Alocasia cucullata Exhibits Strong Antitumor Effect In Vivo by Activating Antitumor Immunity
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{"title"=>"Alocasia cucullata Exhibits Strong Antitumor Effect In Vivo by Activating Antitumor Immunity", "type"=>"journal", "authors"=>[{"first_name"=>"Qiuxian", "last_name"=>"Peng", "scopus_author_id"=>"54993074000"}, {"first_name"=>"Hongbing", "last_name"=>"Cai", "scopus_author_id"=>"56701584500"}, {"first_name"=>"Xuegang", "last_name"=>"Sun", "scopus_author_id"=>"23499609800"}, {"first_name"=>"Xin", "last_name"=>"Li", "scopus_author_id"=>"55315044900"}, {"first_name"=>"Zhixian", "last_name"=>"Mo", "scopus_author_id"=>"7103200610"}, {"first_name"=>"Jue", "last_name"=>"Shi", "scopus_author_id"=>"55236617700"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"24086508", "sgr"=>"84884541984", "doi"=>"10.1371/journal.pone.0075328", "scopus"=>"2-s2.0-84884541984", "pui"=>"369883047", "issn"=>"19326203"}, "id"=>"f2b65eef-24dc-372d-bceb-ea3ceb2087af", "abstract"=>"Chinese herbal medicines have long been used to treat various illnesses by modulating the human immune response. In this study, we investigate the immuno-modulating effect and antitumor activity of Alocasia Cucullata (AC), a Chinese herb traditionally used to treat infection and cancer. We found that the whole water extract of AC roots could significantly attenuate tumor growth in mouse tumor models. The median survival time of the AC-treated mice was 43 days, 16 days longer than that of the control group. Moreover, the AC-treated mice showed substantially higher induction of key antitumor cytokines, such as IL-2, IFN-γ, and TNF-α, indicating that AC may exert antitumor effect by activating antitumor immunity. To further pinpoint the cellular and molecular mechanism of AC, we studied the dose response of a human monocytic cell line, THP-1, to the whole water extract of AC. Treatment of the AC extract significantly induced THP-1 differentiation into macrophage-like cells and the differentiated THP-1 showed expression of specific macrophage surface markers, such as CD11b and CD14, as well as productions of antitumor cytokines, e.g. IFN-γ and TNF-α. Our data thus point to AC as potentially a new, alternative immuno-modulating herbal remedy for anticancer treatment.", "link"=>"http://www.mendeley.com/research/alocasia-cucullata-exhibits-strong-antitumor-effect-vivo-activating-antitumor-immunity", "reader_count"=>8, "reader_count_by_academic_status"=>{"Student > Doctoral Student"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>1, "Student > Master"=>1, "Unspecified"=>1}, "reader_count_by_user_role"=>{"Student > Doctoral Student"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>1, "Student > Master"=>1, "Unspecified"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>3, "Chemistry"=>1, "Immunology and Microbiology"=>1, "Unspecified"=>1}, "reader_count_by_subdiscipline"=>{"Chemistry"=>{"Chemistry"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"United Kingdom"=>1}, "group_count"=>0}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1215498"], "description"=>"<div><p>Chinese herbal medicines have long been used to treat various illnesses by modulating the human immune response. In this study, we investigate the immuno-modulating effect and antitumor activity of <i>Alocasia Cucullata</i> (AC), a Chinese herb traditionally used to treat infection and cancer. We found that the whole water extract of AC roots could significantly attenuate tumor growth in mouse tumor models. The median survival time of the AC-treated mice was 43 days, 16 days longer than that of the control group. Moreover, the AC-treated mice showed substantially higher induction of key antitumor cytokines, such as IL-2, IFN-γ, and TNF-α, indicating that AC may exert antitumor effect by activating antitumor immunity. To further pinpoint the cellular and molecular mechanism of AC, we studied the dose response of a human monocytic cell line, THP-1, to the whole water extract of AC. Treatment of the AC extract significantly induced THP-1 differentiation into macrophage-like cells and the differentiated THP-1 showed expression of specific macrophage surface markers, such as CD11b and CD14, as well as productions of antitumor cytokines, e.g. IFN-γ and TNF-α. Our data thus point to AC as potentially a new, alternative immuno-modulating herbal remedy for anticancer treatment.</p></div>", "links"=>[], "tags"=>["exhibits", "antitumor", "vivo", "activating", "immunity"], "article_id"=>807924, "categories"=>["Biological Sciences"], "users"=>["Qiuxian Peng", "Hongbing Cai", "Xuegang Sun", "Xin Li", "Zhixian Mo", "Jue Shi"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0075328", "stats"=>{"downloads"=>1, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Alocasia_cucullata_Exhibits_Strong_Antitumor_Effect_In_Vivo_by_Activating_Antitumor_Immunity/807924", "title"=>"<i>Alocasia cucullata</i> Exhibits Strong Antitumor Effect In Vivo by Activating Antitumor Immunity", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-09-25 01:44:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/1215493"], "description"=>"<p>Data are shown as mean ± S.D. averaged from nine or ten mice. Nctrl: negative control group; Pctrl: positive control group; lAC: low-dose AC treatment group; mAC: medium-dose AC treatment group; hAC: high-dose AC treatment group. **p<0.01 <i>vs</i> Nctrl group.