A Large Animal Model for CNGB1 Autosomal Recessive Retinitis Pigmentosa
Publication Date
August 19, 2013
Journal
PLOS ONE
Authors
Paige A. Winkler, Kari J. Ekenstedt, Laurence M. Occelli, Anton V. Frattaroli, et al
Volume
8
Issue
8
Pages
e72229
DOI
https://dx.plos.org/10.1371/journal.pone.0072229
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0072229
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/23977260
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747135
Europe PMC
http://europepmc.org/abstract/MED/23977260
Web of Science
000323425700153
Scopus
84898608640
Mendeley
http://www.mendeley.com/research/large-animal-model-cngb1-autosomal-recessive-retinitis-pigmentosa
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"A large animal model for CNGB1 autosomal recessive retinitis pigmentosa", "type"=>"journal", "authors"=>[{"first_name"=>"Paige A.", "last_name"=>"Winkler", "scopus_author_id"=>"55607950900"}, {"first_name"=>"Kari J.", "last_name"=>"Ekenstedt", "scopus_author_id"=>"8631603200"}, {"first_name"=>"Laurence M.", "last_name"=>"Occelli", "scopus_author_id"=>"48662570800"}, {"first_name"=>"Anton V.", "last_name"=>"Frattaroli", "scopus_author_id"=>"56510206500"}, {"first_name"=>"Joshua T.", "last_name"=>"Bartoe", "scopus_author_id"=>"6701817705"}, {"first_name"=>"Patrick J.", "last_name"=>"Venta", "scopus_author_id"=>"7005464645"}, {"first_name"=>"Simon M.", "last_name"=>"Petersen-Jones", "scopus_author_id"=>"6701354436"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84898608640", "doi"=>"10.1371/journal.pone.0072229", "pui"=>"604820682", "pmid"=>"23977260", "scopus"=>"2-s2.0-84898608640", "issn"=>"19326203"}, "id"=>"a0056e45-55b5-3234-957b-925321c9b423", "abstract"=>"Retinal dystrophies in dogs are invaluable models of human disease. Progressive retinal atrophy (PRA) is the canine equivalent of retinitis pigmentosa (RP). Similar to RP, PRA is a genetically heterogenous condition. We investigated PRA in the Papillon breed of dog using homozygosity mapping and haplotype construction of single nucleotide polymorphisms within a small family group to identify potential positional candidate genes. Based on the phenotypic similarities between the PRA-affected Papillons, mouse models and human patients, CNGB1 was selected as the most promising positional candidate gene. CNGB1 was sequenced and a complex mutation consisting of the combination of a one basepair deletion and a 6 basepair insertion was identified in exon 26 (c.2387delA;2389_2390insAGCTAC) leading to a frameshift and premature stop codon. Immunohistochemistry (IHC) of pre-degenerate retinal sections from a young affected dog showed absence of labeling using a C-terminal CNGB1 antibody. Whereas an antibody directed against the N-terminus of the protein, which also recognizes the glutamic acid rich proteins arising from alternative splicing of the CNGB1 transcript (upstream of the premature stop codon), labeled rod outer segments. CNGB1 combines with CNGA1 to form the rod cyclic nucleotide gated channel and previous studies have shown the requirement of CNGB1 for normal targeting of CNGA1 to the rod outer segment. In keeping with these previous observations, IHC showed a lack of detectable CNGA1 protein in the rod outer segments of the affected dog. A population study did not identify the CNGB1 mutation in PRA-affected dogs in other breeds and documented that the CNGB1 mutation accounts for ~70% of cases of Papillon PRA in our PRA-affected canine DNA bank. CNGB1 mutations are one cause of autosomal recessive RP making the CNGB1 mutant dog a valuable large animal model of the condition.", "link"=>"http://www.mendeley.com/research/large-animal-model-cngb1-autosomal-recessive-retinitis-pigmentosa", "reader_count"=>12, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Researcher"=>1, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>1, "Student > Master"=>2, "Other"=>2, "Student > Bachelor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Researcher"=>1, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>1, "Student > Master"=>2, "Other"=>2, "Student > Bachelor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Nursing and Health Professions"=>1, "Agricultural and Biological Sciences"=>7, "Medicine and Dentistry"=>1, "Veterinary Science and Veterinary Medicine"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>7}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Unspecified"=>{"Unspecified"=>1}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>2}}, "group_count"=>0}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84898608640"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84898608640?