Dietary Omega-3 Fatty Acids Promote Arrhythmogenic Remodeling of Cellular Ca2+ Handling in a Postinfarction Model of Sudden Cardiac Death
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{"title"=>"Dietary Omega-3 Fatty Acids Promote Arrhythmogenic Remodeling of Cellular Ca2+ Handling in a Postinfarction Model of Sudden Cardiac Death", "type"=>"journal", "authors"=>[{"first_name"=>"Andriy E.", "last_name"=>"Belevych", "scopus_author_id"=>"6506917957"}, {"first_name"=>"Hsiang Ting", "last_name"=>"Ho", "scopus_author_id"=>"39161344100"}, {"first_name"=>"Radmila", "last_name"=>"Terentyeva", "scopus_author_id"=>"8836398900"}, {"first_name"=>"Ingrid M.", "last_name"=>"Bonilla", "scopus_author_id"=>"25921649300"}, {"first_name"=>"Dmitry", "last_name"=>"Terentyev", "scopus_author_id"=>"6602960184"}, {"first_name"=>"Cynthia A.", "last_name"=>"Carnes", "scopus_author_id"=>"6701801586"}, {"first_name"=>"Sandor", "last_name"=>"Gyorke", "scopus_author_id"=>"16156531200"}, {"first_name"=>"George E.", "last_name"=>"Billman", "scopus_author_id"=>"7006159942"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"24205228", "sgr"=>"84885728407", "pui"=>"370052358", "scopus"=>"2-s2.0-84885728407", "issn"=>"19326203", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "doi"=>"10.1371/journal.pone.0078414"}, "id"=>"d11c5352-a213-3e0e-bd3f-ad7d6495704c", "abstract"=>"It has been proposed that dietary omega-3 polyunsaturated fatty acids (n-3 PUFAs) can reduce the risk of ventricular arrhythmias in post-MI patients. Abnormal Ca2+ handling has been implicated in the genesis of post-MI ventricular arrhythmias. Therefore, we tested the hypothesis that dietary n-3 PUFAs alter the vulnerability of ventricular myocytes to cellular arrhythmia by stabilizing intracellular Ca2+ cycling. To test this hypothesis, we used a canine model of post-MI ventricular fibrillation (VF) and assigned the animals to either placebo (1 g/day corn oil) or n-3 PUFAs (1-4 g/day) groups. Using Ca2+ imaging techniques, we examined the intracellular Ca2+ handling in myocytes isolated from post-MI hearts resistant (VF-) and susceptible (VF+) to VF. Frequency of occurrence of diastolic Ca2+ waves (DCWs) in VF+ myocytes from placebo group was significantly higher than in placebo-treated VF- myocytes. n-3 PUFA treatment did not decrease frequency of DCWs in VF+ myocytes. In contrast, VF- myocytes from the n-3 PUFA group had a significantly higher frequency of DCWs than myocytes from the placebo group. In addition, n-3 PUFA treatment increased beat-to-beat alterations in the amplitude of Ca2+ transients (Ca2+ alternans) in VF- myocytes. These n-3 PUFAs effects in VF- myocytes were associated with an increased Ca2+ spark frequency and reduced sarcoplasmic reticulum Ca2+ content, indicative of increased activity of ryanodine receptors. Thus, dietary n-3 PUFAs do not alleviate intracellular Ca2+ cycling remodeling in myocytes isolated from post-MI VF+ hearts. Furthermore, dietary n-3 PUFAs increase vulnerability of ventricular myocytes to cellular arrhythmia in post-MI VF- hearts by destabilizing intracellular Ca2+ handling. © 2013 Belevych et al.", "link"=>"http://www.mendeley.com/research/dietary-omega3-fatty-acids-promote-arrhythmogenic-remodeling-cellular-ca2-handling-postinfarction-mo", "reader_count"=>12, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Librarian"=>1, "Researcher"=>2, "Student > Ph. D. Student"=>4, "Student > Master"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Librarian"=>1, "Researcher"=>2, "Student > Ph. D. Student"=>4, "Student > Master"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Medicine and Dentistry"=>7, "Agricultural