jin", "Mary Ann Lila"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0072215.g006", "stats"=>{"downloads"=>0, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Serum_hippurate_interaction_effect_P_8202_8202_0_0245_group_contrasts_immediately_and_14_h_post_exercise_P_8202_8202_0_006_and_0_022_respectively_Q_8202_8202_0_116_and_0_2648_respectively_/773936", "title"=>"Serum hippurate (interaction effect, P = 0.0245; group contrasts immediately- and 14-h-post-exercise, P = 0.006 and 0.022, respectively; Q = 0.116 and 0.2648, respectively).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-08-15 03:35:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/1171574"], "description"=>"<p>Serum 4-methylcatechol sulfate (interaction effect, P = 0.0017; group contrasts 14-days supplementation, P = 0.002, and immediately- and 14-h-post-exercise, P<0.001 and 0.0015, respectively; Q = 0.4392, 0.0083, and 0.1797, respectively).</p>", "links"=>[], "tags"=>["Biochemistry", "lipids", "Lipid metabolism", "metabolism", "Protein metabolism", "Clinical immunology", "immunity", "inflammation", "Clinical research design", "clinical trials", "Diagnostic medicine", "pathology", "General pathology", "biomarkers", "Drugs and devices", "pharmacokinetics", "Drug metabolism", "nutrition", "Sports and exercise medicine", "4-methylcatechol", "sulfate", "contrasts", "14-days", "immediately-"], "article_id"=>773938, "categories"=>["Medicine", "Biological Sciences"], "users"=>["David C. Nieman", "Nicholas D. Gillitt", "Amy M. Knab", "R. Andrew Shanely", "Kirk L. Pappan", "Fuxia Jin", "Mary Ann Lila"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0072215.g007", "stats"=>{"downloads"=>6, "page_views"=>221, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Serum_4_methylcatechol_sulfate_interaction_effect_P_8202_8202_0_0017_group_contrasts_14_days_supplementation_P_8202_8202_0_002_and_immediately_and_14_h_post_exercise_P_lt_0_001_and_0_0015_respectively_Q_8202_8202_0_4392_0_0083_and_0_1797_respectively_/773938", "title"=>"Serum 4-methylcatechol sulfate (interaction effect, P = 0.0017; group contrasts 14-days supplementation, P = 0.002, and immediately- and 14-h-post-exercise, P<0.001 and 0.0015, respectively; Q = 0.4392, 0.0083, and 0.1797, respectively).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-08-15 03:35:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/1171576"], "description"=>"<p>Serum 4-hydroxyhippurate (interaction effect, P = 0.0014; group contrast immediately-post-exercise, P = 0.0014).</p>", "links"=>[], "tags"=>["Biochemistry", "lipids", "Lipid metabolism", "metabolism", "Protein metabolism", "Clinical immunology", "immunity", "inflammation", "Clinical research design", "clinical trials", "Diagnostic medicine", "pathology", "General pathology", "biomarkers", "Drugs and devices", "pharmacokinetics", "Drug metabolism", "nutrition", "Sports and exercise medicine", "4-hydroxyhippurate"], "article_id"=>773940, "categories"=>["Medicine", "Biological Sciences"], "users"=>["David C. Nieman", "Nicholas D. Gillitt", "Amy M. Knab", "R. Andrew Shanely", "Kirk L. Pappan", "Fuxia Jin", "Mary Ann Lila"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0072215.g008", "stats"=>{"downloads"=>4, "page_views"=>36, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Serum_4_hydroxyhippurate_interaction_effect_P_8202_8202_0_0014_group_contrast_immediately_post_exercise_P_8202_8202_0_0014_/773940", "title"=>"Serum 4-hydroxyhippurate (interaction effect, P = 0.0014; group contrast immediately-post-exercise, P = 0.0014).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-08-15 03:35:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/1171578"], "description"=>"<p>Serum cinnamoylglycine (interaction effect, P = 0.0017; group contrasts immediately- and 14-h-post-exercise, P = 0.008 and 0.009, respectively; Q = 0.1421 and 0.265, respectively).</p>", "links"=>[], "tags"=>["Biochemistry", "lipids", "Lipid metabolism", "metabolism", "Protein metabolism", "Clinical immunology", "immunity", "inflammation", "Clinical research design", "clinical trials", "Diagnostic medicine", "pathology", "General pathology", "biomarkers", "Drugs and devices", "pharmacokinetics", "Drug metabolism", "nutrition", "Sports and exercise medicine", "cinnamoylglycine", "contrasts", "immediately-"], "article_id"=>773942, "categories"=>["Medicine", "Biological Sciences"], "users"=>["David C. Nieman", "Nicholas D. Gillitt", "Amy M. Knab", "R. Andrew Shanely", "Kirk L. Pappan", "Fuxia Jin", "Mary Ann Lila"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0072215.g009", "stats"=>{"downloads"=>0, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Serum_cinnamoylglycine_interaction_effect_P_8202_8202_0_0017_group_contrasts_immediately_and_14_h_post_exercise_P_8202_8202_0_008_and_0_009_respectively_Q_8202_8202_0_1421_and_0_265_respectively_/773942", "title"=>"Serum cinnamoylglycine (interaction effect, P = 0.0017; group contrasts immediately- and 14-h-post-exercise, P = 0.008 and 0.009, respectively; Q = 0.1421 and 0.265, respectively).