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84898608640&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84898608640&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84898608640", "dc:identifier"=>"SCOPUS_ID:84898608640", "eid"=>"2-s2.0-84898608640", "dc:title"=>"A large animal model for CNGB1 autosomal recessive retinitis pigmentosa", "dc:creator"=>"Winkler P.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"8", "prism:issueIdentifier"=>"8", "prism:pageRange"=>nil, "prism:coverDate"=>"2013-08-19", "prism:coverDisplayDate"=>"19 August 2013", "prism:doi"=>"10.1371/journal.pone.0072229", "citedby-count"=>"21", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Michigan State University", "affiliation-city"=>"East Lansing", "affiliation-country"=>"United States"}], "pubmed-id"=>"23977260", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e72229", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0072229", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"26", "xml_views"=>"3", "html_views"=>"156"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"19", "xml_views"=>"1", "html_views"=>"125"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"11", "xml_views"=>"4", "html_views"=>"50"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"12", "xml_views"=>"2", "html_views"=>"88"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"74"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"60"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"89"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"9", "xml_views"=>"2", "html_views"=>"232"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"151"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"112"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"97"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"92"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"2", "html_views"=>"46"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"54"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"2", "html_views"=>"34"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"12", "xml_views"=>"3", "html_views"=>"28"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"28"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"16"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"47"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"17"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"79"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"82"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"71"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"45"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"60"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"39"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"36"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"36"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"24"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"59"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"33"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"14"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"15"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"5", "html_views"=>"7"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"6"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"9"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"17"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"7"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1174169", "https://ndownloader.figshare.com/files/1174175", "https://ndownloader.figshare.com/files/1174176", "https://ndownloader.figshare.com/files/1174177", "https://ndownloader.figshare.com/files/1174178", "https://ndownloader.figshare.com/files/1174179"], "description"=>"<div><p>Retinal dystrophies in dogs are invaluable models of human disease. Progressive retinal atrophy (PRA) is the canine equivalent of retinitis pigmentosa (RP). Similar to RP, PRA is a genetically heterogenous condition. We investigated PRA in the Papillon breed of dog using homozygosity mapping and haplotype construction of single nucleotide polymorphisms within a small family group to identify potential positional candidate genes. Based on the phenotypic similarities between the PRA-affected Papillons, mouse models and human patients, <i>CNGB1</i> was selected as the most promising positional candidate gene. <i>CNGB1</i> was sequenced and a complex mutation consisting of the combination of a one basepair deletion and a 6 basepair insertion was identified in exon 26 (c.2387delA;2389_2390insAGCTAC) leading to a frameshift and premature stop codon. Immunohistochemistry (IHC) of pre-degenerate retinal sections from a young affected dog showed absence of labeling using a C-terminal CNGB1 antibody. Whereas an antibody directed against the N-terminus of the protein, which also recognizes the glutamic acid rich proteins arising from alternative splicing of the CNGB1 transcript (upstream of the premature stop codon), labeled rod outer segments. CNGB1 combines with CNGA1 to form the rod cyclic nucleotide gated channel and previous studies have shown the requirement of CNGB1 for normal targeting of CNGA1 to the rod outer segment. In keeping with these previous observations, IHC showed a lack of detectable CNGA1 protein in the rod outer segments of the affected dog. A population study did not identify the <i>CNGB1</i> mutation in PRA-affected dogs in other breeds and documented that the <i>CNGB1</i> mutation accounts for ∼70% of cases of Papillon PRA in our PRA-affected canine DNA bank. <i>CNGB1</i> mutations are one cause of autosomal recessive RP making the <i>CNGB1</i> mutant dog a valuable large animal model of the condition.