Effects of a Skin Neuropeptide (Substance P) on Cutaneous Microflora
Publication Date
November 08, 2013
Journal
PLOS ONE
Authors
Lily Mijouin, Mélanie Hillion, Yasmina Ramdani, Thomas Jaouen, et al
Volume
8
Issue
11
Pages
e78773
DOI
https://dx.plos.org/10.1371/journal.pone.0078773
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0078773
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/24250813
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826737
Europe PMC
http://europepmc.org/abstract/MED/24250813
Web of Science
000327216200046
Scopus
84892575924
Mendeley
http://www.mendeley.com/research/effects-skin-neuropeptide-substance-p-cutaneous-microflora
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Effects of a skin neuropeptide (substance P) on cutaneous microflora", "type"=>"journal", "authors"=>[{"first_name"=>"Lily", "last_name"=>"Mijouin", "scopus_author_id"=>"37012070500"}, {"first_name"=>"Mélanie", "last_name"=>"Hillion", "scopus_author_id"=>"55366715700"}, {"first_name"=>"Yasmina", "last_name"=>"Ramdani", "scopus_author_id"=>"36242397000"}, {"first_name"=>"Thomas", "last_name"=>"Jaouen", "scopus_author_id"=>"6503950990"}, {"first_name"=>"Cécile", "last_name"=>"Duclairoir-Poc", "scopus_author_id"=>"26635055000"}, {"first_name"=>"Marie Laure", "last_name"=>"Follet-Gueye", "scopus_author_id"=>"6506309262"}, {"first_name"=>"Elian", "last_name"=>"Lati", "scopus_author_id"=>"6602276498"}, {"first_name"=>"Florent", "last_name"=>"Yvergnaux", "scopus_author_id"=>"24381139000"}, {"first_name"=>"Azzedine", "last_name"=>"Driouich", "scopus_author_id"=>"7003327335"}, {"first_name"=>"Luc", "last_name"=>"Lefeuvre", "scopus_author_id"=>"23025148100"}, {"first_name"=>"Christine", "last_name"=>"Farmer", "scopus_author_id"=>"55138989800"}, {"first_name"=>"Laurent", "last_name"=>"Misery", "scopus_author_id"=>"7006142770"}, {"first_name"=>"Marc G.J.", "last_name"=>"Feuilloley", "scopus_author_id"=>"7004364532"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84892575924", "sgr"=>"84892575924", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0078773", "pmid"=>"24250813", "isbn"=>"1932-6203", "pui"=>"372133946"}, "id"=>"41c562d1-8339-3e35-abf2-f774420207d5", "abstract"=>"BACKGROUND: Skin is the largest human neuroendocrine organ and hosts the second most numerous microbial population but the interaction of skin neuropeptides with the microflora has never been investigated. We studied the effect of Substance P (SP), a peptide released by nerve endings in the skin on bacterial virulence.\\n\\nMETHODOLOGY/PRINCIPAL FINDINGS: Bacillus cereus, a member of the skin transient microflora, was used as a model. Exposure to SP strongly stimulated the cytotoxicity of B. cereus (+553±3% with SP 10(-6) M) and this effect was rapid (<5 min). Infection of keratinocytes with SP treated B. cereus led to a rise in caspase1 and morphological alterations of the actin cytoskeleton. Secretome analysis revealed that SP stimulated the release of collagenase and superoxide dismutase. Moreover, we also noted a shift in the surface polarity of the bacteria linked to a peel-off of the S-layer and the release of S-layer proteins. Meanwhile, the biofilm formation activity of B. cereus was increased. The Thermo unstable ribosomal Elongation factor (Ef-Tu) was identified as the SP binding site in B. cereus. Other Gram positive skin bacteria, namely Staphylococcus aureus and Staphylococcus epidermidis also reacted to SP by an increase of virulence. Thermal water from Uriage-les-Bains and an artificial polysaccharide (Teflose®) were capable to antagonize the effect of SP on bacterial virulence.\\n\\nCONCLUSIONS/SIGNIFICANCE: SP is released in sweat during stress and is known to be involved in the pathogenesis of numerous skin diseases through neurogenic inflammation. Our study suggests that a direct effect of SP on the skin microbiote should be another mechanism.", "link"=>"http://www.mendeley.com/research/effects-skin-neuropeptide-substance-p-cutaneous-microflora", "reader_count"=>34, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>5, "Researcher"=>7, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>10, "Student > Postgraduate"=>1, "Student > Master"=>4, "Other"=>2, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>5, "Researcher"=>7, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>10, "Student > Postgraduate"=>1, "Student > Master"=>4, "Other"=>2, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>5, "Agricultural and Biological Sciences"=>16, "Medicine and Dentistry"=>5, "Neuroscience"=>1, "Chemistry"=>1, "Immunology and Microbiology"=>4, "Earth and Planetary Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Neuroscience"=>{"Neuroscience"=>1}, "Chemistry"=>{"Chemistry"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>4}, "Earth and Planetary Sciences"=>{"Earth and Planetary Sciences"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>16}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>5}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"Indonesia"=>1}, "group_count"=>0}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84892575924"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84892575924?