Resveratrol Inhibits CD4+ T Cell Activation by Enhancing the Expression and Activity of Sirt1
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Mendeley | Further Information

{"title"=>"Resveratrol Inhibits CD4+ T cell activation by enhancing the expression and activity of Sirt1.", "type"=>"journal", "authors"=>[{"first_name"=>"Ting", "last_name"=>"Zou"}, {"first_name"=>"Yi", "last_name"=>"Yang"}, {"first_name"=>"Fei", "last_name"=>"Xia"}, {"first_name"=>"Anfei", "last_name"=>"Huang"}, {"first_name"=>"Xiaoming", "last_name"=>"Gao"}, {"first_name"=>"Deyu", "last_name"=>"Fang"}, {"first_name"=>"Sidong", "last_name"=>"Xiong"}, {"first_name"=>"Jinping", "last_name"=>"Zhang"}], "year"=>2013, "source"=>"PloS one", "identifiers"=>{"issn"=>"1932-6203", "pmid"=>"24073240", "doi"=>"10.1371/journal.pone.0075139", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)"}, "keywords"=>["Acetylation", "Acetylation: drug effects", "Animals", "Anti-Inflammatory Agents, Non-Steroidal", "Anti-Inflammatory Agents, Non-Steroidal: pharmacol", "Arthritis, Experimental", "Arthritis, Experimental: chemically induced", "Arthritis, Experimental: drug therapy", "Arthritis, Experimental: metabolism", "Blotting, Western", "CD4-Positive T-Lymphocytes", "CD4-Positive T-Lymphocytes: drug effects", "CD4-Positive T-Lymphocytes: metabolism", "CD4-Positive T-Lymphocytes: pathology", "Cell Nucleus", "Cell Nucleus: metabolism", "Cell Proliferation", "Cell Proliferation: drug effects", "Collagen", "Collagen: toxicity", "Enzyme-Linked Immunosorbent Assay", "Gene Expression Regulation", "Gene Expression Regulation: drug effects", "Immunoprecipitation", "JNK Mitogen-Activated Protein Kinases", "JNK Mitogen-Activated Protein Kinases: metabolism", "Lymphocyte Activation", "Lymphocyte Activation: drug effects", "Male", "Mice", "Mice, Inbred C57BL", "Mice, Inbred DBA", "Mice, Knockout", "Sirtuin 1", "Sirtuin 1: metabolism", "Stilbenes", "Stilbenes: pharmacology"], "id"=>"6d1dd370-a36a-32e9-95e1-f83862a39a85", "abstract"=>"Resveratrol, a natural polyphenol compound, has broad effects on critical events, including inflammation, oxidation, cancer and aging. However, the function and molecular mechanisms of resveratrol on T cell activation are controversial. In the present study, we found that resveratrol significantly inhibits the activation and cytokine production of T cells in vitro and in vivo. Sirt1 expression was up-regulated in resveratrol-treated T cells. Once Sirt1 was down-regulated in the T cells, the resveratrol-induced inhibition of T cell activation noticeably diminished. The acetylation of c-Jun decreased and its translocation was impeded in the resveratrol-treated T cells. The incidence and severity of collagen-induced arthritis in the resveratrol-treated mice were considerably reduced.", "link"=>"http://www.mendeley.com/research/resveratrol-inhibits-cd4-t-cell-activation-enhancing-expression-activity-sirt1-1", "reader_count"=>8, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>2, "Student > Ph. D. Student"=>4, "Student > Master"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>2, "Student > Ph. D. Student"=>4, "Student > Master"=>1}, "reader_count_by_subject_area"=>{"Agricultural and Biological Sciences"=>6, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>6}}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1211223"], "description"=>"<p>(<b>a</b>) The incidence of CIA in resveratrol-treated DBA1 mice was significantly lower compared to that of untreated CIA DBA1 mice. (<b>b</b>) The thickness of footpad in resveratrol-treated and untreated CIA DBA1. (<b>c</b>) CIA mouse joint sections were stained with H&E (*<i>P</i> < 0.05, **<i>P</i> < 0.01, ***<i>P</i> < 0.001). Each group had six mice. The experiments were repeated three times.</p>", "links"=>[], "tags"=>["reduced", "incidence", "severity"], "article_id"=>804606, "categories"=>["Biological Sciences"], "users"=>["Ting Zou", "Yi Yang", "Fei Xia", "Anfei Huang", "Xiaoming Gao", "Deyu Fang", "Sidong Xiong", "Jinping Zhang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0075139.g007", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Resveratrol_reduced_the_incidence_and_severity_of_CIA_/804606", "title"=>"Resveratrol reduced the incidence and severity of CIA.