Nkd1 Functions as a Passive Antagonist of Wnt Signaling
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{"title"=>"Nkd1 Functions as a Passive Antagonist of Wnt Signaling", "type"=>"journal", "authors"=>[{"first_name"=>"Diane", "last_name"=>"Angonin", "scopus_author_id"=>"57193825823"}, {"first_name"=>"Terence J.", "last_name"=>"van Raay", "scopus_author_id"=>"6602427223"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84883216300", "pui"=>"369700110", "doi"=>"10.1371/journal.pone.0074666", "isbn"=>"0018726708094", "sgr"=>"84883216300", "pmid"=>"27182982"}, "id"=>"6d4cdbf9-85e8-3d35-ab13-1d0f0734f159", "abstract"=>"Maternal sun exposure in gestation and throughout the lifetime is necessary for vitamin D synthesis, and living near the sea is a population level index of seafood consumption. The aim of this study was to estimate the incidence rate of multiple sclerosis (MS) in Wales and examine its association with sun exposure, coastal living, and latitude. The study used a database of MS hospital visits and admissions in Wales between 2002 and 2013. For the 1,909 lower layer super output areas (LSOAs) in Wales, coastal status, population, longitude/latitude, and average sunshine hours per day were obtained. Age-specific and age-standardised MS incidence were calculated and modelled using Poisson regression. The distribution of births by month was compared between MS cases and the combined England and Wales population. There were 3,557 new MS cases between 2002 and 2013, with an average annual incidence of 8.14 (95% CI: 7.69-8.59) among males and 12.97 (95% CI: 12.44-13.50) among females per 100,000 population. The female-to-male ratio was 1.86:1. For both sexes combined, the average annual incidence rate was 9.10 (95% CI: 8.80-9.40). All figures are age-standardized to the 1976 European standard population. Compared to the combined England and Wales population, more people with MS were born in April, observed-to-expected ratio: 1.21 (95% CI: 1.08-1.36). MS incidence varied directly with latitude and inversely with sunshine hours. Proximity to the coast was associated with lower MS incidence only in easterly areas. This study shows that MS incidence rate in Wales is comparable to the rate in Scotland and is associated with environmental factors that probably represent levels of vitamin D.", "link"=>"http://www.mendeley.com/research/nkd1-functions-passive-antagonist-wnt-signaling", "reader_count"=>28, "reader_count_by_academic_status"=>{"Researcher"=>3, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>1, "Student > Master"=>8, "Student > Bachelor"=>4, "Professor"=>1, "Professor > Associate Professor"=>1}, "reader_count_by_user_role"=>{"Researcher"=>3, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>1, "Student > Master"=>8, "Student > Bachelor"=>4, "Professor"=>1, "Professor > Associate Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>4, "Agricultural and Biological Sciences"=>20, "Neuroscience"=>2}, "reader_count_by_subdiscipline"=>{"Neuroscience"=>{"Neuroscience"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>20}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}, "Unspecified"=>{"Unspecified"=>1}, "Environmental Science"=>{"Environmental Science"=>1}}, "reader_count_by_country"=>{"South Africa"=>1}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1185654"], "description"=>"<p>Injection of <i>nkd1</i> mRNA or morpholino (MO) does not have an obvious affect during early somitogenesis (A–F) or at 1 dpf (G–I). The number and width of somites in injected individuals is indistinguishable from uninjected embryos. At 1 dpf, injection of <i>nkd1</i> MO results in neural necrosis, which ranges from moderate (H) to more severe (I).</p>", "links"=>[], "tags"=>["patterning"], "article_id"=>784704, "categories"=>["Biological Sciences"], "users"=>["Diane Angonin", "Terence J. Van Raay"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0074666.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Nkd1_does_not_influence_normal_development_and_patterning_of_the_early_embryo_/784704", "title"=>"Nkd1 does not influence normal development and patterning of the early embryo.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-08-29 07:29:09"}
