Integrated Analysis of Dysregulated lncRNA Expression in Fetal Cardiac Tissues with Ventricular Septal Defect
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{"title"=>"Integrated Analysis of Dysregulated lncRNA Expression in Fetal Cardiac Tissues with Ventricular Septal Defect", "type"=>"journal", "authors"=>[{"first_name"=>"Guixian", "last_name"=>"Song", "scopus_author_id"=>"55191164100"}, {"first_name"=>"Yahui", "last_name"=>"Shen", "scopus_author_id"=>"55191439300"}, {"first_name"=>"Jingai", "last_name"=>"Zhu", "scopus_author_id"=>"35091554900"}, {"first_name"=>"Hailang", "last_name"=>"Liu", "scopus_author_id"=>"55191054800"}, {"first_name"=>"Ming", "last_name"=>"Liu", "scopus_author_id"=>"56595920300"}, {"first_name"=>"Ya Qing", "last_name"=>"Shen", "scopus_author_id"=>"55888531500"}, {"first_name"=>"Shasha", "last_name"=>"Zhu", "scopus_author_id"=>"55364794200"}, {"first_name"=>"Xiangqing", "last_name"=>"Kong", "scopus_author_id"=>"7202794522"}, {"first_name"=>"Zhangbin", "last_name"=>"Yu", "scopus_author_id"=>"24171996200"}, {"first_name"=>"Lingmei", "last_name"=>"Qian", "scopus_author_id"=>"15843884100"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84885801238", "sgr"=>"84885801238", "pui"=>"370046495", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pmid"=>"24147006", "doi"=>"10.1371/journal.pone.0077492"}, "id"=>"df827d7d-8a05-37d7-a3fa-bcde1e5bca2c", "abstract"=>"Ventricular septal defects (VSD) are the most common form of congenital heart disease, which is the leading non-infectious cause of death in children; nevertheless, the exact cause of VSD is not yet fully understood. Long non-coding RNAs (lncRNAs) have been shown to play key roles in various biological processes, such as imprinting control, circuitry controlling pluripotency and differentiation, immune responses and chromosome dynamics. Notably, a growing number of lncRNAs have been implicated in disease etiology, although an association with VSD has not been reported. In the present study, we conducted an integrated analysis of dysregulated lncRNAs, focusing specifically on the identification and characterization of lncRNAs potentially involving in initiation of VSD. Comparison of the transcriptome profiles of cardiac tissues from VSD-affected and normal hearts was performed using a second-generation lncRNA microarray, which covers the vast majority of expressed RefSeq transcripts (29,241 lncRNAs and 30,215 coding transcripts). In total, 880 lncRNAs were upregulated and 628 were downregulated in VSD. Furthermore, our established filtering pipeline indicated an association of two lncRNAs, ENST00000513542 and RP11-473L15.2, with VSD. This dysregulation of the lncRNA profile provides a novel insight into the etiology of VSD and furthermore, illustrates the intricate relationship between coding and ncRNA transcripts in cardiac development. These data may offer a background/reference resource for future functional studies of lncRNAs related to VSD.", "link"=>"http://www.mendeley.com/research/integrated-analysis-dysregulated-lncrna-expression-fetal-cardiac-tissues-ventricular-septal-defect", "reader_count"=>30, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Librarian"=>2, "Researcher"=>6, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>4, "Student > Master"=>7, "Student > Bachelor"=>1, "Lecturer"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Librarian"=>2, "Researcher"=>6, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>4, "Student > Master"=>7, "Student > Bachelor"=>1, "Lecturer"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>10, "Medicine and Dentistry"=>2, "Agricultural and Biological Sciences"=>15, "Neuroscience"=>2, "Sports and Recreations"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Neuroscience"=>{"Neuroscience"=>2}, "Sports and Recreations"=>{"Sports and Recreations"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>15}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>10}}, "reader_count_by_country"=>{"Canada"=>1}, "group_count"=>2}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1239745"], "description"=>"<p>(<b>A</b>) Among the dysregulated lncRNAs, there were 905 intergenic, 201 intronic antisense, 175 natural antisense, 61 bidirectional, 38 exon sense and 28 intron sense-overlapping sequences. (<b>B</b> and <b>C</b>) The lncRNAs were mainly between 200 bp and 3000 bp in length. (<b>D</b>) In accordance with the order from large to small, the distance between lncRNAs and the closest coding gene is intergenic 98 kb, bidirectional 69 kb, natural antisense 49 kb, intronic antisense 48 kb , exon sense18 kb and intron sense-overlapping 10 kb.</p>", "links"=>[], "tags"=>["dysregulated", "lncrnas", "vsd-affected", "cardiac"], "article_id"=>824781, "categories"=>["Biological Sciences", "Ecology"], "users"=>["Guixian Song", "Yahui Shen", "Jingai Zhu", "Hailang Liu", "Ming Liu", "Ya-Qing Shen", "Shasha Zhu", "Xiangqing Kong", "Zhangbin Yu", "Lingmei Qian"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0077492.g002", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_General_characteristics_of_dysregulated_lncRNAs_in_VSD_affected_cardiac_tissue_/824781", "title"=>"General characteristics of dysregulated lncRNAs in VSD-affected cardiac tissue.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-10-16 04:03:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/1239744"], "description"=>"<p>(<b>A</b>) Microarray v2.0 recovered the vast majority of expressed RefSeq transcripts; 29,241 lncRNAs and 30,215 coding transcripts can be detected using this this microarray. The lncRNAs are carefully collected from the most authoritative databases such as RefSeq, UCSC Knowngenes, Ensembl and related literature. (<b>B</b>) The scatterplot is a visualization of the variation (or reproducibility) between chips. (<b>C</b>) Hierarchical Clustering was performed to show the distinguishable lncRNAs and mRNA expression pattern among samples. (<b>D</b>) Our qRT-PCR data were confirmed to be consistent with the microarray results.