The Effects of Caffeine on Sleep and Maturational Markers in the Rat
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{"title"=>"The Effects of Caffeine on Sleep and Maturational Markers in the Rat", "type"=>"journal", "authors"=>[{"first_name"=>"Nadja", "last_name"=>"Olini", "scopus_author_id"=>"55842334400"}, {"first_name"=>"Salomé", "last_name"=>"Kurth", "scopus_author_id"=>"36059654200"}, {"first_name"=>"Reto", "last_name"=>"Huber", "scopus_author_id"=>"7402557868"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84883378601", "sgr"=>"84883378601", "pui"=>"369736993", "isbn"=>"1932-6203 (Electronic)\r1932-6203 (Linking)", "pmid"=>"24023748", "doi"=>"10.1371/journal.pone.0072539"}, "id"=>"562e365e-8235-3023-8601-489e1806fcce", "abstract"=>"Adolescence is a critical period for brain maturation during which a massive reorganization of cortical connectivity takes place. In humans, slow wave activity (<4.5 Hz) during NREM sleep was proposed to reflect cortical maturation which relies on use-dependent processes. A stimulant like caffeine, whose consumption has recently increased especially in adolescents, is known to affect sleep wake regulation. The goal of this study was to establish a rat model allowing to assess the relationship between cortical maturation and sleep and to further investigate how these parameters are affected by caffeine consumption. To do so, we assessed sleep and markers of maturation by electrophysiological recordings, behavioral and structural readouts in the juvenile rat. Our results show that sleep slow wave activity follows a similar inverted U-shape trajectory as already known in humans. Caffeine treatment exerted short-term stimulating effects and altered the trajectory of slow wave activity. Moreover, caffeine affected behavioral and structural markers of maturation. Thus, caffeine consumption during a critical developmental period shows long lasting effects on sleep and brain maturation.", "link"=>"http://www.mendeley.com/research/effects-caffeine-sleep-maturational-markers-rat", "reader_count"=>47, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>8, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>9, "Student > Postgraduate"=>1, "Student > Master"=>6, "Other"=>1, "Student > Bachelor"=>16, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>8, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>9, "Student > Postgraduate"=>1, "Student > Master"=>6, "Other"=>1, "Student > Bachelor"=>16, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Nursing and Health Professions"=>2, "Medicine and Dentistry"=>12, "Agricultural and Biological Sciences"=>18, "Neuroscience"=>4, "Business, Management and Accounting"=>4, "Psychology"=>4}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>12}, "Neuroscience"=>{"Neuroscience"=>4}, "Psychology"=>{"Psychology"=>4}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>18}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>2}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>4}, "Unspecified"=>{"Unspecified"=>3}}, "reader_count_by_country"=>{"Austria"=>2, "Sweden"=>1, "United States"=>1, "France"=>1}, "group_count"=>4}

