Adiponectin Provides Additional Information to Conventional Cardiovascular Risk Factors for Assessing the Risk of Atherosclerosis in Both Genders
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{"title"=>"Adiponectin Provides Additional Information to Conventional Cardiovascular Risk Factors for Assessing the Risk of Atherosclerosis in Both Genders", "type"=>"journal", "authors"=>[{"first_name"=>"Jin Ha", "last_name"=>"Yoon", "scopus_author_id"=>"35766041900"}, {"first_name"=>"Sung Kyung", "last_name"=>"Kim", "scopus_author_id"=>"47561290500"}, {"first_name"=>"Ho June", "last_name"=>"Choi", "scopus_author_id"=>"55900712500"}, {"first_name"=>"Soo In", "last_name"=>"Choi", "scopus_author_id"=>"57199723809"}, {"first_name"=>"So Youn", "last_name"=>"Cha", "scopus_author_id"=>"55900551900"}, {"first_name"=>"Sang Baek", "last_name"=>"Koh", "scopus_author_id"=>"7202062425"}, {"first_name"=>"Hee Taik", "last_name"=>"Kang", "scopus_author_id"=>"37101607600"}, {"first_name"=>"Song Vogue", "last_name"=>"Ahn", "scopus_author_id"=>"47360986600"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "pui"=>"369979225", "doi"=>"10.1371/journal.pone.0075535", "sgr"=>"84885156608", "scopus"=>"2-s2.0-84885156608", "isbn"=>"1932-6203", "pmid"=>"24116054"}, "id"=>"773957ac-7969-3e3d-8a66-47b639391c1a", "abstract"=>"BACKGROUND: This study evaluated the relation between adiponectin and atherosclerosis in both genders, and investigated whether adiponectin provides useful additional information for assessing the risk of atherosclerosis. METHODS: We measured serum adiponectin levels and other cardiovascular risk factors in 1033 subjects (454 men, 579 women) from the Korean Genomic Rural Cohort study. Carotid intima-media-thickness (CIMT) was used as measure of atherosclerosis. Odds ratios (ORs) with 95% confidence intervals (95% CI) were calculated using multiple logistic regression, and receiver operating characteristic curves (ROC), the category-free net reclassification improvement (NRI) and integrated discrimination improvement (IDI) were calculated. RESULTS: After adjustment for conventional cardiovascular risk factors, such as age, waist circumference, smoking history, low-density and high-density lipoprotein cholesterol, triglycerides, systolic blood pressure and insulin resistance, the ORs (95%CI) of the third tertile adiponectin group were 0.42 (0.25-0.72) in men and 0.47 (0.29-0.75) in women. The area under the curve (AUC) on the ROC analysis increased significantly by 0.025 in men and 0.022 in women when adiponectin was added to the logistic model of conventional cardiovascular risk factors (AUC in men: 0.655 to 0.680, p = 0.038; AUC in women: 0.654 to 0.676, p = 0.041). The NRI was 0.32 (95%CI: 0.13-0.50, p<0.001), and the IDI was 0.03 (95%CI: 0.01-0.04, p<0.001) for men. For women, the category-free NRI was 0.18 (95%CI: 0.02-0.34, p = 0.031) and the IDI was 0.003 (95%CI: -0.002-0.008, p = 0.189). CONCLUSION: Adiponectin and atherosclerosis were significantly related in both genders, and these relationships were independent of conventional cardiovascular risk factors. Furthermore, adiponectin provided additional information to conventional cardiovascular risk factors regarding the risk of atherosclerosis.", "link"=>"http://www.mendeley.com/research/adiponectin-provides-additional-information-conventional-cardiovascular-risk-factors-assessing-risk", "reader_count"=>9, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>2, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>2, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Nursing and Health Professions"=>1, "Medicine and Dentistry"=>6}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>6}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Unspecified"=>{"Unspecified"=>2}}, "reader_count_by_country"=>{"Spain"=>1}, "group_count"=>1}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1228392"], "description"=>"<p>SBP, systolic blood pressure; DBP, diastolic blood pressure; FBG, fasting blood glucose; FBI, fasting blood insulin;, HOMA-IR, Homeostasis model assessment-insulin resistance; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; CIMT, carotid intima media thickness.</p>", "links"=>[], "tags"=>["metabolic"], "article_id"=>817520, "categories"=>["Biological Sciences"], "users"=>["Jin-Ha Yoon", "Sung-Kyung Kim", "Ho-June Choi", "Soo-In Choi", "So-Youn Cha", "Sang-Baek Koh", "Hee-Taik Kang", "Song Vogue Ahn"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0075535.t001", "stats"=>{"downloads"=>3, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Anthropometric_and_metabolic_characteristics_of_study_population_/817520", "title"=>"Anthropometric and metabolic characteristics of study population.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-10-08 08:24:57"}