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84892575924&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84892575924&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84892575924", "dc:identifier"=>"SCOPUS_ID:84892575924", "eid"=>"2-s2.0-84892575924", "dc:title"=>"Effects of a skin neuropeptide (substance P) on cutaneous microflora", "dc:creator"=>"Mijouin L.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"8", "prism:issueIdentifier"=>"11", "prism:pageRange"=>nil, "prism:coverDate"=>"2013-11-08", "prism:coverDisplayDate"=>"8 November 2013", "prism:doi"=>"10.1371/journal.pone.0078773", "citedby-count"=>"24", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Université de Rouen Normandie", "affiliation-city"=>"Mont Saint Aignan", "affiliation-country"=>"France"}], "pubmed-id"=>"24250813", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e78773", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0078773", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Twitter

Counter

  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"50", "xml_views"=>"12", "html_views"=>"389"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"24", "xml_views"=>"2", "html_views"=>"214"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"26", "xml_views"=>"0", "html_views"=>"130"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"123"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"11", "xml_views"=>"2", "html_views"=>"141"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"145"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"104"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"119"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"86"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"2", "html_views"=>"62"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"61"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"61"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"6", "xml_views"=>"3", "html_views"=>"39"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"60"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"47"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"54"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"58"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"52"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"55"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"46"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"78"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"105"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"108"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"106"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"91"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"80"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"45"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"41"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"59"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"58"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"79"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"61"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"55"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"3", "html_views"=>"43"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"19"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"2", "html_views"=>"57"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"79"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"54"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"25"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"35", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"24"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"4", "html_views"=>"19"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"22"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"11", "xml_views"=>"2", "html_views"=>"25"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"10", "xml_views"=>"3", "html_views"=>"23"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"15"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1273543"], "description"=>"<p>(A) Before infection, bacteria were exposed to SP in the presence of thermal water from Uriage-les-Bains (UTW) or (B) Teflose® (TF) ( = <i>p<0.05</i>,  = <i>p<0.01</i>,  = <i>p<0.001</i>).