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-08-15 03:35:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/1171579"], "description"=>"<p>Serum arabinose (interaction effect, P<0.001; group contrast immediately-post-exercise, P<0.001, Q<0.001).</p>", "links"=>[], "tags"=>["Biochemistry", "lipids", "Lipid metabolism", "metabolism", "Protein metabolism", "Clinical immunology", "immunity", "inflammation", "Clinical research design", "clinical trials", "Diagnostic medicine", "pathology", "General pathology", "biomarkers", "Drugs and devices", "pharmacokinetics", "Drug metabolism", "nutrition", "Sports and exercise medicine", "arabinose"], "article_id"=>773943, "categories"=>["Medicine", "Biological Sciences"], "users"=>["David C. Nieman", "Nicholas D. Gillitt", "Amy M. Knab", "R. Andrew Shanely", "Kirk L. Pappan", "Fuxia Jin", "Mary Ann Lila"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0072215.g010", "stats"=>{"downloads"=>0, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Serum_arabinose_interaction_effect_P_lt_0_001_group_contrast_immediately_post_exercise_P_lt_0_001_Q_lt_0_001_/773943", "title"=>"Serum arabinose (interaction effect, P<0.001; group contrast immediately-post-exercise, P<0.001, Q<0.001).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-08-15 03:35:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/1171581"], "description"=>"<p>Serum caffeine (interaction effect, P<0.001; group contrast immediately-post-exercise, P = 0.0012, Q = 0.0626).</p>", "links"=>[], "tags"=>["Biochemistry", "lipids", "Lipid metabolism", "metabolism", "Protein metabolism", "Clinical immunology", "immunity", "inflammation", "Clinical research design", "clinical trials", "Diagnostic medicine", "pathology", "General pathology", "biomarkers", "Drugs and devices", "pharmacokinetics", "Drug metabolism", "nutrition", "Sports and exercise medicine", "caffeine"], "article_id"=>773945, "categories"=>["Medicine", "Biological Sciences"], "users"=>["David C. Nieman", "Nicholas D. Gillitt", "Amy M. Knab", "R. Andrew Shanely", "Kirk L. Pappan", "Fuxia Jin", "Mary Ann Lila"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0072215.g011", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Serum_caffeine_interaction_effect_P_lt_0_001_group_contrast_immediately_post_exercise_P_8202_8202_0_0012_Q_8202_8202_0_0626_/773945", "title"=>"Serum caffeine (interaction effect, P<0.001; group contrast immediately-post-exercise, P = 0.0012, Q = 0.0626).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-08-15 03:35:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/1171583"], "description"=>"*<p>The first P-value for each variable is the group×time interaction effect, and the second is the time effect.</p><p>Abbreviations: PSPC = polyphenol soy protein complex; WBC = white blood cell count; CRP = C-reactive protein; IL = interleukin; MCP = monocyte chemoattractant protein; MPO = myeloperoxidase; FRAP = ferric reducing ability of plasma (expressed as ascorbic acid equivalents).</p>", "links"=>[], "tags"=>["Biochemistry", "lipids", "Lipid metabolism", "metabolism", "Protein metabolism", "Clinical immunology", "immunity", "inflammation", "Clinical research design", "clinical trials", "Diagnostic medicine", "pathology", "General pathology", "biomarkers", "Drugs and devices", "pharmacokinetics", "Drug metabolism", "nutrition", "Sports and exercise medicine", "oxidative", "markers", "pspc", "placebo", "groups"], "article_id"=>773947, "categories"=>["Medicine", "Biological Sciences"], "users"=>["David C. Nieman", "Nicholas D. Gillitt", "Amy M. Knab", "R. Andrew Shanely", "Kirk L. Pappan", "Fuxia Jin", "Mary Ann Lila"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0072215.t002", "stats"=>{"downloads"=>7, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Selected_inflammation_and_oxidative_stress_capacity_markers_in_PSPC_N_8202_8202_16_and_placebo_N_8202_8202_15_groups_mean_177_SD_/773947", "title"=>"Selected inflammation and oxidative stress/capacity markers in PSPC (N = 16) and placebo (N = 15) groups (mean±SD).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-08-15 03:35:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/1171584"], "description"=>"*<p>PSPC = polyphenol soy protein complex.