Circulating Liver-Specific miR-122 as a Novel Potential Biomarker for Diagnosis of Cholestatic Liver Injury
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{"title"=>"Circulating Liver-Specific miR-122 as a Novel Potential Biomarker for Diagnosis of Cholestatic Liver Injury", "type"=>"journal", "authors"=>[{"first_name"=>"Huang", "last_name"=>"Shifeng", "scopus_author_id"=>"56275219200"}, {"first_name"=>"Wang", "last_name"=>"Danni", "scopus_author_id"=>"35208091200"}, {"first_name"=>"Chen", "last_name"=>"Pu", "scopus_author_id"=>"55866023900"}, {"first_name"=>"Yang", "last_name"=>"Ping", "scopus_author_id"=>"55865609200"}, {"first_name"=>"Cao", "last_name"=>"Ju", "scopus_author_id"=>"55866001500"}, {"first_name"=>"Zhang", "last_name"=>"Liping", "scopus_author_id"=>"56490474600"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"isbn"=>"10.1371/journal.pone.0073133", "pmid"=>"24086271", "doi"=>"10.1371/journal.pone.0073133", "pui"=>"369903728", "issn"=>"19326203", "sgr"=>"84884678063", "scopus"=>"2-s2.0-84884678063"}, "id"=>"64939254-10c4-3756-9e8a-fe7b4d4a3211", "abstract"=>"BACKGROUND: Circulating microRNA-122 (miR-122) has been increasingly reported to be a potential biomarker for drug-, viral-, alcohol- and chemical-induced liver injury. The present study was initiated to determine the potential of circulating miR-122 as a biomarker for cholestatic liver injury.\\n\\nMETHODS: Both bile-duct ligation (BDL) mice and patients with biliary calculi were employed as cholestatic liver injury models, and serum miR-122 level was determined by stem-loop real-time reverse-transcription PCR (SLqRT-PCR). All quantitative PCR values were normalized to those for U6 RNA and calculated with the 2(-△Ct) method.\\n\\nRESULTS: Serum miR-122 increased significantly after BDL-induced cholestatic injury and showed a similar time course to ALT concentrations. Compared with the sham controls, BDL mice had increased serum levels of miR-122 by 24.36±12.86, 423.63±322.89, 4.43±2.02 and 12.23±8.92 folds after 1, 3, 7 and 14 days, respectively. Moreover, serum miR-122 level was substantially higher in patients with biliary calculi than that in the healthy control group. In addition, patients with severe liver injury showed significantly higher levels of serum miR-122 when compared with healthy controls or patients with mild or moderate liver injury. Furthermore, serum miR-122 was found to show significant diagnostic value for biliary calculi by yielding an AUC (the areas under the receiver operating characteristic curve) of 0.931 with 77.4% sensitivity and 96.4% specificity in discriminating biliary calculi from healthy controls.\\n\\nCONCLUSION: Collectively, these data suggest that serum miR-122 has strong potential as a novel, specific and noninvasive biomarker for diagnosis of cholestasis-induced liver injury.", "link"=>"http://www.mendeley.com/research/circulating-liverspecific-mir122-novel-potential-biomarker-diagnosis-cholestatic-liver-injury-1", "reader_count"=>16, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Researcher"=>4, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Student > Master"=>1, "Other"=>1, "Student > Bachelor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Researcher"=>4, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Student > Master"=>1, "Other"=>1, "Student > Bachelor"=>2}, "reader_count_by_subject_area"=>{"Engineering"=>2, "Unspecified"=>2, "Medicine and Dentistry"=>4, "Agricultural and Biological Sciences"=>7, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>2}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>7}, "Unspecified"=>{"Unspecified"=>2}}, "reader_count_by_country"=>{"Belgium"=>1, "United States"=>1, "Germany"=>1}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1218356"], "description"=>"<p>(A) Comparison of miR-122 concentrations between healthy controls and patients; (B) Serum miR-122 concentrations in correlation with the liver injury degree (mild injury, 80 U/L300 U/L, n = 9). ***P<0.001.</p>", "links"=>[], "tags"=>["serum", "mir-122", "concentrations", "patients", "cholestatic"], "article_id"=>810016, "categories"=>["Uncategorised"], "users"=>["Huang Shifeng", "Wang Danni", "Chen Pu", "Yang Ping", "Cao Ju", "Zhang Liping"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0073133.g003", "stats"=>{"downloads"=>1, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Increased_serum_miR_122_concentrations_in_patients_with_cholestatic_liver_injury_/810016", "title"=>"Increased serum miR-122 concentrations in patients with cholestatic liver injury.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-09-27 01:59:03"}
