A Randomized Cross-Over Trial of the Postprandial Effects of Three Different Diets in Patients with Type 2 Diabetes
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{"title"=>"A randomized cross-over trial of the postprandial effects of three different diets in patients with type 2 diabetes", "type"=>"journal", "authors"=>[{"first_name"=>"Hanna", "last_name"=>"Fernemark", "scopus_author_id"=>"56079289300"}, {"first_name"=>"Christine", "last_name"=>"Jaredsson", "scopus_author_id"=>"56080102000"}, {"first_name"=>"Bekim", "last_name"=>"Bunjaku", "scopus_author_id"=>"55207312700"}, {"first_name"=>"Ulf", "last_name"=>"Rosenqvist", "scopus_author_id"=>"24406483900"}, {"first_name"=>"Fredrik H.", "last_name"=>"Nystrom", "scopus_author_id"=>"7003806204"}, {"first_name"=>"Hans", "last_name"=>"Guldbrand", "scopus_author_id"=>"55205917200"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84896691809", "sgr"=>"84896691809", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0079324", "pmid"=>"24312178", "isbn"=>"1932-6203 (Electronic)\\n1932-6203 (Linking)", "pui"=>"372438349"}, "id"=>"c9f8281d-57c1-312e-8d20-4e515647a924", "abstract"=>"BACKGROUND: In the clinic setting both fasting levels of glucose and the area under the curve (AUC) of glucose, by determination of HbA1c levels, are used for risk assessments, in type 2 diabetes (NIDDM). However little is known about postprandial levels, and hence AUC, regarding other traditional risk factors such as insulin and blood-lipids and how this is affected by different diets.\\n\\nOBJECTIVE: To study postprandial effects of three diets, during a single day, in NIDDM.\\n\\nMETHODS: A low-fat diet (45-56 energy-% from carbohydrates), and a low-carbohydrate diet (16-24 energy-% from carbohydrates) was compared with a Mediterranean-style diet (black coffee for breakfast and the same total-caloric intake as the other two diets for lunch with red wine, 32-35 energy-% from carbohydrates) in a randomized cross-over design. Total-caloric intake/test-day at the clinic from food was 1025-1080 kCal in men and 905-984 kCal in women. The test meals were consumed at a diabetes ward under supervision.\\n\\nRESULTS: Twenty-one participants were recruited and 19 completed the studies. The low-carbohydrate diet induced lower insulin and glucose excursions compared with the low-fat diet (p<0.0005 for both AUC). The insulin-response following the single Mediterranean-style lunch-meal was more pronounced than during the low-fat diet lunch (insulin increase-ratio of the low-fat diet: 4.35 ± 2.2, of Mediterranean-style diet: 8.12 ± 5.2, p = 0.001) while postprandial glucose levels were similar. The increase-ratio of insulin correlated with the elevation of the incretin glucose-dependent insulinotropic-polypeptide following the Mediterranean-style diet lunch (Spearman, r = 0.64, p = 0.003).\\n\\nCONCLUSIONS: The large Mediterranean-style lunch-meal induced similar postprandial glucose-elevations as the low-fat meal despite almost double amount of calories due to a pronounced insulin-increase. This suggests that accumulation of caloric intake from breakfast and lunch to a single large Mediterranean style lunch-meal in NIDDM might be advantageous from a metabolic perspective.\\n\\nTRIAL REGISTRATION: ClinicalTrials.gov NCT01522157 NCT01522157.", "link"=>"http://www.mendeley.com/research/randomized-crossover-trial-postprandial-effects-three-different-diets-patients-type-2-diabetes", "reader_count"=>81, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>4, "Librarian"=>2, "Researcher"=>12, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>3, "Student > Master"=>16, "Other"=>9, "Student > Bachelor"=>20, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>3, "Professor"=>2}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>4, "Librarian"=>2, "Researcher"=>12, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>3, "Student > Master"=>16, "Other"=>9, "Student > Bachelor"=>20, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>3, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Engineering"=>1, "Environmental Science"=>1, "Nursing and Health Professions"=>10, "Biochemistry, Genetics and Molecular Biology"=>3, "Medicine and Dentistry"=>34, "Agricultural and Biological Sciences"=>10, "Sports and Recreations"=>9, "Psychology"=>1, "Chemistry"=>1, "Social Sciences"=>8, "Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>34}, "Chemistry"=>{"Chemistry"=>1}, "Social Sciences"=>{"Social Sciences"=>8}, "Sports and Recreations"=>{"Sports and Recreations"=>9}, "Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>10}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>10}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>2}, "Environmental Science"=>{"Environmental Science"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"New Zealand"=>1, "Netherlands"=>2, "United States"=>2, "Norway"=>1, "Brazil"=>1, "Denmark"=>1, "United Kingdom"=>1, "Australia"=>1}, "group_count"=>3}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1296583"], "description"=>"<p>Women received the low-energy meals (LE) and men received the high-energy (HE) meals. Energy % (E%) was calculated based on protein, fat and carbohydrate content.