</p></div>", "links"=>[], "tags"=>["genetics", "Model organisms", "Animal models", "neuroscience", "Sensory systems", "Visual system", "systems biology", "ophthalmology", "Inherited eye disorders", "Retinal disorders", "Veterinary diseases", "autosomal", "recessive", "retinitis", "pigmentosa"], "article_id"=>775817, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Paige A. Winkler", "Kari J. Ekenstedt", "Laurence M. Occelli", "Anton V. Frattaroli", "Joshua T. Bartoe", "Patrick J. Venta", "Simon M. Petersen-Jones"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0072229.s001", "https://dx.doi.org/10.1371/journal.pone.0072229.s002", "https://dx.doi.org/10.1371/journal.pone.0072229.s003", "https://dx.doi.org/10.1371/journal.pone.0072229.s004", "https://dx.doi.org/10.1371/journal.pone.0072229.s005", "https://dx.doi.org/10.1371/journal.pone.0072229.s006"], "stats"=>{"downloads"=>25, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/A_Large_Animal_Model_for_CNGB1_Autosomal_Recessive_Retinitis_Pigmentosa/775817", "title"=>"A Large Animal Model for <i>CNGB1</i> Autosomal Recessive Retinitis Pigmentosa", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-08-19 02:31:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/1174167"], "description"=>"<p>1. Locations are all in respect to UCSC Genome Browser CanFam2.0 (<a href=\"http://genome.ucsc.edu\" target=\"_blank\">http://genome.ucsc.edu</a>).</p><p>2. Reference allele from UCSC Genome Browser CanFam2.0.</p><p>3. Variant allele from sequenced gDNA of Papillons.</p><p>4. Protein change due to the SNV found in either Papillons and/or cDNA. Change is in respect to CanFam2.0.</p><p>5. SNP number from Broad Institute SNP collection (<a href=\"http://www.broadinstitute.org/mammals/dog/snp2\" target=\"_blank\">http://www.broadinstitute.org/mammals/dog/snp2</a>).</p>", "links"=>[], "tags"=>["genetics", "Model organisms", "Animal models", "neuroscience", "Sensory systems", "Visual system", "systems biology", "ophthalmology", "Inherited eye disorders", "Retinal disorders", "Veterinary diseases", "nucleotide", "variant", "locations", "genomic", "papillon"], "article_id"=>775815, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Paige A. Winkler", "Kari J. Ekenstedt", "Laurence M. Occelli", "Anton V. Frattaroli", "Joshua T. Bartoe", "Patrick J. Venta", "Simon M. Petersen-Jones"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0072229.t003", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Single_nucleotide_variant_SNV_locations_in_genomic_Papillon_CNGB1_/775815", "title"=>"Single nucleotide variant (SNV) locations in genomic Papillon CNGB1.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-08-19 02:31:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/1174149"], "description"=>"<p>The SNPs are located in a 1.84 Mb region of homozygosity among the affected dogs (Only SNPs near the center of the region are shown). <i>CNGB1</i> is located at chr2:61,454,476–61,520,336 in the reference genome (canFam2.0). SNP genotypes are given in columns for each dog, with the family group data displayed to the left of the black back and all others to the right of the black bar. All affected dogs (1–3) share the same haplotype, obligate carriers (C1–2) each have one copy of the haplotype seen in the affected dogs and none of the unaffected dogs (U1–11) possess the haplotype seen in the affected dogs. A-Major allele, B-minor allele, as designated by Illumina (Illumin Inc, San Diego, CA).</p>", "links"=>[], "tags"=>["genetics", "Model organisms", "Animal models", "neuroscience", "Sensory systems", "Visual system", "systems biology", "ophthalmology", "Inherited eye disorders", "Retinal disorders", "Veterinary diseases", "affected", "unaffected"], "article_id"=>775797, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Paige A. Winkler", "Kari J. Ekenstedt", "Laurence M. Occelli", "Anton V. Frattaroli", "Joshua T. Bartoe", "Patrick J. Venta", "Simon M. Petersen-Jones"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0072229.g003", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_SNP_analysis_in_the_CNGB1_region_using_a_small_family_group_of_affected_and_unaffected_Papillons_/775797", "title"=>"SNP analysis in the <i>CNGB1</i> region using a small family group of affected and unaffected Papillons.