</p>", "links"=>[], "tags"=>["Biochemistry", "lipids", "Lipid metabolism", "metabolism", "Protein metabolism", "Clinical immunology", "immunity", "inflammation", "Clinical research design", "clinical trials", "Diagnostic medicine", "pathology", "General pathology", "biomarkers", "Drugs and devices", "pharmacokinetics", "Drug metabolism", "nutrition", "Sports and exercise medicine"], "article_id"=>773948, "categories"=>["Medicine", "Biological Sciences"], "users"=>["David C. Nieman", "Nicholas D. Gillitt", "Amy M. Knab", "R. Andrew Shanely", "Kirk L. Pappan", "Fuxia Jin", "Mary Ann Lila"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0072215.t001", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Subject_characteristics_mean_177_SD_/773948", "title"=>"Subject characteristics (mean±SD).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-08-15 03:35:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/1171587", "https://ndownloader.figshare.com/files/1171588", "https://ndownloader.figshare.com/files/1171589", "https://ndownloader.figshare.com/files/1171591", "https://ndownloader.figshare.com/files/1171592", "https://ndownloader.figshare.com/files/1171596"], "description"=>"<div><p>Objectives</p><p>Polyphenol supplementation was tested as a countermeasure to inflammation and oxidative stress induced by 3-d intensified training.</p><p>Methods</p><p>Water soluble polyphenols from blueberry and green tea extracts were captured onto a polyphenol soy protein complex (PSPC). Subjects were recruited, and included 38 long-distance runners ages 19–45 years who regularly competed in road races. Runners successfully completing orientation and baseline testing (N = 35) were randomized to 40 g/d PSPC (N = 17) (2,136 mg/d gallic acid equivalents) or placebo (N = 18) for 17 d using double-blinded methods and a parallel group design, with a 3-d running period inserted at day 14 (2.5 h/d, 70% VO<sub>2max</sub>). Blood samples were collected pre- and post-14 d supplementation, and immediately and 14 h after the third day of running in subjects completing all aspects of the study (N = 16 PSPC, N = 15 placebo), and analyzed using a metabolomics platform with GC-MS and LC-MS.</p><p>Results</p><p>Metabolites characteristic of gut bacteria metabolism of polyphenols were increased with PSPC and 3 d running (e.g., hippurate, 4-hydroxyhippurate, 4-methylcatechol sulfate, 1.8-, 1.9-, 2.5-fold, respectively, P<0.05), an effect which persisted for 14-h post-exercise. Fatty acid oxidation and ketogenesis were induced by exercise in both groups, with more ketones at 14-h post-exercise in PSPC (3-hydroxybutyrate, 1.8-fold, P<0.05). Established biomarkers for inflammation (CRP, cytokines) and oxidative stress (protein carbonyls) did not differ between groups.</p><p>Conclusions</p><p>PSPC supplementation over a 17-d period did not alter established biomarkers for inflammation and oxidative stress but was linked to an enhanced gut-derived phenolic signature and ketogenesis in runners during recovery from 3-d heavy exertion.</p><p>Trial Registration</p><p>ClinicalTrials.gov, U.S. National Institutes of Health, identifier: <a href=\"http://clinicaltrials.gov/ct2/show/NCT01775384\" target=\"_blank\">NCT01775384</a></p></div>", "links"=>[], "tags"=>["Biochemistry", "lipids", "Lipid metabolism", "metabolism", "Protein metabolism", "Clinical immunology", "immunity", "inflammation", "Clinical research design", "clinical trials", "Diagnostic medicine", "pathology", "General pathology", "biomarkers", "Drugs and devices", "pharmacokinetics", "Drug metabolism", "nutrition", "Sports and exercise medicine", "polyphenol-enriched", "exercise-induced", "oxidative", "randomized", "metabolomics"], "article_id"=>773951, "categories"=>["Medicine", "Biological Sciences"], "users"=>["David C. Nieman", "Nicholas D. Gillitt", "Amy M. Knab", "R. Andrew Shanely", "Kirk L. Pappan", "Fuxia Jin", "Mary Ann Lila"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0072215.s001", "https://dx.doi.org/10.1371/journal.pone.0072215.s002", "https://dx.doi.org/10.1371/journal.pone.0072215.s003", "https://dx.doi.org/10.1371/journal.pone.0072215.s004", "https://dx.doi.org/10.1371/journal.pone.0072215.s005", "https://dx.doi.org/10.1371/journal.pone.0072215.s006"], "stats"=>{"downloads"=>29, "page_views"=>22, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Influence_of_a_Polyphenol_Enriched_Protein_Powder_on_Exercise_Induced_Inflammation_and_Oxidative_Stress_in_Athletes_A_Randomized_Trial_Using_a_Metabolomics_Approach_/773951", "title"=>"Influence of a Polyphenol-Enriched Protein Powder on Exercise-Induced Inflammation and Oxidative Stress in Athletes: A Randomized Trial Using a Metabolomics Approach", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-08-15 03:35:34"}

PMC Usage Stats | Further Information

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Relative Metric

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