Transcriptome Comparison of Human Neurons Generated Using Induced Pluripotent Stem Cells Derived from Dental Pulp and Skin Fibroblasts
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Transcriptome Comparison of Human Neurons Generated Using Induced Pluripotent Stem Cells Derived from Dental Pulp and Skin Fibroblasts", "type"=>"journal", "authors"=>[{"first_name"=>"Jian", "last_name"=>"Chen", "scopus_author_id"=>"55869690000"}, {"first_name"=>"Mingyan", "last_name"=>"Lin", "scopus_author_id"=>"53164153500"}, {"first_name"=>"John J.", "last_name"=>"Foxe", "scopus_author_id"=>"7004128491"}, {"first_name"=>"Erika", "last_name"=>"Pedrosa", "scopus_author_id"=>"11141772300"}, {"first_name"=>"Anastasia", "last_name"=>"Hrabovsky", "scopus_author_id"=>"49961409000"}, {"first_name"=>"Reed", "last_name"=>"Carroll", "scopus_author_id"=>"7201449093"}, {"first_name"=>"Deyou", "last_name"=>"Zheng", "scopus_author_id"=>"7202567035"}, {"first_name"=>"Herbert M.", "last_name"=>"Lachman", "scopus_author_id"=>"7003903842"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"369937789", "issn"=>"19326203", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "doi"=>"10.1371/journal.pone.0075682", "scopus"=>"2-s2.0-84884826708", "pmid"=>"24098394", "sgr"=>"84884826708"}, "id"=>"b79489be-2ad2-3db1-9eab-12195331bb10", "abstract"=>"Induced pluripotent stem cell (iPSC) technology is providing an opportunity to study neuropsychiatric disorders through the capacity to grow patient-specific neurons in vitro. Skin fibroblasts obtained by biopsy have been the most reliable source of cells for reprogramming. However, using other somatic cells obtained by less invasive means would be ideal, especially in children with autism spectrum disorders (ASD) and other neurodevelopmental conditions. In addition to fibroblasts, iPSCs have been developed from cord blood, lymphocytes, hair keratinocytes, and dental pulp from deciduous teeth. Of these, dental pulp would be a good source for neurodevelopmental disorders in children because obtaining material is non-invasive. We investigated its suitability for disease modeling by carrying out gene expression profiling, using RNA-seq, on differentiated neurons derived from iPSCs made from dental pulp extracted from deciduous teeth (T-iPSCs) and fibroblasts (F-iPSCs). This is the first RNA-seq analysis comparing gene expression profiles in neurons derived from iPSCs made from different somatic cells. For the most part, gene expression profiles were quite similar with only 329 genes showing differential expression at a nominally significant p-value (p<0.05), of which 63 remained significant after correcting for genome-wide analysis (FDR <0.05). The most striking difference was the lower level of expression detected for numerous members of the all four HOX gene families in neurons derived from T-iPSCs. In addition, an increased level of expression was seen for several transcription factors expressed in the developing forebrain (FOXP2, OTX1, and LHX2, for example). Overall, pathway analysis revealed that differentially expressed genes that showed higher levels of expression in neurons derived from T-iPSCs were enriched for genes implicated in schizophrenia (SZ). The findings suggest that neurons derived from T-iPSCs are suitable for disease-modeling neuropsychiatric disorder and may have some advantages over those derived from F-iPSCs.", "link"=>"http://www.mendeley.com/research/transcriptome-comparison-human-neurons-generated-using-induced-pluripotent-stem-cells-derived-dental", "reader_count"=>84, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>6, "Student > Doctoral Student"=>4, "Researcher"=>24, "Student > Ph. D. Student"=>15, "Student > Postgraduate"=>6, "Student > Master"=>12, "Other"=>3, "Student > Bachelor"=>8, "Lecturer"=>2, "Professor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>6, "Student > Doctoral Student"=>4, "Researcher"=>24, "Student > Ph. D. Student"=>15, "Student > Postgraduate"=>6, "Student > Master"=>12, "Other"=>3, "Student > Bachelor"=>8, "Lecturer"=>2, "Professor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>12, "Materials Science"=>1, "Medicine and Dentistry"=>14, "Agricultural and Biological Sciences"=>43, "Neuroscience"=>8, "Psychology"=>3, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Materials Science"=>{"Materials Science"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>14}, "Neuroscience"=>{"Neuroscience"=>8}, "Psychology"=>{"Psychology"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>43}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>12}, "Unspecified"=>{"Unspecified"=>2}}, "reader_count_by_country"=>{"United States"=>1, "China"=>1, "Brazil"=>3, "United Kingdom"=>1, "France"=>1, "Portugal"=>1, "Spain"=>1}, "group_count"=>3}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84884826708"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84884826708?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84884826708&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84884826708&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84884826708", "dc:identifier"=>"SCOPUS_ID:84884826708", "eid"=>"2-s2.0-84884826708", "dc:title"=>"Transcriptome Comparison of Human Neurons Generated Using Induced Pluripotent Stem Cells Derived from Dental Pulp and Skin Fibroblasts", "dc:creator"=>"Chen J.