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-08-19 02:31:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/1174163"], "description"=>"<p>1. Genotyping results: (+/+) means wild-type <i>CNGB1</i> sequence. M = mutant (c.2387delA;2389_2390insAGCTAC) genotype.</p><p>2. Not including colony dogs to avoid inflation of mutation presence in the general population of Papillon dogs.</p>", "links"=>[], "tags"=>["genetics", "Model organisms", "Animal models", "neuroscience", "Sensory systems", "Visual system", "systems biology", "ophthalmology", "Inherited eye disorders", "Retinal disorders", "Veterinary diseases", "genotypes", "139"], "article_id"=>775811, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Paige A. Winkler", "Kari J. Ekenstedt", "Laurence M. Occelli", "Anton V. Frattaroli", "Joshua T. Bartoe", "Patrick J. Venta", "Simon M. Petersen-Jones"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0072229.t004", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_PRA_type_1_genotypes_and_clinical_status_for_139_Papillons_/775811", "title"=>"PRA type 1 genotypes and clinical status for 139 Papillons.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-08-19 02:31:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/1174162"], "description"=>"<p>Images on the left are from the control dog and images on the right are from the affected dog. Panels A and B are stained with GARP-CNGB1 N-terminal antibody (green) and DAPI (blue). GARP proteins are present in both the control and affected samples. Panels C and D were stained with CNGB1 C-terminal antibody (green) and DAPI. CNGB1 full length protein is not detected in the affected sample. Panels E and F are stained with CNGA1 antibody (green) and DAPI. CNGA1 is not detected in the affected sample, presumably due to necessity for CNGB1 to form viable channels and normal trafficking. Size bar: 20 µm. OS- photoreceptor outer segment, IS – photoreceptor inner segment, ONL – outer nuclear layer, IPL – inner plexiform layer, INL – inner nuclear layer.</p>", "links"=>[], "tags"=>["genetics", "Model organisms", "Animal models", "neuroscience", "Sensory systems", "Visual system", "systems biology", "ophthalmology", "Inherited eye disorders", "Retinal disorders", "Veterinary diseases", "retinal", "sections", "matched", "affected"], "article_id"=>775810, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Paige A. Winkler", "Kari J. Ekenstedt", "Laurence M. Occelli", "Anton V. Frattaroli", "Joshua T. Bartoe", "Patrick J. Venta", "Simon M. Petersen-Jones"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0072229.g005", "stats"=>{"downloads"=>2, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Immunohistochemistry_on_frozen_retinal_sections_from_age_8_wk_and_sex_matched_female_control_and_affected_dogs_/775810", "title"=>"Immunohistochemistry on frozen retinal sections from age (8 wk) and sex matched (female) control and affected dogs.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-08-19 02:31:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/1174144"], "description"=>"<p>Note the progressive thinning of the outer nuclear layer of the retina in the affected animals. NFL/GCL – nerve fiber layer/ganglion cell layer; IPL – inner plexiform layer; INL – inner nuclear layer; OPL – outer plexiform layer; ONL – outer nuclear layer; PR – photoreceptor inner and outer segments; C – choroid. (Note the retinal pigment epithelium is not labeled).</p>", "links"=>[], "tags"=>["genetics", "Model organisms", "Animal models", "neuroscience", "Sensory systems", "Visual system", "systems biology", "ophthalmology", "Inherited eye disorders", "Retinal disorders", "Veterinary diseases", "sectional", "images", "retina", "mutant", "papillons", "wild-type"], "article_id"=>775792, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Paige A. Winkler", "Kari J. Ekenstedt", "Laurence M. Occelli", "Anton V. Frattaroli", "Joshua T. Bartoe", "Patrick J. Venta", "Simon M. Petersen-Jones"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0072229.g002", "stats"=>{"downloads"=>0, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_SD_OCT_cross_sectional_images_of_the_central_retina_from_CNGB1_mutant_Papillons_and_wild_type_controls_/775792", "title"=>"SD-OCT cross sectional images of the central retina from <i>CNGB1</i> mutant Papillons and wild-type controls.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-08-19 02:31:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/1174142"], "description"=>"<p>A. Dark-adapted ERG recordings at −2.4, −1.2 and 0.4 log cdS/m<sup>2</sup>. B. Light-adapted flash and flicker (33 Hz) ERG tracings. Background white light of 30 cd/m<sup>2</sup> and flash intensity of 0.4 log cdS/m<sup>2</sup>. The vertical bars on the flicker ERG indicates the flash timing.