Sex Differences in Itch Perception and Modulation by Distraction – an fMRI Pilot Study in Healthy Volunteers
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{"title"=>"Sex differences in itch perception and modulation by distraction - An fMRI pilot study in healthy volunteers", "type"=>"journal", "authors"=>[{"first_name"=>"Astrid", "last_name"=>"Stumpf", "scopus_author_id"=>"12784552300"}, {"first_name"=>"Markus", "last_name"=>"Burgmer", "scopus_author_id"=>"6602845724"}, {"first_name"=>"Gudrun", "last_name"=>"Schneider", "scopus_author_id"=>"56220808000"}, {"first_name"=>"Gereon", "last_name"=>"Heuft", "scopus_author_id"=>"7006775961"}, {"first_name"=>"Martin", "last_name"=>"Schmelz", "scopus_author_id"=>"7005076635"}, {"first_name"=>"Ngoc Quan", "last_name"=>"Phan", "scopus_author_id"=>"25923075900"}, {"first_name"=>"Sonja", "last_name"=>"Ständer", "scopus_author_id"=>"7003440723"}, {"first_name"=>"Bettina", "last_name"=>"Pfleiderer", "scopus_author_id"=>"7003378643"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84894181073", "doi"=>"10.1371/journal.pone.0079123", "sgr"=>"84894181073", "isbn"=>"1932-6203", "pmid"=>"24260163", "issn"=>"19326203", "pui"=>"372403002"}, "id"=>"7f866f5c-1107-31fd-908a-f65e8a8dd150", "abstract"=>"Background: Even though itch is a common syndrome of many diseases there is only little knowledge about sex and gender differences in pruritus, especially in central itch perception and modulation. To our knowledge, this is the first fMRI study examining sex differences in perception and its modulation by distraction.", "link"=>"http://www.mendeley.com/research/sex-differences-itch-perception-modulation-distraction-fmri-pilot-study-healthy-volunteers", "reader_count"=>20, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>1, "Other"=>3, "Student > Master"=>2, "Student > Bachelor"=>2, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>1, "Other"=>3, "Student > Master"=>2, "Student > Bachelor"=>2, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Medicine and Dentistry"=>12, "Agricultural and Biological Sciences"=>1, "Arts and Humanities"=>2, "Neuroscience"=>1, "Psychology"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>12}, "Neuroscience"=>{"Neuroscience"=>1}, "Psychology"=>{"Psychology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Unspecified"=>{"Unspecified"=>2}, "Arts and Humanities"=>{"Arts and Humanities"=>2}}, "group_count"=>1}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1285240"], "description"=>"*<p>inf. = inferior, sup. = superior, DLPFC = dorsolateral prefrontal cortex, SMA = supplementary motor area.</p>", "links"=>[], "tags"=>["contrasts", "sex-specific", "activation", "voxel"], "article_id"=>854208, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Astrid Stumpf", "Markus Burgmer", "Gudrun Schneider", "Gereon Heuft", "Martin Schmelz", "Ngoc Quan Phan", "Sonja Stander", "Bettina Pfleiderer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0079123.t003", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Differential_contrasts_t_tests_of_sex_specific_activation_under_8216_itch_8217_condition_uncorrected_p_lt_0_001_with_a_voxel_threshold_k_gt_47_/854208", "title"=>"Differential contrasts (t-tests) of sex-specific activation under ‘itch’ condition (uncorrected, p<0.001, with a voxel threshold k>47).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-11-18 03:01:23"}
  • {"files"=>["https://ndownloader.figshare.com/files/1285241"], "description"=>"<p>(*uncorrected, p<0.001, with a voxel threshold k>47;</p>**<p>uncorrected, p<0.005, with a voxel threshold k>70;</p>***<p>FWE corrected, p<0.05, with a voxel threshold k>10).</p>†<p>inf. = inferior, sup. = superior, DLPFC = dorsolateral prefrontal cortex.</p>", "links"=>[], "tags"=>["correlations", "itch", "stimulation"], "article_id"=>854209, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Astrid Stumpf", "Markus Burgmer", "Gudrun Schneider", "Gereon Heuft", "Martin Schmelz", "Ngoc Quan Phan", "Sonja Stander", "Bettina Pfleiderer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0079123.t008", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Sex_specific_correlations_of_itch_intensity_with_brain_activity_during_second_lower_leg_stimulation_B2_during_8216_itch_8217_condition_/854209", "title"=>"Sex-specific correlations of itch intensity with brain activity during second lower leg stimulation (B2) during ‘itch’ condition.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-11-18 03:01:23"}