</p>", "links"=>[], "tags"=>["cytotoxic"], "article_id"=>845321, "categories"=>["Biological Sciences", "Ecology"], "users"=>["Lily Mijouin", "Mélanie Hillion", "Yasmina Ramdani", "Thomas Jaouen", "Cécile Duclairoir-Poc", "Marie-Laure Follet-Gueye", "Elian Lati", "Florent Yvergnaux", "Azzedine Driouich", "Luc Lefeuvre", "Christine Farmer", "Laurent Misery", "Marc G. J. Feuilloley"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0078773.g009", "stats"=>{"downloads"=>0, "page_views"=>23, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Inhibition_of_the_effects_of_Substance_P_SP_on_the_cytotoxic_activity_of_Bacillus_cereus_Staphylococcus_aureus_and_Staphylococcus_epidermidis_/845321", "title"=>"Inhibition of the effects of Substance P (SP) on the cytotoxic activity of <i>Bacillus cereus</i>, <i>Staphylococcus aureus</i> and <i>Staphylococcus epidermidis</i>.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-11-08 03:21:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/1273541"], "description"=>"<p>The biofilm formation was observed after 2, 5 and 24 h. (A) Two dimensions (2D) and reconstructed three-dimensions (3D) and ortho cuts (3D/z) images showed that the density of the biofilm was essentially unchanged. (B) In contrast, the thickness of the biofilm was significantly increased after 5 and 24 h inclubation with SP (NS = <i>non significant</i>;  = <i>p<0.01</i>;  = <i>p<0.001</i>).</p>", "links"=>[], "tags"=>["biofilm"], "article_id"=>845319, "categories"=>["Biological Sciences", "Ecology"], "users"=>["Lily Mijouin", "Mélanie Hillion", "Yasmina Ramdani", "Thomas Jaouen", "Cécile Duclairoir-Poc", "Marie-Laure Follet-Gueye", "Elian Lati", "Florent Yvergnaux", "Azzedine Driouich", "Luc Lefeuvre", "Christine Farmer", "Laurent Misery", "Marc G. J. Feuilloley"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0078773.g007", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_Substance_P_reverse_SPrev_and_Substance_P_SP_10_8722_6_M_on_the_biofilm_formation_activity_of_Bacillus_cereus_/845319", "title"=>"Effect of Substance P reverse (SPrev) and Substance P (SP) (10<sup>−6</sup> M) on the biofilm formation activity of <i>Bacillus cereus</i>.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-11-08 03:21:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/1273542"], "description"=>"<p>SP was found able to bind on a 43-TOF/TOF as the Thermo Unstable ribosomal Elongation factor Ef-Tu (arrow: 43 kDa). SPrev was also capable of binding to this protein but with a reduced effectiveness. Results are representative of three independent experiments.</p>", "links"=>[], "tags"=>["binding", "proteins", "separated", "immunoprecipitation", "sp", "antibody-associated"], "article_id"=>845320, "categories"=>["Biological Sciences", "Ecology"], "users"=>["Lily Mijouin", "Mélanie Hillion", "Yasmina Ramdani", "Thomas Jaouen", "Cécile Duclairoir-Poc", "Marie-Laure Follet-Gueye", "Elian Lati", "Florent Yvergnaux", "Azzedine Driouich", "Luc Lefeuvre", "Christine Farmer", "Laurent Misery", "Marc G. J. Feuilloley"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0078773.g008", "stats"=>{"downloads"=>6, "page_views"=>50, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_SDS_page_analysis_of_Bacillus_cereus_Substance_P_SP_binding_proteins_separated_by_immunoprecipitation_using_SP_antibody_associated_beads_/845320", "title"=>"SDS page analysis of <i>Bacillus cereus</i> Substance P (SP) binding proteins separated by immunoprecipitation using SP antibody-associated beads.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-11-08 03:21:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/1273517"], "description"=>"<p>(<b>A</b>) Cells exposed to SP treated bacteria showed an increase of caspase 1 production ( = <i>p<0.05</i>). (<b>B</b>) After a 30 min infection with control bacteria the morphology of HaCaT cells remained unchanged but when the cells were exposed to SP treated <i>B. cereus</i> we observed a complete disorganization of the actin cytoskeleton (□) and the formation of multiple cytoplasmic vacuoles (γ). Bar = 20 µm.