and Biological Sciences"=>1, "Design"=>1, "Veterinary Science and Veterinary Medicine"=>2}, "reader_count_by_subdiscipline"=>{"Design"=>{"Design"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>7}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Unspecified"=>{"Unspecified"=>1}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>2}}, "reader_count_by_country"=>{"United Kingdom"=>1}, "group_count"=>1}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1251977"], "description"=>"<p>Representative line-scan images and corresponding profiles of Rhod-2 fluorescence during periodic (0.3 Hz) electrical stimulation recorded in myocytes from placebo/untreated and n-3 PUFA-treated controls (<b>A</b>), VF- (B) and VF+ (C) groups, respectively. Data were obtained in the presence of 100 nM isoproterenol, a β-adrenergic receptor agonist. <b>D</b>, Average frequency of DCWs (per second) was: 0.11±0.03 (n=15) and 0.14±0.03 (n=40) in control untreated and n-3 PUFA-treated myocytes, respectively (P=0.5); 0.07±0.03 (n=20) and 0.21±0.04 (n=20) in VF- myocytes from placebo and n-3 PUFAs groups, respectively (P=0.014); 0.23±0.05 (n=8) and 0.32±0.05 (n=8), in VF+ myocytes from placebo and n-3 PUFAs groups, respectively (P=0.22). *, P<0.05 <i>vs</i>. VF- placebo; †, P<0.05 <i>vs</i>. n-3 PUFA-treated controls. <b>E</b>, Bar graph shows proportion of myocytes displaying DCWs. In control groups DCWs were recorded in 9 out of 15 untreated cells and in 24 out of 40 n-3 PUFA-treated cells, respectively. In VF- groups DCWs were recorded in 4 out of 20 placebo-treated cells and in 14 out of 20 n-3 PUFA-treated cells, respectively. In VF+ groups DCWs were recorded in 7 out of 8 placebo-treated cells and in 8 out of 8 n-3 PUFA-treated cells, respectively. </p>", "links"=>[], "tags"=>["n-3", "pufas", "induce", "pro-arrhythmic", "remodeling", "intracellular", "handling", "vf-"], "article_id"=>827869, "categories"=>["Biological Sciences"], "users"=>["Andriy E. Belevych", "Hsiang-Ting Ho", "Radmila Terentyeva", "Ingrid M. Bonilla", "Dmitry Terentyev", "Cynthia A. Carnes", "Sandor Gyorke", "George E. Billman"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0078414.g001", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Dietary_n_3_PUFAs_induce_pro_arrhythmic_remodeling_of_intracellular_Ca_2_handling_in_VF_myocytes_/827869", "title"=>"Dietary n-3 PUFAs induce pro-arrhythmic remodeling of intracellular Ca<sup>2+</sup> handling in VF- myocytes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-10-18 03:24:45"}
  • {"files"=>["https://ndownloader.figshare.com/files/1251981"], "description"=>"<p><b>A</b>, Representative line-scan images of Ca<sup>2+</sup> sparks recorded in saponin-permeabilized myocytes from indicated groups. Insets show scaled up image of Ca<sup>2+</sup> spark with corresponding time-dependent fluorescence profile. <b>B</b>, Representative traces of Ca<sup>2+</sup> transients evoked by 10 mM caffeine recorded in permeabilized myocytes from indicated groups. <b>C</b>, Average Ca<sup>2+</sup> spark frequency (in 100 µm<sup>-1</sup>*s<sup>-1</sup>) was 1.23±0.13 (n=52) in untreated control myocytes, 2.01±0.19 (n=47) and 3.31±0.38 (n=45) in untreated and n-3 PUFA-treated VF- myocytes, respectively. <b>D</b>, Average amplitude of caffeine-induced Ca<sup>2+</sup> transients ([Ca<sup>2+</sup>]<sub>CAFF</sub>, ΔF/F<sub>0</sub>) was 2.76±0.34 (n=7) in untreated control myocytes, 2.19±0.11 (n=5) and 1.42±0.06 (n=4) in untreated and n-3 PUFA-treated VF- myocytes, respectively. *, P<0.05 <i>vs</i>. control; †, P<0.05 <i>vs</i>. VF- untreated.