Influence of COMT val158met Genotype on the Depressed Brain during Emotional Processing and Working Memory
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{"title"=>"Influence of COMT val158met Genotype on the Depressed Brain during Emotional Processing and Working Memory", "type"=>"journal", "authors"=>[{"first_name"=>"Esther M.", "last_name"=>"Opmeer", "scopus_author_id"=>"36188680900"}, {"first_name"=>"Rudie", "last_name"=>"Kortekaas", "scopus_author_id"=>"23977851700"}, {"first_name"=>"Marie José", "last_name"=>"van Tol", "scopus_author_id"=>"15048810700"}, {"first_name"=>"Nic J.A.", "last_name"=>"van der Wee", "scopus_author_id"=>"6603371837"}, {"first_name"=>"Saskia", "last_name"=>"Woudstra", "scopus_author_id"=>"55178953900"}, {"first_name"=>"Mark A.", "last_name"=>"van Buchem", "scopus_author_id"=>"7005065927"}, {"first_name"=>"Brenda W.", "last_name"=>"Penninx", "scopus_author_id"=>"55800249300"}, {"first_name"=>"Dick J.", "last_name"=>"Veltman", "scopus_author_id"=>"7003711554"}, {"first_name"=>"André", "last_name"=>"Aleman", "scopus_author_id"=>"7006820955"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"369822173", "issn"=>"19326203", "isbn"=>"1932-6203", "doi"=>"10.1371/journal.pone.0073290", "scopus"=>"2-s2.0-84884184565", "pmid"=>"24069183", "sgr"=>"84884184565"}, "id"=>"4b5ecc9a-3bb8-3ba6-af83-9ce44495cbe1", "abstract"=>"Major depressive disorder (MDD) has been associated with abnormal prefrontal-limbic interactions and altered catecholaminergic neurotransmission. The val158met polymorphism on the catechol-O-methyltransferase (COMT) gene has been shown to influence prefrontal cortex (PFC) activation during both emotional processing and working memory (WM). Although COMT-genotype is not directly associated with MDD, it may affect MDD pathology by altering PFC activation, an endophenotype associated with both COMT and MDD. 125 participants, including healthy controls (HC, n=28) and MDD patients were genotyped for the COMT val158met polymorphism and underwent functional magnetic resonance imaging (fMRI-neuroimaging) during emotion processing (viewing of emotional facial expressions) and a WM task (visuospatial planning). Within HC, we observed a positive correlation between the number of met-alleles and right inferior frontal gyrus activation during emotional processing, whereas within patients the number of met-alleles was not correlated with PFC activation. During WM a negative correlation between the number of met-alleles and middle frontal gyrus activation was present in the total sample. In addition, during emotional processing there was an effect of genotype in a cluster including the amygdala and hippocampus. These results demonstrate that COMT genotype is associated with relevant endophenotypes for MDD. In addition, presence of MDD only interacts with genotype during emotional processing and not working memory.", "link"=>"http://www.mendeley.com/research/influence-comt-val158met-genotype-depressed-brain-during-emotional-processing-working-memory", "reader_count"=>33, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Researcher"=>3, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>1, "Student > Master"=>7, "Other"=>2, "Student > Bachelor"=>6, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Researcher"=>3, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>1, "Student > Master"=>7, "Other"=>2, "Student > Bachelor"=>6, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Medicine and Dentistry"=>13, "Agricultural and Biological Sciences"=>4, "Neuroscience"=>2, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Business, Management and Accounting"=>1, "Psychology"=>9}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>13}, "Neuroscience"=>{"Neuroscience"=>2}, "Psychology"=>{"Psychology"=>9}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>4}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Unspecified"=>{"Unspecified"=>3}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Denmark"=>1, "South Africa"=>1}, "group_count"=>2}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1203629"], "description"=>"<p>Red represents a positive correlation between number of met-alleles during processing of negative emotional facial expressions only in HC. The graph depicting the correlation between activity and number of met-alleles is located on the left. Blue represents a negative correlation between number of met-alleles and activity during working memory over all subjects. The graph depicting the correlation between activity and number of met-alleles is located on the right. The threshold was set at p<.001 uncorrected and the peak voxel had to survive <i>p</i><.05 family wise error (FWE) corrected for the spatial extent of the PFC with a small volume correction (see methods).