</p><p>Abbreviations: alc, alcohol; E%, energy percent; MUFA, mono-unsaturated fatty acid; PUFA, poly-unsaturated fatty acid; SFA, saturated fatty acid.</p>", "links"=>[], "tags"=>[], "article_id"=>863184, "categories"=>["Biological Sciences"], "users"=>["Hanna Fernemark", "Christine Jaredsson", "Bekim Bunjaku", "Ulf Rosenqvist", "Fredrik H. Nystrom", "Hans Guldbrand"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0079324.t001", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Compositions_of_breakfast_and_lunch_/863184", "title"=>"Compositions of breakfast and lunch.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-11-27 02:59:46"}
  • {"files"=>["https://ndownloader.figshare.com/files/1296584", "https://ndownloader.figshare.com/files/1296585", "https://ndownloader.figshare.com/files/1296586", "https://ndownloader.figshare.com/files/1296587", "https://ndownloader.figshare.com/files/1296588", "https://ndownloader.figshare.com/files/1296589"], "description"=>"<div><p>Background</p><p>In the clinic setting both fasting levels of glucose and the area under the curve (AUC) of glucose, by determination of HbA1c levels, are used for risk assessments, in type 2 diabetes (NIDDM). However little is known about postprandial levels, and hence AUC, regarding other traditional risk factors such as insulin and blood-lipids and how this is affected by different diets.</p><p>Objective</p><p>To study postprandial effects of three diets, during a single day, in NIDDM.</p><p>Methods</p><p>A low-fat diet (45–56 energy-% from carbohydrates), and a low-carbohydrate diet (16–24 energy-% from carbohydrates) was compared with a Mediterranean-style diet (black coffee for breakfast and the same total-caloric intake as the other two diets for lunch with red wine, 32–35 energy−% from carbohydrates) in a randomized cross-over design. Total-caloric intake/test-day at the clinic from food was 1025–1080 kCal in men and 905–984 kCal in women. The test meals were consumed at a diabetes ward under supervision.</p><p>Results</p><p>Twenty-one participants were recruited and 19 completed the studies. The low-carbohydrate diet induced lower insulin and glucose excursions compared with the low-fat diet (p<0.0005 for both AUC). The insulin-response following the single Mediterranean-style lunch-meal was more pronounced than during the low-fat diet lunch (insulin increase-ratio of the low-fat diet: 4.35±2.2, of Mediterranean-style diet: 8.12±5.2, p = 0.001) while postprandial glucose levels were similar. The increase-ratio of insulin correlated with the elevation of the incretin glucose-dependent insulinotropic-polypeptide following the Mediterranean-style diet lunch (Spearman, r = 0.64, p = 0.003).</p><p>Conclusions</p><p>The large Mediterranean-style lunch-meal induced similar postprandial glucose-elevations as the low-fat meal despite almost double amount of calories due to a pronounced insulin-increase. This suggests that accumulation of caloric intake from breakfast and lunch to a single large Mediterranean style lunch-meal in NIDDM might be advantageous from a metabolic perspective.</p><p>Trial Registration</p><p>ClinicalTrials.gov NCT01522157 <a href=\"http://clinicaltrials.gov/ct2/show/NCT01522157\" target=\"_blank\">NCT01522157</a></p></div>", "links"=>[], "tags"=>["randomized", "cross-over", "postprandial", "diets", "patients"], "article_id"=>863185, "categories"=>["Biological Sciences"], "users"=>["Hanna Fernemark", "Christine Jaredsson", "Bekim Bunjaku", "Ulf Rosenqvist", "Fredrik H. Nystrom", "Hans Guldbrand"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0079324.s001", "https://dx.doi.org/10.1371/journal.pone.0079324.s002", "https://dx.doi.org/10.1371/journal.pone.0079324.s003", "https://dx.doi.org/10.1371/journal.pone.0079324.s004", "https://dx.doi.org/10.1371/journal.pone.0079324.s005", "https://dx.doi.org/10.1371/journal.pone.0079324.s006"], "stats"=>{"downloads"=>20, "page_views"=>22, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_A_Randomized_Cross_Over_Trial_of_the_Postprandial_Effects_of_Three_Different_Diets_in_Patients_with_Type_2_Diabetes_/863185", "title"=>"A Randomized Cross-Over Trial of the Postprandial Effects of Three Different Diets in Patients with Type 2 Diabetes", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-11-27 02:59:46"}
  • {"files"=>["https://ndownloader.figshare.com/files/1296579"], "description"=>"<p>Abbreviations: LF, low-fat diet; LC, low-carbohydrate diet; M, Mediterranean diet.</p>", "links"=>[], "tags"=>[], "article_id"=>863180, "categories"=>["Biological Sciences"], "users"=>["Hanna Fernemark", "Christine Jaredsson", "Bekim Bunjaku", "Ulf Rosenqvist", "Fredrik H. Nystrom", "Hans Guldbrand"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0079324.g001", "stats"=>{"downloads"=>5, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_CONSORT_Flow_Diagram_/863180", "title"=>"CONSORT Flow Diagram.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-11-27 02:59:46"}
