Mitochondrial Respiration Regulates Adipogenic Differentiation of Human Mesenchymal Stem Cells
Publication Date
October 18, 2013
Journal
PLOS ONE
Authors
Yanmin Zhang, Glenn Marsboom, Peter T. Toth & Jalees Rehman
Volume
8
Issue
10
Pages
e77077
DOI
https://dx.plos.org/10.1371/journal.pone.0077077
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0077077
Mendeley
http://www.mendeley.com/research/mitochondrial-respiration-regulates-adipogenic-differentiation-human-mesenchymal-stem-cells-2
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Mendeley | Further Information

{"title"=>"Mitochondrial Respiration Regulates Adipogenic Differentiation of Human Mesenchymal Stem Cells", "type"=>"journal", "authors"=>[{"first_name"=>"Yanmin", "last_name"=>"Zhang", "scopus_author_id"=>"56712088100"}, {"first_name"=>"Glenn", "last_name"=>"Marsboom", "scopus_author_id"=>"8892805600"}, {"first_name"=>"Peter T.", "last_name"=>"Toth", "scopus_author_id"=>"7102285293"}, {"first_name"=>"Jalees", "last_name"=>"Rehman", "scopus_author_id"=>"7006233867"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"24204740", "doi"=>"10.1371/journal.pone.0077077", "sgr"=>"84885795369", "scopus"=>"2-s2.0-84885795369", "issn"=>"19326203", "pui"=>"370052188"}, "id"=>"39649527-2d04-3316-80bb-ac61bdb93bf4", "abstract"=>"Human mesenchymal stem cells (MSCs) are adult multipotent stem cells which can be isolated from bone marrow, adipose tissue as well as other tissues and have the capacity to differentiate into a variety of mesenchymal cell types such as adipocytes, osteoblasts and chondrocytes. Differentiation of stem cells into mature cell types is guided by growth factors and hormones, but recent studies suggest that metabolic shifts occur during differentiation and can modulate the differentiation process. We therefore investigated mitochondrial biogenesis, mitochondrial respiration and the mitochondrial membrane potential during adipogenic differentiation of human MSCs. In addition, we inhibited mitochondrial function to assess its effects on adipogenic differentiation. Our data show that mitochondrial biogenesis and oxygen consumption increase markedly during adipogenic differentiation, and that reducing mitochondrial respiration by hypoxia or by inhibition of the mitochondrial electron transport chain significantly suppresses adipogenic differentiation. Furthermore, we used a novel approach to suppress mitochondrial activity using a specific siRNA-based knockdown of the mitochondrial transcription factor A (TFAM), which also resulted in an inhibition of adipogenic differentiation. Taken together, our data demonstrates that increased mitochondrial activity is a prerequisite for MSC differentiation into adipocytes. These findings suggest that metabolic modulation of adult stem cells can maintain stem cell pluripotency or direct adult stem cell differentiation.", "link"=>"http://www.mendeley.com/research/mitochondrial-respiration-regulates-adipogenic-differentiation-human-mesenchymal-stem-cells-2", "reader_count"=>79, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>3, "Researcher"=>20, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>20, "Student > Postgraduate"=>3, "Student > Master"=>10, "Other"=>3, "Student > Bachelor"=>10, "Lecturer"=>3, "Lecturer > Senior Lecturer"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>3, "Researcher"=>20, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>20, "Student > Postgraduate"=>3, "Student > Master"=>10, "Other"=>3, "Student > Bachelor"=>10, "Lecturer"=>3, "Lecturer > Senior Lecturer"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Engineering"=>4, "Unspecified"=>4, "Biochemistry, Genetics and Molecular Biology"=>15, "Nursing and Health Professions"=>1, "Agricultural and Biological Sciences"=>33, "Medicine and Dentistry"=>12, "Sports and Recreations"=>1, "Physics and Astronomy"=>1, "Chemistry"=>2, "Psychology"=>3, "Immunology and Microbiology"=>2, "Earth and Planetary Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>4}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>12}, "Chemistry"=>{"Chemistry"=>2}, "Sports and Recreations"=>{"Sports and Recreations"=>1}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Psychology"=>{"Psychology"=>3}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Earth and Planetary Sciences"=>{"Earth and Planetary Sciences"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>33}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>15}, "Unspecified"=>{"Unspecified"=>4}}, "reader_count_by_country"=>{"Netherlands"=>1, "United States"=>3, "United Kingdom"=>3, "Germany"=>1}, "group_count"=>2}

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  • {"unique-ip"=>"27", "full-text"=>"28", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"28", "full-text"=>"37", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
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Net::HTTPUnauthorized

Source
Scopus
Time
2019-04-19 15:08:12 UTC
Target URL
https://api.elsevier.com/content/search/index:SCOPUS?query=DOI(10.1371%2Fjournal.pone.0077077)
Trace

/app/models/concerns/networkable.rb:21:in `get_result'
/app/models/source.rb:165:in `get_data'
/app/models/retrieval_status.rb:47:in `perform_get_data'
/app/jobs/source_job.rb:52:in `block (2 levels) in perform'
/app/jobs/source_job.rb:51:in `block in perform'
/app/jobs/source_job.rb:35:in `each'
/app/jobs/source_job.rb:35:in `perform'