Association of Polymorphisms in Pharmacogenetic Candidate Genes (OPRD1, GAL, ABCB1, OPRM1) with Opioid Dependence in European Population: A Case-Control Study
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{"title"=>"Association of Polymorphisms in Pharmacogenetic Candidate Genes (OPRD1, GAL, ABCB1, OPRM1) with Opioid Dependence in European Population: A Case-Control Study", "type"=>"journal", "authors"=>[{"first_name"=>"Beate", "last_name"=>"Beer", "scopus_author_id"=>"36022212800"}, {"first_name"=>"Robert", "last_name"=>"Erb", "scopus_author_id"=>"51763432600"}, {"first_name"=>"Marion", "last_name"=>"Pavlic", "scopus_author_id"=>"6701392175"}, {"first_name"=>"Hanno", "last_name"=>"Ulmer", "scopus_author_id"=>"55059852800"}, {"first_name"=>"Salvatore", "last_name"=>"Giacomuzzi", "scopus_author_id"=>"7004065295"}, {"first_name"=>"Yvonne", "last_name"=>"Riemer", "scopus_author_id"=>"6602284589"}, {"first_name"=>"Herbert", "last_name"=>"Oberacher", "scopus_author_id"=>"6701512865"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"369883002", "sgr"=>"84884559745", "issn"=>"19326203", "pmid"=>"24086514", "scopus"=>"2-s2.0-84884559745", "doi"=>"10.1371/journal.pone.0075359", "isbn"=>"10.1371/journal.pone.0075359"}, "id"=>"34a0dcca-27ee-30de-9066-7a48df2221ab", "abstract"=>"It is becoming increasingly evident that genetic variants contribute to the development of opioid addiction. An elucidation of these genetic factors is crucial for a better understanding of this chronic disease and may help to develop novel therapeutic strategies. In recent years, several candidate genes were implicated in opioid dependence. However, most study findings have not been replicated and additional studies are required before reported associations can be considered robust. Thus, the major objective of this study was to replicate earlier findings and to identify new genetic polymorphisms contributing to the individual susceptibility to opioid addiction, respectively. Therefore, a candidate gene association study was conducted including 142 well-phenotyped long-term opioid addicts undergoing opioid maintenance therapy and 142 well-matched healthy controls. In both study groups, 24 single nucleotide polymorphisms predominantly located in pharmacogenetic candidate genes have been genotyped using an accurate mass spectrometry based method. The most significant associations with opioid addiction (remaining significant after adjustment for multiple testing) were observed for the rs948854 SNP in the galanin gene (GAL, p = 0.001) and the rs2236861 SNP in the delta opioid receptor gene (OPRD1, p = 0.001). Moreover, an association of the ATP binding cassette transporter 1 (ABCB1) variant rs1045642 and the Mu Opioid receptor (OPRM1) variant rs9479757 with opioid addiction was observed. The present study provides further support for a contribution of GAL and OPRD1 variants to the development of opioid addiction. Furthermore, our results indicate a potential contribution of OPRM1 and ABCB1 SNPs to the development of this chronic relapsing disease. Therefore it seems important that these genes are addressed in further addiction related studies.", "link"=>"http://www.mendeley.com/research/association-polymorphisms-pharmacogenetic-candidate-genes-oprd1-gal-abcb1-oprm1-opioid-dependence-eu", "reader_count"=>33, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>3, "Librarian"=>1, "Researcher"=>7, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>5, "Student > Master"=>3, "Other"=>2, "Student > Bachelor"=>7}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>3, "Librarian"=>1, "Researcher"=>7, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>5, "Student > Master"=>3, "Other"=>2, "Student > Bachelor"=>7}, "reader_count_by_subject_area"=>{"Engineering"=>3, "Unspecified"=>4, "Biochemistry, Genetics and Molecular Biology"=>4, "Nursing and Health Professions"=>1, "Medicine and Dentistry"=>8, "Agricultural and Biological Sciences"=>5, "Neuroscience"=>3, "Pharmacology, Toxicology and Pharmaceutical Science"=>3, "Social Sciences"=>1, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>3}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>8}, "Neuroscience"=>{"Neuroscience"=>3}, "Social Sciences"=>{"Social