  • {"files"=>["https://ndownloader.figshare.com/files/1285242"], "description"=>"*<p>DLPFC = dorsolateral prefrontal cortex, SMA = supplementary motor area.</p>", "links"=>[], "tags"=>["correlations", "itch", "stimulation", "voxel"], "article_id"=>854210, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Astrid Stumpf", "Markus Burgmer", "Gudrun Schneider", "Gereon Heuft", "Martin Schmelz", "Ngoc Quan Phan", "Sonja Stander", "Bettina Pfleiderer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0079123.t009", "stats"=>{"downloads"=>1, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Sex_specific_correlations_of_itch_intensity_with_brain_activity_during_second_lower_leg_stimulation_B2_during_8216_Stroop_8217_condition_uncorrected_p_lt_0_001_with_a_voxel_threshold_k_gt_47_/854210", "title"=>"Sex-specific correlations of itch intensity with brain activity during second lower leg stimulation (B2) during ‘Stroop’ condition (uncorrected, p<0.001, with a voxel threshold k>47).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-11-18 03:01:23"}
  • {"files"=>["https://ndownloader.figshare.com/files/1285243", "https://ndownloader.figshare.com/files/1285244", "https://ndownloader.figshare.com/files/1285245", "https://ndownloader.figshare.com/files/1285246", "https://ndownloader.figshare.com/files/1285247"], "description"=>"<div><p>Background</p><p>Even though itch is a common syndrome of many diseases there is only little knowledge about sex and gender differences in pruritus, especially in central itch perception and modulation. To our knowledge, this is the first fMRI study examining sex differences in perception and its modulation by distraction.</p><p>Methods</p><p>Experimental itch was induced by application of histamine (0.1 mM) via microdialysis fibers twice at the left forearm and twice at the left lower leg in 33 healthy volunteers (17 females, 16 males). The brain activation patterns were assessed by fMRI during itch without and with distraction (Stroop task). Between the various conditions, subjects were asked to rate itch intensity, desire to scratch and pain intensity. In a second experiment in 10 of the 33 volunteers histamine was replaced by saline solution to serve as control for the ‘Stroop’ condition.</p><p>Results</p><p>Women generally presented higher itch intensities compared to men during itch over the course of the experiment. A more specific analysis revealed higher itch intensities and desire to scratch in women during experimental induced itch that can be reduced by distraction at the lower legs when itch is followed by ‘Stroop’. In contrast, men depicted significant reduction of ‘itch’ by ‘Stroop’ at the forearms. Women depicted higher brain activation of structures responsible for integration of sensory, affective information and motor integration/planning during ‘itch’ and ‘Stroop’ condition when compared to men. No sex differences were seen in the saline control condition.</p><p>Conclusion</p><p>Women and men exhibited localisation dependent differences in their itch perception with women presenting higher itch intensities and desire to scratch. Our findings parallel clinical observations of women reporting higher itch intensities depending on itch localisation and suffering more from itch as compared to men.</p></div>", "links"=>[], "tags"=>["differences", "itch", "modulation", "distraction", "fmri"], "article_id"=>854211, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Astrid Stumpf", "Markus Burgmer", "Gudrun Schneider", "Gereon Heuft", "Martin Schmelz", "Ngoc Quan Phan", "Sonja Stander", "Bettina Pfleiderer"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0079123.s001", "https://dx.doi.org/10.1371/journal.pone.0079123.s002", "https://dx.doi.org/10.1371/journal.pone.0079123.s003", "https://dx.doi.org/10.1371/journal.pone.0079123.s004", "https://dx.doi.org/10.1371/journal.pone.0079123.s005"], "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Sex_Differences_in_Itch_Perception_and_Modulation_by_Distraction_8211_an_fMRI_Pilot_Study_in_Healthy_Volunteers_/854211", "title"=>"Sex Differences in Itch Perception and Modulation by Distraction – an fMRI Pilot Study in Healthy Volunteers", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-11-18 03:01:23"}