</p>", "links"=>[], "tags"=>["cortical", "correlated", "met-alleles"], "article_id"=>798797, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Esther M. Opmeer", "Rudie Kortekaas", "Marie-José van Tol", "Nic J. A. van der Wee", "Saskia Woudstra", "Mark A. van Buchem", "Brenda W. Penninx", "Dick J. Veltman", "André Aleman"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0073290.g001", "stats"=>{"downloads"=>3, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Prefrontal_cortical_activity_correlated_with_number_of_met_alleles_during_emotional_and_working_memory_processing_hypothesis_testing_/798797", "title"=>"Prefrontal cortical activity correlated with number of met-alleles during emotional and working memory processing: hypothesis testing.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-09-12 03:41:55"}
  • {"files"=>["https://ndownloader.figshare.com/files/1203630"], "description"=>"<p>A. Positive correlation between the number of met-alleles and activitation in the left hippocampus/amygdala. A threshold was set at p<.001 uncorrected.</p>", "links"=>[], "tags"=>["activation", "correlations", "exploratory"], "article_id"=>798798, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Esther M. Opmeer", "Rudie Kortekaas", "Marie-José van Tol", "Nic J. A. van der Wee", "Saskia Woudstra", "Mark A. van Buchem", "Brenda W. Penninx", "Dick J. Veltman", "André Aleman"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0073290.g002", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Hippocampal_activation_during_emotional_processing_showing_correlations_with_number_of_met_alleles_exploratory_analysis_/798798", "title"=>"Hippocampal activation during emotional processing showing correlations with number of met-alleles: exploratory analysis.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-09-12 03:41:55"}
  • {"files"=>["https://ndownloader.figshare.com/files/1203632"], "description"=>"<div><p>Major depressive disorder (MDD) has been associated with abnormal prefrontal-limbic interactions and altered catecholaminergic neurotransmission. The val158met polymorphism on the catechol-O-methyltransferase (COMT) gene has been shown to influence prefrontal cortex (PFC) activation during both emotional processing and working memory (WM). Although COMT-genotype is not directly associated with MDD, it may affect MDD pathology by altering PFC activation, an endophenotype associated with both COMT and MDD. 125 participants, including healthy controls (HC, n=28) and MDD patients were genotyped for the COMT val158met polymorphism and underwent functional magnetic resonance imaging (fMRI-neuroimaging) during emotion processing (viewing of emotional facial expressions) and a WM task (visuospatial planning). Within HC, we observed a positive correlation between the number of met-alleles and right inferior frontal gyrus activation during emotional processing, whereas within patients the number of met-alleles was not correlated with PFC activation. During WM a negative correlation between the number of met-alleles and middle frontal gyrus activation was present in the total sample. In addition, during emotional processing there was an effect of genotype in a cluster including the amygdala and hippocampus. These results demonstrate that COMT genotype is associated with relevant endophenotypes for MDD. In addition, presence of MDD only interacts with genotype during emotional processing and not working memory.</p> </div>", "links"=>[], "tags"=>["comt", "val158met", "genotype"], "article_id"=>798799, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Esther M. Opmeer", "Rudie Kortekaas", "Marie-José van Tol", "Nic J. A. van der Wee", "Saskia Woudstra", "Mark A. van Buchem", "Brenda W. Penninx", "Dick J. Veltman", "André Aleman"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0073290", "stats"=>{"downloads"=>0, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Influence_of_COMT_val158met_Genotype_on_the_Depressed_Brain_during_Emotional_Processing_and_Working_Memory_/798799", "title"=>"Influence of COMT val158met Genotype on the Depressed Brain during Emotional Processing and Working Memory", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-09-12 03:41:55"}

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Relative Metric

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