  • {"files"=>["https://ndownloader.figshare.com/files/1296580"], "description"=>"<p>Effects of a low-fat diet (open circles, regular lines), low-carbohydrate diet (open squares, dashed lines) and a Mediterranean-type diet (open triangles, dotted lines) with similar total energy intake as the low-fat and low-carbohydrate diets contained for both breakfast and lunch combined but eaten only at lunch paired with a glass of red wine (a, effects on glucose; b, effects on insulin; c, effects on serum triglyceride levels; d, effects on the incretin hormone glucose-dependent insulinotropic-polypeptide). All 19 patients with type 2 diabetes tested the three different diets for breakfast and lunch, *corresponds to Wilcoxon's signed rank paired test in comparison with the control (low-fat diet) at the same time-point (p<0.0063) for those variables that displayed differences in AUC (except GIP, see statistics section).</p>", "links"=>[], "tags"=>["diets", "triglycerides", "glucose-dependent", "insulinotropic-polypeptide"], "article_id"=>863181, "categories"=>["Biological Sciences"], "users"=>["Hanna Fernemark", "Christine Jaredsson", "Bekim Bunjaku", "Ulf Rosenqvist", "Fredrik H. Nystrom", "Hans Guldbrand"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0079324.g002", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effects_of_three_different_diets_on_glucose_insulin_triglycerides_and_glucose_dependent_insulinotropic_polypeptide_GIP_/863181", "title"=>"Effects of three different diets on glucose, insulin, triglycerides and glucose-dependent insulinotropic-polypeptide (GIP).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-11-27 02:59:46"}
  • {"files"=>["https://ndownloader.figshare.com/files/1296581"], "description"=>"<p>A p-value of <0.0063 was considered statistically significant.</p><p>Abbreviations, Low-carb., low-carbohydrate diet; GIP, glucose-dependent insulinotropic polypeptide; SD, standard deviation.</p>", "links"=>[], "tags"=>["areas", "curves", "tested", "deviation", "p-value", "comparing", "low-fat", "signed", "ranks"], "article_id"=>863182, "categories"=>["Biological Sciences"], "users"=>["Hanna Fernemark", "Christine Jaredsson", "Bekim Bunjaku", "Ulf Rosenqvist", "Fredrik H. Nystrom", "Hans Guldbrand"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0079324.t003", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Levels_of_the_areas_under_the_curves_for_the_tested_variables_standard_deviation_and_the_p_value_when_comparing_with_the_low_fat_control_group_at_the_same_time_period_Wilcoxon_Signed_Ranks_Test_/863182", "title"=>"Levels of the areas under the curves for the tested variables, standard deviation and the p-value when comparing with the low-fat (control) group at the same time period (Wilcoxon Signed Ranks Test).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-11-27 02:59:46"}
  • {"files"=>["https://ndownloader.figshare.com/files/1296582"], "description"=>"<p>Abbreviations: BMI, body mass index; BP, blood pressure; n, number; m, mean value; SD, standard deviation.</p>", "links"=>[], "tags"=>["patients"], "article_id"=>863183, "categories"=>["Biological Sciences"], "users"=>["Hanna Fernemark", "Christine Jaredsson", "Bekim Bunjaku", "Ulf Rosenqvist", "Fredrik H. Nystrom", "Hans Guldbrand"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0079324.t002", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Baseline_characteristics_of_the_patients_in_the_morning_of_the_first_individual_test_meal_/863183", "title"=>"Baseline characteristics of the patients in the morning of the first individual test meal.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-11-27 02:59:46"}

PMC Usage Stats | Further Information

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Relative Metric

{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[269, 466, 588, 697, 800, 896, 988, 1076, 1165, 1254, 1340, 1417]}, {"subject_area"=>"/Biology and life sciences/Biochemistry", "average_usage"=>[266, 468, 593, 703, 804, 903, 993, 1084, 1171, 1256, 1339, 1422, 1492]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[264, 460, 584, 692, 794, 887, 978, 1067, 1154, 1241, 1328, 1408, 1474]}, {"subject_area"=>"/Medicine and health sciences/Nutrition", "average_usage"=>[273, 476, 611, 714, 821, 911, 1005, 1103, 1201, 1287, 1388, 1478, 1557]}, {"subject_area"=>"/Physical sciences", "average_usage"=>[254, 431, 547, 651, 748, 842, 932, 1017, 1098, 1178, 1259, 1336, 1404]}, {"subject_area"=>"/Physical sciences/Chemistry", "average_usage"=>[247, 429, 544, 647, 747, 842, 929, 1012, 1099, 1179, 1263, 1339, 1409]}]}
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