  • {"files"=>["https://ndownloader.figshare.com/files/1285226"], "description"=>"<p>After a baseline period, histamine was injected on the forearm. After 60‘itch’ condition began, and the Stroop task had to be performed (90 s each) (A1_J+A1_S). Then, itch was terminated by xylocaine and an ice bag (90 s, upper panels). After a break, this procedure was carried out on the lower leg. To avoid habituation, the order of the second run was switched to first ‘Stroop’ and then the ‘itch’ condition (lower panels) (B1_S+B1_J). The procedure ‘Stroop-itch’ was carried out on the forearm (third run; A2_S+A2_J) and finally the procedure ‘itch-Stroop’ was carried out on the lower leg (fourth run; B2_J+B2_S). Thus, the tests were carried out in two different orders, once on the forearm and once on the lower leg. In a second experiment with 10 participants of the former study, histamine and xylocaine were replaced by saline solution. *NRS = numeric rating scale. Between each test block, the intensity of the itch sensation, the desire to scratch, and the experienced pain was determined with help of a numeric rating scale. **A1_J = first run forearm during ‘itch’, A1_S = first run forearm during ‘Stroop’, B1_J = first run lower leg during ‘itch’, B1_S = first run lower leg during ‘Stroop’, A2_J = second run forearm during ‘itch’, A2_S = second run forearm during ‘Stroop’, B2_J = second run lower leg during ‘itch’, B2_S = second run lower leg during ‘Stroop’.</p>", "links"=>[], "tags"=>["itch"], "article_id"=>854194, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Astrid Stumpf", "Markus Burgmer", "Gudrun Schneider", "Gereon Heuft", "Martin Schmelz", "Ngoc Quan Phan", "Sonja Stander", "Bettina Pfleiderer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0079123.g001", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Experimental_block_design_of_itch_stimulation_/854194", "title"=>"Experimental block design of itch stimulation.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-11-18 03:01:23"}
  • {"files"=>["https://ndownloader.figshare.com/files/1285227"], "description"=>"<p>A) Plot of the female’s itch intensity and desire to scratch during ‘itch’ and ‘Stroop’ condition and B) Plot of male’s itch intensity and desire to scratch during ‘itch’ and ‘Stroop’ condition. In C) sex-specific comparison of itch intensity during ‘itch’ and ‘Stroop’ condition und in D) sex-specific comparison of desire to scratch during ‘itch’ and ‘Stroop’ condition are plotted. ** = p≤0.05, ** = p≤0.01, *** = p≤0.0001. **A1_J = first run forearm during ‘itch’, A1_S = first run forearm during ‘Stroop’, B1_J = first run lower leg during ‘itch’, B1_S = first run lower leg during ‘Stroop’, A2_J = second run forearm during ‘itch’, A2_S = second run forearm during ‘Stroop’, B2_J = second run lower leg during ‘itch’, B2_S = second run lower leg during ‘Stroop’.</p>", "links"=>[], "tags"=>["differences", "itch"], "article_id"=>854195, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Astrid Stumpf", "Markus Burgmer", "Gudrun Schneider", "Gereon Heuft", "Martin Schmelz", "Ngoc Quan Phan", "Sonja Stander", "Bettina Pfleiderer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0079123.g002", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Sex_specific_differences_in_itch_intensity_and_desire_to_scratch_/854195", "title"=>"Sex-specific differences in itch intensity and desire to scratch.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-11-18 03:01:23"}
  • {"files"=>["https://ndownloader.figshare.com/files/1285230"], "description"=>"<p>The figure shows the different brain activity maps during ‘itch’ and ‘Stroop’ condition for ‘females’>‘males’. The results are corrected for multiple comparisons (uncorrected, p<0.001, voxel threshold k>47 voxels). *SMA = supplementary motor area; post. = posterior.</p>", "links"=>[], "tags"=>["differences", "fmri", "stimulation"], "article_id"=>854198, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Astrid Stumpf", "Markus Burgmer", "Gudrun Schneider", "Gereon Heuft", "Martin Schmelz", "Ngoc Quan Phan", "Sonja Stander", "Bettina Pfleiderer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0079123.g003", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Sex_specific_differences_in_fMRI_BOLD_response_during_8216_itch_8217_and_8216_Stroop_8217_condition_during_stimulation_at_the_lower_legs_/854198", "title"=>"Sex-specific differences in fMRI BOLD response during ‘itch’ and ‘Stroop’ condition during stimulation at the lower legs.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-11-18 03:01:23"}