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"8", "prism:issueIdentifier"=>"10", "prism:pageRange"=>nil, "prism:coverDate"=>"2013-10-03", "prism:coverDisplayDate"=>"3 October 2013", "prism:doi"=>"10.1371/journal.pone.0075682", "citedby-count"=>"28", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Albert Einstein College of Medicine of Yeshiva University", "affiliation-city"=>"New York", "affiliation-country"=>"United States"}], "pubmed-id"=>"24098394", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e75682", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0075682", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"130", "xml_views"=>"9", "html_views"=>"544"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"57", "xml_views"=>"0", "html_views"=>"132"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"43", "xml_views"=>"0", "html_views"=>"151"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"41", "xml_views"=>"1", "html_views"=>"177"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"36", "xml_views"=>"0", "html_views"=>"135"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"24", "xml_views"=>"1", "html_views"=>"97"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"16", "xml_views"=>"2", "html_views"=>"90"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"46"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"96"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"31", "xml_views"=>"0", "html_views"=>"85"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"23", "xml_views"=>"2", "html_views"=>"79"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"86"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"17", "xml_views"=>"3", "html_views"=>"63"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"14", "xml_views"=>"4", "html_views"=>"75"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"51"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"51"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"48"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"87"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"64"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"108"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"56"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"71"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"40"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"72"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"55"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"68"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"56"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"19", "xml_views"=>"1", "html_views"=>"58"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"67"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"86"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"61"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"56"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"99"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"58"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"57"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"64"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"63"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"55"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"56"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"58"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"59"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"60"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"55"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"58"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"49"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"51"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"2", "html_views"=>"46"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"53"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"10", "xml_views"=>"2", "html_views"=>"57"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"78"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"38"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"26"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"20"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"3", "html_views"=>"19"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"15"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"28"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"32"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"20"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"18"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"12", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"5"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1223451"], "description"=>"<p>Pathway Analysis for genes that increase in neurons.</p>", "links"=>[], "tags"=>["genes"], "article_id"=>813737, "categories"=>["Biological Sciences"], "users"=>["Jian Chen", "Mingyan Lin", "John J. Foxe", "Erika Pedrosa", "Anastasia Hrabovsky", "Reed Carroll", "Deyou Zheng", "Herbert M. Lachman"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0075682.t004", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Pathway_Analysis_for_genes_that_increase_in_neurons_/813737", "title"=>"Pathway Analysis for genes that increase in neurons.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-10-03 02:06:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/1223450"], "description"=>"<p>Largest fold change (FC) increase in gene expression during transition from iPSCs to Neurons.