Direct Contra Naïve-Indirect Comparison of Clinical Failure Rates between High-Viscosity GIC and Conventional Amalgam Restorations: An Empirical Study
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{"title"=>"Direct Contra Naïve-Indirect Comparison of Clinical Failure Rates between High-Viscosity GIC and Conventional Amalgam Restorations: An Empirical Study", "type"=>"journal", "authors"=>[{"first_name"=>"Steffen", "last_name"=>"Mickenautsch", "scopus_author_id"=>"6603131822"}, {"first_name"=>"Veerasamy", "last_name"=>"Yengopal", "scopus_author_id"=>"23570240300"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84886618618", "doi"=>"10.1371/journal.pone.0078397", "issn"=>"19326203", "pmid"=>"24205220", "pui"=>"370137473", "sgr"=>"84886618618"}, "id"=>"581bd5b5-cfe7-386d-bff0-f051fd09fc0a", "abstract"=>"BACKGROUND: Naïve-indirect comparisons are comparisons between competing clinical interventions' evidence from separate (uncontrolled) trials. Direct comparisons are comparisons within randomised control trials (RCTs). The objective of this empirical study is to test the null-hypothesis that trends and performance differences inferred from naïve-indirect comparisons and from direct comparisons/RCTs regarding the failure rates of amalgam and direct high-viscosity glass-ionomer cement (HVGIC) restorations in permanent posterior teeth have similar direction and magnitude.\\n\\nMETHODS: A total of 896 citations were identified through systematic literature search. From these, ten and two uncontrolled clinical longitudinal studies for HVGIC and amalgam, respectively, were included for naïve-indirect comparison and could be matched with three out twenty RCTs. Summary effects sizes were computed as Odds ratios (OR; 95% Confidence intervals) and compared with those from RCTs. Trend directions were inferred from 95% Confidence interval overlaps and direction of point estimates; magnitudes of performance differences were inferred from the median point estimates (OR) with 25% and 75% percentile range, for both types of comparison. Mann-Whitney U test was applied to test for statistically significant differences between point estimates of both comparison types.\\n\\nRESULTS: Trends and performance differences inferred from naïve-indirect comparison based on evidence from uncontrolled clinical longitudinal studies and from direct comparisons based on RCT evidence are not the same. The distributions of the point estimates differed significantly for both comparison types (Mann-Whitney U  =  25, n(indirect)  =  26; n(direct)  =  8; p  =  0.0013, two-tailed).\\n\\nCONCLUSION: The null-hypothesis was rejected. Trends and performance differences inferred from either comparison between HVGIC and amalgam restorations failure rates in permanent posterior teeth are not the same. It is recommended that clinical practice guidance regarding HVGICs should rest on direct comparisons via RCTs and not on naïve-indirect comparisons based on uncontrolled longitudinal studies in order to avoid inflation of effect estimates.", "link"=>"http://www.mendeley.com/research/direct-contra-na%C3%AFveindirect-comparison-clinical-failure-rates-between-highviscosity-gic-conventional", "reader_count"=>9, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Librarian"=>1, "Student > Ph. D. Student"=>2, "Student > Master"=>1, "Student > Bachelor"=>2, "Professor"=>1, "Unspecified"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Librarian"=>1, "Student > Ph. D. Student"=>2, "Student > Master"=>1, "Student > Bachelor"=>2, "Professor"=>1, "Unspecified"=>1}, "reader_count_by_subject_area"=>{"Materials Science"=>1, "Medicine and Dentistry"=>6, "Computer Science"=>1, "Unspecified"=>1}, "reader_count_by_subdiscipline"=>{"Materials Science"=>{"Materials Science"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>6}, "Computer Science"=>{"Computer Science"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>0}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1259731"], "description"=>"<p>RCT  =  Matched randomised control trials from systematic review <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0078397#pone.0078397-Heintze2\" target=\"_blank\">[13]</a>; HVGIC  =  high-viscosity glass-ionomer cement.