Sciences"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>5}, "Computer Science"=>{"Computer Science"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}, "Unspecified"=>{"Unspecified"=>4}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>3}}, "reader_count_by_country"=>{"United States"=>1, "Mexico"=>1}, "group_count"=>10}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1215501", "https://ndownloader.figshare.com/files/1215502"], "description"=>"<div><p>It is becoming increasingly evident that genetic variants contribute to the development of opioid addiction. An elucidation of these genetic factors is crucial for a better understanding of this chronic disease and may help to develop novel therapeutic strategies. In recent years, several candidate genes were implicated in opioid dependence. However, most study findings have not been replicated and additional studies are required before reported associations can be considered robust. Thus, the major objective of this study was to replicate earlier findings and to identify new genetic polymorphisms contributing to the individual susceptibility to opioid addiction, respectively. Therefore, a candidate gene association study was conducted including 142 well-phenotyped long-term opioid addicts undergoing opioid maintenance therapy and 142 well-matched healthy controls. In both study groups, 24 single nucleotide polymorphisms predominantly located in pharmacogenetic candidate genes have been genotyped using an accurate mass spectrometry based method. The most significant associations with opioid addiction (remaining significant after adjustment for multiple testing) were observed for the rs948854 SNP in the galanin gene (<i>GAL</i>, p = 0.001) and the rs2236861 SNP in the delta opioid receptor gene (<i>OPRD1</i>, p = 0.001). Moreover, an association of the ATP binding cassette transporter 1 (<i>ABCB1</i>) variant rs1045642 and the Mu Opioid receptor (<i>OPRM1</i>) variant rs9479757 with opioid addiction was observed. The present study provides further support for a contribution of <i>GAL</i> and <i>OPRD1</i> variants to the development of opioid addiction. Furthermore, our results indicate a potential contribution of <i>OPRM1</i> and <i>ABCB1</i> SNPs to the development of this chronic relapsing disease. Therefore it seems important that these genes are addressed in further addiction related studies.</p> </div>", "links"=>[], "tags"=>["polymorphisms", "pharmacogenetic", "genes", "opioid", "dependence", "european", "case-control"], "article_id"=>807927, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Beate Beer", "Robert Erb", "Marion Pavlic", "Hanno Ulmer", "Salvatore Giacomuzzi", "Yvonne Riemer", "Herbert Oberacher"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0075359.s001", "https://dx.doi.org/10.1371/journal.pone.0075359.s002"], "stats"=>{"downloads"=>0, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Association_of_Polymorphisms_in_Pharmacogenetic_Candidate_Genes_OPRD1_GAL_ABCB1_OPRM1_with_Opioid_Dependence_in_European_Population_A_Case_Control_Study_/807927", "title"=>"Association of Polymorphisms in Pharmacogenetic Candidate Genes (OPRD1, GAL, ABCB1, OPRM1) with Opioid Dependence in European Population: A Case-Control Study", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-09-25 01:45:17"}

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Relative Metric

{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[269, 466, 588, 697, 800, 896, 988, 1076, 1165, 1254, 1340, 1417]}, {"subject_area"=>"/Biology and life sciences/Psychology", "average_usage"=>[284, 458, 579, 688, 782, 879, 957, 1048, 1126, 1204, 1280, 1357, 1415]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[264, 460, 584, 692, 794, 887, 978, 1067, 1154, 1241, 1328, 1408, 1474]}, {"subject_area"=>"/Medicine and health sciences/Pain management", "average_usage"=>[259, 460, 588, 720, 834, 951, 1056, 1139, 1222, 1315, 1391, 1497, 1570]}, {"subject_area"=>"/Medicine and health sciences/Pharmacology", "average_usage"=>[265, 471, 604, 723, 827, 926, 1022, 1113, 1210, 1290, 1377, 1454, 1532]}, {"subject_area"=>"/Social sciences", "average_usage"=>[289, 475, 593, 703, 805, 902, 990, 1078, 1158, 1250, 1336, 1417, 1482]}]}
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