  • {"files"=>["https://ndownloader.figshare.com/files/1185657"], "description"=>"<p>Overexpression of Wnt8a (25pg) results in an eyeless phenotype that can be rescued by co-injection of <i>nkd1</i> (A, B) which is quantified in (C). Numbers above each column represent n values. Overexpression of high Wnt8a (200pg) results in ectopic <i>gsc</i> expression along the ventral-lateral domain at 50% epiboly (E). Co-injection of high <i>wnt8a</i> with <i>nkd1</i> mRNAs dramatically reduces the ectopic <i>gsc</i> expression, but leaves the putative endogenous <i>gsc</i> domain intact (F).</p>", "links"=>[], "tags"=>["antagonize", "ectopic"], "article_id"=>784706, "categories"=>["Biological Sciences"], "users"=>["Diane Angonin", "Terence J. Van Raay"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0074666.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Nkd1_is_sufficient_to_antagonize_ectopic_Wnt8a_/784706", "title"=>"Nkd1 is sufficient to antagonize ectopic Wnt8a.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-08-29 07:29:09"}
  • {"files"=>["https://ndownloader.figshare.com/files/1185658"], "description"=>"<p>Overexpression of ∆N-β-catenin results in a spectrum of dorsal-ventral (D–V) phenotypes ranging from a severe phenotype (A), which shows dramatic reduction in both dorsal and ventral structures to a moderate phenotype (B), which have reduced dorsal and ventral structures. The addition of Nkd1 does not ameliorate the effect of ∆N-β-catenin. The distribution of phenotypes in <i>∆N-β-catenin</i> and <i>nkd1</i> injections is quantified in (D), with numbers above each column representing n values. Consistent with the 1 dpf phenotype, ∆N-β-catenin overexpression results in expansion of <i>gsc</i> expression (E, F), which is not reduced by the addition of Nkd1 (G) (uninj n=40; <i>∆N-</i>β-<i>catenin</i> n=32; <i>∆N-</i>β-<i>catenin+nkd1</i> n=34).</p>", "links"=>[], "tags"=>["insufficient", "antagonize", "constitutively"], "article_id"=>784708, "categories"=>["Biological Sciences"], "users"=>["Diane Angonin", "Terence J. Van Raay"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0074666.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Nkd1_is_insufficient_to_antagonize_constitutively_active_946_catenin_/784708", "title"=>"Nkd1 is insufficient to antagonize constitutively active β-catenin.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-08-29 07:29:09"}
  • {"files"=>["https://ndownloader.figshare.com/files/1185660"], "description"=>"<p>Homozygous deletion of <i>tcf7l1a</i> results in an eyeless phenotype due to activated canonical Wnt signaling (D). Overexpression of Nkd1 in embryos from a homozygous hdl-/- parental cross (B, E) does not rescue the eyeless phenotype (E) and does not affect development of the early embryo (B), although at 1 dpf, <i>nkd1</i> injected embryos typically have a kinked axis. Injection of <i>nkd1</i> MO into embryos from a <i>hdl</i> +/- X <i>hdl</i> -/- parental cross has no affect on early (C) or 1 dpf (F) development (Uninj <i>hdl</i> +/- n= 14, <i>hdl</i> -/-n= 16; Nkd1 MO injected <i>hdl</i> +/- n= 15, <i>hdl</i> -/-n=22). Experiments in embryos from homozygous hdl-/- parental crosses had similar results (not shown).</p>", "links"=>[], "tags"=>[], "article_id"=>784709, "categories"=>["Biological Sciences"], "users"=>["Diane Angonin", "Terence J. Van Raay"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0074666.g004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Nkd1_does_not_rescue_the_hdl_tcf7l1a_mutant_/784709", "title"=>"Nkd1 does not rescue the <i>hdl</i>/<i>tcf7l1a</i> mutant.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-08-29 07:29:09"}
  • {"files"=>["https://ndownloader.figshare.com/files/1185662"], "description"=>"<p>The <i>slb</i> mutant undergoes normal convergence and extension (A), which is not affected by knockdown of Nkd1 with morpholinos (B). Overexpression of Nkd1 in slb-/- reduces <i>gsc</i> (D) and <i>chd</i> (F) expression (arrows), relative to controls (C, E) at 50% epiboly (Nkd1 injected: 47% of embryos with reduced <i>chd</i> expression (n=81); 50% of embryos with reduced <i>gsc</i> expression (n=46)). In contrast, knockdown of Nkd1 results in a slight expansion of <i>gsc</i> expression at 30% epiboly (G: ave <i>gsc</i> width=0.35 mm; n=13, H: ave <i>gsc</i> width=0.38 mm; n=22). All embryos are homozygous <i>slb</i>, derived from homozygous <i>slb</i> parents.</p>", "links"=>[], "tags"=>["mutant"], "article_id"=>784711, "categories"=>["Biological Sciences"], "users"=>["Diane Angonin", "Terence J. Van Raay"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0074666.g005"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_silberblick_Wnt11_mutant_is_sensitive_to_Nkd1_/784711", "title"=>"The <i>silberblick</i> (<i>Wnt11</i>) mutant is sensitive to Nkd1.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-08-29 07:29:09"}
