Common Genetic Variation near MC4R Has a Sex-Specific Impact on Human Brain Structure and Eating Behavior
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{"title"=>"Common Genetic Variation near MC4R Has a Sex-Specific Impact on Human Brain Structure and Eating Behavior", "type"=>"journal", "authors"=>[{"first_name"=>"Annette", "last_name"=>"Horstmann", "scopus_author_id"=>"9734598600"}, {"first_name"=>"Peter", "last_name"=>"Kovacs", "scopus_author_id"=>"55728560000"}, {"first_name"=>"Stefan", "last_name"=>"Kabisch", "scopus_author_id"=>"41561576900"}, {"first_name"=>"Yvonne", "last_name"=>"Boettcher", "scopus_author_id"=>"14055482600"}, {"first_name"=>"Haiko", "last_name"=>"Schloegl", "scopus_author_id"=>"11141419100"}, {"first_name"=>"Anke", "last_name"=>"Tönjes", "scopus_author_id"=>"6508158868"}, {"first_name"=>"Michael", "last_name"=>"Stumvoll", "scopus_author_id"=>"56965303600"}, {"first_name"=>"Burkhard", "last_name"=>"Pleger", "scopus_author_id"=>"6603629269"}, {"first_name"=>"Arno", "last_name"=>"Villringer", "scopus_author_id"=>"7007157177"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84884171659", "sgr"=>"84884171659", "issn"=>"19326203", "isbn"=>"1932-6203", "pmid"=>"24066140", "doi"=>"10.1371/journal.pone.0074362", "pui"=>"369822331"}, "id"=>"1fd23e62-12a4-3661-869b-32f99113acbb", "abstract"=>"Obesity is associated with genetic and environmental factors but the underlying mechanisms remain poorly understood. Recent genome-wide association studies (GWAS) identified obesity- and type 2 diabetes-associated genetic variants located within or near genes that modulate brain activity and development. Among the top hits is rs17782313 near MC4R, encoding for the melanocortin-4-receptor, which is expressed in brain regions that regulate eating. Here, we hypothesized rs17782313-associated changes in human brain regions that regulate eating behavior. Therefore, we examined effects of common variants at rs17782313 near MC4R on brain structure and eating behavior. Only in female homozygous carriers of the risk allele we found significant increases of gray matter volume (GMV) in the right amygdala, a region known to influence eating behavior, and the right hippocampus, a structure crucial for memory formation and learning. Further, we found bilateral increases in medial orbitofrontal cortex, a multimodal brain structure encoding the subjective value of reinforcers, and bilateral prefrontal cortex, a higher order regulation area. There was no association between rs17782313 and brain structure in men. Moreover, among female subjects only, we observed a significant increase of 'disinhibition', and, more specifically, on 'emotional eating' scores of the Three Factor Eating Questionnaire in carriers of the variant rs17782313's risk allele. These findings suggest that rs17782313's effect on eating behavior is mediated by central mechanisms and that these effects are sex-specific.", "link"=>"http://www.mendeley.com/research/common-genetic-variation-near-mc4r-sexspecific-impact-human-brain-structure-eating-behavior-2", "reader_count"=>33, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>8, "Student > Doctoral Student"=>8, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>1, "Student > Master"=>3, "Other"=>1, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>8, "Student > Doctoral Student"=>8, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>1, "Student > Master"=>3, "Other"=>1, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>3, "Medicine and Dentistry"=>7, "Agricultural and Biological Sciences"=>14, "Neuroscience"=>4, "Veterinary Science and Veterinary Medicine"=>1, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>7}, "Neuroscience"=>{"Neuroscience"=>4}, "Social Sciences"=>{"Social Sciences"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>14}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>3}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"United States"=>1, "Germany"=>1}, "group_count"=>5}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1205044"], "description"=>"<p>Detailed description of regions with a significant interaction between gender and rs17782313 near <i>MC4R</i>.</p>", "links"=>[], "tags"=>["regions", "rs17782313"], "article_id"=>799885, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Annette Horstmann", "Peter Kovacs", "Stefan Kabisch", "Yvonne Boettcher", "Haiko Schloegl", "Anke Tönjes", "Michael Stumvoll", "Burkhard Pleger", "Arno Villringer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0074362.t003", "stats"=>{"downloads"=>1, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Detailed_description_of_regions_with_a_significant_interaction_between_gender_and_rs17782313_near_MC4R_/799885", "title"=>"Detailed description of regions with a significant interaction between gender and rs17782313 near <i>MC4R</i>.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-09-16 01:39:26"}