  • {"files"=>["https://ndownloader.figshare.com/files/1285231"], "description"=>"<p>The figure shows positive (in red) and negative (in blue) correlations of brain BOLD-activity with itch intensity ratings during second stimulation at the lower legs (B2) for females and males separately (Females: positive correlation: uncorrected, p<0.005, with a voxel threshold k>70, negative correlation: uncorrected, p<0.001, with a voxel threshold k>47; males: positive correlation: uncorrected, p<0.005, with a voxel threshold k>70, negative correlation: FWE corrected, with a voxel threshold k>10). *DLPFC = dorsolateral prefrontal cortex; inf. = inferior; sup. = superior.</p>", "links"=>[], "tags"=>["itch", "ratings", "activities"], "article_id"=>854199, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Astrid Stumpf", "Markus Burgmer", "Gudrun Schneider", "Gereon Heuft", "Martin Schmelz", "Ngoc Quan Phan", "Sonja Stander", "Bettina Pfleiderer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0079123.g004", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Correlation_analysis_of_itch_intensity_ratings_with_brain_activities_during_8216_itch_8217_condition_B2_/854199", "title"=>"Correlation analysis of itch intensity ratings with brain activities during ‘itch’ condition (B2).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-11-18 03:01:23"}
  • {"files"=>["https://ndownloader.figshare.com/files/1285232"], "description"=>"<p>The figure shows positive (in red) and negative (in blue) correlations of brain BOLD-activity with itch intensity ratings during second stimulation at the lower legs (B2), for females and males separately. The results are corrected for multiple comparisons (uncorrected, p<0.001, voxel threshold k>47 voxels). *SMA = supplementary motor area; DLPFC = dorsolateral prefrontal cortex; inf. = inferior.</p>", "links"=>[], "tags"=>["itch", "ratings", "activities"], "article_id"=>854200, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Astrid Stumpf", "Markus Burgmer", "Gudrun Schneider", "Gereon Heuft", "Martin Schmelz", "Ngoc Quan Phan", "Sonja Stander", "Bettina Pfleiderer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0079123.g005", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Correlation_analysis_of_itch_intensity_ratings_with_brain_activities_during_8216_Stroop_8217_condition_B2_/854200", "title"=>"Correlation analysis of itch intensity ratings with brain activities during ‘Stroop’ condition (B2).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-11-18 03:01:23"}
  • {"files"=>["https://ndownloader.figshare.com/files/1285234"], "description"=>"*<p>inf. = inferior, sup. = superior, DLPFC = dorsolateral prefrontal cortex.</p>", "links"=>[], "tags"=>["contrasts", "sex-specific", "activation", "voxel"], "article_id"=>854201, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Astrid Stumpf", "Markus Burgmer", "Gudrun Schneider", "Gereon Heuft", "Martin Schmelz", "Ngoc Quan Phan", "Sonja Stander", "Bettina Pfleiderer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0079123.t004", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Differential_contrasts_t_tests_of_sex_specific_activation_under_8216_Stroop_8217_condition_uncorrected_p_lt_0_001_with_a_voxel_threshold_k_gt_47_/854201", "title"=>"Differential contrasts (t-tests) of sex-specific activation under ‘Stroop’ condition (uncorrected, p<0.001, with a voxel threshold k>47).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-11-18 03:01:23"}
  • {"files"=>["https://ndownloader.figshare.com/files/1285235"], "description"=>"*<p>inf. = inferior.</p>", "links"=>[], "tags"=>["contrasts", "sex-specific", "activation", "forearm", "stimulation", "voxel"], "article_id"=>854203, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Astrid Stumpf", "Markus Burgmer", "Gudrun Schneider", "Gereon Heuft", "Martin Schmelz", "Ngoc Quan Phan", "Sonja Stander", "Bettina Pfleiderer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0079123.t005", "stats"=>{"downloads"=>1, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Differential_contrasts_t_test_of_sex_specific_activation_during_forearm_stimulation_during_8216_itch_8217_condition_uncorrected_p_lt_0_001_with_a_voxel_threshold_k_gt_47_/854203", "title"=>"Differential contrasts (t-test) of sex-specific activation during forearm stimulation during ‘itch’ condition (uncorrected, p<0.001, with a voxel threshold k>47).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-11-18 03:01:23"}
