Splicing Variants of SERPINA1 Gene in Ovine Milk: Characterization of cDNA and Identification of Polymorphisms
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{"title"=>"Splicing Variants of SERPINA1 Gene in Ovine Milk: Characterization of cDNA and Identification of Polymorphisms", "type"=>"journal", "authors"=>[{"first_name"=>"Cinzia", "last_name"=>"Marchitelli", "scopus_author_id"=>"6507073143"}, {"first_name"=>"Alessandra", "last_name"=>"Crisà", "scopus_author_id"=>"6602430555"}, {"first_name"=>"Elisa", "last_name"=>"Mostarda", "scopus_author_id"=>"55834428800"}, {"first_name"=>"Francesco", "last_name"=>"Napolitano", "scopus_author_id"=>"35238425500"}, {"first_name"=>"Bianca", "last_name"=>"Moioli", "scopus_author_id"=>"6602432431"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "pui"=>"369642366", "doi"=>"10.1371/journal.pone.0073020", "sgr"=>"84882977720", "scopus"=>"2-s2.0-84882977720", "pmid"=>"24009725"}, "id"=>"d2ba6071-3f5e-3b51-af94-c321a9c648fa", "abstract"=>"The serine protease inhibitor, clade A, member 1 (SERPINA1) is the gene for a protein called alpha-1-antitrypsin (AAT), which is a member of the serine protease inhibitor (serpin) superfamily of proteins. By conformational change, serpins control several chemical reactions inhibiting the activity of proteases. AAT is the most abundant endogenous serpin in blood circulation and it is present in relatively high concentration in human milk as well as in bovine and porcine colostrum. Here we report for the first time the molecular characterization and sequence variability of the ovine SERPINA1 cDNA and gene. cDNAs from mammary gland and from milk were PCR amplified, and three different transcripts (1437, 1166 and 521bp) of the SERPINA1 gene were identified. We amplified and sequenced different regions of the gene (5' UTR, from exon 2 to exon 5 and 3' UTR), and we found that the exon-intron structure of the gene is similar to that of human and bovine. We detected a total of 97 SNPs in cDNAs and gene sequences from 10 sheep of three different breeds. In adult sheep tissues a SERPINA1 gene expression analysis indicated a differential expression of the three different transcripts. The finding reported in this paper will aid further studies on possible involvement of the SERPINA1 gene in different physiological states and its possible association with production traits.", "link"=>"http://www.mendeley.com/research/splicing-variants-serpina1-gene-ovine-milk-characterization-cdna-identification-polymorphisms", "reader_count"=>10, "reader_count_by_academic_status"=>{"Student > Doctoral Student"=>2, "Researcher"=>3, "Student > Ph. D. Student"=>1, "Other"=>1, "Student > Master"=>1, "Student > Bachelor"=>1, "Unspecified"=>1}, "reader_count_by_user_role"=>{"Student > Doctoral Student"=>2, "Researcher"=>3, "Student > Ph. D. Student"=>1, "Other"=>1, "Student > Master"=>1, "Student > Bachelor"=>1, "Unspecified"=>1}, "reader_count_by_subject_area"=>{"Environmental Science"=>1, "Medicine and Dentistry"=>1, "Agricultural and Biological Sciences"=>5, "Veterinary Science and Veterinary Medicine"=>2, "Unspecified"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>5}, "Environmental Science"=>{"Environmental Science"=>1}, "Unspecified"=>{"Unspecified"=>1}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>2}}, "reader_count_by_country"=>{"Germany"=>1}, "group_count"=>1}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1180866"], "description"=>"<p>RCL region is dotted underlined. The two amino acids important for the inhibitory AAT function are highlighted with a box.</p>", "links"=>[], "tags"=>["reactive", "aat"], "article_id"=>780994, "categories"=>["Biological Sciences"], "users"=>["Cinzia Marchitelli", "Alessandra Crisà", "Elisa Mostarda", "Francesco Napolitano", "Bianca Moioli"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0073020.g003", "stats"=>{"downloads"=>2, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Alignment_of_the_reactive_center_loop_RCL_region_25_aa_for_AAT_protein_in_different_mammalian_/780994", "title"=>"Alignment of the reactive center loop (RCL) region (25 aa) for AAT protein in different mammalian.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-08-23 01:37:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/1180862"], "description"=>"<p>Molecular weight markers on the left (lane M), cDNA from mammary gland Sarda (lane 1) and Gentile di Puglia (lane 2) breeds, and cDNA from milk cells of Sarda (lane 3) and Gentile di Puglia (lane 4) breeds. The three identified splicing variants are indicated by arrows on right side of pictograph.</p>", "links"=>[], "tags"=>["electrophoresis", "ovine", "cdna", "transcript"], "article_id"=>780990, "categories"=>["Biological Sciences"], "users"=>["Cinzia Marchitelli", "Alessandra Crisà", "Elisa Mostarda", "Francesco Napolitano", "Bianca Moioli"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0073020.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Gel_electrophoresis_of_ovine_SERPINA1_cDNA_transcript_variants_/780990", "title"=>"Gel electrophoresis of ovine <i>SERPINA1</i> cDNA transcript variants.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-08-23 01:37:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/1180863"], "description"=>"<p>A) Expression of <i>SERPINA1</i> transcript variants (indicated by arrows on right) and B) expression of ATPB5 control gene in various tissues. Lanes represent molecular weight marker (M) spleen (1), <i>semitendinosus</i> muscle (2), longissimus dorsi muscle (3), mammary gland (4), brain (5), cerebellum (6), rumen (7), bladder (8), adrenal (9), uterus (10) and liver (11)..</p>", "links"=>[], "tags"=>["ovine"], "article_id"=>780991, "categories"=>["Biological Sciences"], "users"=>["Cinzia Marchitelli", "Alessandra Crisà", "Elisa Mostarda", "Francesco Napolitano", "Bianca Moioli"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0073020.g002", "stats"=>{"downloads"=>1, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Representative_results_of_SERPINA1_gene_expression_in_different_ovine_tissues_/780991", "title"=>"Representative results of <i>SERPINA1</i> gene expression in different ovine tissues.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-08-23 01:37:37"}

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