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-09-20 01:47:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/1211219"], "description"=>"<p>Naïve CD4<sup>+</sup> T cells, anti-CD3/CD28 antibody-activated CD4<sup>+</sup> T cells, and resveratrol-treated CD4<sup>+</sup> T cells were stained with Cy5-labeled anti-c-Jun antibody and DAPI, and then observed under a confocal microscope. Experiments were repeated more than four times.</p>", "links"=>[], "tags"=>["blocked", "translocation", "c-jun"], "article_id"=>804603, "categories"=>["Biological Sciences"], "users"=>["Ting Zou", "Yi Yang", "Fei Xia", "Anfei Huang", "Xiaoming Gao", "Deyu Fang", "Sidong Xiong", "Jinping Zhang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0075139.g006", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Resveratrol_blocked_the_translocation_of_c_Jun_into_the_nucleus_/804603", "title"=>"Resveratrol blocked the translocation of c-Jun into the nucleus.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-09-20 01:47:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/1211213"], "description"=>"<p>(<b>a</b>) Collagen-specific IgM in the serum from immunized mice was detected by ELISA. (<b>b</b>) The proliferation of collagen-specific T cell prepared from collagen-immunized mice spleen were measured through BrdU proliferation assay. (<b>c</b>–<b>f</b>) The cytokines in the serum from mice immunized with collagen were detected by ELISA (*<i>P</i> < 0.05, ** <i>P</i> < 0.01, ***<i>P</i> < 0.001). The data shown are representative of three independent experiments.</p>", "links"=>[], "tags"=>["inhibited", "activation", "antigen-specific", "antibody"], "article_id"=>804597, "categories"=>["Biological Sciences"], "users"=>["Ting Zou", "Yi Yang", "Fei Xia", "Anfei Huang", "Xiaoming Gao", "Deyu Fang", "Sidong Xiong", "Jinping Zhang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0075139.g002", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Resveratrol_inhibited_T_cell_activation_and_antigen_specific_antibody_production_in_vivo_/804597", "title"=>"Resveratrol inhibited T cell activation and antigen-specific antibody production in vivo.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-09-20 01:47:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/1211212"], "description"=>"<p>(<b>a</b>) The proliferation of CD4<sup>+</sup> T cells treated with different concentrations of resveratrol was evaluated by CFSE labeling assay. (<b>b</b>) The proliferation of CD4<sup>+</sup> T cells treated with different concentrations of resveratrol was measured by BrdU proliferation assay. (<b>c</b>–<b>f</b>) The productions of cytokines in supernatant of cell cultures, including IL-2 (<b>c</b>), IFNγ (<b>d</b>), IL-4 (<b>e</b>) and IL-5 (<b>f</b>), were measured by ELISA (*<i>P</i> < 0.05, **<i>P</i> < 0.01, ***<i>P</i> < 0.001). The data are representative of at least five independent experiments.</p>", "links"=>[], "tags"=>["inhibited", "activation", "vitro"], "article_id"=>804596, "categories"=>["Biological Sciences"], "users"=>["Ting Zou", "Yi Yang", "Fei Xia", "Anfei Huang", "Xiaoming Gao", "Deyu Fang", "Sidong Xiong", "Jinping Zhang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0075139.g001", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Resveratrol_inhibited_T_cell_activation_in_vitro_and_in_vivo_/804596", "title"=>"Resveratrol inhibited T cell activation in vitro and in vivo.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-09-20 01:47:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/1211217"], "description"=>"<p>Cells were then treated with Res (10µg/ml) for additional 8 hours. (<b>a</b>) c-Jun acetylation in the lysates of treated cells was determined by immunoprecipitation with anti-c-Jun antibody and western blotting with anti-acetyl-lysine Abs (top panel). The expression levels of c-Jun (middle panel) and Sirt1 (bottom panel) in the whole cell lysate were confirmed by western blotting. (<b>b</b>) The levels of acetylated c-Jun were quantified and normalized with total c-Jun and its relative levels are shown. Error bars represent data from three independent experiments (mean + SD).