  • {"files"=>["https://ndownloader.figshare.com/files/1205043"], "description"=>"<p>Data are presented as medians and interquartile range in round brackets, 95% confidence intervals of the median based on 1,000 bootstrap samples are given in squared brackets. n: number of participants per category, TFEQ 51: Three Factor Eating Questionnaire, TFEQ R18: Revised and shortened version of the TFEQ, MAF: Minor Allele Frequency (describes the fraction of the minor allele, C, considering the sum of all alleles), p<sup>a</sup>: p-value of Kruskal-Wallis one-way analysis of variance, p<sup>b</sup>: p-value of Kruskal-Wallis one-way analysis of variance on residuals after correcting for age and BMI. * =  significant (p<.05) association with BMI in linear regression model, <sup>#</sup> = significant (p<.05) association with age in linear regression model.</p>", "links"=>[], "tags"=>["rs17782313"], "article_id"=>799884, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Annette Horstmann", "Peter Kovacs", "Stefan Kabisch", "Yvonne Boettcher", "Haiko Schloegl", "Anke Tönjes", "Michael Stumvoll", "Burkhard Pleger", "Arno Villringer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0074362.t002", "stats"=>{"downloads"=>1, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Detailed_demographic_and_questionnaire_data_split_by_gender_and_rs17782313_near_MC4R_/799884", "title"=>"Detailed demographic and questionnaire data split by gender and rs17782313 near MC4R.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-09-16 01:39:26"}
  • {"files"=>["https://ndownloader.figshare.com/files/1205040"], "description"=>"<p>Sex-specific effects of genotype at rs17782313 on GMV in the right amygdala/hippocampus (z-value 3.97, x = 14, y = −6, z = −22) and bilateral medial orbitofrontal cortex (OFC; left OFC: z-value 3.95, x = −12, y = 24, z = −22; right OFC: z-value 3.76, x = 12, y = 20, z = −20), adjusted for participant’s BMI, age, global gray and white matter volume (interaction between gender and genotype, voxel-wise threshold p<.005, cluster threshold p<.05, corrected for non-isotropic smoothness, indicated by red color). Female homozygous carriers of the minor allele (CC) had higher values than heterozygous subjects (AC) or non-carriers (AA, voxel-wise threshold p<.001, cluster threshold p<.05, corrected for non-isotropic smoothness). No significant difference was found for men.</p>", "links"=>[], "tags"=>["rs17782313"], "article_id"=>799881, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Annette Horstmann", "Peter Kovacs", "Stefan Kabisch", "Yvonne Boettcher", "Haiko Schloegl", "Anke Tönjes", "Michael Stumvoll", "Burkhard Pleger", "Arno Villringer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0074362.g002", "stats"=>{"downloads"=>2, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Sex_specific_association_between_rs17782313_and_gray_matter_volume_GMV_/799881", "title"=>"Sex-specific association between rs17782313 and gray matter volume (GMV).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-09-16 01:39:26"}
  • {"files"=>["https://ndownloader.figshare.com/files/1205039"], "description"=>"<p>Female homozygous carriers of the minor allele (CC) had significantly higher scores than both female heterozygous subjects (AC; difference in means 3.42, standard error 1.25, p = .024) and female subjects carrying no minor allele (AA; difference in means 4.93, standard error 1.22, p<.001). No significant difference was found for men (F<sub>2,107</sub><1.5).</p>", "links"=>[], "tags"=>["rs17782313", "mc4r", "scores"], "article_id"=>799880, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Annette Horstmann", "Peter Kovacs", "Stefan Kabisch", "Yvonne Boettcher", "Haiko Schloegl", "Anke Tönjes", "Michael Stumvoll", "Burkhard Pleger", "Arno Villringer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0074362.g001", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Sex_specific_effect_of_rs17782313_near_MC4R_on_disinhibition_scores_interaction_F_2_177_8202_8202_4_7_p_8202_8202_01_/799880", "title"=>"Sex-specific effect of rs17782313 near MC4R on ‘disinhibition’ scores (interaction F<sub>2,177</sub> = 4.7, p = .01).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-09-16 01:39:26"}