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  • {"files"=>["https://ndownloader.figshare.com/files/1189942"], "description"=>"<p>(<b>A, B, C</b>) The amount of grooming, quiet waking and exploration expressed as a percentage of total behavior are shown for P28 and P42. Significant changes across age are illustrated by an asterisk (p<0.05, paired Student's t-test). (<b>D</b>) The increase in object exploration time from P28 to P42 was reduced in caffeine (n = 9) compared to sham (n = 8) treated animals (#p<0.05, Mann-Whitney U-test).</p>", "links"=>[], "tags"=>[], "article_id"=>787934, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Nadja Olini", "Salomé Kurth", "Reto Huber"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0072539.g004", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Behavioral_changes_across_age_/787934", "title"=>"Behavioral changes across age.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-09-04 01:44:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/1189939"], "description"=>"<p>(<b>A</b>) Sample ECoG traces of a sham and caffeine treated animal on P30 and P38, respectively. (<b>B</b>) Trajectory of sleep slow wave activity (ECoG power between 1 and 4 Hz, averaged over the first 3 hours after light onset) between postnatal day 25 (P25) and P45 for sham (n = 17) and caffeine (n = 11) treated animals. The grey shaded background illustrates the period of caffeine administration. A two-way repeated measures ANOVA with factor age (P25–P45) and condition (caffeine and sham) was significant for age and condition (p<0.05). Crosses indicate increased SWA in caffeine compared to sham treated animals (black, p<0.05, gray, p<0.08), unpaired Student's t-test).</p>", "links"=>[], "tags"=>["trajectory", "sham", "caffeine", "treated"], "article_id"=>787931, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Nadja Olini", "Salomé Kurth", "Reto Huber"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0072539.g002", "stats"=>{"downloads"=>2, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_SWA_trajectory_across_age_in_sham_and_caffeine_treated_animals_/787931", "title"=>"SWA trajectory across age in sham and caffeine treated animals.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-09-04 01:44:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/1189951"], "description"=>"<p>Filled circles represent accumulated SWE (see Materials and Methods for details) in 3 hour intervals during the period when caffeine was initiated on P30 until the end of the second day of treatment (P31). The period of caffeine administration is illustrated by the grey shaded background. The white and black bars at the top of each graph indicate the 12 hour light and the 12 hour dark period, respectively. Crosses indicate reduced SWE in caffeine (n = 11) compared to sham (n = 17) treated animals (p<0.05, unpaired t-test). Error bars indicate SEM.</p>", "links"=>[], "tags"=>["caffeine"], "article_id"=>787943, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Nadja Olini", "Salomé Kurth", "Reto Huber"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0072539.g006", "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Caffeine_reduces_the_build_up_of_slow_wave_energy_SWE_during_early_caffeine_treatment_/787943", "title"=>"Caffeine reduces the build up of slow wave energy (SWE) during early caffeine treatment.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-09-04 01:44:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/1189940"], "description"=>"<p>Average NREM sleep EEG power between 0.5 and 25 Hz across 24 hours for sham treated animals is shown for P26 (n = 17), P28 (n = 17) and P38 (n = 15). Crosses indicate power differences across age (grey, p<0.05, black, p<0.01), paired Student's t-test).</p>", "links"=>[], "tags"=>["nrem"], "article_id"=>787933, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Nadja Olini", "Salomé Kurth", "Reto Huber"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0072539.g003", "stats"=>{"downloads"=>4, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_EEG_NREM_sleep_spectrum_across_age_/787933", "title"=>"EEG NREM sleep spectrum across age.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-09-04 01:44:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/1189937"], "description"=>"<p>Wakefulness and non rapid eye movement (NREM) sleep in sham (sh, n = 15) and caffeine (caf, n = 11) treated animals, expressed as a percentage of 12 hours recording time (rec. time) for the light and dark period before (P29), during (P31) and after (P38) caffeine treatment. A two-way repeated measures ANOVA with factor age (P29, P31 and P38) and condition (caffeine and sham) performed for NREM sleep and wakefulness during the light period was significant for age. The same analyses for NREM sleep and wakefulness during the dark period revealed an effect of age and an interaction between condition and age (all, p<0.05). The group comparison during caffeine application (P31) showed increased wakefulness and decreased NREM sleep during the dark period, respectively (#p<0.05, unpaired Student's t-test).</p>", "links"=>[], "tags"=>["states"], "article_id"=>787929, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Nadja Olini", "Salomé Kurth", "Reto Huber"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0072539.g001", "stats"=>{"downloads"=>2, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Vigilance_states_across_age_/787929", "title"=>"Vigilance states across age.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-09-04 01:44:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/1189949"], "description"=>"<p>(<b>A</b>) Representative example image of a coronal section stained for vesicular acetylcholine transporter protein (VAChT), a specific marker for cholinergic presynaptic terminals. The dotted black box indicates the location of the randomly selected images for further analyses. One example, indicated by the solid black box is enlarged for postnatal day 30 (P30, right image). Below representative images for P42 after either sham or caffeine treatment are shown. (<b>B</b>) Reduction of the VAChT stained area, assumed to reflect cholinergic presynaptic terminals from P30 to P42 (n = 6 per group, *p<0.05, Mann-Whitney U-test). Caffeine treated animals show a diminished reduction of presynaptic cholinergic terminals at P42.</p>", "links"=>[], "tags"=>[], "article_id"=>787941, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Nadja Olini", "Salomé Kurth", "Reto Huber"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0072539.g005", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Structural_changes_across_age_/787941", "title"=>"Structural changes across age.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-09-04 01:44:10"}

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  • {"unique-ip"=>"25", "full-text"=>"27", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
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  • {"unique-ip"=>"23", "full-text"=>"22", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
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  • {"unique-ip"=>"23", "full-text"=>"24", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"24", "full-text"=>"23", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"20", "full-text"=>"22", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"50", "full-text"=>"59", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
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  • {"unique-ip"=>"44", "full-text"=>"52", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
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  • {"unique-ip"=>"15", "full-text"=>"16", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}
  • {"unique-ip"=>"15", "full-text"=>"21", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"7"}
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Relative Metric

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