Early Elevation of Serum MMP-3 and MMP-12 Predicts Protection from World Trade Center-Lung Injury in New York City Firefighters: A Nested Case-Control Study
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{"title"=>"Early Elevation of Serum MMP-3 and MMP-12 Predicts Protection from World Trade Center-Lung Injury in New York City Firefighters: A Nested Case-Control Study", "type"=>"journal", "authors"=>[{"first_name"=>"Sophia", "last_name"=>"Kwon", "scopus_author_id"=>"55674891700"}, {"first_name"=>"Michael D.", "last_name"=>"Weiden", "scopus_author_id"=>"7005725007"}, {"first_name"=>"Ghislaine C.", "last_name"=>"Echevarria", "scopus_author_id"=>"57198017720"}, {"first_name"=>"Ashley L.", "last_name"=>"Comfort", "scopus_author_id"=>"35933300300"}, {"first_name"=>"Bushra", "last_name"=>"Naveed", "scopus_author_id"=>"33068124600"}, {"first_name"=>"David J.", "last_name"=>"Prezant", "scopus_author_id"=>"7003745546"}, {"first_name"=>"William N.", "last_name"=>"Rom", "scopus_author_id"=>"34573666300"}, {"first_name"=>"Anna", "last_name"=>"Nolan", "scopus_author_id"=>"7006539837"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pmid"=>"24146820", "doi"=>"10.1371/journal.pone.0076099", "pui"=>"370046360", "issn"=>"19326203", "sgr"=>"84885796867", "scopus"=>"2-s2.0-84885796867"}, "id"=>"62cad106-eca7-325d-a9f2-638bddcf6109", "abstract"=>"OBJECTIVE: After 9/11/2001, some Fire Department of New York (FDNY) workers had excessive lung function decline. We hypothesized that early serum matrix metalloproteinases (MMP) expression predicts World Trade Center-Lung Injury (WTC-LI) years later. METHODS: This is a nested case-control analysis of never-smoking male firefighters with normal pre-exposure Forced Expiratory Volume in one second (FEV1) who had serum drawn up to 155 days post 9/11/2001. Serum MMP-1, 2,3,7,8, 9, 12 and 13 were measured. Cases of WTC-LI (N = 70) were defined as having an FEV1 one standard deviation below the mean (FEV1 </= 77%) at subspecialty pulmonary evaluation (SPE) which was performed 32 months (IQR 21-53) post-9/11. Controls (N = 123) were randomly selected. We modeled MMP's ability as a predictor of cases status with logistic regression adjusted for time to blood draw, exposure intensity, weight gain and pre-9/11 FEV1. RESULTS: Each log-increase in MMP-3 and MMP-12 showed reduced odds of developing WTC-LI by 73% and 54% respectively. MMP-3 and MMP-12 consistently clustered together in cases, controls, and the cohort. Increasing time to blood draw significantly and independently increased the risk of WTC-LI. CONCLUSIONS: Elevated serum levels of MMP-3 and MMP-12 reduce the risk of developing WTC-LI. At any level of MMP-3 or 12, increased time to blood draw is associated with a diminished protective effect.", "link"=>"http://www.mendeley.com/research/early-elevation-serum-mmp3-mmp12-predicts-protection-world-trade-centerlung-injury-new-york-city-fir", "reader_count"=>12, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>2, "Researcher"=>2, "Student > Ph. D. Student"=>3, "Student > Master"=>3, "Other"=>1, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>2, "Researcher"=>2, "Student > Ph. D. Student"=>3, "Student > Master"=>3, "Other"=>1, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Environmental Science"=>2, "Biochemistry, Genetics and Molecular Biology"=>1, "Medicine and Dentistry"=>5, "Agricultural and Biological Sciences"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>2}, "Environmental Science"=>{"Environmental Science"=>2}}, "group_count"=>3}