  • {"files"=>["https://ndownloader.figshare.com/files/1205042"], "description"=>"<p>Data are presented as medians and interquartile range in round brackets, 95% confidence intervals of the median based on 1,000 bootstrap samples are given in squared brackets. n: number of participants per category, TFEQ 51: Three Factor Eating Questionnaire, TFEQ R18: Revised and shortened version of the TFEQ, MAF: Minor Allele Frequency (describes the fraction of the minor allele, C, considering the sum of all alleles), p<sup>a</sup>: p-value of Kruskal-Wallis one-way analysis of variance, p<sup>b</sup>: p-value of Kruskal-Wallis one-way analysis of variance on residuals after correcting for age and BMI. * =  significant (p<.05) association with BMI in linear regression model, <sup>#</sup> = significant (p<.05) association with age in linear regression model.</p>", "links"=>[], "tags"=>["rs17782313"], "article_id"=>799883, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Annette Horstmann", "Peter Kovacs", "Stefan Kabisch", "Yvonne Boettcher", "Haiko Schloegl", "Anke Tönjes", "Michael Stumvoll", "Burkhard Pleger", "Arno Villringer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0074362.t001", "stats"=>{"downloads"=>3, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Detailed_demographic_and_questionnaire_data_split_by_rs17782313_near_MC4R_/799883", "title"=>"Detailed demographic and questionnaire data split by rs17782313 near MC4R.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-09-16 01:39:26"}
  • {"files"=>["https://ndownloader.figshare.com/files/1205041"], "description"=>"<p>Gray matter volume (GMV) in right amygdala (upper row), left orbitofrontal cortex (second row), left dorsolateral prefrontal cortex (third row) and right prefrontal cortex (bottom row) plotted against values on the ‘disinhibition’ subscale of the Three Factor Eating Questionnaire (TFEQ 51) for women (middle column) and men (right column) separately. Left column indicates the brain region where gray matter volume was extracted. Filled dark circles indicate homozygous carriers of the risk allele (CC) at rs17782313, filled gray circles indicate heterozygous subjects (AC) and open circles indicate homozygous carriers of the wildtype allele (AA). pr = partial correlation coefficient controlling for BMI, p = p-value of partial correlation analysis.</p>", "links"=>[], "tags"=>["scores", "areas"], "article_id"=>799882, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Annette Horstmann", "Peter Kovacs", "Stefan Kabisch", "Yvonne Boettcher", "Haiko Schloegl", "Anke Tönjes", "Michael Stumvoll", "Burkhard Pleger", "Arno Villringer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0074362.g003", "stats"=>{"downloads"=>2, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Distribution_of_gray_matter_volume_and_8216_disinhibition_8217_scores_for_brain_areas_showing_a_significant_interaction_between_gender_and_genotype_/799882", "title"=>"Distribution of gray matter volume and ‘disinhibition’ scores for brain areas showing a significant interaction between gender and genotype.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-09-16 01:39:26"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"24", "full-text"=>"27", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"24", "full-text"=>"28", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}

Relative Metric

{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[269, 466, 588, 697, 800, 896, 988, 1076, 1165, 1254, 1340, 1417]}, {"subject_area"=>"/Biology and life sciences/Anatomy", "average_usage"=>[248, 440, 562, 666, 765, 856, 944, 1028, 1112, 1198, 1282, 1362, 1430]}, {"subject_area"=>"/Biology and life sciences/Behavior", "average_usage"=>[306, 490, 611, 718, 817, 916, 999, 1091, 1185, 1258, 1341, 1412, 1476]}, {"subject_area"=>"/Medicine and health sciences/Anatomy", "average_usage"=>[248, 441, 564, 668, 769, 859, 948, 1034, 1117, 1202, 1290, 1368, 1437]}, {"subject_area"=>"/Medicine and health sciences/Anatomy and physiology", "average_usage"=>[253, 430]}]}
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