</p>", "links"=>[], "tags"=>["genetics", "Model organisms", "Animal models", "neuroscience", "Sensory systems", "Visual system", "systems biology", "ophthalmology", "Inherited eye disorders", "Retinal disorders", "Veterinary diseases", "erg", "tracings", "papillon", "pra-affected", "10", "weeks"], "article_id"=>775790, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Paige A. Winkler", "Kari J. Ekenstedt", "Laurence M. Occelli", "Anton V. Frattaroli", "Joshua T. Bartoe", "Patrick J. Venta", "Simon M. Petersen-Jones"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0072229.g001", "stats"=>{"downloads"=>1, "page_views"=>25, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Representative_ERG_tracings_from_a_normal_control_Papillon_and_a_PRA_affected_Papillon_both_10_weeks_of_age_/775790", "title"=>"Representative ERG tracings from a normal control Papillon and a PRA-affected Papillon, both 10 weeks of age.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-08-19 02:31:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/1174151"], "description"=>"<p>Sanger dideoxy-sequencing traces for part of <i>CNGB1</i> exon 26 are shown for an unaffected (A) and an affected (B) Papillon. Panel C shows the codon and amino acid alignment inferred from the traces in panels A and B, for the unaffected sequence (top) and affected Papillon mutation sequence (bottom). The complex Papillon mutation includes a 6 bp AGCTAC insertion between reference bases chr2:61,502,599–61,502,600 (yellow highlight in panel C and within yellow box in panel B) and an adenine deletion at chr2: 61,502,597 (red highlight in panel C and red triangle in panel B). The deletion causes a frameshift and premature stop codon within seven residues, including the two new, inserted codons.</p>", "links"=>[], "tags"=>["genetics", "Model organisms", "Animal models", "neuroscience", "Sensory systems", "Visual system", "systems biology", "ophthalmology", "Inherited eye disorders", "Retinal disorders", "Veterinary diseases", "mutation", "exon"], "article_id"=>775800, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Paige A. Winkler", "Kari J. Ekenstedt", "Laurence M. Occelli", "Anton V. Frattaroli", "Joshua T. Bartoe", "Patrick J. Venta", "Simon M. Petersen-Jones"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0072229.g004", "stats"=>{"downloads"=>0, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Papillon_mutation_in_CNGB1_exon_26_/775800", "title"=>"Papillon mutation in <i>CNGB1</i> exon 26.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-08-19 02:31:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/1174165"], "description"=>"<p>1. Locations are all in respect to UCSC Genome Browser CanFam2.0 (<a href=\"http://genome.ucsc.edu\" target=\"_blank\">http://genome.ucsc.edu</a>).</p><p>2. Capital letters are exonic DNA sequences and lower case bases are intronic regions.</p><p>End of coding region marked in Exon 33 row by underlined TGA.</p>", "links"=>[], "tags"=>["genetics", "Model organisms", "Animal models", "neuroscience", "Sensory systems", "Visual system", "systems biology", "ophthalmology", "Inherited eye disorders", "Retinal disorders", "Veterinary diseases", "exon", "boundries", "canine", "cngb1"], "article_id"=>775813, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Paige A. Winkler", "Kari J. Ekenstedt", "Laurence M. Occelli", "Anton V. Frattaroli", "Joshua T. Bartoe", "Patrick J. Venta", "Simon M. Petersen-Jones"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0072229.t002", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Intron_and_exon_boundries_for_canine_CNGB1_gene_/775813", "title"=>"Intron and exon boundries for canine CNGB1 gene.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-08-19 02:31:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/1174164"], "description"=>"<p>1. Locations are all in respect to UCSC Genome Browser CanFam2.0 (<a href=\"http://genome.ucsc.edu\" target=\"_blank\">http://genome.ucsc.edu</a>).</p><p>2. arRP - autosomal recessive retinitis pigmentosa. Gene abbreviations: <i>RBP3</i> - retinol binding protein 3, <i>RGR</i> - retinal G protein coupled receptor, <i>RD3</i> - retinal degeneration protein 3, <i>CRB1</i> - crumbs homolog 1, <i>TULP1</i> - tubby like protein 1, <i>CNGB1</i> - cyclic nucleotide gated channel beta 1.