  • {"files"=>["https://ndownloader.figshare.com/files/1228387"], "description"=>"<p>The dot lines indicate the median level of adiponectin in each tertile levels (4.71 in 1<sup>st</sup> tertile, 7.85 in 2<sup>nd</sup> tertile, 12.52 in 3<sup>rd</sup> tertile in men; 7.36 in 1<sup>st</sup> tertile, 11.53 in 2<sup>nd</sup> tertile, 16.72 in 3<sup>rd</sup> tertile in women, unit = mg/L).</p>", "links"=>[], "tags"=>["regression", "subclinical", "atherosclerosis", "intima", "thickness", "adiponectin"], "article_id"=>817515, "categories"=>["Biological Sciences"], "users"=>["Jin-Ha Yoon", "Sung-Kyung Kim", "Ho-June Choi", "Soo-In Choi", "So-Youn Cha", "Sang-Baek Koh", "Hee-Taik Kang", "Song Vogue Ahn"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0075535.g001", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Logistic_regression_plot_for_risk_of_subclinical_atherosclerosis_carotid_intima_media_thickness_gt_0_9_mm_according_to_adiponectin_level_/817515", "title"=>"Logistic regression plot for risk of subclinical atherosclerosis (carotid intima media thickness >0.9 mm) according to adiponectin level.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-10-08 08:24:57"}
  • {"files"=>["https://ndownloader.figshare.com/files/1228389"], "description"=>"<p>The additional contribution of adiponectin to predicting risk of high CIMT Model I include the age, waist circumference, smoking history, low density lipoprotein cholesterol, high density lipoprotein cholesterol, triglyceride and homeostasis model assessment-insulin resistance (and menopause history in women).</p>", "links"=>[], "tags"=>["adiponectin", "predicting", "cimt", "smoking", "lipoprotein", "triglyceride", "homeostasis", "assessment-insulin", "menopause"], "article_id"=>817517, "categories"=>["Biological Sciences"], "users"=>["Jin-Ha Yoon", "Sung-Kyung Kim", "Ho-June Choi", "Soo-In Choi", "So-Youn Cha", "Sang-Baek Koh", "Hee-Taik Kang", "Song Vogue Ahn"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0075535.g002", "stats"=>{"downloads"=>2, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_additional_contribution_of_adiponectin_to_predicting_risk_of_high_CIMT_Model_I_include_the_age_waist_circumference_smoking_history_low_density_lipoprotein_cholesterol_high_density_lipoprotein_cholesterol_triglyceride_and_homeostasis_model_assessment_/817517", "title"=>"The additional contribution of adiponectin to predicting risk of high CIMT Model I include the age, waist circumference, smoking history, low density lipoprotein cholesterol, high density lipoprotein cholesterol, triglyceride and homeostasis model assessment-insulin resistance (and menopause history in women).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-10-08 08:24:57"}
  • {"files"=>["https://ndownloader.figshare.com/files/1228390"], "description"=>"<p>Model I: adjusted for age.</p><p>Model II: model I+waist circumference and smoking history (and menopause status in women).</p><p>Model III: model II+low density lipoprotein cholesterol, high density lipoprotein cholesterol, triglyceride, systolic blood pressure and homeostasis model assessment-insulin resistance.</p>", "links"=>[], "tags"=>["adiponectin", "subclinical", "atherosclerosis", "intima", "thickness"], "article_id"=>817518, "categories"=>["Biological Sciences"], "users"=>["Jin-Ha Yoon", "Sung-Kyung Kim", "Ho-June Choi", "Soo-In Choi", "So-Youn Cha", "Sang-Baek Koh", "Hee-Taik Kang", "Song Vogue Ahn"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0075535.t003", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Odds_ratio_according_to_adiponectin_of_subclinical_atherosclerosis_carotid_intima_media_thickness_gt_0_9_/817518", "title"=>"Odds ratio according to adiponectin of subclinical atherosclerosis (carotid intima media thickness >0.9).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-10-08 08:24:57"}
  • {"files"=>["https://ndownloader.figshare.com/files/1228391"], "description"=>"<p>SBP, systolic blood pressure; DBP, diastolic blood pressure; FBG, fasting blood glucose; FBI, fasting blood insulin;, HOMA-IR, Homeostasis model assessment-insulin resistance; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; CIMT, carotid intima media thickness.</p>*<p>p for trend.</p>", "links"=>[], "tags"=>["tertile", "increment", "adiponectin"], "article_id"=>817519, "categories"=>["Biological Sciences"], "users"=>["Jin-Ha Yoon", "Sung-Kyung Kim", "Ho-June Choi", "Soo-In Choi", "So-Youn Cha", "Sang-Baek Koh", "Hee-Taik Kang", "Song Vogue Ahn"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0075535.t002", "stats"=>{"downloads"=>2, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Basic_characteristics_according_to_tertile_increment_of_adiponectin_based_on_each_genders_/817519", "title"=>"Basic characteristics according to tertile increment of adiponectin based on each genders.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-10-08 08:24:57"}

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Relative Metric

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