</p>", "links"=>[], "tags"=>["diagram", "uncontrolled", "longitudinal"], "article_id"=>833667, "categories"=>["Biological Sciences"], "users"=>["Steffen Mickenautsch", "Veerasamy Yengopal"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0078397.g001", "stats"=>{"downloads"=>5, "page_views"=>85, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Flow_diagram_of_uncontrolled_clinical_longitudinal_study_selection_/833667", "title"=>"Flow diagram of uncontrolled clinical longitudinal study selection.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-10-28 03:04:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/1259732"], "description"=>"<p>OR  =  Odds ratio; CI  =  Confidence interval; n  =  Number of failed restorations; N  =  Number of evaluated restorations; h-v.  =  high-viscosity; GIC  =  Glass-ionomer cement; ‘1-arm study’  =  Naïve-indirect comparisons of uncontrolled longitudinal study; 2-arm study’  =  Direct comparison within a randomised control trial; Not estimable  =  Both interventions have essentially the same n/N data; i.e. OR  =  1.00; ‘Study or sub-category’  =  Dataset number of comparison (see <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0078397#pone-0078397-t003\" target=\"_blank\">Table 3</a>).</p>", "links"=>[], "tags"=>["estimates", "rates", "restorations", "posterior"], "article_id"=>833668, "categories"=>["Biological Sciences"], "users"=>["Steffen Mickenautsch", "Veerasamy Yengopal"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0078397.g002", "stats"=>{"downloads"=>5, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Computed_effect_estimates_of_studies_Failure_rates_of_Class_I_restorations_in_posterior_permanent_teeth_/833668", "title"=>"Computed effect estimates of studies: Failure rates of Class I restorations in posterior permanent teeth.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-10-28 03:04:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/1259733"], "description"=>"<p>OR  =  Odds ratio; CI  =  Confidence interval; n  =  Number of failed restorations; N  =  Number of evaluated restorations; h-v.  =  high-viscosity; GIC  =  Glass-ionomer cement; ‘1-arm study’  =  Naïve-indirect comparisons of uncontrolled longitudinal study; 2-arm study’  =  Direct comparison within a randomised control trial; Not estimable  =  Both interventions have essentially the same n/N data; i.e. OR  =  1.00; ‘Study or sub-category’  =  Dataset number of comparison (see <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0078397#pone-0078397-t003\" target=\"_blank\">Table 3</a>).</p>", "links"=>[], "tags"=>["estimates", "rates", "ii", "restorations", "posterior"], "article_id"=>833669, "categories"=>["Biological Sciences"], "users"=>["Steffen Mickenautsch", "Veerasamy Yengopal"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0078397.g003", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Computed_effect_estimates_of_studies_Failure_rates_of_Class_II_restorations_in_posterior_permanent_teeth_/833669", "title"=>"Computed effect estimates of studies: Failure rates of Class II restorations in posterior permanent teeth.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-10-28 03:04:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/1259734"], "description"=>"<p>SD  =  Standard deviation.</p>", "links"=>[], "tags"=>["uncontrolled", "longitudinal"], "article_id"=>833670, "categories"=>["Biological Sciences"], "users"=>["Steffen Mickenautsch", "Veerasamy Yengopal"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0078397.t001", "stats"=>{"downloads"=>0, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Included_uncontrolled_clinical_longitudinal_studies_/833670", "title"=>"Included uncontrolled clinical longitudinal studies.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-10-28 03:04:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/1259735"], "description"=>"<p>SD  =  Standard deviation; HVGIC  =  High-viscosity glass-ionomer cement; RCT  =  Randomised controlled trial.</p>", "links"=>[], "tags"=>["studies", "cavity", "follow-up"], "article_id"=>833671, "categories"=>["Biological Sciences"], "users"=>["Steffen Mickenautsch", "Veerasamy Yengopal"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0078397.t002", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Matched_studies_as_per_cavity_class_and_follow_up_period_/833671", "title"=>"Matched studies as per cavity class and follow-up period.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-10-28 03:04:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/1259736"], "description"=>"<p>DS  =  Datasets number; n  =  Number of failed restorations; N  =  Number of evaluated restorations; RCT  =  Randomised control trial;</p><p>HVGIC  =  High-viscosity glass-ionomer cement. *HVGIC  =  ChemFlex; **HVGIC  =  Fuji IX.