  • {"files"=>["https://ndownloader.figshare.com/files/1185664"], "description"=>"<p>Knockdown of Nkd1 in <i>kny</i> -/- (C, D) or in <i>kny</i> +/+; +/- (G, H) does not have any affect on the <i>kny</i> mutant phenotype during somitogenesis (A–H) or at 1 dpf (I; n=19 kny-/-). Note the high levels of neural necrosis in <i>nkd1</i> MO injected embryos at 1 dpf (I). Consistent with the lack of sensitivity, overexpression of Nkd1 has no obvious effects during early somitogenesis (J–M) or at 1 dpf (N; n=31 <i>kny</i> -/-). There is no change in the ratio of wild-type: mutant phenotypes.</p>", "links"=>[], "tags"=>["mutant"], "article_id"=>784713, "categories"=>["Biological Sciences"], "users"=>["Diane Angonin", "Terence J. Van Raay"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0074666.g006"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_knypek_glypican_6_mutant_is_not_sensitive_to_Nkd1_/784713", "title"=>"The <i>knypek</i> (glypican 6) mutant is not sensitive to Nkd1.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-08-29 07:29:09"}
  • {"files"=>["https://ndownloader.figshare.com/files/1185665"], "description"=>"<p>Knockdown of Nkd1 with morpholinos (D, E) or overexpression of Nkd1 (I, J) does not have an obvious effect during early somitogenesis. However, at 1 dpf, knockdown or overexpression of Nkd1 in <i>tri</i> mutants results in an increase in cyclopia (K, L, O). Before the onset of gastrulation, at 50% epiboly, embryos generated from a tri+/- X tri+/- parental cross are sensitive to Nkd1 overexpression, demonstrated by a reduction or absence of <i>gsc</i> expression (M; n=32, N; 56% of embryos with reduced expression, n=25). (O) The cyclopic index was calculated using criteria established in Marlow et al., 1998 [<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0074666#B43\" target=\"_blank\">43</a>]. n values reflect the number of tri-/- embryos. Error bars represent standard error.</p>", "links"=>[], "tags"=>["mutants"], "article_id"=>784714, "categories"=>["Biological Sciences"], "users"=>["Diane Angonin", "Terence J. Van Raay"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0074666.g007"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Trilobite_vangl2_mutants_are_sensitive_to_Nkd1_/784714", "title"=>"<i>Trilobite</i> (<i>vangl2</i>) mutants are sensitive to Nkd1.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-08-29 07:29:09"}
  • {"files"=>["https://ndownloader.figshare.com/files/1185667"], "description"=>"<p>Injection of a low dose (5pg) of <i>wnt8a</i> into embryos from a tri+/- X tri+/- parental cross results in extremely dorsalized embryos and significant lethality (A–D, I). Different classes of phenotypes are shown in (A–D) with an uninjected wild-type sibling shown at the top in (A), and an uninjected tri mutant shown at the top in (B) for comparison. Addition of Nkd1 is capable of fully suppressing the <i>wnt8a</i> overexpression lethality and dorsalization (I). n values are for all genotypes. In contrast to the extreme phenotypes seen at 1 dpf, there is no effect of Wnt8a on the early organizer (E–H) shown by expression of <i>gsc</i> (E, F) and <i>bozozok</i> (<i>boz</i>) (G, H) an early and direct transcription target of maternal Wnt signaling. (J–M) Injection of <i>vangl2</i> MO does not alter the expression of <i>gsc</i> (K), nor does the low level of <i>wnt8a</i> (M). However, co-injection of <i>vangl2</i> MO and <i>wnt8a</i> results in ectopic <i>gsc</i> expression about 2-5% of the time (red arrowheads, n= 21).</p>", "links"=>[], "tags"=>["mutants", "canonical"], "article_id"=>784716, "categories"=>["Biological Sciences"], "users"=>["Diane Angonin", "Terence J. Van Raay"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0074666.g008"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Trilobite_vangl2_mutants_are_highly_sensitive_to_canonical_signaling_/784716", "title"=>"Trilobite (<i>vangl2</i>) mutants are highly sensitive to canonical signaling.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-08-29 07:29:09"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"2", "full-text"=>"3", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"8", "full-text"=>"10", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"3", "full-text"=>"4", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}

Relative Metric

{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Developmental biology", "average_usage"=>[275, 472, 605, 720, 822, 921, 1013, 1106, 1200, 1289, 1378, 1459, 1531]}, {"subject_area"=>"/Biology and life sciences/Molecular biology", "average_usage"=>[272, 466, 589, 702, 806, 903, 995, 1086, 1176, 1258, 1347, 1422, 1493]}, {"subject_area"=>"/Medicine and health sciences/Infectious diseases", "average_usage"=>[297, 523, 655, 765, 866, 971, 1070, 1159, 1256, 1337, 1424, 1496, 1568]}]}
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