  • {"files"=>["https://ndownloader.figshare.com/files/1218354"], "description"=>"<p>The values of miR-122 fold change and ALT, AST, ALP, TBIL and DBIL levels are the average of 5 independent samples from each time point, and data are presented as the mean and SD.</p>", "links"=>[], "tags"=>["courses", "serum", "concentrations", "tbil", "dbil"], "article_id"=>810014, "categories"=>["Uncategorised"], "users"=>["Huang Shifeng", "Wang Danni", "Chen Pu", "Yang Ping", "Cao Ju", "Zhang Liping"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0073133.g002", "stats"=>{"downloads"=>3, "page_views"=>49, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Time_courses_of_serum_concentrations_of_miR_122_ALT_AST_ALP_TBIL_and_DBIL_after_BDL_/810014", "title"=>"Time courses of serum concentrations of miR-122, ALT, AST, ALP, TBIL and DBIL after BDL.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-09-27 01:59:03"}
  • {"files"=>["https://ndownloader.figshare.com/files/1218359"], "description"=>"<p>Comparative ROC analysis for miR-122 and ALT /AST for discriminating cholestatic liver injury in human patients.</p>", "links"=>[], "tags"=>["roc", "mir-122", "alt", "discriminating", "cholestatic"], "article_id"=>810019, "categories"=>["Uncategorised"], "users"=>["Huang Shifeng", "Wang Danni", "Chen Pu", "Yang Ping", "Cao Ju", "Zhang Liping"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0073133.g005", "stats"=>{"downloads"=>1, "page_views"=>24, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparative_ROC_analysis_for_miR_122_and_ALT_AST_for_discriminating_cholestatic_liver_injury_in_human_patients_/810019", "title"=>"Comparative ROC analysis for miR-122 and ALT /AST for discriminating cholestatic liver injury in human patients.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-09-27 01:59:03"}
  • {"files"=>["https://ndownloader.figshare.com/files/1218358"], "description"=>"<p>ROC curve analysis of serum miR-122 concentration for discriminating cholestatic liver injury in human patients.</p>", "links"=>[], "tags"=>["serum", "mir-122", "discriminating", "cholestatic"], "article_id"=>810018, "categories"=>["Uncategorised"], "users"=>["Huang Shifeng", "Wang Danni", "Chen Pu", "Yang Ping", "Cao Ju", "Zhang Liping"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0073133.g004", "stats"=>{"downloads"=>3, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_ROC_curve_analysis_of_serum_miR_122_concentration_for_discriminating_cholestatic_liver_injury_in_human_patients_/810018", "title"=>"ROC curve analysis of serum miR-122 concentration for discriminating cholestatic liver injury in human patients.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-09-27 01:59:03"}
  • {"files"=>["https://ndownloader.figshare.com/files/1218352"], "description"=>"<p>The values of miR-122 fold change are the average of 5 independent samples from each time point, and the standard derivations are shown as error bars. Data are presented as the mean and SD. *P<0.05, and **P <0.005, Student t-test with Bonferroni correction.</p>", "links"=>[], "tags"=>["serum", "mir-122", "concentrations", "bdl"], "article_id"=>810012, "categories"=>["Uncategorised"], "users"=>["Huang Shifeng", "Wang Danni", "Chen Pu", "Yang Ping", "Cao Ju", "Zhang Liping"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0073133.g001", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Increased_serum_miR_122_concentrations_in_BDL_mice_/810012", "title"=>"Increased serum miR-122 concentrations in BDL mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-09-27 01:59:03"}