</p>", "links"=>[], "tags"=>[], "article_id"=>824780, "categories"=>["Biological Sciences", "Ecology"], "users"=>["Guixian Song", "Yahui Shen", "Jingai Zhu", "Hailang Liu", "Ming Liu", "Ya-Qing Shen", "Shasha Zhu", "Xiangqing Kong", "Zhangbin Yu", "Lingmei Qian"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0077492.g001", "stats"=>{"downloads"=>3, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Profile_of_microarray_/824780", "title"=>"Profile of microarray.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-10-16 04:03:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/1239749", "https://ndownloader.figshare.com/files/1239750", "https://ndownloader.figshare.com/files/1239751"], "description"=>"<div><p>Ventricular septal defects (VSD) are the most common form of congenital heart disease, which is the leading non-infectious cause of death in children; nevertheless, the exact cause of VSD is not yet fully understood. Long non-coding RNAs (lncRNAs) have been shown to play key roles in various biological processes, such as imprinting control, circuitry controlling pluripotency and differentiation, immune responses and chromosome dynamics. Notably, a growing number of lncRNAs have been implicated in disease etiology, although an association with VSD has not been reported. In the present study, we conducted an integrated analysis of dysregulated lncRNAs, focusing specifically on the identification and characterization of lncRNAs potentially involving in initiation of VSD. Comparison of the transcriptome profiles of cardiac tissues from VSD-affected and normal hearts was performed using a second-generation lncRNA microarray, which covers the vast majority of expressed RefSeq transcripts (29,241 lncRNAs and 30,215 coding transcripts). In total, 880 lncRNAs were upregulated and 628 were downregulated in VSD. Furthermore, our established filtering pipeline indicated an association of two lncRNAs, ENST00000513542 and RP11-473L15.2, with VSD. This dysregulation of the lncRNA profile provides a novel insight into the etiology of VSD and furthermore, illustrates the intricate relationship between coding and ncRNA transcripts in cardiac development. These data may offer a background/reference resource for future functional studies of lncRNAs related to VSD.</p> </div>", "links"=>[], "tags"=>["dysregulated", "lncrna", "fetal", "cardiac", "tissues", "ventricular", "septal"], "article_id"=>824785, "categories"=>["Biological Sciences", "Ecology"], "users"=>["Guixian Song", "Yahui Shen", "Jingai Zhu", "Hailang Liu", "Ming Liu", "Ya-Qing Shen", "Shasha Zhu", "Xiangqing Kong", "Zhangbin Yu", "Lingmei Qian"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0077492.s001", "https://dx.doi.org/10.1371/journal.pone.0077492.s002", "https://dx.doi.org/10.1371/journal.pone.0077492.s003"], "stats"=>{"downloads"=>9, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Integrated_Analysis_of_Dysregulated_lncRNA_Expression_in_Fetal_Cardiac_Tissues_with_Ventricular_Septal_Defect_/824785", "title"=>"Integrated Analysis of Dysregulated lncRNA Expression in Fetal Cardiac Tissues with Ventricular Septal Defect", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-10-16 04:03:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/1239747"], "description"=>"<p>(<b>A</b>) The overview of the pipeline for validation of lncRNA candidates in VSD. (<b>B</b>) Analysis of the conservation of all classes of dysregulated lncRNAs compared to conservative coding genes revealed an absence of high levels of conservation across species among the majority of lncRNAs. (<b>C</b>) The expression of the 10 selected heart expressed lncRNAs transcripts was validated by quantitative PCR in five human fetal tissues. The majority of the tested lncRNAs transcripts are predominately expressed in heart (percentage range; white, 0% to black, 100%). (<b>D</b>) To estimate the correlation of these two lncRNAs and the associated genes, we detected SMAD 1 and FGF10 expression in fetal heart tissues. We found that the expression of SMAD1 is significantly lower in VSD heart tissues than NC heart. No significant difference in FGF10 expression was observed between the two groups.</p>", "links"=>[], "tags"=>["lncrna", "candidates", "vsd-affected", "cardiac"], "article_id"=>824783, "categories"=>["Biological Sciences", "Ecology"], "users"=>["Guixian Song", "Yahui Shen", "Jingai Zhu", "Hailang Liu", "Ming Liu", "Ya-Qing Shen", "Shasha Zhu", "Xiangqing Kong", "Zhangbin Yu", "Lingmei Qian"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0077492.g004", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Validation_of_lncRNA_candidates_in_VSD_affected_cardiac_tissue_/824783", "title"=>"Validation of lncRNA candidates in VSD-affected cardiac tissue.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-10-16 04:03:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/1239748"], "description"=>"<p>(<b>A</b>) ENST00000513542 is a natural antisense lncRNA, transcribed from 2,105 bp downstream of the second exon of the <i>Smad1</i> gene. (<b>B</b>) Several tracks of interest, including conservation, histone markings, DNase hypersensitivity, and TFBS are displayed. Integrated Regulation track data for a region spanning the ENST0000051354 are shown. The red box shows a region of overlap between the various tracks. (<b>C</b>) Transcription factor binding sites (TFBS) prediction indicated that ENST0000051354 loci combine with AP-1 as a cis-acting element. (<b>D</b>) Further catRAPID analysis indicated a strong RNA-protein interaction between ENST0000051354 and TCF-4, which is the TF of SMAD1.