  • {"files"=>["https://ndownloader.figshare.com/files/1285236"], "description"=>"*<p>inf. = inferior, sup. = superior, SMA = supplementary motor area.</p>", "links"=>[], "tags"=>["contrasts", "sex-specific", "activation", "stimulation", "voxel"], "article_id"=>854204, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Astrid Stumpf", "Markus Burgmer", "Gudrun Schneider", "Gereon Heuft", "Martin Schmelz", "Ngoc Quan Phan", "Sonja Stander", "Bettina Pfleiderer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0079123.t006", "stats"=>{"downloads"=>0, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Differential_contrasts_t_test_of_sex_specific_activation_during_lower_leg_stimulation_during_8216_itch_8217_condition_uncorrected_p_lt_0_001_with_a_voxel_threshold_k_gt_47_/854204", "title"=>"Differential contrasts (t-test) of sex-specific activation during lower leg stimulation during ‘itch’ condition (uncorrected, p<0.001, with a voxel threshold k>47).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-11-18 03:01:23"}
  • {"files"=>["https://ndownloader.figshare.com/files/1285237"], "description"=>"<p>Differential contrasts (t-test) of sex-specific activation during lower leg stimulation during ‘Stroop’ condition (uncorrected, p<0.001, with a voxel threshold k>47).</p>", "links"=>[], "tags"=>["contrasts", "sex-specific", "activation", "stimulation", "voxel"], "article_id"=>854205, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Astrid Stumpf", "Markus Burgmer", "Gudrun Schneider", "Gereon Heuft", "Martin Schmelz", "Ngoc Quan Phan", "Sonja Stander", "Bettina Pfleiderer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0079123.t007", "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Differential_contrasts_t_test_of_sex_specific_activation_during_lower_leg_stimulation_during_8216_Stroop_8217_condition_uncorrected_p_lt_0_001_with_a_voxel_threshold_k_gt_47_/854205", "title"=>"Differential contrasts (t-test) of sex-specific activation during lower leg stimulation during ‘Stroop’ condition (uncorrected, p<0.001, with a voxel threshold k>47).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-11-18 03:01:23"}
  • {"files"=>["https://ndownloader.figshare.com/files/1285238"], "description"=>"*<p>A1_J = first run forearm during ‘itch’, A1_S = first run forearm during ‘Stroop’, B1_J = first run lower leg during ‘itch’, B1_ S = first run lower leg during ‘Stroop’, A2_J = second run forearm during ‘itch’, A2_ S = second run forearm during ‘Stroop’, B2_J = second run lower leg during ‘itch’, B2_ S = second run lower leg during ‘Stroop’.</p>", "links"=>[], "tags"=>["two-sided", "t-test", "psychophysical", "females", "males", "histamine"], "article_id"=>854206, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Astrid Stumpf", "Markus Burgmer", "Gudrun Schneider", "Gereon Heuft", "Martin Schmelz", "Ngoc Quan Phan", "Sonja Stander", "Bettina Pfleiderer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0079123.t001", "stats"=>{"downloads"=>2, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Students_two_sided_t_test_of_psychophysical_data_for_females_and_males_NRS_during_histamine_perfusion_/854206", "title"=>"Students two-sided t-test of psychophysical data for females and males (NRS) during histamine perfusion.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-11-18 03:01:23"}
  • {"files"=>["https://ndownloader.figshare.com/files/1285239"], "description"=>"<p>Reduction of reaction times can be clearly depicted over the course of the experiment due to a practice effect. Reaction times did not differ between males and females.</p>*<p>A1 =  first run forearm; A2 =  second run forearm; B1 =  first run lower leg; B2 =  second run lower leg.</p>**<p> = p≤0.01;</p>***<p> = p≤0.0001.</p>", "links"=>[], "tags"=>["answers", "stroop", "univariate", "variance", "post-hoc", "bonferroni", "correction"], "article_id"=>854207, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Astrid Stumpf", "Markus Burgmer", "Gudrun Schneider", "Gereon Heuft", "Martin Schmelz", "Ngoc Quan Phan", "Sonja Stander", "Bettina Pfleiderer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0079123.t002", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mean_reaction_time_of_correct_answers_mean_177_SD_in_the_Stroop_test_by_univariate_variance_analysis_and_post_hoc_Bonferroni_correction_for_all_participants_/854207", "title"=>"Mean reaction time of correct answers (mean ± SD) in the Stroop test by univariate variance analysis and post-hoc Bonferroni correction for all participants.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-11-18 03:01:23"}

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