  • {"files"=>["https://ndownloader.figshare.com/files/1218361"], "description"=>"<p>Clinical characteristics of the healthy control and patient group.</p>", "links"=>[], "tags"=>[], "article_id"=>810021, "categories"=>["Uncategorised"], "users"=>["Huang Shifeng", "Wang Danni", "Chen Pu", "Yang Ping", "Cao Ju", "Zhang Liping"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0073133.t001", "stats"=>{"downloads"=>2, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Clinical_characteristics_of_the_healthy_control_and_patient_group_/810021", "title"=>"Clinical characteristics of the healthy control and patient group.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-09-27 01:59:03"}
  • {"files"=>["https://ndownloader.figshare.com/files/1218360"], "description"=>"<p>Distribution of patients based on clinical feature.</p>", "links"=>[], "tags"=>["patients"], "article_id"=>810020, "categories"=>["Uncategorised"], "users"=>["Huang Shifeng", "Wang Danni", "Chen Pu", "Yang Ping", "Cao Ju", "Zhang Liping"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0073133.t002", "stats"=>{"downloads"=>3, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Distribution_of_patients_based_on_clinical_feature_/810020", "title"=>"Distribution of patients based on clinical feature.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-09-27 01:59:03"}
  • {"files"=>["https://ndownloader.figshare.com/files/1218377", "https://ndownloader.figshare.com/files/1218378", "https://ndownloader.figshare.com/files/1218379"], "description"=>"<div><p>Background</p><p>Circulating microRNA-122 (miR-122) has been increasingly reported to be a potential biomarker for drug-, viral-, alcohol- and chemical-induced liver injury. The present study was initiated to determine the potential of circulating miR-122 as a biomarker for cholestatic liver injury.</p><p>Methods</p><p>Both bile-duct ligation (BDL) mice and patients with biliary calculi were employed as cholestatic liver injury models, and serum miR-122 level was determined by stem-loop real-time reverse-transcription PCR (SLqRT-PCR). All quantitative PCR values were normalized to those for U6 RNA and calculated with the 2<sup>−△Ct</sup> method.</p><p>Results</p><p>Serum miR-122 increased significantly after BDL-induced cholestatic injury and showed a similar time course to ALT concentrations. Compared with the sham controls, BDL mice had increased serum levels of miR-122 by 24.36±12.86, 423.63±322.89, 4.43±2.02 and 12.23±8.92 folds after 1, 3, 7 and 14 days, respectively. Moreover, serum miR-122 level was substantially higher in patients with biliary calculi than that in the healthy control group. In addition, patients with severe liver injury showed significantly higher levels of serum miR-122 when compared with healthy controls or patients with mild or moderate liver injury. Furthermore, serum miR-122 was found to show significant diagnostic value for biliary calculi by yielding an AUC (the areas under the receiver operating characteristic curve) of 0.931 with 77.4% sensitivity and 96.4% specificity in discriminating biliary calculi from healthy controls.</p><p>Conclusion</p><p>Collectively, these data suggest that serum miR-122 has strong potential as a novel, specific and noninvasive biomarker for diagnosis of cholestasis-induced liver injury.</p></div>", "links"=>[], "tags"=>["liver-specific", "mir-122", "biomarker", "cholestatic"], "article_id"=>810034, "categories"=>["Uncategorised"], "users"=>["Huang Shifeng", "Wang Danni", "Chen Pu", "Yang Ping", "Cao Ju", "Zhang Liping"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0073133.s001", "https://dx.doi.org/10.1371/journal.pone.0073133.s002", "https://dx.doi.org/10.1371/journal.pone.0073133.s003"], "stats"=>{"downloads"=>9, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Circulating_Liver_Specific_miR_122_as_a_Novel_Potential_Biomarker_for_Diagnosis_of_Cholestatic_Liver_Injury_/810034", "title"=>"Circulating Liver-Specific miR-122 as a Novel Potential Biomarker for Diagnosis of Cholestatic Liver Injury", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-09-27 01:59:03"}

PMC Usage Stats | Further Information

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Relative Metric

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