</p>", "links"=>[], "tags"=>["treated", "caspase", "induction", "morphology", "hacat"], "article_id"=>845300, "categories"=>["Biological Sciences", "Ecology"], "users"=>["Lily Mijouin", "Mélanie Hillion", "Yasmina Ramdani", "Thomas Jaouen", "Cécile Duclairoir-Poc", "Marie-Laure Follet-Gueye", "Elian Lati", "Florent Yvergnaux", "Azzedine Driouich", "Luc Lefeuvre", "Christine Farmer", "Laurent Misery", "Marc G. J. Feuilloley"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0078773.g002", "stats"=>{"downloads"=>1, "page_views"=>20, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_Substance_P_treated_Bacillus_cereus_on_caspase_1_induction_and_on_the_morphology_of_HaCaT_cells_/845300", "title"=>"Effect of Substance P treated <i>Bacillus cereus</i> on caspase 1 induction and on the morphology of HaCaT cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-11-08 03:21:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/1273534"], "description"=>"<p>Whereas control bacteria presented a continuous intact surface (<b>A</b>), bacteria exposed to SP showed a detachment of the S-layer (γ) (<b>B</b>). Long amorphous structures were observed in the vicinity of bacterial, suggesting a desquamation of the S-layer (<b>C, D</b>).</p>", "links"=>[], "tags"=>["treated"], "article_id"=>845314, "categories"=>["Biological Sciences", "Ecology"], "users"=>["Lily Mijouin", "Mélanie Hillion", "Yasmina Ramdani", "Thomas Jaouen", "Cécile Duclairoir-Poc", "Marie-Laure Follet-Gueye", "Elian Lati", "Florent Yvergnaux", "Azzedine Driouich", "Luc Lefeuvre", "Christine Farmer", "Laurent Misery", "Marc G. J. Feuilloley"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0078773.g005", "stats"=>{"downloads"=>0, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_TEM_observation_of_control_SPrev_and_Substance_P_SP_treated_Bacillus_cereus_/845314", "title"=>"TEM observation of control (SPrev) and Substance P (SP) treated <i>Bacillus cereus</i>.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-11-08 03:21:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/1273545"], "description"=>"<p>MALDI-TOF/TOF identification of the proteins in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0078773#pone-0078773-g004\" target=\"_blank\">Figure 4</a> which expression was modified by Substance P in <i>Bacillus cereus</i>.</p>", "links"=>[], "tags"=>["proteins", "modified"], "article_id"=>845323, "categories"=>["Biological Sciences", "Ecology"], "users"=>["Lily Mijouin", "Mélanie Hillion", "Yasmina Ramdani", "Thomas Jaouen", "Cécile Duclairoir-Poc", "Marie-Laure Follet-Gueye", "Elian Lati", "Florent Yvergnaux", "Azzedine Driouich", "Luc Lefeuvre", "Christine Farmer", "Laurent Misery", "Marc G. J. Feuilloley"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0078773.t001", "stats"=>{"downloads"=>5, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_MALDI_TOF_TOF_identification_of_the_proteins_in_Figure_4_which_expression_was_modified_by_Substance_P_in_Bacillus_cereus_/845323", "title"=>"MALDI-TOF/TOF identification of the proteins in Figure 4 which expression was modified by Substance P in <i>Bacillus cereus</i>.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-11-08 03:21:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/1273528"], "description"=>"<p>(<b>A</b>) Twelve spots were modified after exposure of the bacteria to SP. (<b>B</b>) Two proteins (1 and 2) were over produced whereas the expression of 10 others was down regulated. Identified proteins are presented in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0078773#pone-0078773-t001\" target=\"_blank\">Table 1</a>. Results are representative of three independent experiments.</p>", "links"=>[], "tags"=>["electrophoresis", "secreted", "proteins", "13"], "article_id"=>845308, "categories"=>["Biological Sciences", "Ecology"], "users"=>["Lily Mijouin", "Mélanie Hillion", "Yasmina Ramdani", "Thomas Jaouen", "Cécile Duclairoir-Poc", "Marie-Laure Follet-Gueye", "Elian Lati", "Florent Yvergnaux", "Azzedine Driouich", "Luc Lefeuvre", "Christine Farmer", "Laurent Misery", "Marc G. J. Feuilloley"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0078773.g004", "stats"=>{"downloads"=>2, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Bidimensional_electrophoresis_analysis_of_secreted_proteins_by_Bacillus_cereus_after_a_13_h_exposure_to_Substance_P_reverse_Control_or_Substance_P_SP_10_8722_6_M_/845308", "title"=>"Bidimensional electrophoresis analysis of secreted proteins by <i>Bacillus cereus</i> after a 13 h exposure to Substance P reverse (Control) or Substance P (SP) (10<sup>−6</sup> M).