</p>", "links"=>[], "tags"=>["serum", "4t1-bearing"], "article_id"=>807919, "categories"=>["Biological Sciences"], "users"=>["Qiuxian Peng", "Hongbing Cai", "Xuegang Sun", "Xin Li", "Zhixian Mo", "Jue Shi"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0075328.g002", "stats"=>{"downloads"=>1, "page_views"=>28, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Levels_of_IL_2_INF_947_and_TNF_945_in_the_blood_serum_of_the_4T1_bearing_mice_/807919", "title"=>"Levels of IL-2, INF-γ and TNF-α in the blood serum of the 4T1-bearing mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-09-25 01:44:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/1215494"], "description"=>"<p>(A) Bright-field images of control THP-1 cells and THP-1 treated with 2 mg/ml AC extract for 72 hours. (B) Dose response of THP-1 cells to AC extract with respect to morpholgoical change from suspesion to adherence. Data were shown as mean ± S.D. averaged from three independent experiments. **p<0.01 <i>vs</i> control cells.</p>", "links"=>[], "tags"=>["extract", "induced", "thp-1", "differentiation", "dose-dependent"], "article_id"=>807920, "categories"=>["Biological Sciences"], "users"=>["Qiuxian Peng", "Hongbing Cai", "Xuegang Sun", "Xin Li", "Zhixian Mo", "Jue Shi"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0075328.g003", "stats"=>{"downloads"=>1, "page_views"=>54, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_AC_extract_induced_THP_1_differentiation_in_a_dose_dependent_manner_/807920", "title"=>"AC extract induced THP-1 differentiation in a dose-dependent manner.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-09-25 01:44:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/1215492"], "description"=>"<p>(A) Comparison of tumor weight in the five treatment groups. Nctrl: negative control group; Pctrl: positive control group; lAC: low-dose AC treatment group; mAC: medium-dose AC treatment group; hAC: high-dose AC treatment group. (B) Morphological structures of tumor tissues from the five treatment groups. Hematoxylin and eosin staining. 200×. (C) Comparison of the spleen and thymus index in the five treatment groups (n = 9 or 10). Data are shown as mean ± S.D. *p<0.05, **p<0.01 <i>vs</i> Nctrl group. (D) Cumulative survival curves of the control mice (treated with water) and mice treated daily with medium dose of AC extract (n = 10).</p>", "links"=>[], "tags"=>["ac", "extract"], "article_id"=>807918, "categories"=>["Biological Sciences"], "users"=>["Qiuxian Peng", "Hongbing Cai", "Xuegang Sun", "Xin Li", "Zhixian Mo", "Jue Shi"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0075328.g001", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Antitumor_effect_of_AC_extract_in_vivo_/807918", "title"=>"Antitumor effect of AC extract <i>in vivo.</i>", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-09-25 01:44:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/1215497"], "description"=>"<p>(A) Human chemokine array. PC, positive control; 1: RANTES; 2: IL-8/CXCL8; 3: MIP-1α, β; 4: GRO-α. (B) Human cytokine array. PC, positive control. 1: MIF; 2: MIP-1α; 3: MIP-1β; 4: IL-8; 5: GRO-α; 6: TNF-α; 7: IL-1ra; 8: RANTES.</p>", "links"=>[], "tags"=>["chemokines", "cytokines", "thp-1", "cells", "treated", "ac", "extract", "48", "hours"], "article_id"=>807923, "categories"=>["Biological Sciences"], "users"=>["Qiuxian Peng", "Hongbing Cai", "Xuegang Sun", "Xin Li", "Zhixian Mo", "Jue Shi"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0075328.g005", "stats"=>{"downloads"=>0, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Expressions_of_human_chemokines_and_cytokines_from_control_THP_1_cells_control_vs_THP_1_treated_with_AC_extract_at_2_mg_ml_for_48_hours_AC_representative_of_three_independent_experiments_/807923", "title"=>"Expressions of human chemokines and cytokines from control THP-1 cells (control) vs. THP-1 treated with AC extract at 2 mg/ml for 48 hours (AC) (representative of three independent experiments).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-09-25 01:44:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/1215496"], "description"=>"<p>(A) Representative flow cytometric diagrams that showed the distributions of THP-1 cells with respect to expression of surface markers, CD14 and CD11b, under control (no treatment), PMA and AC treatment. (B) The ratio of surface marker positive THP-1 cells (left panel) and the fluorescence intensity of the surface markers (right panel) obtained from the flow cytometric diagrams. Data are shown as mean ± S.D. averaged from three independent experiments. *p<0.05, **p<0.01 vs control group. (C) ELISA analysis of IL-1β and TNF-α expression in THP-1 cells treated with AC at 2 mg/ml for 48 hours. Data are shown as mean ± S.D. averaged from two independent experiments. *p<0.05, **p<0.01 vs. control group.</p>", "links"=>[], "tags"=>["differentiated", "thp-1", "cells", "induced"], "article_id"=>807922, "categories"=>["Biological Sciences"], "users"=>["Qiuxian Peng", "Hongbing Cai", "Xuegang Sun", "Xin Li", "Zhixian Mo", "Jue Shi"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0075328.g004", "stats"=>{"downloads"=>0, "page_views"=>19, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characteristics_of_the_differentiated_THP_1_cells_induced_by_AC_/807922", "title"=>"Characteristics of the differentiated THP-1 cells induced by AC.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-09-25 01:44:27"}

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Relative Metric

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