</p>", "links"=>[], "tags"=>["ipscs"], "article_id"=>813736, "categories"=>["Biological Sciences"], "users"=>["Jian Chen", "Mingyan Lin", "John J. Foxe", "Erika Pedrosa", "Anastasia Hrabovsky", "Reed Carroll", "Deyou Zheng", "Herbert M. Lachman"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0075682.t003", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Largest_fold_change_FC_increase_in_gene_expression_during_transition_from_iPSCs_to_Neurons_/813736", "title"=>"Largest fold change (FC) increase in gene expression during transition from iPSCs to Neurons.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-10-03 02:06:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/1223448"], "description"=>"<p>Largest fold change (FC) increase in gene expression during transition from iPSCs to NPCs.</p>", "links"=>[], "tags"=>["ipscs"], "article_id"=>813734, "categories"=>["Biological Sciences"], "users"=>["Jian Chen", "Mingyan Lin", "John J. Foxe", "Erika Pedrosa", "Anastasia Hrabovsky", "Reed Carroll", "Deyou Zheng", "Herbert M. Lachman"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0075682.t002", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Largest_fold_change_FC_increase_in_gene_expression_during_transition_from_iPSCs_to_NPCs_/813734", "title"=>"Largest fold change (FC) increase in gene expression during transition from iPSCs to NPCs.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-10-03 02:06:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/1223458", "https://ndownloader.figshare.com/files/1223459", "https://ndownloader.figshare.com/files/1223460", "https://ndownloader.figshare.com/files/1223461", "https://ndownloader.figshare.com/files/1223462", "https://ndownloader.figshare.com/files/1223463", "https://ndownloader.figshare.com/files/1223464", "https://ndownloader.figshare.com/files/1223465", "https://ndownloader.figshare.com/files/1223466", "https://ndownloader.figshare.com/files/1223467", "https://ndownloader.figshare.com/files/1223468"], "description"=>"<div><p>Induced pluripotent stem cell (iPSC) technology is providing an opportunity to study neuropsychiatric disorders through the capacity to grow patient-specific neurons <i>in vitro</i>. Skin fibroblasts obtained by biopsy have been the most reliable source of cells for reprogramming. However, using other somatic cells obtained by less invasive means would be ideal, especially in children with autism spectrum disorders (ASD) and other neurodevelopmental conditions. In addition to fibroblasts, iPSCs have been developed from cord blood, lymphocytes, hair keratinocytes, and dental pulp from deciduous teeth. Of these, dental pulp would be a good source for neurodevelopmental disorders in children because obtaining material is non-invasive. We investigated its suitability for disease modeling by carrying out gene expression profiling, using RNA-seq, on differentiated neurons derived from iPSCs made from dental pulp extracted from deciduous teeth (T-iPSCs) and fibroblasts (F-iPSCs). This is the first RNA-seq analysis comparing gene expression profiles in neurons derived from iPSCs made from different somatic cells. For the most part, gene expression profiles were quite similar with only 329 genes showing differential expression at a nominally significant p-value (p<0.05), of which 63 remained significant after correcting for genome-wide analysis (FDR <0.05). The most striking difference was the lower level of expression detected for numerous members of the all four <i>HOX</i> gene families in neurons derived from T-iPSCs. In addition, an increased level of expression was seen for several transcription factors expressed in the developing forebrain (<i>FOXP2, OTX1, and LHX2</i>, for example). Overall, pathway analysis revealed that differentially expressed genes that showed higher levels of expression in neurons derived from T-iPSCs were enriched for genes implicated in schizophrenia (SZ). The findings suggest that neurons derived from T-iPSCs are suitable for disease-modeling neuropsychiatric disorder and may have some advantages over those derived from F-iPSCs.</p></div>", "links"=>[], "tags"=>["neurons", "generated", "induced", "pluripotent", "cells", "derived", "dental", "pulp"], "article_id"=>813744, "categories"=>["Biological Sciences"], "users"=>["Jian Chen", "Mingyan Lin", "John J. Foxe", "Erika Pedrosa", "Anastasia Hrabovsky", "Reed Carroll", "Deyou Zheng", "Herbert M. Lachman"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0075682.s001", "https://dx.doi.org/10.1371/journal.pone.0075682.s002", "https://dx.doi.org/10.1371/journal.pone.0075682.s003", "https://dx.doi.org/10.1371/journal.pone.0075682.s004", "https://dx.doi.org/10.1371/journal.pone.0075682.s005", "https://dx.doi.org/10.1371/journal.pone.0075682.s006", "https://dx.doi.org/10.1371/journal.pone.0075682.s007", "https://dx.doi.org/10.1371/journal.pone.0075682.s008", "https://dx.doi.org/10.1371/journal.pone.0075682.s009", "https://dx.doi.org/10.1371/journal.pone.0075682.s010", "https://dx.doi.org/10.1371/journal.pone.0075682.s011"], "stats"=>{"downloads"=>7, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Transcriptome_Comparison_of_Human_Neurons_Generated_Using_Induced_Pluripotent_Stem_Cells_Derived_from_Dental_Pulp_and_Skin_Fibroblasts_/813744", "title"=>"Transcriptome Comparison of Human Neurons Generated Using Induced Pluripotent Stem Cells Derived from Dental Pulp and Skin Fibroblasts", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-10-03 02:06:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/1223454"], "description"=>"<p>Pathway analysis for differentially expressed genes (uncorrected) T-iPSC neurons vs F-iPSC neurons.