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-11-08 03:21:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/1273522"], "description"=>"<p>Bacteria exposed for 1 h to SP showed an increase in the production of the collagenase (ColT) and of superoxide dismutase (SOD). Bacteria treated for 13 h with SP presented in contrast an increase in the S-layer crystal protein (SL). Results are representative of three independent experiments.</p>", "links"=>[], "tags"=>["secreted", "bacillus", "cereus", "proteins"], "article_id"=>845305, "categories"=>["Biological Sciences", "Ecology"], "users"=>["Lily Mijouin", "Mélanie Hillion", "Yasmina Ramdani", "Thomas Jaouen", "Cécile Duclairoir-Poc", "Marie-Laure Follet-Gueye", "Elian Lati", "Florent Yvergnaux", "Azzedine Driouich", "Luc Lefeuvre", "Christine Farmer", "Laurent Misery", "Marc G. J. Feuilloley"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0078773.g003", "stats"=>{"downloads"=>0, "page_views"=>23, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_SDS_page_analysis_of_secreted_Bacillus_cereus_proteins_after_1_or_13_SP_or_Substance_P_reverse_SPrev_10_8722_6_M_/845305", "title"=>"SDS page analysis of secreted Bacillus cereus proteins after 1 or 13(SP) or Substance P reverse (SPrev) (10<sup>−6</sup> M).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-11-08 03:21:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/1273538"], "description"=>"<p>chloroform (CH), hexadecane (HD), decane (De) and ethyl acetate (EA) ( = <i>P<0.05</i>,  = <i>P<0.01</i>,  = <i>P<0.001</i>). Each value represents the mean ± SEM of three independent experiments.</p>", "links"=>[], "tags"=>["affinity", "solvents"], "article_id"=>845316, "categories"=>["Biological Sciences", "Ecology"], "users"=>["Lily Mijouin", "Mélanie Hillion", "Yasmina Ramdani", "Thomas Jaouen", "Cécile Duclairoir-Poc", "Marie-Laure Follet-Gueye", "Elian Lati", "Florent Yvergnaux", "Azzedine Driouich", "Luc Lefeuvre", "Christine Farmer", "Laurent Misery", "Marc G. J. Feuilloley"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0078773.g006", "stats"=>{"downloads"=>0, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_Substance_P_reverse_SPrev_and_Substance_P_10_8722_6_M_on_the_affinity_of_Bacillus_cereus_to_solvents_of_different_polarities_/845316", "title"=>"Effect of Substance P reverse (SPrev) and Substance P (10<sup>−6</sup> M) on the affinity of <i>Bacillus cereus</i> to solvents of different polarities.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-11-08 03:21:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/1273515"], "description"=>"<p>(<b>A</b>) Dose response curve of the effect of Substance P (SP) and of the reversed sequence peptide (SPrev). (<b>B</b>) Time course response of the bacteria to SP and SPrev (10<sup>−6</sup> M). ( = p<0.001).</p>", "links"=>[], "tags"=>["cytotoxic"], "article_id"=>845298, "categories"=>["Biological Sciences", "Ecology"], "users"=>["Lily Mijouin", "Mélanie Hillion", "Yasmina Ramdani", "Thomas Jaouen", "Cécile Duclairoir-Poc", "Marie-Laure Follet-Gueye", "Elian Lati", "Florent Yvergnaux", "Azzedine Driouich", "Luc Lefeuvre", "Christine Farmer", "Laurent Misery", "Marc G. J. Feuilloley"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0078773.g001", "stats"=>{"downloads"=>1, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_Substance_P_on_the_cytotoxic_activity_of_Bacillus_cereus_/845298", "title"=>"Effect of Substance P on the cytotoxic activity of <i>Bacillus cereus</i>.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-11-08 03:21:48"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"21", "full-text"=>"19", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"35", "full-text"=>"31", "pdf"=>"21", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"30", "full-text"=>"26", "pdf"=>"16", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"26", "full-text"=>"30", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"32", "full-text"=>"31", "pdf"=>"15", "abstract"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"18", "full-text"=>"19", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"13", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"21", "full-text"=>"23", "pdf"=>"16", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"28", "full-text"=>"33", "pdf"=>"14", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"17", "full-text"=>"17", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"24", "full-text"=>"28", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"19", "full-text"=>"19", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"20", "full-text"=>"23", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"22", "full-