</p>", "links"=>[], "tags"=>["genetics", "Model organisms", "Animal models", "neuroscience", "Sensory systems", "Visual system", "systems biology", "ophthalmology", "Inherited eye disorders", "Retinal disorders", "Veterinary diseases", "homozygosity", "mb", "papillon"], "article_id"=>775812, "categories"=>["Medicine", "Biological Sciences"], "users"=>["Paige A. Winkler", "Kari J. Ekenstedt", "Laurence M. Occelli", "Anton V. Frattaroli", "Joshua T. Bartoe", "Patrick J. Venta", "Simon M. Petersen-Jones"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0072229.t001", "stats"=>{"downloads"=>5, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Regions_of_homozygosity_above_1_5_MB_from_small_Papillon_family_/775812", "title"=>"Regions of homozygosity above 1.5 MB from small Papillon family.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-08-19 02:31:19"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"8", "full-text"=>"13", "pdf"=>"1", "abstract"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"39", "full-text"=>"36", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"19", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"16", "full-text"=>"15", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"15", "full-text"=>"14", "pdf"=>"3", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"5", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"3", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"9", "full-text"=>"12", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"8", "full-text"=>"3", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"11", "full-text"=>"26", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"11", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"17", "full-text"=>"18", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"13", "full-text"=>"8", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"11", "full-text"=>"13", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"18", "full-text"=>"17", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"17", "full-text"=>"23", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"4", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"24", "full-text"=>"17", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"6", "cited-by"=>"1", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"16", "full-text"=>"13", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"29", "full-text"=>"42", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"9", "full-text"=>"6", "pdf"=>"3", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"40", "full-text"=>"42", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"38", "full-text"=>"69", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"39", "full-text"=>"61", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"26", "full-text"=>"42", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"22", "full-text"=>"25", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"34", "full-text"=>"40", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"18", "full-text"=>"18", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"23", "full-text"=>"23", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"8", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"10", "full-text"=>"7", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"5", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"4", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"12", "full-text"=>"9", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"12", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"2", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"12", "full-text"=>"8", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"11", "full-text"=>"13", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"14", "full-text"=>"11", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"11", "full-text"=>"9", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"15", "full-text"=>"13", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}

Relative Metric

{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[269, 466, 588, 697, 800, 896, 988, 1076, 1165, 1254, 1340, 1417]}, {"subject_area"=>"/Biology and life sciences/Cell biology", "average_usage"=>[272, 472, 600, 713, 815, 911, 1004, 1094, 1185, 1273, 1358, 1441]}, {"subject_area"=>"/Biology and life sciences/Evolutionary biology", "average_usage"=>[302, 488, 607, 717, 832, 931, 1024, 1117, 1212, 1302, 1389, 1469, 1535]}, {"subject_area"=>"/Biology and life sciences/Organisms", "average_usage"=>[281, 484, 611, 728, 835, 934, 1030, 1123, 1214, 1299, 1383, 1464]}, {"subject_area"=>"/Biology and life sciences/Population biology", "average_usage"=>[269, 448, 558, 658, 744, 830, 914, 995, 1068, 1139, 1214, 1284, 1349]}, {"subject_area"=>"/Biology and life sciences/Veterinary science", "average_usage"=>[313, 571, 709, 825, 944, 1048, 1145, 1261, 1354, 1434, 1524, 1599, 1684]}, {"subject_area"=>"/Biology and life sciences/Zoology", "average_usage"=>[294, 473, 591, 693, 788, 883, 972, 1054, 1140, 1222, 1299, 1381, 1446]}]}
Loading … Spinner
There are currently no alerts