</p>", "links"=>[], "tags"=>["n-3", "pufas", "sparks", "vf-"], "article_id"=>827873, "categories"=>["Biological Sciences"], "users"=>["Andriy E. Belevych", "Hsiang-Ting Ho", "Radmila Terentyeva", "Ingrid M. Bonilla", "Dmitry Terentyev", "Cynthia A. Carnes", "Sandor Gyorke", "George E. Billman"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0078414.g003", "stats"=>{"downloads"=>1, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Dietary_n_3_PUFAs_increase_frequency_of_Ca_2_sparks_in_VF_myocytes_/827873", "title"=>"Dietary n-3 PUFAs increase frequency of Ca<sup>2+</sup> sparks in VF- myocytes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-10-18 03:24:45"}
  • {"files"=>["https://ndownloader.figshare.com/files/1251982"], "description"=>"<p><b>A</b>-<b>C</b>, Representative immunoblots of left ventricle homogenates prepared from placebo and n-3 PUFA-treated control (sham) and VF- groups. NCX1, Na<sup>+</sup>/Ca<sup>2+</sup> exchanger type 1; SERCA2a, cardiac isoform of SR Ca<sup>2+</sup>-ATPase; GAPDH, Glyceraldehyde 3-phosphate dehydrogenase; PLN, phospholamban; Cav1.2, α1C subunit of L-type Ca<sup>2+</sup> channel. Data were obtained using 2-4 heart samples. Quantitative analysis is presented in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0078414#pone-0078414-t002\" target=\"_blank\">Table 2</a>.</p>", "links"=>[], "tags"=>["n-3", "pufas", "phosphorylation", "proteins", "cardiac"], "article_id"=>827874, "categories"=>["Biological Sciences"], "users"=>["Andriy E. Belevych", "Hsiang-Ting Ho", "Radmila Terentyeva", "Ingrid M. Bonilla", "Dmitry Terentyev", "Cynthia A. Carnes", "Sandor Gyorke", "George E. Billman"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0078414.g004", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Dietary_n_3_PUFAs_do_not_affect_expression_and_phosphorylation_levels_of_proteins_involved_in_cardiac_Ca_2_cycling_/827874", "title"=>"Dietary n-3 PUFAs do not affect expression and phosphorylation levels of proteins involved in cardiac Ca<sup>2+</sup> cycling.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-10-18 03:24:45"}
  • {"files"=>["https://ndownloader.figshare.com/files/1251979"], "description"=>"<p>Representative line-scan images and corresponding profiles of Rhod-2 fluorescence recorded in myocytes from indicated groups at 0.5 (<b>A</b>) and 1 Hz (<b>B</b>) stimulation. Bar graphs show amplitude (<b>C</b>) and incidence (<b>D</b>) of Ca<sup>2+</sup> alternans recorded in control untreated myocytes and VF- myocytes from placebo and n-3 PUFAs groups at 0.5 and 1Hz. Number of myocytes with amplitude of Ca<sup>2+</sup> alternans larger than 10 % (numerator) and total number of myocytes studied (denominator) are indicated for each group presented in panel D bar graph. *, P<0.05 <i>vs</i>. control (1Hz); †, P<0.05 <i>vs</i>. VF- placebo (1Hz).</p>", "links"=>[], "tags"=>["n-3", "pufas", "susceptibility", "vf-", "myocytes", "pro-arrhythmic"], "article_id"=>827871, "categories"=>["Biological Sciences"], "users"=>["Andriy E. Belevych", "Hsiang-Ting Ho", "Radmila Terentyeva", "Ingrid M. Bonilla", "Dmitry Terentyev", "Cynthia A. Carnes", "Sandor Gyorke", "George E. Billman"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0078414.g002", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Dietary_n_3_PUFAs_increase_susceptibility_of_VF_myocytes_to_pro_arrhythmic_Ca_2_alternans_/827871", "title"=>"Dietary n-3 PUFAs increase susceptibility of VF- myocytes to pro-arrhythmic Ca<sup>2+</sup> alternans.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-10-18 03:24:45"}

PMC Usage Stats | Further Information

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Relative Metric

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