Scopus | Further Information

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/1239603"], "description"=>"<p>Derivation of Study Cohort from N = 1720 symptomatic FDNY firefighters who presented for subspecialty pulmonary testing. Serum available and inclusion criteria met for N = 70/100 cases and N = 123/153 controls.</p>", "links"=>[], "tags"=>[], "article_id"=>824652, "categories"=>["Biological Sciences"], "users"=>["Sophia Kwon", "Michael D. Weiden", "Ghislaine C. Echevarria", "Ashley L. Comfort", "Bushra Naveed", "David J. Prezant", "William N. Rom", "Anna Nolan"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0076099.g001", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Study_Design_/824652", "title"=>"Study Design.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-10-16 03:51:10"}
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  • {"files"=>["https://ndownloader.figshare.com/files/1239606"], "description"=>"<p>Contour Plots express probability isopleths for the development of WTC-LI with all other covariates held constant. When either MMP-3 (A) or MMP-12 (B) increases, the probability of lung injury decreases. As time to blood draw increases, the probability of lung Injury increases.</p>", "links"=>[], "tags"=>[], "article_id"=>824655, "categories"=>["Biological Sciences"], "users"=>["Sophia Kwon", "Michael D. Weiden", "Ghislaine C. Echevarria", "Ashley L. Comfort", "Bushra Naveed", "David J. Prezant", "William N. Rom", "Anna Nolan"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0076099.g004", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Probability_of_Developing_WTC_LI_/824655", "title"=>"Probability of Developing WTC-LI.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-10-16 03:51:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/1239607"], "description"=>"*<p>Median (IQR).</p><p>WTC, World Trade Center; MME, Medical Monitoring Exam; SPE, Subspecialty Pulmonary Exam; PFT, Pulmonary Function Test; BMI, Body Mass Index.</p>", "links"=>[], "tags"=>[], "article_id"=>824656, "categories"=>["Biological Sciences"], "users"=>["Sophia Kwon", "Michael D. Weiden", "Ghislaine C. Echevarria", "Ashley L. Comfort", "Bushra Naveed", "David J. Prezant", "William N. Rom", "Anna Nolan"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0076099.t001", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Demographics_of_Cohort_/824656", "title"=>"Demographics of Cohort.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-10-16 03:51:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/1239605"], "description"=>"<p>Clustering of MMPs in the cohort, N = 193 showed that MMP3 and MMP-12 clustered together.</p>", "links"=>[], "tags"=>["clustering", "serum"], "article_id"=>824654, "categories"=>["Biological Sciences"], "users"=>["Sophia Kwon", "Michael D. Weiden", "Ghislaine C. Echevarria", "Ashley L. Comfort", "Bushra Naveed", "David J. Prezant", "William N. Rom", "Anna Nolan"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0076099.g003", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Hierarchical_Clustering_of_Serum_MMPs_/824654", "title"=>"Hierarchical Clustering of Serum MMPs.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-10-16 03:51:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/1239610"], "description"=>"*<p>Each Model Includes: ΔBMI between MME and SPE, Exposure Group, Pre-9/11 FEV<sub>1</sub>% Predicted, Time to MME (days) and MMP (Log<sub>10 </sub>pg/mL).</p><p>OR, Odds Ratio; CI, Confidence Interval; AUC, Area Under the Curve; HL, Hosmer Lemeshow.</p>", "links"=>[], "tags"=>["susceptibility"], "article_id"=>824659, "categories"=>["Biological Sciences"], "users"=>["Sophia Kwon", "Michael D. Weiden", "Ghislaine C. Echevarria", "Ashley L. Comfort", "Bushra Naveed", "David J. Prezant", "William N. Rom", "Anna Nolan"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0076099.t004", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Models_of_Susceptibility_to_Lung_Injury_/824659", "title"=>"Models of Susceptibility to Lung Injury.<sup>*</sup>", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-10-16 03:51:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/1239609"], "description"=>"*<p>Median (IQR).</p><p>FEV<sub>1</sub>, Forced Expiratory Volume in one second; FVC, Forced Vital capacity; BDR, Bronchodilator Response; MCT, Methacholine Challenge Testing; PC<sub>20</sub>, Provocative concentration of methacholine that results in a 20% drop in FEV<sub>1</sub>; TLC, Total Lung Capacity; RV, Residual Volume; DL<sub>co,</sub> Diffusing Capacity of the Lung for Carbon Monoxide; VA, Alveolar Ventilation; BWT, Bronchial Wall Thickening.</p>", "links"=>[], "tags"=>[], "article_id"=>824658, "categories"=>["Biological Sciences"], "users"=>["Sophia Kwon", "Michael D. Weiden", "Ghislaine C. Echevarria", "Ashley L. Comfort", "Bushra Naveed", "David J. Prezant", "William N. Rom", "Anna Nolan"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0076099.t002", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Longitudinal_Lung_Function_Assessment_of_Cohort_/824658", "title"=>"Longitudinal Lung Function Assessment of Cohort.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-10-16 03:51:10"}

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Relative Metric

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