</p>", "links"=>[], "tags"=>["differentially", "genes", "t-ipsc", "neurons", "f-ipsc"], "article_id"=>813739, "categories"=>["Biological Sciences"], "users"=>["Jian Chen", "Mingyan Lin", "John J. Foxe", "Erika Pedrosa", "Anastasia Hrabovsky", "Reed Carroll", "Deyou Zheng", "Herbert M. Lachman"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0075682.t006", "stats"=>{"downloads"=>2, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Pathway_analysis_for_differentially_expressed_genes_uncorrected_T_iPSC_neurons_vs_F_iPSC_neurons_/813739", "title"=>"Pathway analysis for differentially expressed genes (uncorrected) T-iPSC neurons vs F-iPSC neurons.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-10-03 02:06:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/1223452"], "description"=>"<p>Pathway Analysis for genes that decrease in neurons.</p>", "links"=>[], "tags"=>["genes"], "article_id"=>813738, "categories"=>["Biological Sciences"], "users"=>["Jian Chen", "Mingyan Lin", "John J. Foxe", "Erika Pedrosa", "Anastasia Hrabovsky", "Reed Carroll", "Deyou Zheng", "Herbert M. Lachman"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0075682.t005", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Pathway_Analysis_for_genes_that_decrease_in_neurons_/813738", "title"=>"Pathway Analysis for genes that decrease in neurons.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-10-03 02:06:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/1223447"], "description"=>"<p>Top differentially expressed genes (fold change; FC) that decrease during differentiation into NPCs.</p>", "links"=>[], "tags"=>["differentially", "genes", "differentiation"], "article_id"=>813733, "categories"=>["Biological Sciences"], "users"=>["Jian Chen", "Mingyan Lin", "John J. Foxe", "Erika Pedrosa", "Anastasia Hrabovsky", "Reed Carroll", "Deyou Zheng", "Herbert M. Lachman"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0075682.t001", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Top_differentially_expressed_genes_fold_change_FC_that_decrease_during_differentiation_into_NPCs_/813733", "title"=>"Top differentially expressed genes (fold change; FC) that decrease during differentiation into NPCs.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-10-03 02:06:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/1223446"], "description"=>"<p>Asterisk denotes FDR<0.05.</p>", "links"=>[], "tags"=>["t-ipscs", "f-ipscs", "log2", "genes", "fpkm"], "article_id"=>813732, "categories"=>["Biological Sciences"], "users"=>["Jian Chen", "Mingyan Lin", "John J. Foxe", "Erika Pedrosa", "Anastasia Hrabovsky", "Reed Carroll", "Deyou Zheng", "Herbert M. Lachman"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0075682.g002", "stats"=>{"downloads"=>2, "page_views"=>35, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Differential_expression_between_T_iPSCs_and_F_iPSCs_mean_log2_fold_change_for_all_HOX_genes_expressed_at_FPKM_1_/813732", "title"=>"Differential expression between T-iPSCs and F-iPSCs (mean log2 fold change) for all <i>HOX</i> genes expressed at FPKM >1.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-10-03 02:06:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/1223443"], "description"=>"<p>Lower right: Train of action potentials with and without tetrodoxin (TTX) in day 35 neurons.</p>", "links"=>[], "tags"=>["vglut2", "tips4", "neurons", "psd95", "synaptophysin", "56"], "article_id"=>813729, "categories"=>["Biological Sciences"], "users"=>["Jian Chen", "Mingyan Lin", "John J. Foxe", "Erika Pedrosa", "Anastasia Hrabovsky", "Reed Carroll", "Deyou Zheng", "Herbert M. Lachman"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0075682.g001", "stats"=>{"downloads"=>0, "page_views"=>53, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_immunostaining_for_GAD_TH_946_III_tubulin_and_VGLUT2_in_TIPS4_neurons_day_14_and_PSD95_and_synaptophysin_SYN_in_day_56_neurons_/813729", "title"=>"immunostaining for GAD, TH, βIII-tubulin and VGLUT2 in TIPS4 neurons (day 14), and PSD95 and synaptophysin (SYN) in day 56 neurons.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-10-03 02:06:59"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"76", "full-text"=>"77", "pdf"=>"38", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"19", "supp-data"=>"64", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"74", "full-text"=>"67", "pdf"=>"35", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"23", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"43", "full-text"=>"43", "pdf"=>"19", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"36", "full-text"=>"29", "pdf"=>"20", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"33", "full-text"=>"30", "pdf"=>"16", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"11", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"27", "full-text"=>"23", "pdf"=>"13", "abstract"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"26", "full-text"=>"21", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"26", "full-text"=>"33", "pdf"=>"10", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"15", "full-text"=>"20", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"34", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"24", "full-text"=>"24", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"5", "cited-by"=>"2", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"16", "full-text"=>"16", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"17", "full-text"=>"24", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"5", "cited-by"=>"2", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"34", "full-text"=>"33", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"22", "full-text"=>"23", "pdf"=>"25", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"17", "full-text"=>"17", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"17", "full-text"=>"19", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"34", "full-text"=>"24", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"11", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"28", "full-text"=>"28", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"29", "full-text"=>"26", "pdf"=>"9", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"16", "full-text"=>"21", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"24", "full-text"=>"25", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"17", "full-text"=>"12", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"17", "full-text"=>"21", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"17", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"48", "full-text"=>"33", "pdf"=>"11", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"20", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"14", "full-text"=>"16", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"28", "full-text"=>"26", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"24", "full-text"=>"24", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"5", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"20", "full-text"=>"18", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"7", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"16", "full-text"=>"15", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"31", "full-text"=>"26", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"1", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"8", "full-text"=>"10", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"19", "full-text"=>"23", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"17", "full-text"=>"14", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"32", "full-text"=>"35", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"14", "full-text"=>"19", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"18", "full-text"=>"11", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"1", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"14", "full-text"=>"13", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"14", "full-text"=>"16", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"9", "full-text"=>"11", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"14", "full-text"=>"19", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"18", "full-text"=>"11", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"20", "full-text"=>"13", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"10", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"12", "full-text"=>"10", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"12", "full-text"=>"15", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"2"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"10", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"15", "full-text"=>"13", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"15", "full-text"=>"12", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"12", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"10", "full-text"=>"15", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"4", "full-text"=>"6", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"18", "full-text"=>"26", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"14", "full-text"=>"11", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"23", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}

Relative Metric

{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[269, 466, 588, 697, 800, 896, 988, 1076, 1165, 1254, 1340, 1417]}, {"subject_area"=>"/Biology and life sciences/Anatomy", "average_usage"=>[248, 440, 562, 666, 765, 856, 944, 1028, 1112, 1198, 1282, 1362, 1430]}, {"subject_area"=>"/Biology and life sciences/Anatomy and physiology", "average_usage"=>[256, 428]}, {"subject_area"=>"/Biology and life sciences/Cell biology", "average_usage"=>[272, 472, 600, 713, 815, 911, 1004, 1094, 1185, 1273, 1358, 1441]}, {"subject_area"=>"/Biology and life sciences/Developmental biology", "average_usage"=>[275, 472, 605, 720, 822, 921, 1013, 1106, 1200, 1289, 1378, 1459, 1531]}, {"subject_area"=>"/Biology and life sciences/Genetics", "average_usage"=>[284, 491, 620, 738, 843, 945, 1043, 1137, 1225, 1315, 1400, 1479, 1555]}, {"subject_area"=>"/Medicine and health sciences/Anatomy", "average_usage"=>[248, 441, 564, 668, 769, 859, 948, 1034, 1117, 1202, 1290, 1368, 1437]}]}
Loading … Spinner
There are currently no alerts