</p>", "links"=>[], "tags"=>[], "article_id"=>824784, "categories"=>["Biological Sciences", "Ecology"], "users"=>["Guixian Song", "Yahui Shen", "Jingai Zhu", "Hailang Liu", "Ming Liu", "Ya-Qing Shen", "Shasha Zhu", "Xiangqing Kong", "Zhangbin Yu", "Lingmei Qian"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0077492.g005", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Bioinformatics_analysis_of_ENST00000513542_/824784", "title"=>"Bioinformatics analysis of ENST00000513542.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-10-16 04:03:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/1239746"], "description"=>"<p>The first 10 Go ID (<b>A</b>) and first six pathways (<b>B</b>) that exhibited significant differences between VSD and NC groups are listed (left and Right panel show the associated coding genes of downregulated and upregulated lncRNAs, respectively).</p>", "links"=>[], "tags"=>["pathway"], "article_id"=>824782, "categories"=>["Biological Sciences", "Ecology"], "users"=>["Guixian Song", "Yahui Shen", "Jingai Zhu", "Hailang Liu", "Ming Liu", "Ya-Qing Shen", "Shasha Zhu", "Xiangqing Kong", "Zhangbin Yu", "Lingmei Qian"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0077492.g003", "stats"=>{"downloads"=>3, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_GO_and_pathway_analysis_/824782", "title"=>"GO and pathway analysis.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-10-16 04:03:47"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"49", "full-text"=>"52", "pdf"=>"29", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"38", "full-text"=>"34", "pdf"=>"26", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"31", "full-text"=>"30", "pdf"=>"20", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"35", "full-text"=>"32", "pdf"=>"28", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"22", "full-text"=>"23", "pdf"=>"17", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"16", "full-text"=>"16", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"19", "full-text"=>"15", "pdf"=>"22", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"12", "full-text"=>"16", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"24", "full-text"=>"17", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"21", "full-text"=>"20", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"14", "full-text"=>"16", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"21", "full-text"=>"23", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"21", "full-text"=>"23", "pdf"=>"20", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"15", "full-text"=>"13", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"18", "full-text"=>"17", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"18", "full-text"=>"16", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"29", "full-text"=>"28", "pdf"=>"13", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"13", "full-text"=>"14", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"1", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"32", "full-text"=>"27", "pdf"=>"22", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"12", "full-text"=>"9", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"13", "full-text"=>"9", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"14", "full-text"=>"10", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"15", "full-text"=>"14", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"1", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"16", "full-text"=>"17", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"10", "full-text"=>"5", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"9", "full-text"=>"4", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"10", "full-text"=>"12", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"18", "full-text"=>"16", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"11", "full-text"=>"9", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"13", "full-text"=>"19", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"11", "full-text"=>"15", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"10", "full-text"=>"12", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"16", "full-text"=>"14", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"8", "full-text"=>"5", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"11", "full-text"=>"14", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"11", "full-text"=>"18", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}

Relative Metric

{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[269, 466, 588, 697, 800, 896, 988, 1076, 1165, 1254, 1340, 1417]}, {"subject_area"=>"/Biology and life sciences/Biochemistry", "average_usage"=>[266, 468, 593, 703, 804, 903, 993, 1084, 1171, 1256, 1339, 1422, 1492]}, {"subject_area"=>"/Biology and life sciences/Genetics", "average_usage"=>[284, 491, 620, 738, 843, 945, 1043, 1137, 1225, 1315, 1400, 1479, 1555]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[264, 460, 584, 692, 794, 887, 978, 1067, 1154, 1241, 1328, 1408, 1474]}, {"subject_area"=>"/Medicine and health sciences/Cardiology", "average_usage"=>[233, 405, 515, 618, 700, 797, 883, 958, 1036, 1108, 1178, 1238, 1299]}, {"subject_area"=>"/Medicine and health sciences/Congenital disorders", "average_usage"=>[314, 451, 556, 681, 833, 938, 1054, 1118, 1187, 1251, 1325, 1434, 1494, 1568]}]}
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