Subcutaneous Interferon β-1a May Protect against Cognitive Impairment in Patients with Relapsing–Remitting Multiple Sclerosis: 5-Year Follow-up of the COGIMUS Study
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{"title"=>"Subcutaneous Interferon β-1a May Protect against Cognitive Impairment in Patients with Relapsing-Remitting Multiple Sclerosis: 5-Year Follow-up of the COGIMUS Study", "type"=>"journal", "authors"=>[{"first_name"=>"Francesco", "last_name"=>"Patti", "scopus_author_id"=>"7006700571"}, {"first_name"=>"Vincenzo Brescia", "last_name"=>"Morra", "scopus_author_id"=>"6603751678"}, {"first_name"=>"Maria Pia", "last_name"=>"Amato", "scopus_author_id"=>"7103061535"}, {"first_name"=>"Maria", "last_name"=>"Trojano", "scopus_author_id"=>"7005165969"}, {"first_name"=>"Stefano", "last_name"=>"Bastianello", "scopus_author_id"=>"7006402583"}, {"first_name"=>"Maria Rosalia", "last_name"=>"Tola", "scopus_author_id"=>"7006509370"}, {"first_name"=>"Salvatore", "last_name"=>"Cottone", "scopus_author_id"=>"35606424800"}, {"first_name"=>"Andrea", "last_name"=>"Plant", "scopus_author_id"=>"57196846406"}, {"first_name"=>"Orietta", "last_name"=>"Picconi", "scopus_author_id"=>"35068545000"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84883416256", "pui"=>"369734484", "doi"=>"10.1371/journal.pone.0074111", "isbn"=>"1932-6203 (Electronic)\r1932-6203 (Linking)", "sgr"=>"84883416256", "pmid"=>"24137499"}, "id"=>"52aff39e-47a2-3353-a893-be172a9af8de", "abstract"=>"OBJECTIVE: To assess the effects of subcutaneous (sc) interferon (IFN) -1a on cognition over 5 years in mildly disabled patients with relapsing-remitting multiple sclerosis (RRMS).\\n\\nMETHODS: Patients aged 18-50 years with RRMS (Expanded Disability Status Scale score ≤4.0) who had completed the 3-year COGIMUS study underwent standardized magnetic resonance imaging, neurological examination, and neuropsychological testing at years 4 and 5. Predictors of cognitive impairment at year 5 were identified using multivariate analysis.\\n\\nRESULTS: Of 331 patients who completed the 3-year COGIMUS study, 265 participated in the 2-year extension study, 201 of whom (75.8%; sc IFN β-1a three times weekly: 44 µg, n = 108; 22 µg, n = 93) completed 5 years' follow-up. The proportion of patients with cognitive impairment in the study population overall remained stable between baseline (18.0%) and year 5 (22.6%). The proportion of patients with cognitive impairment also remained stable in both treatment groups between baseline and year 5, and between year 3 and year 5. However, a significantly higher proportion of men than women had cognitive impairment at year 5 (26.5% vs 14.4%, p = 0.046). Treatment with the 22 versus 44 µg dose was predictive of cognitive impairment at year 5 (hazard ratio 0.68; 95% confidence interval 0.48-0.97).\\n\\nCONCLUSIONS: This study suggests that sc IFN β-1a dose-dependently stabilizes or delays cognitive impairment over a 5-year period in most patients with mild RRMS. Women seem to be more protected against developing cognitive impairment, which may indicate greater response to therapy or the inherently better prognosis associated with female sex in MS.", "link"=>"http://www.mendeley.com/research/subcutaneous-interferon-%CE%B21a-protect-against-cognitive-impairment-patients-relapsingremitting-multipl", "reader_count"=>30, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>2, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>7, "Student > Postgraduate"=>2, "Student > Master"=>4, "Other"=>5, "Student > Bachelor"=>2, "Lecturer"=>1, "Professor"=>4}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>2, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>7, "Student > Postgraduate"=>2, "Student > Master"=>4, "Other"=>5, "Student > Bachelor"=>2, "Lecturer"=>1, "Professor"=>4}, "reader_count_by_subject_area"=>{"Nursing and Health Professions"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Medicine and Dentistry"=>14, "Agricultural and Biological Sciences"=>1, "Neuroscience"=>6, "Psychology"=>6, "Unspecified"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>14}, "Neuroscience"=>{"Neuroscience"=>6}, "Psychology"=>{"Psychology"=>6}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"Brazil"=>1, "Spain"=>1}, "group_count"=>2}

Scopus | Further Information

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Figshare

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Relative Metric

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