</p>", "links"=>[], "tags"=>["datasets", "studies"], "article_id"=>833672, "categories"=>["Biological Sciences"], "users"=>["Steffen Mickenautsch", "Veerasamy Yengopal"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0078397.t003", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Extracted_datasets_from_studies_for_analysis_/833672", "title"=>"Extracted datasets from studies for analysis.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-10-28 03:04:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/1259737", "https://ndownloader.figshare.com/files/1259738", "https://ndownloader.figshare.com/files/1259739"], "description"=>"<div><p>Background</p><p>Naïve-indirect comparisons are comparisons between competing clinical interventions’ evidence from separate (uncontrolled) trials. Direct comparisons are comparisons within randomised control trials (RCTs). The objective of this empirical study is to test the null-hypothesis that trends and performance differences inferred from naïve-indirect comparisons and from direct comparisons/RCTs regarding the failure rates of amalgam and direct high-viscosity glass-ionomer cement (HVGIC) restorations in permanent posterior teeth have similar direction and magnitude.</p><p>Methods</p><p>A total of 896 citations were identified through systematic literature search. From these, ten and two uncontrolled clinical longitudinal studies for HVGIC and amalgam, respectively, were included for naïve-indirect comparison and could be matched with three out twenty RCTs. Summary effects sizes were computed as Odds ratios (OR; 95% Confidence intervals) and compared with those from RCTs. Trend directions were inferred from 95% Confidence interval overlaps and direction of point estimates; magnitudes of performance differences were inferred from the median point estimates (OR) with 25% and 75% percentile range, for both types of comparison. Mann-Whitney U test was applied to test for statistically significant differences between point estimates of both comparison types.</p><p>Results</p><p>Trends and performance differences inferred from naïve-indirect comparison based on evidence from uncontrolled clinical longitudinal studies and from direct comparisons based on RCT evidence are not the same. The distributions of the point estimates differed significantly for both comparison types (Mann–Whitney U  =  25, n<sub>indirect</sub>  =  26; n<sub>direct</sub>  =  8; p  =  0.0013, two-tailed).</p><p>Conclusion</p><p>The null-hypothesis was rejected. Trends and performance differences inferred from either comparison between HVGIC and amalgam restorations failure rates in permanent posterior teeth are not the same. It is recommended that clinical practice guidance regarding HVGICs should rest on direct comparisons via RCTs and not on naïve-indirect comparisons based on uncontrolled longitudinal studies in order to avoid inflation of effect estimates.</p></div>", "links"=>[], "tags"=>["contra", "rates", "high-viscosity", "gic", "amalgam", "empirical"], "article_id"=>833673, "categories"=>["Biological Sciences"], "users"=>["Steffen Mickenautsch", "Veerasamy Yengopal"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0078397.s001", "https://dx.doi.org/10.1371/journal.pone.0078397.s002", "https://dx.doi.org/10.1371/journal.pone.0078397.s003"], "stats"=>{"downloads"=>27, "page_views"=>19, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Direct_Contra_Na_239_ve_Indirect_Comparison_of_Clinical_Failure_Rates_between_High_Viscosity_GIC_and_Conventional_Amalgam_Restorations_An_Empirical_Study_/833673", "title"=>"Direct Contra Naïve-Indirect Comparison of Clinical Failure Rates between High-Viscosity GIC and Conventional Amalgam Restorations: An Empirical Study", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-10-28 03:04:59"}

PMC Usage Stats | Further Information

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Relative Metric

{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Anatomy and physiology", "average_usage"=>[256, 428]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[264, 460, 584, 692, 794, 887, 978, 1067, 1154, 1241, 1328, 1408, 1474]}, {"subject_area"=>"/Physical sciences/Mathematics", "average_usage"=>[259, 431, 541, 639, 727, 816, 898, 980, 1061, 1136, 1214, 1294, 1356]}]}
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