</p>", "links"=>[], "tags"=>["cells", "wt", "mice", "cultivated", "anti-cd3", "anti-CD28"], "article_id"=>804601, "categories"=>["Biological Sciences"], "users"=>["Ting Zou", "Yi Yang", "Fei Xia", "Anfei Huang", "Xiaoming Gao", "Deyu Fang", "Sidong Xiong", "Jinping Zhang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0075139.g005", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Primary_T_cells_were_isolated_from_WT_and_Sirt1_mice_and_cultivated_with_anti_CD3_5_181_g_ml_and_anti_CD28_2_181_g_ml_for_overnight_/804601", "title"=>"Primary T cells were isolated from WT and Sirt1<sup>-/-</sup> mice and cultivated with anti-CD3 (5 µg/ml) and anti-CD28 (2 µg/ml) for overnight.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-09-20 01:47:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/1211215"], "description"=>"<p>(<b>a</b>) The expression of Sirt1 in resveratrol treated (<b>R</b>), anti-CD3/CD28 antibody-activated (<b>A</b>), and naïve T cells (<b>N</b>) cells were detected through Western blot. GAPDH was used as loading reference. (<b>b</b>) The expression of Sirt1 in wild-type T cells (<b>N</b>), resveratrol-treated T cells (<b>R</b>), and mir-34a TG mouse T cells (<b>34a</b>). GAPDH was used as loading reference. (<b>c</b>, <b>d</b>) The proliferation of CD4<sup>+</sup> T cells from wild-type mice and mir-34a TG mice, some of which were treated with resveratrol (**<i>P</i> < 0.01). The data are representative of three time-independent repetitions.</p>", "links"=>[], "tags"=>["inhibited", "activation", "enhancing"], "article_id"=>804599, "categories"=>["Biological Sciences"], "users"=>["Ting Zou", "Yi Yang", "Fei Xia", "Anfei Huang", "Xiaoming Gao", "Deyu Fang", "Sidong Xiong", "Jinping Zhang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0075139.g003", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Resveratrol_inhibited_T_cell_activation_by_enhancing_the_expression_of_Sirt1_/804599", "title"=>"Resveratrol inhibited T cell activation by enhancing the expression of Sirt1.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-09-20 01:47:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/1211216"], "description"=>"<p>The cell lysis of activated T cells was precipitated with antibodies against c-Jun, NFκB, or NFAT, blotted with anti-acetylase antibody, and then blotted with antibodies against C-Jun, NFκB, NFAT, and GAPDH as references. The pictures are representative of three more repetitions.</p>", "links"=>[], "tags"=>["enhanced", "acetylase", "sirt1"], "article_id"=>804600, "categories"=>["Biological Sciences"], "users"=>["Ting Zou", "Yi Yang", "Fei Xia", "Anfei Huang", "Xiaoming Gao", "Deyu Fang", "Sidong Xiong", "Jinping Zhang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0075139.g004", "stats"=>{"downloads"=>1, "page_views"=>41, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Resveratrol_enhanced_the_acetylase_activity_of_Sirt1_on_c_Jun_/804600", "title"=>"Resveratrol enhanced the acetylase activity of Sirt1 on c-Jun.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-09-20 01:47:47"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"100", "full-text"=>"93", "pdf"=>"56", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"13", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"54", "full-text"=>"49", "pdf"=>"29", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"38", "full-text"=>"51", "pdf"=>"20", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"27", "full-text"=>"28", "pdf"=>"14", "abstract"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"23", "full-text"=>"29", "pdf"=>"8", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"13", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"25", "full-text"=>"20", "pdf"=>"11", "abstract"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"16", "full-text"=>"14", "pdf"=>"7", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"31", "full-text"=>"29", "pdf"=>"30", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"22", "full-text"=>"19", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"20", "full-text"=>"20", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"22", "full-text"=>"22", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"16", "full-text"=>"14", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"15", "full-text"=>"13", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"21", "full-text"=>"23", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"20", "full-text"=>"17", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"18", "full-text"=>"16", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"20", "full-text"=>"18", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"26", "full-text"=>"24", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"24", "full-text"=>"25", "pdf"=>"10", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"25", "full-text"=>"20", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"23", "full-text"=>"25", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"15", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"22", "full-text"=>"19", "pdf"=>"7", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"33", "full-text"=>"44", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"27", "full-text"=>"28", "pdf"=>"14", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"23", "full-text"=>"20", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"18", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"32", "full-text"=>"34", "pdf"=>"18", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"17", "full-text"=>"16", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"11", "full-text"=>"13", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"26", "full-text"=>"25", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"21", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"92", "full-text"=>"115", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"29", "full-text"=>"39", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"56", "full-text"=>"66", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"21", "full-text"=>"26", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"18", "full-text"=>"17", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"16", "full-text"=>"18", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"18", "full-text"=>"22", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"16", "full-text"=>"16", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"16", "full-text"=>"22", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"13", "full-text"=>"11", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"14", "full-text"=>"12", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"17", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"13", "full-text"=>"16", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"11", "full-text"=>"13", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"17", "full-text"=>"17", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"18", "full-text"=>"23", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"2"}
  • {"unique-ip"=>"20", "full-text"=>"17", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"12", "full-text"=>"14", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"18", "full-text"=>"18", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"16", "full-text"=>"21", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"20", "full-text"=>"21", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"13", "full-text"=>"14", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"21", "full-text"=>"21", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"18", "full-text"=>"24", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"23", "full-text"=>"29", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"15", "full-text"=>"17", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"24", "full-text"=>"30", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}

Relative Metric

{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[269, 466, 588, 697, 800, 896, 988, 1076, 1165, 1254, 1340, 1417]}, {"subject_area"=>"/Biology and life sciences/Anatomy and physiology", "average_usage"=>[256, 428]}, {"subject_area"=>"/Biology and life sciences/Biochemistry", "average_usage"=>[266, 468, 593, 703, 804, 903, 993, 1084, 1171, 1256, 1339, 1422, 1492]}, {"subject_area"=>"/Biology and life sciences/Developmental biology", "average_usage"=>[275, 472, 605, 720, 822, 921, 1013, 1106, 1200, 1289, 1378, 1459, 1531]}, {"subject_area"=>"/Biology and life sciences/Physiology", "average_usage"=>[256, 449, 572, 676, 775, 866, 955, 1041, 1127, 1213, 1290, 1370, 1437]}, {"subject_area"=>"/Medicine and health sciences/Immunology", "average_usage"=>[262, 463, 587, 693, 790, 882, 965, 1051, 1135, 1218, 1300, 1376, 1438]}, {"subject_area"=>"/Medicine and health sciences/Physiology", "average_usage"=>[258, 449, 572, 679, 775, 866, 956, 1041, 1124, 1211, 1291, 1371, 1437]}, {"subject_area"=>"/Physical sciences/Chemistry", "average_usage"=>[247, 429, 544, 647, 747, 842, 929, 1012, 1099, 1179, 1263, 1339, 1409]}]}
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