Association of Multiple Sclerosis Susceptibility Variants and Early Attack Location in the CNS
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{"title"=>"Association of Multiple Sclerosis Susceptibility Variants and Early Attack Location in the CNS", "type"=>"journal", "authors"=>[{"first_name"=>"Ellen M.", "last_name"=>"Mowry", "scopus_author_id"=>"16177709800"}, {"first_name"=>"Robert F.", "last_name"=>"Carey", "scopus_author_id"=>"55877342700"}, {"first_name"=>"Maria R.", "last_name"=>"Blasco", "scopus_author_id"=>"6504097298"}, {"first_name"=>"Jean", "last_name"=>"Pelletier", "scopus_author_id"=>"7201763066"}, {"first_name"=>"Pierre", "last_name"=>"Duquette", "scopus_author_id"=>"7005094902"}, {"first_name"=>"Pablo", "last_name"=>"Villoslada", "scopus_author_id"=>"6602074839"}, {"first_name"=>"Irina", "last_name"=>"Malikova", "scopus_author_id"=>"6602189200"}, {"first_name"=>"Elaine", "last_name"=>"Roger", "scopus_author_id"=>"36143360800"}, {"first_name"=>"R. Phillip", "last_name"=>"Kinkel", "scopus_author_id"=>"7004296151"}, {"first_name"=>"Jamie", "last_name"=>"McDonald", "scopus_author_id"=>"54405684700"}, {"first_name"=>"Peter", "last_name"=>"Bacchetti", "scopus_author_id"=>"7004977420"}, {"first_name"=>"Emmanuelle", "last_name"=>"Waubant", "scopus_author_id"=>"7003751368"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"24130718", "sgr"=>"84885399550", "scopus"=>"2-s2.0-84885399550", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "doi"=>"10.1371/journal.pone.0075565", "pui"=>"370004454", "issn"=>"19326203"}, "id"=>"c62445a9-de53-321f-8351-a7fbcc52fd4e", "abstract"=>"OBJECTIVE: The anatomic location of subsequent relapses in early multiple sclerosis (MS) appears to be predicted by the first attack location. We sought to determine if genetic polymorphisms associated with MS susceptibility are associated with attack location.\\n\\nMETHODS: 17 genome-wide association study-identified MS susceptibility polymorphisms were genotyped in 503 white, non-Hispanic patients seen within a year of MS onset. Their association with the CNS location of the first two MS attacks was assessed in multivariate repeated measures analyses (generalized estimating equations with robust standard errors).\\n\\nRESULTS: The IL12A polymorphism was independently associated with increased odds of attacks involving the spinal cord (OR = 1.52, 95% CI 1.11, 2.07, p = 0.009), as was the IRF8 polymorphism (OR = 2.40, 95% CI [1.04, 5.50], p = 0.040). The IL7R polymorphism was associated with reduced odds of attacks involving the brainstem/cerebellum (OR = 0.46, 95% CI 0.22, 0.97, p = 0.041), as were the TNFRSF1A and IL12A polymorphisms. The CD6 polymorphism conferred reduced odds of optic neuritis as an attack location (OR = 0.69, 95% CI [0.49, 0.97], p = 0.034). Several other genes showed trends for association with attack location.\\n\\nCONCLUSIONS: Some of the MS susceptibility genes may be associated with MS attack location. The IL12A polymorphism is of particular interest given that interferon beta therapy appears to influence IL12 levels. These findings may lead to improved understanding of MS pathogenesis and treatment.", "link"=>"http://www.mendeley.com/research/association-multiple-sclerosis-susceptibility-variants-early-attack-location-cns", "reader_count"=>14, "reader_count_by_academic_status"=>{"Librarian"=>1, "Student > Doctoral Student"=>2, "Researcher"=>3, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Student > Master"=>3, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Librarian"=>1, "Student > Doctoral Student"=>2, "Researcher"=>3, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Student > Master"=>3, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>2, "Medicine and Dentistry"=>7, "Agricultural and Biological Sciences"=>3, "Neuroscience"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>7}, "Neuroscience"=>{"Neuroscience"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}}, "group_count"=>3}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1232898"], "description"=>"<div><p>Objective</p><p>The anatomic location of subsequent relapses in early multiple sclerosis (MS) appears to be predicted by the first attack location. We sought to determine if genetic polymorphisms associated with MS susceptibility are associated with attack location.</p><p>Methods</p><p>17 genome-wide association study-identified MS susceptibility polymorphisms were genotyped in 503 white, non-Hispanic patients seen within a year of MS onset. Their association with the CNS location of the first two MS attacks was assessed in multivariate repeated measures analyses (generalized estimating equations with robust standard errors).</p><p>Results</p><p>The <i>IL12A</i> polymorphism was independently associated with increased odds of attacks involving the spinal cord (OR = 1.52, 95% CI 1.11, 2.07, p = 0.009), as was the IRF8 polymorphism (OR = 2.40, 95% CI [1.04, 5.50], p = 0.040). The <i>IL7R</i> polymorphism was associated with reduced odds of attacks involving the brainstem/cerebellum (OR = 0.46, 95% CI 0.22, 0.97, p = 0.041), as were the <i>TNFRSF1A</i> and <i>IL12A</i> polymorphisms. The <i>CD6</i> polymorphism conferred reduced odds of optic neuritis as an attack location (OR = 0.69, 95% CI [0.49, 0.97], p = 0.034). Several other genes showed trends for association with attack location.</p><p>Conclusions</p><p>Some of the MS susceptibility genes may be associated with MS attack location. The <i>IL12A</i> polymorphism is of particular interest given that interferon beta therapy appears to influence IL12 levels. These findings may lead to improved understanding of MS pathogenesis and treatment.</p></div>", "links"=>[], "tags"=>["sclerosis", "susceptibility", "variants"], "article_id"=>819979, "categories"=>["Biological Sciences"], "users"=>["Ellen M. Mowry", "Robert F. Carey", "Maria R. Blasco", "Jean Pelletier", "Pierre Duquette", "Pablo Villoslada", "Irina Malikova", "Elaine Roger", "R. Phillip Kinkel", "Jamie McDonald", "Peter Bacchetti", "Emmanuelle Waubant"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0075565", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Association_of_Multiple_Sclerosis_Susceptibility_Variants_and_Early_Attack_Location_in_the_CNS_/819979", "title"=>"Association of Multiple Sclerosis Susceptibility Variants and Early Attack Location in the CNS", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-10-10 07:52:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/1232897"], "description"=>"<p>Results presented as odds ratios (95% confidence intervals), p values. The analyses take into account first and second attack locations. Of the entire cohort (n = 503), 349 had a second attack. Attack location could not be resolved for 3 initial attacks and 47 second attacks.</p>", "links"=>[], "tags"=>[], "article_id"=>819978, "categories"=>["Biological Sciences"], "users"=>["Ellen M. Mowry", "Robert F. Carey", "Maria R. Blasco", "Jean Pelletier", "Pierre Duquette", "Pablo Villoslada", "Irina Malikova", "Elaine Roger", "R. Phillip Kinkel", "Jamie McDonald", "Peter Bacchetti", "Emmanuelle Waubant"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0075565.t001", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Predictors_of_attack_location_multivariate_models_/819978", "title"=>"Predictors of attack location (multivariate models).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-10-10 07:52:58"}

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Relative Metric

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