text"=>"21", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"23", "full-text"=>"35", "pdf"=>"46", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"28", "full-text"=>"26", "pdf"=>"11", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"26", "full-text"=>"32", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"31", "full-text"=>"31", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"45", "full-text"=>"61", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"28", "full-text"=>"30", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"13", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"30", "full-text"=>"42", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"10", "full-text"=>"15", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"27", "full-text"=>"31", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"25", "full-text"=>"25", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"27", "full-text"=>"27", "pdf"=>"72", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"21", "full-text"=>"17", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"23", "full-text"=>"19", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"26", "full-text"=>"26", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"15", "full-text"=>"30", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"18", "full-text"=>"25", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"15", "full-text"=>"20", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"16", "full-text"=>"15", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"16", "full-text"=>"16", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"25", "full-text"=>"25", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"20", "full-text"=>"22", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"23", "full-text"=>"24", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"16", "full-text"=>"19", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"20", "full-text"=>"20", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"16", "full-text"=>"16", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"16", "full-text"=>"16", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"24", "full-text"=>"25", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"18", "full-text"=>"18", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"16", "full-text"=>"16", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"27", "full-text"=>"31", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"24", "full-text"=>"25", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"26", "full-text"=>"30", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"18", "full-text"=>"17", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"24", "full-text"=>"24", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"21", "full-text"=>"25", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"19", "full-text"=>"22", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"21", "full-text"=>"28", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"22", "full-text"=>"22", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"24", "full-text"=>"22", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"22", "full-text"=>"21", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"20", "full-text"=>"23", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"35", "full-text"=>"40", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"39", "full-text"=>"51", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"31", "full-text"=>"28", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}

Relative Metric

{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[269, 466, 588, 697, 800, 896, 988, 1076, 1165, 1254, 1340, 1417]}, {"subject_area"=>"/Biology and life sciences/Anatomy and physiology", "average_usage"=>[256, 428]}, {"subject_area"=>"/Biology and life sciences/Cell biology", "average_usage"=>[272, 472, 600, 713, 815, 911, 1004, 1094, 1185, 1273, 1358, 1441]}, {"subject_area"=>"/Biology and life sciences/Microbiology", "average_usage"=>[293, 503, 638, 755, 861, 960, 1056, 1146, 1239, 1323, 1403, 1491, 1568]}, {"subject_area"=>"/Ecology and environmental sciences/Ecology", "average_usage"=>[298, 487, 610, 722, 827, 929, 1029, 1125, 1217, 1306, 1388, 1464, 1535]}, {"subject_area"=>"/Ecology and environmental sciences/Microbial ecology", "average_usage"=>[327, 538]}, {"subject_area"=>"/Medicine and health sciences/Pathology and laboratory medicine", "average_usage"=>[267, 466, 592, 709, 806, 901, 989, 1075, 1162, 1254, 1342, 1424, 1486]}]}
Loading … Spinner
There are currently no alerts